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Introduction: Ovarian cancer remains despite ogress in imaging, biology and treatment prognosis wrong with survival at 5 years to 48.4%. Objective: The aim of our work is to have an epidemiological and clinical profile of these cancers and insight regarding its support within our service. Materials and Methods: This is a retrospective study of patient records with cancer of the ovary and treated at Medical Oncology Service of the University Hospital Sidi Bel Abbes for 20 months in the period from January 2013 to September 2015. Results: 34 cases were treated, including 31 for ovarian pathology, 2 carcinomatous ascites of unknown origin, 1 case of gelatinous ascites. Among the 31 cases of ovarian neoplasia, 13 cases were classified (stage IIIc, IV). The average age was 54.6 years with extremes [28-72 years]. 03 patients were single (23%). The notion of family neoplasia grade 1 was found in 02 patients (breast cancer). 01 single patient presented with primary infertility (7%) and treated by fertility drugs. The most common histological type was serous cystadenocarcinoma in 23% of cases and papillary serous cystadenocarcinoma-in 15% of cases. it was decided no treatment in 02 of our patients, 03 patients were treated by another protocol and 8 patients were treated with triple therapy (paclitaxel-carboplatin + bevacizumab) in 80% of cases. The cytoreduction surgery was done in 61% of cases. Surgical revision was performed in three of our patients (37%). The average number of treatment was 06 cures. For Tolerance; 01 single case requiring the reduction of 75% for doses leukoneutropenia. As for the therapeutic response we got 50% partial response, 01 cases and 01 Complete Response progression. The average progression-free survival (PFS) = 11.6 months, Global Survival average was 15 months. Discussion: The average age 54.6 Vs 65 years in literature. -As risk factors - Nulliparity 3 of our patients were single (23%). -The concept of family neoplasia was found in 2 of our patients (15%), and 2 cases it was 1 degree, breast cancer, suggesting a BRCA mutation? impossible to confirm without Genetic analysis vs 10% in the literature. -1 Single patient presented with primary infertility (7%) treated by fertility drugs -The Most common histological type serous cystadenocarcinoma (23%), followed by papillary cystadenoarcinome-serous (15%). -It was decided no treatment in 2 of our patients, three patients were treated by another protocol to unavailability of one of the products or poor tolerance, and 8 patients were treated by the protocol studied Taxol-Carboplatin-Bevacizumab (80%) of our patients received an average of 6 treatments, we used the Taxol dose 175 mg/m2, carboplatin AUC = 5/6, and bevacizumab at a dose of 15MH / kg, as used in GOG4218 studies and ICON7. -The Median survival below the median are cited in different studies, this may be explained by the advanced stage of disease at diagnosis, the initial surgical management is the main weapon was not always done or suboptimal, which determines the further management and prognosis. Conclusion: VEGF expression and the degree of tumor angiogenesis are associated with ascites in tumor progression and low prognostic characterize advanced stages. In advanced ovarian cancer stage, the risk of relapse after treatment is the first large, conventional chemotherapy combining bevacizumab may delay this relapse to 50% longer. [ABSTRACT FROM AUTHOR]

In this study, we set out to modify poly(lactic acid) (PLA) by incorporating epoxidized ionic liquids (ILs) that were specifically designed with imidazolium-NTf 2 moieties. First, we synthesized di-, tri- and tetra-epoxidized ILs, which were incorporated into a PLA matrix at 3, 5, and 10 wt% through a melt extrusion process. We investigated the relationship between the structure and properties of the resulting materials in terms of thermal, mechanical, rheological, and surface properties. The results showed the potential of ILs to impact these properties. Notably, the tri- and tetra-epoxidized ILs enhanced the thermal stability of the PLA matrix as well as the crystallinity while reducing the glass transition temperature and melting point, which is promising for reactive extrusion processing. Overall, this research opens new routes for using reactive ILs to improve the processing and properties of PLA polymers.

The study of the viscoelastic properties of polymer systems containing huge internal two-dimensional interfacial areas, such as blends, foams and multilayer films, is of growing interest and plays a significant role in a variety of industrial fields. Hence, interfacial rheology can represent a powerful tool to directly investigate these complex polymer-polymer interfaces. First, the current review summarizes the theoretical basics and fundamentals of interfacial shear rheology. Particular attention has been devoted to the double-wall ring (DWR), bicone, Du Noüy ring and oscillating needle (ISR) systems. The measurement of surface and interfacial rheological properties requires a consideration of the relative contributions of the surface stress arising from the bulk sub-phases. Here, the experimental procedures and methodologies used to correct the numerical data are described considering the viscoelastic nature of the interface. Second, the interfacial dilational rheology is discussed, starting with the theory and underlying principles. In particular, the Langmuir trough method, the oscillating spinning drop technique and the oscillating pendant drop technique are investigated. The major pioneering studies and latest innovations dedicated to interfacial rheology in both shear and dilatation-compression are highlighted. Finally, the major challenges and limits related to the development of high-temperature interfacial rheology at the molten state are presented. The latter shows great potential for assessing the interfaces of polymer systems encountered in many high-value applications.