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19 results on '"El Khawanky, Nadia"'

1. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

Author

Vinnakota, Janaki Manoja, Biavasco, Francesca, Schwabenland, Marius, Chhatbar, Chintan, Adams, Rachael C., Erny, Daniel, Duquesne, Sandra, El Khawanky, Nadia, Schmidt, Dominik, Fetsch, Viktor, Zähringer, Alexander, Salié, Henrike, Athanassopoulos, Dimitrios, Braun, Lukas M., Javorniczky, Nora R., Ho, Jenny N. H. G., Kierdorf, Katrin, Marks, Reinhard, Wäsch, Ralph, Simonetta, Federico, Andrieux, Geoffroy, Pfeifer, Dietmar, Monaco, Gianni, Capitini, Christian, Fry, Terry J., Blank, Thomas, Blazar, Bruce R., Wagner, Eva, Theobald, Matthias, Sommer, Clemens, Stelljes, Matthias, Reicherts, Christian, Jeibmann, Astrid, Schittenhelm, Jens, Monoranu, Camelia-Maria, Rosenwald, Andreas, Kortüm, Martin, Rasche, Leo, Einsele, Hermann, Meyer, Philipp T., Brumberg, Joachim, Völkl, Simon, Mackensen, Andreas, Coras, Roland, von Bergwelt-Baildon, Michael, Albert, Nathalie L., Bartos, Laura M., Brendel, Matthias, Holzgreve, Adrien, Mack, Matthias, Boerries, Melanie, Mackall, Crystal L., Duyster, Justus, Henneke, Philipp, Priller, Josef, Köhler, Natalie, Strübing, Felix, Bengsch, Bertram, Ruella, Marco, Subklewe, Marion, von Baumgarten, Louisa, Gill, Saar, Prinz, Marco, and Zeiser, Robert

Published
2024
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2. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Author

Maas-Bauer, Kristina, Stell, Anna-Verena, Yan, Kai-Li, de Vega, Enrique, Vinnakota, Janaki Manoja, Unger, Susanne, Núñez, Nicolas, Norona, Johana, Talvard-Balland, Nana, Koßmann, Stefanie, Schwan, Carsten, Miething, Cornelius, Martens, Uta S., Shoumariyeh, Khalid, Nestor, Rosa P., Duquesne, Sandra, Hanke, Kathrin, Rackiewicz, Michal, Hu, Zehan, El Khawanky, Nadia, Taromi, Sanaz, Andrlova, Hana, Faraidun, Hemin, Walter, Stefanie, Pfeifer, Dietmar, Follo, Marie, Waldschmidt, Johannes, Melchinger, Wolfgang, Rassner, Michael, Wehr, Claudia, Schmitt-Graeff, Annette, Halbach, Sebastian, Liao, James, Häcker, Georg, Brummer, Tilman, Dengjel, Joern, Andrieux, Geoffroy, Grosse, Robert, Tugues, Sonia, Blazar, Bruce R., Becher, Burkhard, Boerries, Melanie, and Zeiser, Robert

Published
2024
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4. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F., Brown, Michael P., Duyster, Justus, Hein, Lutz, Manz, Markus G., Hughes, Timothy P., White, Deborah L., Yong, Agnes S. M., and Zeiser, Robert

Published
2021
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5. Contributors

Author

Abram, Quinn H., primary, Addas-Carvalho, Marcelo, additional, Alpuche-Lazcano, Sergio P., additional, Alves, Maria João, additional, Alves-Leon, Soniza Vieira, additional, Amaro, Fátima, additional, Araújo, Josélio Maria Galvão de, additional, Araujo-Pereira, Mariana, additional, Aspahan, Maíra Cardoso, additional, Barbosa, Maria Helena de M., additional, Barnard, Trisha R., additional, Beck, Cécile, additional, Benites, Bruno Deltreggia, additional, Beys-da-Silva, Walter Orlando, additional, Bloom, Marshall E., additional, Boivin, Guy, additional, Brault, Aaron C., additional, Cabral-Marques, Otavio, additional, de Caires Junior, Luiz Carlos, additional, Cardoso, Cynthia Chester, additional, Carrillo-Hernández, Marlen Yelitza, additional, Chimelli, Leila, additional, Christo, Paulo Pereira, additional, Chu, Dinh-Toi, additional, Coombs, Kevin M., additional, Costa, Fabio T.M., additional, Costa Monteiro, Lucia Maria, additional, Cristina, Juan, additional, Cunha, Marielton Dos Passos, additional, da Silva Augusto, Lia Giraldo, additional, Desprès, Philippe, additional, Diaz, Adrián, additional, Diderichsen, Finn, additional, Duarte, Alberto José da Silva, additional, Dumarest, Marine, additional, El Khawanky, Nadia, additional, Fernandes, José Veríssimo, additional, Fonseca, Simone G., additional, Fontes-Dantas, Fabrícia Lima, additional, Gadea, Gilles, additional, Gallo, Luciana Guerra, additional, Gatignol, Anne, additional, Gaytán, David Alejandro Cabrera, additional, Gonzalez, Gaelle, additional, Goulart, Ernesto, additional, Gregorio, Ernesto R., additional, Guedes, Paulo Marcos Matta, additional, Hamel, Rodolphe, additional, Hofer, Cristina Barroso, additional, Ismail, Amni Adilah, additional, Jääskeläinen, Anne J., additional, Jen, Soe Hui, additional, Judice, Carla, additional, Kaid, Carolini, additional, Kobayashi, Jun, additional, Lecollinet, Sylvie, additional, Leyser, Marcio, additional, de Magalhães-Barbosa, Maria Clara, additional, Manikam, Rishya, additional, Marques, Fernanda J.P., additional, Martínez-Gutiérrez, Marlen, additional, Martins, Felipe, additional, de Matos, António Pedro Alves, additional, McDonald, Erin M., additional, Meltzer, Eyal, additional, Mendoza, Teresita Rojas, additional, Mitsugi, Thiago, additional, Mlera, Luwanika, additional, Muñiz, Concepción Grajales, additional, Nakaya, Helder I., additional, Nascimento, Andrezza, additional, Nascimento, Gilmara Lima, additional, Nascimento, Manuela Sales Lima, additional, Nascimento, Osvaldo J.M., additional, Nguyen, Tiep Tien, additional, Nieto, Lumumba Arriaga, additional, de Oliveira, Maria Regina Fernandes, additional, Owczarek, Katarzyna, additional, Parás, Alfonso Vallejos, additional, Patel, Vinood B., additional, Peixoto, Henry Maia, additional, Pereira-Gómez, Marianoel, additional, Pfrimer, Irmtraut Araci H., additional, Phumee, Atchara, additional, Piret, Jocelyne, additional, Prata-Barbosa, Arnaldo, additional, Preedy, Victor R., additional, Pyrć, Krzysztof, additional, Rajendram, Rajkumar, additional, Raju, Chandramathi Samudi, additional, Rossi, Átila Duque, additional, Rueda-Lopes, Fernanda Cristina, additional, Ruiz-Saenz, Julian, additional, Sagan, Selena M., additional, Salmeron, Amanda Costa Ayres, additional, Sanabani, Sabri Saeed, additional, Santi, Lucélia, additional, Santos, Wilo Victor dos, additional, Schuch, Viviane, additional, Sekaran, Shamala Devi, additional, Sherwood, Matt, additional, Shrivastava, Prateek Saurabh, additional, Shrivastava, Saurabh RamBihariLal, additional, Siriyasatien, Padet, additional, Son, Nguyen Thai, additional, Tatara, Juliana Miranda, additional, Ten Caten, Felipe, additional, Tho, Ho Huu, additional, Viranaicken, Wildriss, additional, Vivacqua, Daniela Pires Ferreira, additional, Xu, Dan, additional, Xu, Zhiheng, additional, Zatz, Mayana, additional, and Zé-Zé, Libia, additional

Published
2021
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6. Systems immunology of flavivirus infection

Author

Schuch, Viviane, primary, Martins, Felipe, additional, Ten Caten, Felipe, additional, Araujo-Pereira, Mariana, additional, Cunha, Marielton Dos Passos, additional, El Khawanky, Nadia, additional, Cabral-Marques, Otavio, additional, and Nakaya, Helder I., additional

Published
2021
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8. Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease.

Author

Czech, Marie, Schneider, Sophia, Peltokangas, Nina, El Khawanky, Nadia, Ghimire, Sakhila, Andrieux, Geoffroy, Hülsdünker, Jan, Krausz, Máté, Proietti, Michele, Braun, Lukas M., Rückert, Tamina, Langenbach, Marlene, Schmidt, Dominik, Martin, Ina, Wenger, Valentin, de Vega, Enrique, Haring, Eileen, Pourjam, Mohsen, Pfeifer, Dietmar, and Schmitt-Graeff, Annette

Subjects
ACUTE diseases, GRAFT versus host disease, INSULIN-like growth factor receptors, SOMATOMEDIN C, LIPOCALIN-2, NEUTROPHILS
Abstract

Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited. Strategies to promote intestinal tissue tolerance during aGVHD may improve patient outcomes. Using single-cell RNA sequencing, we identified a lipocalin-2 (LCN2)–expressing neutrophil population in mice with intestinal aGVHD. Transfer of LCN2-overexpressing neutrophils or treatment with recombinant LCN2 reduced aGVHD severity, whereas the lack of epithelial or hematopoietic LCN2 enhanced aGVHD severity and caused microbiome alterations. Mechanistically, LCN2 induced insulin-like growth factor 1 receptor (IGF-1R) signaling in macrophages through the LCN2 receptor SLC22A17, which increased interleukin-10 (IL-10) production and reduced major histocompatibility complex class II (MHCII) expression. Transfer of LCN2-pretreated macrophages reduced aGVHD severity but did not reduce graft-versus-leukemia effects. Furthermore, LCN2 expression correlated with IL-10 expression in intestinal biopsies in multiple cohorts of patients with aGVHD, and LCN2 induced IGF-1R signaling in human macrophages. Collectively, we identified a LCN2-expressing intestinal neutrophil population that reduced aGVHD severity by decreasing MHCII expression and increasing IL-10 production in macrophages. This work provides the foundation for administration of LCN2 as a therapeutic approach for aGVHD. Editor's summary: An approach to treating aGVHD. Acute graft-versus-host disease (aGVHD) is a major complication after allogeneic hematopoietic cell transplant (allo-HCT) for which there are limited treatment options. As aGVHD often presents with gastrointestinal (GI) tract inflammation, studying drivers of disease in the GI tract may identify new therapeutic avenues. Here, Czech et al. identified a population of lipocalin-2 (LCN2)–expressing neutrophils that were increased in the GI tract of mice with aGVHD and exhibited a tolerogenic effect by promoting IL-10 production and decreasing MHCII expression on macrophages; similar observations were made across multiple cohorts of patients who received allo-HCT. Transfer of LCN2-overexpressing neutrophils or administration of recombinant LCN2 reduced aGVHD severity across multiple murine allo-HCT models, supporting further development of LCN2 as a therapeutic for aGVHD. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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11. The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations

Author

Filgueiras, Igor Salerno, primary, Torrentes de Carvalho, Amanda, additional, Cunha, Daniela Prado, additional, Mathias da Fonseca, Dennyson Leandro, additional, El Khawanky, Nadia, additional, Freire, Paula Paccielli, additional, Cabral-Miranda, Gustavo, additional, Schimke, Lena F., additional, Camara, Niels Olsen Saraiva, additional, Ochs, Hans D., additional, Peron, Jean Pierre Schatzmann, additional, Cabral-Marques, Otávio, additional, and de Vasconcelos, Zilton Farias Meira, additional

Published
2021
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12. Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome (ICANS) Pathophysiology Is Mediated By Microglia TGF-β-Activated Kinase-1 Signaling

Author

Vinnakota, Janaki Manoja, Biavasco, Francesca, Schwabenland, Marius, Chhatbar, Chintan, Adams, Rachael C, Erny, Daniel, Duquesne, Sandra, El Khawanky, Nadia, Salié, Henrike, Athanassopoulos, Dimitrios, Braun, Lukas, Schmidt, Dominik, Fetsch, Viktor, Javorniczky, Rebeka N., Ho, Jenny N.H.G, Marks, Reinhard, Wäsch, Ralph, Simonetta, Federico, Andrieux, Geoffroy, Pfeifer, Dietmar, Monaco, Gianni, Capitini, Christian, Fry, Terry J., Blank, Thomas, Blazar, Bruce R, Wagner Drouet, Eva-Maria, Theobald, Matthias, Sommer, Clemens, Stelljes, Matthias, Reicherts, Christian, Jeibmann, Astrid, Schittenhelm, Jens, Monoranu, Camelia-Maria, Rosenwald, Andreas, Kortüm, K. Martin, Rasche, Leo, Einsele, Hermann, Meyer, Philipp Tobias, Brumberg, Joachim, Mackensen, Andreas, von Bergwelt-Baildon, Michael, Coras, Roland, Albert, Nathalie L., Bartos, Laura M., Brendel, Matthias, Holzgreve, Adrien, Boerries, Melanie, Mackall, Crystal L., Duyster, Justus, Koehler, Natalie, Strübing, Felix, Bengsch, Bertram, Ruella, Marco, Subklewe, Marion, Baumgarten, Louisa von, Gill, Saar, Prinz, Marco, and Zeiser, Robert

Published
2023
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14. The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age

Author

Freire, Paula P., primary, Marques, Alexandre H.C., additional, Baiocchi, Gabriela C., additional, Schimke, Lena F., additional, Fonseca, Dennyson L.M., additional, Salgado, Ranieri C., additional, Filgueiras, Igor S., additional, Napoleao, Sarah M.S., additional, Plaça, Desirée R., additional, Akashi, Karen T., additional, Hirata, Thiago Dominguez Crespo, additional, El Khawanky, Nadia, additional, Giil, Lasse M., additional, Cabral-Miranda, Gustavo, additional, Carvalho, Robson F., additional, Ferreira, Luis Carlos S., additional, Condino-Neto, Antonio, additional, Nakaya, Helder I., additional, Jurisica, Igor, additional, Ochs, Hans D., additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia G., additional, and Cabral-Marques, Otavio, additional

Published
2021
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15. Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patients

Author

Freire, Paula Paccielli, primary, Marques, Alexandre H. C., additional, Baiocchi, Gabriela Crispim, additional, Schimke, Lena F., additional, Fonseca, Dennyson Leandro M., additional, Salgado, Ranieri Coelho, additional, Filgueiras, Igor Salerno, additional, da Silva Napoleao, Sarah Maria, additional, Plaça, Desirée Rodrigues, additional, Hirata, Thiago Dominguez Crespo, additional, El Khawanky, Nadia, additional, Giil, Lasse Melvaer, additional, de Miranda, Gustavo Cabral, additional, Carvalho, Robson Francisco, additional, de Souza Ferreira, Luis Carlos, additional, Condino-Neto, Antonio, additional, Nakaya, Helder Takashi Imoto, additional, Jurisica, Igor, additional, Ochs, Hans D., additional, Camara, Niels Olsen Saraiva, additional, Calich, Vera Lúcia Garcia, additional, and Cabral-Marques, Otavio, additional

Published
2020
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16. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Author

Mathew, Nimitha R., primary, Vinnakota, Janaki M., additional, Apostolova, Petya, additional, Erny, Daniel, additional, Hamarsheh, Shaimaa, additional, Andrieux, Geoffroy, additional, Kim, Jung-Seok, additional, Hanke, Kathrin, additional, Goldmann, Tobias, additional, Chappell-Maor, Louise, additional, El-Khawanky, Nadia, additional, Ihorst, Gabriele, additional, Schmidt, Dominik, additional, Duyster, Justus, additional, Finke, Jürgen, additional, Blank, Thomas, additional, Boerries, Melanie, additional, Blazar, Bruce R., additional, Jung, Steffen, additional, Prinz, Marco, additional, and Zeiser, Robert, additional

Published
2020
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17. Flow Cytometry Contributions for the Diagnosis and Immunopathological Characterization of Primary Immunodeficiency Diseases With Immune Dysregulation

Author

Cabral-Marques, Otavio, primary, Schimke, Lena F., additional, de Oliveira, Edgar Borges, additional, El Khawanky, Nadia, additional, Ramos, Rodrigo Nalio, additional, Al-Ramadi, Basel K., additional, Segundo, Gesmar Rodrigues Silva, additional, Ochs, Hans D., additional, and Condino-Neto, Antonio, additional

Published
2019
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18. Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells

Author

El Khawanky, Nadia, primary, Hughes, Amy, additional, Yu, Wenbo, additional, Taromi, Sanaz, additional, Clarson, Jade, additional, Lopez, Angel F., additional, Brown, Michael P., additional, Duyster, Justus, additional, Hughes, Timothy P., additional, White, Deborah L., additional, Yong, Agnes S. M., additional, and Zeiser, Robert, additional

Published
2019
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19. Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Author

Markus G. Manz, Deborah L. White, Jade Clarson, Konrad Aumann, Angel F. Lopez, Cornelius Miething, Wenbo Yu, Timothy P. Hughes, Lutz Hein, Janaki Manoja Vinnakota, Amy Hughes, Sanaz Taromi, Robert Zeiser, Tony Matschulla, Justus Duyster, Khalid Shoumariyeh, Agnes S. M. Yong, Renier Myburgh, Michael P. Brown, Nadia El Khawanky, University of Zurich, Yong, Agnes S M, Zeiser, Robert, El Khawanky, Nadia, Hughes, Amy, Yu, Wenbo, Myburgh, Renier, Matschulla, Tony, Taromi, Sanaz, Aumann, Konrad, Clarson, Jade, Vinnakota, Janaki Manoja, Shoumariyeh, Khalid, Miething, Cornelius, Lopez, Angel F, Brown, Michael P, Duyster, Justus, Hein, Lutz, Manz, Markus G, Hughes, Timothy P, White, Deborah L, and Yong, Agnes SM

Subjects
Cytotoxicity, Immunologic, medicine.medical_treatment, Cell, General Physics and Astronomy, Cancer immunotherapy, Kaplan-Meier Estimate, Immunotherapy, Adoptive, hemic and lymphatic diseases, demethylating therapy, Enzyme Inhibitors, cell cytotoxicity, Cytotoxicity, Cells, Cultured, Mice, Knockout, Receptors, Chimeric Antigen, Multidisciplinary, chimeric antigen receptor, Chemistry, Myeloid leukemia, 3100 General Physics and Astronomy, Leukemia, Haematopoiesis, medicine.anatomical_structure, Leukemia, Myeloid, Acute Disease, Azacitidine, Science, T cell, Immunology, Interleukin-3 Receptor alpha Subunit, Receptors, Antigen, T-Cell, HL-60 Cells, 610 Medicine & health, 1600 General Chemistry, acute myeloid leukemia, Article, Acute myeloid leukaemia, General Biochemistry, Genetics and Molecular Biology, 1300 General Biochemistry, Genetics and Molecular Biology, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, General Chemistry, DNA Methylation, medicine.disease, Xenograft Model Antitumor Assays, Chimeric antigen receptor, HEK293 Cells, 10032 Clinic for Oncology and Hematology, Cancer research, human activities, Single-Chain Antibodies
Abstract

Successful treatment of acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) T cells is hampered by toxicity on normal hematopoietic progenitor cells and low CAR T cell persistence. Here, we develop third-generation anti-CD123 CAR T cells with a humanized CSL362-based ScFv and a CD28-OX40-CD3ζ intracellular signaling domain. This CAR demonstrates anti-AML activity without affecting the healthy hematopoietic system, or causing epithelial tissue damage in a xenograft model. CD123 expression on leukemia cells increases upon 5′-Azacitidine (AZA) treatment. AZA treatment of leukemia-bearing mice causes an increase in CTLA-4negative anti-CD123 CAR T cell numbers following infusion. Functionally, the CTLA-4negative anti-CD123 CAR T cells exhibit superior cytotoxicity against AML cells, accompanied by higher TNFα production and enhanced downstream phosphorylation of key T cell activation molecules. Our findings indicate that AZA increases the immunogenicity of AML cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 CAR T cells., The success of CAR-T cells for treating acute myeloid leukaemia (AML) is hampered by toxicity to normal cells and low CAR-T cell persistence. Here, the authors show that the demethylating compound 5′-Azacitdine increases anti-CD123 CAR-T cell cytotoxicity against AML.

Published
2021
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