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1. Functional outcomes in symptomatic versus asymptomatic patients undergoing incisional hernia repair: Replacing one problem with another? A prospective cohort study in 1312 patients

Author

Abet, E., Ain, J.-F., Arnalsteen, L., Baraket, O., Beck, M., Bellouard, A., Benizri, E., Berney, C., Bilem, D., Binot, D., Blanc, B., Blazquez, D., Bonan, A., Boukortt, T., Brehant, O., Cas, O., Champault-Fezais, A., Chau, A., Chollet, J.-M., Constantin, M., Cossa, J.-P., Dabrowski, A., David, A., Demaret, S., Dubuisson, V., Dugue, T., El Nakadi, I., Faure, J.-P., Frileux, P., Fromont, G., Gadiri, N., Gillion, J.-F., Glehen, O., Hennequin, S., Isambert, M., Jurczak, F., Khalil, H., Lamblin, A., Largenton, C., Lavy, M., Lepère, M., Le Toux, N., Magne, E., Manfredelli, S., Mariette, C., Marion, Y., Mercoli, H.-A., Mesli Smain, N., Moszkowicz, D., Najim, M., Oberlin, O., Odet, E., Ortega Deballon, P., Pavis d’Escurac, X., Pichot Delahaye, V., Putinier, J.B., Regimbeau, J.M., Renard, Y., Romain, B., Rouquie, D., Soler, M., Soufron, J., Roos, S., Thillois, J.-M., Tiry, P., Vauchaussade De Chaumont, A., Vinatier, E., Vu, P., Verhaeghe, R., Zaranis, C., Zeineb, M., de Smet, Gijs H.J., Sneiders, Dimitri, Yurtkap, Yagmur, Menon, Anand G., Jeekel, Johannes, Kleinrensink, Gert-Jan, Lange, Johan F., and Gillion, Jean-François

Published
2020
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3. Multicentre study of neoadjuvant chemotherapy for stage I and II oesophageal cancer

Author

Bekkar, S., Gronnier, C., Renaud, F., Duhamel, A., Pasquer, A., Théreaux, J., Gagnière, J., Meunier, B., Collet, D., Mariette, C., Dhahri, A., Lignier, D., Cossé, C., Regimbeau, J.-M., Luc, G., Cabau, M., Jougon, J., Badic, B., Lozach, P., Bail, J. P., Cappeliez, S., El Nakadi, I., Lebreton, G., Alves, A., Flamein, R., Pezet, D., Pipitone, F., Stan-Iuga, B., Contival, N., Pappalardo, E., Coueffe, X., Msika, S., Mantziari, S., Demartines, N., Hec, F., Vanderbeken, M., Tessier, W., Briez, N., Fredon, F., Gainant, A., Mathonnet, M., Bigourdan, J. M., Mezoughi, S., Ducerf, C., Baulieux, J., Mabrut, J.-Y., Baraket, O., Poncet, G., Adam, M., Vaudoyer, D., Enfer, P. Jourdan, Villeneuve, L., Glehen, O., Coste, T., Fabre, J.-M., Marchal, F., Frisoni, R., Ayav, A., Brunaud, L., Bresler, L., Cohen, C., Aze, O., Venissac, N., Pop, D., Mouroux, J., Donici, I., Prudhomme, M., Felli, E., Lisunfui, S., Seman, M., Petit, G. Godiris, Karoui, M., Tresallet, C., Ménégaux, F., Vaillant, J.-C., Hannoun, L., Malgras, B., Lantuas, D., Pautrat, K., Pocard, M., Valleur, P., Lefevre, J. H., Chafai, N., Balladur, P., Lefrançois, M., Parc, Y., Paye, F., Tiret, E., Nedelcu, M., Laface, L., Perniceni, T., Gayet, B., Turner, K., Filipello, A., Porcheron, J., Tiffet, O., Kamlet, N., Chemaly, R., Klipfel, A., Pessaux, P., Brigand, C., Rohr, S., Carrère, N., Da Re, C., Dumont, F., Goéré, D., Elias, D., and Bertrand, C.

Published
2016
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4. A rare presentation of small diaphragmatic epidermoid cyst with extremely elevated serum CA19-9 level

Author

Coppens E, Ali Bohlok, Patrizia Loi, Pieter Demetter, Melody El-Khoury, El Nakadi I, and Youssef A. Sleiman

Subjects
Pathology, medicine.medical_specialty, CA-19-9 Antigen, Diaphragm, Epidermal Cyst, Diaphragmatic breathing, Spleen, 030230 surgery, Elevated serum, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, business.industry, En bloc resection, General Medicine, Epidermoid cyst, Middle Aged, medicine.disease, medicine.anatomical_structure, Online Case Report, Positron-Emission Tomography, Immunohistochemistry, Female, Surgery, CA19-9, Presentation (obstetrics), Tomography, X-Ray Computed, business, Biomarkers
Abstract

Epidermoid cysts are rare lesions that can occur anywhere in the body. They are associated with elevated serum levels of CA 19-9. The spleen represents the most common site of intra-abdominal localisation. Only two cases of diaphragmatic epidermoid cyst are reported in the literature. We present the case of a 61-year-old woman with a small suprasplenic subdiaphragmatic cyst discovered during the investigation of left flank pain. The establishment of an adequate diagnosis was challenging due to the difficulty in specifying the exact localisation of the cyst, the extremely elevated CA 19-9 level of 19,000 and the high uptake on 18-fluoro-2-deoxy-D-glucose positron emission tomography. The definitive diagnosis followed complete surgical excision. Intra-abdominal epidermoid cysts are usually discovered incidentally on imaging for another reason. The cyst is lined by squamous epithelium responsible for the secretion of CA 19-9. The elevation of serum CA 19-9 is due to small rupture or increased intraluminal pressure followed by diffusion to the bloodstream. Surgery with en-bloc resection represents the optimal treatment to avoid any risk of recurrence. The definitive diagnosis is established by demonstrating positive immunohistopathological staining of epithelial cell to CA 19.9.

Published
2020

5. Classification of primary and incisional abdominal wall hernias

Author

Muysoms, F. E., Miserez, M., Berrevoet, F., Campanelli, G., Champault, G. G., Chelala, E., Dietz, U. A., Eker, H. H., El Nakadi, I., Hauters, P., Hidalgo Pascual, M., Hoeferlin, A., Klinge, U., Montgomery, A., Simmermacher, R. K. J., Simons, M. P., Śmietański, M., Sommeling, C., Tollens, T., Vierendeels, T., and Kingsnorth, A.

Published
2009
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8. Functional outcomes in symptomatic versus asymptomatic patients undergoing incisional hernia repair: Replacing one problem with another? A prospective cohort study in 1312 patients

Author

Smet, G.H.J. de, Sneiders, D. (Dimitri), Yurtkap, Y. (Yağmur), Menon, A.G. (Anand), Jeekel, J. (Hans), Kleinrensink, G.J. (Gert Jan), Lange, J.F. (Johan), Gillion, J.-F. (Jean-François), Abet, E. (E.), Ain, J.-F. (J. F.), Arnalsteen, L. (L.), Baraket, O. (O.), Beck, M. (M.), Bellouard, A. (A.), Benizri, E. (E.), Berney, C. (C.), Bilem, D. (D.), Binot, D. (D.), Blanc, B. (B.), Blazquez, D. (D.), Bonan, A. (A.), Boukortt, T. (T.), Brehant, O. (O.), Cas, O. (O.), Champault-Fezais, A. (A.), Chau, A. (A.), Chollet, J.-M. (J. M.), Constantin, M. (M.), Cossa, J.-P. (J. P.), Dabrowski, A. (A.), David, A. (A.), Demaret, S. (S.), Dubuisson, V. (V.), Dugue, T. (T.), El Nakadi, I., Faure, J.-P. (J. P.), Frileux, P. (P.), Fromont, G. (G.), Gadiri, N. (N.), Gillion, J.F. (Jean-Francois), Glehen, O. (O.), Hennequin, S. (S.), Isambert, M. (M.), Jurczak, F. (F.), Khalil, H. (H.), Lamblin, A. (A.), Largenton, C. (C.), Lavy, M. (M.), Lepère, M. (M.), Le Toux, N. (N.), Magne, E. (E.), Manfredelli, S. (S.), Mariette, C. (Christophe), Marion, Y. (Y.), Mercoli, H.-A. (H. A.), Mesli Smain, N. (N.), Moszkowicz, D. (D.), Najim, M. (M.), Oberlin, O. (O.), Odet, E. (E.), Ortega Deballon, P. (P.), Pavis d'Escurac, X. (X.), Pichot Delahaye, V. (V.), Putinier, J.B. (J. B.), Regimbeau, J.M. (J. M.), Renard, Y. (Y.), Romain, B. (B.), Rouquie, D. (D.), Soler, M. (M.), Soufron, J. (J.), Roos, S. (S.), Thillois, J.-M. (J. M.), Tiry, P. (P.), Vauchaussade De Chaumont, A. (A.), Vinatier, E. (E.), Vu, P. (P.), Verhaeghe, R. (R.), Zaranis, C. (C.), Zeineb, M. (M.), Smet, G.H.J. de, Sneiders, D. (Dimitri), Yurtkap, Y. (Yağmur), Menon, A.G. (Anand), Jeekel, J. (Hans), Kleinrensink, G.J. (Gert Jan), Lange, J.F. (Johan), Gillion, J.-F. (Jean-François), Abet, E. (E.), Ain, J.-F. (J. F.), Arnalsteen, L. (L.), Baraket, O. (O.), Beck, M. (M.), Bellouard, A. (A.), Benizri, E. (E.), Berney, C. (C.), Bilem, D. (D.), Binot, D. (D.), Blanc, B. (B.), Blazquez, D. (D.), Bonan, A. (A.), Boukortt, T. (T.), Brehant, O. (O.), Cas, O. (O.), Champault-Fezais, A. (A.), Chau, A. (A.), Chollet, J.-M. (J. M.), Constantin, M. (M.), Cossa, J.-P. (J. P.), Dabrowski, A. (A.), David, A. (A.), Demaret, S. (S.), Dubuisson, V. (V.), Dugue, T. (T.), El Nakadi, I., Faure, J.-P. (J. P.), Frileux, P. (P.), Fromont, G. (G.), Gadiri, N. (N.), Gillion, J.F. (Jean-Francois), Glehen, O. (O.), Hennequin, S. (S.), Isambert, M. (M.), Jurczak, F. (F.), Khalil, H. (H.), Lamblin, A. (A.), Largenton, C. (C.), Lavy, M. (M.), Lepère, M. (M.), Le Toux, N. (N.), Magne, E. (E.), Manfredelli, S. (S.), Mariette, C. (Christophe), Marion, Y. (Y.), Mercoli, H.-A. (H. A.), Mesli Smain, N. (N.), Moszkowicz, D. (D.), Najim, M. (M.), Oberlin, O. (O.), Odet, E. (E.), Ortega Deballon, P. (P.), Pavis d'Escurac, X. (X.), Pichot Delahaye, V. (V.), Putinier, J.B. (J. B.), Regimbeau, J.M. (J. M.), Renard, Y. (Y.), Romain, B. (B.), Rouquie, D. (D.), Soler, M. (M.), Soufron, J. (J.), Roos, S. (S.), Thillois, J.-M. (J. M.), Tiry, P. (P.), Vauchaussade De Chaumont, A. (A.), Vinatier, E. (E.), Vu, P. (P.), Verhaeghe, R. (R.), Zaranis, C. (C.), and Zeineb, M. (M.)

Abstract

Background: Incisional hernias can be associated with pain or discomfort. Surgical repair especially mesh reinforcement, may likewise induce pain. The primary objective was to assess the incidence of pain after hernia repair in patients with and without pre-operative pain or discomfort. The secondary objectives were to determine the preferred mesh type, mesh location and surgical technique in minimizing postoperative pain or discomfort. Materials and methods: A registry-based prospective cohort study was performed, including patients undergoing incisional hernia repair between September 2011 and May 2019. Patients with a minimum follow-up of 3–6 months were included. The incidence of hernia related pain and discomfort was recorded perioperatively. Results: A total of 1312 patients were included. Pre-operatively, 1091 (83%) patients reported pain or discomfort. After hernia repair, 961 (73%) patients did not report pain or discomfort (mean follow-up = 11.1 months). Of the pre-operative asymptomatic patients (n = 221), 44 (20%, moderate or severe pain: n = 14, 32%) reported pain or discomfort after mean follow-up of 10.5 months. Of those patients initially reporting pain or discomfort (n = 1091), 307 (28%, moderate or severe pain: n = 80, 26%) still reported pain or discomfort after a mean follow-up of 11.3 months postoperatively. Conclusion: In symptomatic incisional hernia patients, hernia related complaints may be resolved in the majority of cases undergoing surgical repair. In asymptomatic incisional hernia patients, pain or discomfort may be induced in a considerable number of patients due to surgical repair and one should be aware if this postoperative complication.

Published
2020
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11. Functional outcomes in symptomatic versus asymptomatic patients undergoing incisional hernia repair: Replacing one problem with another? A prospective cohort study in 1312 patients

Author

de Smet, Gijs H.J., primary, Sneiders, Dimitri, additional, Yurtkap, Yagmur, additional, Menon, Anand G., additional, Jeekel, Johannes, additional, Kleinrensink, Gert-Jan, additional, Lange, Johan F., additional, Gillion, Jean-François, additional, Abet, E., additional, Ain, J.-F., additional, Arnalsteen, L., additional, Baraket, O., additional, Beck, M., additional, Bellouard, A., additional, Benizri, E., additional, Berney, C., additional, Bilem, D., additional, Binot, D., additional, Blanc, B., additional, Blazquez, D., additional, Bonan, A., additional, Boukortt, T., additional, Brehant, O., additional, Cas, O., additional, Champault-Fezais, A., additional, Chau, A., additional, Chollet, J.-M., additional, Constantin, M., additional, Cossa, J.-P., additional, Dabrowski, A., additional, David, A., additional, Demaret, S., additional, Dubuisson, V., additional, Dugue, T., additional, El Nakadi, I., additional, Faure, J.-P., additional, Frileux, P., additional, Fromont, G., additional, Gadiri, N., additional, Gillion, J.-F., additional, Glehen, O., additional, Hennequin, S., additional, Isambert, M., additional, Jurczak, F., additional, Khalil, H., additional, Lamblin, A., additional, Largenton, C., additional, Lavy, M., additional, Lepère, M., additional, Le Toux, N., additional, Magne, E., additional, Manfredelli, S., additional, Mariette, C., additional, Marion, Y., additional, Mercoli, H.-A., additional, Mesli Smain, N., additional, Moszkowicz, D., additional, Najim, M., additional, Oberlin, O., additional, Odet, E., additional, Ortega Deballon, P., additional, Pavis d’Escurac, X., additional, Pichot Delahaye, V., additional, Putinier, J.B., additional, Regimbeau, J.M., additional, Renard, Y., additional, Romain, B., additional, Rouquie, D., additional, Soler, M., additional, Soufron, J., additional, Roos, S., additional, Thillois, J.-M., additional, Tiry, P., additional, Vauchaussade De Chaumont, A., additional, Vinatier, E., additional, Vu, P., additional, Verhaeghe, R., additional, Zaranis, C., additional, and Zeineb, M., additional

Published
2020
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20. Wilkie's syndrome

Author

Nana, A.M., Closset, J., Muls, V., Kouame, J., Jeanmart, J., van Gossum, A., Gelin, M., and El Nakadi, I.

Published
2003
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21. Near infrared fluorescence imaging after intraoperative injection of indocyanine green to improve the staging during cytoreductive surgery for peritoneal carcinomatosis of colorectal origin: results of a pilot prospective study (NCT02032485)

Author

Liberale, G., primary, Vankerckhove, S., additional, Gomez Galdon, M., additional, Ahmed, B., additional, El Nakadi, I., additional, Larsimont, D., additional, Donckier, V., additional, and Bourgeois, P., additional

Published
2017
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25. The role of PET scan in the preoperative management of oesophageal cancer

Author

Gabriel Liberale, Jl, Laethem, Gay F, Goldman S, Nagy N, Coppens E, Gelin M, and El Nakadi I

Subjects
Adult, Male, medicine.medical_specialty, Esophageal Neoplasms, Gastroenterology, Sensitivity and Specificity, Fluorodeoxyglucose F18, Internal medicine, TUMOUR DETECTION, Biopsy, medicine, Humans, 18fdg pet, Neoplasm Metastasis, Aged, Neoplasm Staging, Aged, 80 and over, medicine.diagnostic_test, business.industry, Cancer, General Medicine, Second primary cancer, Middle Aged, medicine.disease, Oncology, Lymphatic Metastasis, Surgery, Female, Radiology, Esophagogastric Junction, Radiopharmaceuticals, business, Tomography, X-Ray Computed, Tomography, Emission-Computed
Abstract

Aim The aim of this study was to evaluate the role of the 18F-FDG-PET in the preoperative evaluation of patients with oesophageal or gastro-oesophageal junction (GEJ) cancer and to define its impact on therapeutic management. Patients and methods This study included 58 patients with biopsy proven oesophageal or GEJ cancer who underwent PET in addition to the conventional diagnostic work-up. The sensitivity, specificity and accuracy of CT and PET were calculated for detection of tumour and distant metastases. Results The sensitivity, specificity and accuracy of tumour detection were, respectively, 84, 100 and 84% for CT and 87, 100 and 87% for PET (p=ns). PET permitted detection of distant metastases, which were not seen on CT in seven patients. In two patients, a second primary tumour was detected on PET. Conclusions The sensitivity of PET for loco regional lymph nodes detection is low. The major clinical impact is the detection of distant metastases.

Published
2004

26. Cholangitis caused by Roux-en-Y hepaticojejunostomy obstruction by a biliary stone after liver transplantation

Author

J. Jeanmart, Donckier, El Nakadi I, Michel Gelin, and De Moor

Subjects
Adult, Male, medicine.medical_specialty, Cholangitis, medicine.medical_treatment, Jejunostomy, Liver transplantation, Anastomosis, Scintigraphy, Gastroenterology, Postoperative Complications, Biliary atresia, Cholelithiasis, Internal medicine, medicine, Humans, Radionuclide Imaging, Transplantation, medicine.diagnostic_test, business.industry, Anastomosis, Roux-en-Y, medicine.disease, Roux-en-Y anastomosis, Surgery, Liver Transplantation, Biliary tract, business, Complication
Abstract

Biliary stones may occur after liver transplantation, mostly in relation with biliary strictures. We describe an unusual case of biliary stone developing 18 years after liver transplantation and biliary-enteric anastomosis for biliary atresia, responsible for an acute cholangitis caused by obstruction of the jejunal loop. Surgical exploration allowed the removal of the stone and did not reveal any enteric stricture. Both biliary and enteric anastomosis were patent. An hepatobiliary scintigraphy performed 2 weeks after surgery demonstrated a delayed bile excretion through the jejunal limb and a focal accumulation of the tracer at the level where the stone was found. In conclusion, biliary stone formation could develop after liver transplantation and biliary-enteric anastomosis, in the absence of mechanical stricture, secondarily to bile stasis caused by functional disorder of the efferent jejunal loop. Hepatobiliary scintigraphy plays a central role in the diagnosis and comprehension of such a disorder.

Published
2003

27. Domino hepatic transplantation using the liver from a patient with primary hyperoxaluria

Author

El Nakadi I, Michel Gelin, Hubert Louis, Brigitte Ickx, Donckier, Jean Closset, Michael Adler, Nadine Bourgeois, and Le Moine O

Subjects
Adult, Male, medicine.medical_specialty, Cirrhosis, Tissue and Organ Procurement, medicine.medical_treatment, Liver transplantation, Gastroenterology, Domino, Primary hyperoxaluria, Internal medicine, medicine, Cadaver, Humans, Aged, Hepatitis, Transplantation, Hyperoxaluria, business.industry, Liver and kidney, medicine.disease, Surgery, Liver Transplantation, surgical procedures, operative, Liver, Hepatocellular carcinoma, Tissue and Organ Harvesting, business
Abstract

Background. We report a case of domino liver transplantation using the liver harvested from a patient who underwent a combined liver and kidney transplantation for primary hyperoxaluria (PH). Method. A cadaveric liver transplantation was performed in a 19-year-old man with PH. In a second step, the PH liver harvested from the first patient was transplanted in a 69-year-old man with hepatitis C-related cirrhosis, not a candidate for a classic liver graft owing to multifocal hepatocellular carcinoma. Results. At 8 months after transplantation, the domino recipient has normal hepatic function and no signs of tumoral recurrence, but he progressively developed hyperoxalemia, hyperoxaluria, and renal insufficiency. Conclusion. Regarding the favorable postoperative clinical evolution, domino liver transplantations using livers from PH patients may represent a new opportunity for marginal candidates for liver transplantation. However, the progressive renal insufficiency expected in such domino recipients should limit this procedure to selected cases.

Published
2001

28. Complications of mesh repair in hiatal surgery: about 3 cases and review of the literature.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, De Moor, V, Zalcman, M, Delhaye, M, El Nakadi, I, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, De Moor, V, Zalcman, M, Delhaye, M, and El Nakadi, I

Abstract

Primary repair of large hiatal hernia is associated with high recurrence rate. The use of prosthetic mesh to reinforce the cure seems to lead to less recurrence. Unfortunately, this procedure is still controversial in regard of the possible complications that may occur. We report here 3 cases of complications related to mesh placement in hiatal hernia surgery: an esophageal perforation, an intragastric migration, and a fundic erosion. When a patient complains of epigastric pain or dysphagia with no peritoneal signs, in the postoperative course of mesh placement, an upper endoscopy should be achieved to rule out those complications. The patient must be informed about the mesh placement and he must notify the endoscopist in case of an upper gastrointestinal endoscopy.

Published
2012

29. Increased nerve density in deep infiltrating endometriotic nodules.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Anaf, V, El Nakadi, I, De Moor, V, Chapron, C, Pistofidis, G, Noel, J-C, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Anaf, V, El Nakadi, I, De Moor, V, Chapron, C, Pistofidis, G, and Noel, J-C

Abstract

We hypothesize that the significantly increased number of nerve structures in the endometriotic nodules may contribute to the occurrence of severe and neuropathic pain that characterizes these lesions.

Published
2011

30. Classification of primary and incisional abdominal wall hernias

Author

Muysoms, F.E. (Filip), Miserez, M., Berrevoet, F., Campanelli, G. (Giampiero), Champault, G.G., Chelala, E., Dietz, U.A., Eker, H.H. (Hasan), El Nakadi, I., Hauters, P., Hidalgo Pascual, M., Hoeferlin, A., Klinge, U., Montgomery, A., Simmermacher, R.K.J., Simons, M.P., Śmietański, M., Sommeling, C., Tollens, T., Vierendeels, T., Kingsnorth, A., Muysoms, F.E. (Filip), Miserez, M., Berrevoet, F., Campanelli, G. (Giampiero), Champault, G.G., Chelala, E., Dietz, U.A., Eker, H.H. (Hasan), El Nakadi, I., Hauters, P., Hidalgo Pascual, M., Hoeferlin, A., Klinge, U., Montgomery, A., Simmermacher, R.K.J., Simons, M.P., Śmietański, M., Sommeling, C., Tollens, T., Vierendeels, T., and Kingsnorth, A.

Abstract

Purpose: A classification for primary and incisional abdominal wall hernias is needed to allow comparison of publications and future studies on these hernias. It is important to know whether the populations described in different studies are comparable. Methods: Several membersof the EHS board and some invitees gathered for 2 days to discuss the development of an EHS classific

Published
2009
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31. Actinomycotic abscess of the anterior abdominal wall: a case report and literature review.

Author

UCL - (MGD) Service de chirurgie, Pitot, D, De Moor, V, Demetter, P, Place, S, Gelin, M, El Nakadi, I, UCL - (MGD) Service de chirurgie, Pitot, D, De Moor, V, Demetter, P, Place, S, Gelin, M, and El Nakadi, I

Abstract

Actinomycosis is a rare, chronic, suppurative, pseudotumoral illness caused by an anaerobic gram positive organism usually Actinomyces israelii which can mimick a tumoral pathology leading to a mutilating surgical resection. We report a case of abdominal actinomycosis and a literature review.

Published
2008

32. Role of multidisciplinary meeting in the treatment decision making of patient with Gastro-Intestinal Cancer: Results of a prospective Study

Author

UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer, Liberale, Gabriel, Hendlisz, Alain, Van den Eynde, Marc, Flamen, Patrick, Mahin, C, Bouazza, F, Gomez Galdon, Maria, De Becker, D, Van de Stadt, J, El Nakadi, I, 14th Congress of the European Society of Surgical Oncology, UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer, Liberale, Gabriel, Hendlisz, Alain, Van den Eynde, Marc, Flamen, Patrick, Mahin, C, Bouazza, F, Gomez Galdon, Maria, De Becker, D, Van de Stadt, J, El Nakadi, I, and 14th Congress of the European Society of Surgical Oncology

Abstract

ESSO 2008 best poster awards

Published
2008

41. Intraperitoneal Follicular Dendritic Cell Sarcoma: Role of Chemotherapy and Bone Marrow Allotransplantation in Locally Advanced Disease?

Author

Liberale, G., Keriakos, K., Azerad, M. A., De Saint Aubain, N., and El Nakadi, I.

Abstract

We describe a case of a 44 year-old woman diagnosed with follicular dendritic cell sarcoma (FDCS). FDCS is a very rare disease affecting the dendritic antigen presenting cells and is often misdiagnosed. Surgery is considered the best treatment modality, followed by chemotherapy. In our case, surgical excision was not possible, therefore the patient received two lines of chemotherapy followed by bone marrow allotransplantation, then a third line of chemotherapy with a complete metabolic response seen on PET/computed tomography (CT) follow-up 29 months later. A review of the literature has been performed. [ABSTRACT FROM AUTHOR]

Published
2015
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42. Billary strictures (hilar or anastomotic) after liver transplantation (LT)

Author

Bourgeois, N., primary, Boon, N., additional, Donckier, V., additional, Hut, F., additional, Gustoi, Th., additional, Le Moine, O., additional, Lefebvre, V., additional, El Nakadi, I., additional, Louis, H., additional, Matos, C., additional, Winant, C., additional, Gelin, M., additional, Adler, M., additional, and Deviere, J., additional

Published
2002
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43. Increased Nerve Density in Deep Infiltrating Endometriotic Nodules.

Author

Anaf, V., El Nakadi, I., De Moor, V., Chapron, C., Pistofidis, G., and Noel, J.-C.

Subjects
*ENDOMETRIOSIS, *PAIN, *HYPERALGESIA, *VAGINAL diseases, *MONOCLONAL antibodies
Abstract

Background/Aims: Deep infiltrating endometriosis is a very painful condition and the mechanism of pain is still poorly understood. Pain and hyperalgesia can partly be explained by an increased number of nerve structures in the painful lesion. In order to clarify this issue, we assessed the nerve density in deep infiltrating endometriotic nodules of the posterior vagina and in the adjacent healthy vaginal tissue of the same patient. Methods: A prospective clinical and pathological study of 31 cases of deep infiltrating vaginal endometriotic nodules was conducted. Fifteen patients were in the proliferative phase and 16 in the secretory phase. The nerve density was studied by immunohistochemistry with the monoclonal antibody NF against neurofilaments in deep infiltrating endometriosis and in the adjacent unaffected vaginal tissue in the proliferative and in the secretory phases. Neurofilaments constitute the main structural elements of neuronal axons and dendrites. Results: The nerve density was significantly different in the endometriotic nodule than in the adjacent unaffected vaginal tissue (p = 0.0013). The same significant difference was found between endometriotic nodules and the unaffected vagina in the proliferative phase (p = 0.009) and in the secretory phase (p = 0.04). This difference was not significant between the proliferative and the secretory phases in the endometriotic lesions and in the controls. Conclusions: We hypothesize that the significantly increased number of nerve structures in the endometriotic nodules may contribute to the occurrence of severe and neuropathic pain that characterizes these lesions Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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44. Nissen versus Toupet fundoplication: Results of a randomized and multicenter trial.

Author

Gu&;#x00E9;rin, E., Bétroune, K., Closset, J., Mehdi, A., Lefèbvre, J. C., Houben, J. J., Gelin, M., Vaneukem, P., and El Nakadi, I.

Subjects
FUNDOPLICATION, ESOPHAGEAL surgery, THERAPEUTIC complications, ESOPHAGUS diseases, HEALTH outcome assessment
Abstract

Laparoscopic Toupet fundoplication (TF) is reported to be as effective as Nissen (NF), but to be associated with fewer unfavorable postoperative side-effects. This study evaluates the one- and three-year clinical outcome of 140 randomized patients after a laparoscopic NF or TF. Inclusion criteria included patients over 16 years old with complications of gastro-oesophageal reflux disease (GORD) and persistence or recurrence of symptoms after three months of treatment. Subjects with a previous history of gastric surgery or repeated fundoplication, brachy-oesophagus or severe abnormal manometry results were excluded. Seventy-seven NF and 63 TF were performed. The severity of symptoms was assessed before and after the procedure. One hundred and twenty-one of the 140 patients after one year, and 118 after three years, were evaluated and no statistically significant clinical difference was observed. The level of satisfaction concerning the outcome of the operation remained high after one or three years regardless of the type of fundoplication performed. Functional complications after NF are not avoided with TF. [ABSTRACT FROM AUTHOR]

Published
2007
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45. Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules.

Author

Anaf, V., Simon, Ph., Nakadi, I. El, Fayt, I., Buxant, F., Simonart, Th., Peny, M.-O., Noel, J.-C., Simon, P, El Nakadi, I, and Simonart, T

Abstract

The histological relationships between fibrotic tissue, endometriotic foci and nerves in the rectovaginal septum endometriotic or adenomyotic nodule were studied. This is considered to be one of the most severe forms of deep endometriosis. Masson's trichrome staining for fibrosis detection and immunohistochemistry with the S100 monoclonal antibody for nerve detection were performed in 28 rectovaginal endometriotic nodules from patients presenting with severe dysmenorrhoea and deep dyspareunia (23 patients with no other endometriotic location or potential cause of pain at laparoscopy and ultrasonography; five patients with multiple pelvic endometriotic localizations and other potential causes of pain at laparoscopy). Patients were allocated to two groups on the basis of their preoperative pain scores for pelvic pain, dysmenorrhoea and deep dyspareunia (group 1, score >7; group 2, score < or =7). For each symptom, the mean number of nerves and endometriotic lesions per high-power field and the mean largest diameter of the lesions were not statistically different in groups 1 and 2. The mean percentages of nerves located within the fibrosis of the nodule and within endometriotic lesions were significantly higher in group 1 than in group 2. Among nerves located within endometriotic lesions, there was a significantly higher proportion showing intraneurial and perineurial invasion by endometriosis in group 1 than in group 2. In rectovaginal endometriotic nodules, there was a close histological relationship between nerves and endometriotic foci, and between nerves and the fibrotic component of the nodule. We postulate that such topographical relationships could at least partially explain the strong association between this lesion and pain. [ABSTRACT FROM AUTHOR]

Published
2000
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46. Sigmoid endometriosis and ovarian stimulation.

Author

Anaf, Vincent, Nakadi, Issam El, Simon, Philippe, Englert, Yvon, Peny, Marie-Odile, Fayt, Isabelle, Noel, Jean-Christophe, Anaf, V, El Nakadi, I, Simon, P, Englert, Y, Peny, M O, Fayt, I, and Noel, J C

Abstract

In-vitro fertilization (IVF) and ovarian stimulation are frequently performed in patients with endometriosis. Although endometriosis is a hormone-dependent disease, the rate of IVF complications related to endometriosis is low. We report four cases of severe digestive complications due to the rapid growth of sigmoid endometriosis under ovarian stimulation. In three patients, sigmoid endometriosis was diagnosed at laparoscopy for sterility. Because of the absence of digestive symptoms or repercussion on the bowel, no bowel resection was performed before ovarian stimulation. All patients experienced severe digestive symptoms during ovarian stimulation, and a segmental sigmoid resection had to be performed. Analysis of endoscopic and radiological data demonstrated that bowel lesions of small size may rapidly enlarge and become highly symptomatic under ovarian stimulation. At immunohistochemistry, these infiltrating lesions displayed high populations of steroid receptors and a high proliferative index (Ki-67 activity), suggesting a strong dependence on circulating ovarian hormones and a potential for rapid growth under supraphysiological oestrogen concentrations. Clinicians should be aware of this rare but severe digestive complication of ovarian stimulation. The early diagnosis of such lesions may help the patients to avoid months of morbidity falsely attributed to ovarian stimulation side effects. Further experience is necessary to determine the optimal attitude when diagnosing a small and asymptomatic endometriotic bowel lesion before ovarian stimulation. [ABSTRACT FROM AUTHOR]

Published
2000
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48. Gynaecology. Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules

Author

Anaf, V., Simon, Ph., El Nakadi, I., Fayt, I., Buxant, F., Simonart, Th., Peny, M.-O., and Noel, J.-C.

Abstract

The histological relationships between fibrotic tissue, endometriotic foci and nerves in the rectovaginal septum endometriotic or adenomyotic nodule were studied. This is considered to be one of the most severe forms of deep endometriosis. Masson's trichrome staining for fibrosis detection and immunohistochemistry with the S100 monoclonal antibody for nerve detection were performed in 28 rectovaginal endometriotic nodules from patients presenting with severe dysmenorrhoea and deep dyspareunia (23 patients with no other endometriotic location or potential cause of pain at laparoscopy and ultrasonography; five patients with multiple pelvic endometriotic localizations and other potential causes of pain at laparoscopy). Patients were allocated to two groups on the basis of their preoperative pain scores for pelvic pain, dysmenorrhoea and deep dyspareunia (group 1, score >7; group 2, score ≤7). For each symptom, the mean number of nerves and endometriotic lesions per high-power field and the mean largest diameter of the lesions were not statistically different in groups 1 and 2. The mean percentages of nerves located within the fibrosis of the nodule and within endometriotic lesions were significantly higher in group 1 than in group 2. Among nerves located within endometriotic lesions, there was a significantly higher proportion showing intraneurial and perineurial invasion by endometriosis in group 1 than in group 2. In rectovaginal endometriotic nodules, there was a close histological relationship between nerves and endometriotic foci, and between nerves and the fibrotic component of the nodule. We postulate that such topographical relationships could at least partially explain the strong association between this lesion and pain.

Published
2000

49. Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter.

Author

El Nakadi, I., Closset, J., De Moor, V., Coppens, E., Zalcman, M., Devière, J., Gelin, M., and Devière, J

Subjects
*ESOPHAGEAL surgery, *SPHINCTER surgery, *LAPAROSCOPIC surgery, *FUNDOPLICATION, *GASTROESOPHAGEAL reflux treatment, *DISSECTION, *COMPARATIVE studies, *ESOPHAGUS, *INJECTIONS, *LAPAROSCOPY, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *POLYSTYRENE, *EVALUATION research
Abstract

Background: We investigated the feasibility, safety, and efficacy of laparoscopic antireflux surgery (LARS) after failure of Enteryx injection in the lower esophageal sphincter for the treatment of gastroesophageal reflux disease (GERD).Methods: Four patients underwent LARS after failure of Enteryx injection. Particular care was taken during the procedure to identify unusual material or fibrosis.Results: All patients underwent LARS successfully. In three patients, tight adhesions with fibrous tissues and black foreign material were observed around the esophagus. No complications occurred during the procedures. The postoperative period was uneventful and functional results were excellent.Conclusion: LARS following Enteryx injection is feasible. Careful dissection is mandatory to avoid operative complications. Both techniques may be considered as options for treating GERD. [ABSTRACT FROM AUTHOR]

Published
2004
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