1. Platelet Alpha-2 Receptors in Normotensive and Hypertensive Pregnancies in Blacks
- Author
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Gwyneeda Carter, Baha M. Sibai, Sergio Cardoso, Christopher Walker, El Sayed S. Arafat, Sandra Stringfellow, Monica H. Govan, and Carolyn M. Chesney
- Subjects
medicine.medical_specialty ,business.industry ,Antagonist ,Obstetrics and Gynecology ,medicine.disease ,Preeclampsia ,Yohimbine ,Dissociation constant ,Endocrinology ,Internal medicine ,Internal Medicine ,medicine ,Gestation ,Platelet ,Alpha-2 adrenergic receptor ,Receptor ,business ,medicine.drug - Abstract
It is known that hypertension among blacks starts at earlier ages and has a higher mortality rate as compared to other populations. Alpha-2 receptors were compared in the platelets of normotensive (n=19) and hypertensive pregnant black women (n=29). Characterization and identification of alpha-2 receptors were performed by radio receptor assay. Platelet membranes were incubated with various concentrations of [3H]yohimbine as an alpha-2 antagonist. The maximum number of binding sites (Bmax) and dissociation constant (Kd) were determined by Scatchard analysis. The maximum number of binding sites were 331 fM/mg (normotensive n=19), 286 fM/mg (chronic hypertension n=12), and 357 fM/mg (preeclampsia n=17). These values were not statistically significant. Conclusions: alpha-2 platelet receptors are not altered in hypertensive pregnancies.
- Published
- 1992
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