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Supplemental material, sj-docx-3-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-5-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-4-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-1-opp-10.1177_10781552231187305 for Characteristics of the clinical pharmacist interventions at the National Center for Cancer Care and Research Hospital in Qatar by Sara Al Dali, Daoud Al-Badriyeh, Amaal Gulied, Anas Hamad, Moza Al Hail, Palli Valappila Abdul Rouf, Wessam El-Kassem and Dina Abushanab in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-2-opp-10.1177_10781552231187305 for Characteristics of the clinical pharmacist interventions at the National Center for Cancer Care and Research Hospital in Qatar by Sara Al Dali, Daoud Al-Badriyeh, Amaal Gulied, Anas Hamad, Moza Al Hail, Palli Valappila Abdul Rouf, Wessam El-Kassem and Dina Abushanab in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-2-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

Supplemental material, sj-docx-1-opp-10.1177_10781552231160275 for Cost savings and cost avoidance with the inpatient clinical pharmacist interventions in a tertiary cancer care hospital by Dina Abushanab, Amaal Gulied, Anas Hamad, Mohammad Abu-Tineh, Palli V Abdul Rouf, Moza Al Hail, Wessam El-Kassem, Maguy S El Hajj and Daoud Al-Badriyeh in Journal of Oncology Pharmacy Practice

The aim was to critically appraise, synthesise and present the evidence of medication errors amongst hospitalised patients in Middle Eastern countries, specifically prevalence, nature, severity and contributory factors. CINAHL, Embase, Medline, Pubmed and Science Direct were searched for studies published in English from 2000 to March 2018, with no exclusions. Study selection, quality assessment (using adapted STROBE checklists) and data extraction were conducted independently by two reviewers. A narrative approach to data synthesis was adopted; data related to error causation were synthesised according to Reason’s Accident Causation model. Searching yielded 452 articles, which were reduced to 50 following removal of duplicates and screening of titles, abstracts and full-papers. Studies were largely from Iran, Saudi Arabia, Egypt and Jordan. Thirty-two studies quantified errors; definitions of ‘medication error’ were inconsistent as were approaches to data collection, severity assessment, outcome measures and analysis. Of 13 studies reporting medication errors per ‘total number of medication orders’/ ‘number of prescriptions’, the median across all studies was 10% (IQR 2–35). Twenty-four studies reported contributory factors leading to errors. Synthesis according to Reason’s model identified the most common being active failures, largely slips (10 studies); lapses (9) and mistakes (12); error-provoking conditions, particularly lack of knowledge (13) and insufficient staffing levels (13) and latent conditions, commonly heavy workload (9). There is a need to improve the quality and reporting of studies from Middle Eastern countries. A standardised approach to quantifying medication errors’ prevalence, severity, outcomes and contributory factors is warranted.Other Information Published in: European Journal of Clinical Pharmacology License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1007/s00228-019-02689-y

In 2017, the World Health Organization published “Medication Without Harm, WHO Global Patient Safety Challenge,” to reduce patient harm caused by unsafe medication use practices. While the five objectives emphasise the need to create a framework for action, engaging key stakeholders and others, most published research has focused on the perspectives of health professionals. The aim was to explore the views and experiences of decision-makers in Qatar on organisational safety culture, medication errors and error reporting. Method: Qualitative, semi-structured interviews were conducted with healthcare decision-makers (policy-makers, professional leaders and managers, lead educators and trainers) in Qatar. Participants were recruited via purposive and snowball sampling, continued to the point of data saturation. The interview schedule focused on: error causation and error prevention; engendering a safety culture; and initiatives to encourage error reporting. Interviews were digitally recorded, transcribed and independently analysed by two researchers using the Framework Approach. Results: From the 21 interviews conducted, key themes were the need to: promote trust within the organisation through articulating a fair blame culture; eliminate management, professional and cultural hierarchies; focus on team building, open communication and feedback; promote professional development; and scale-up successful initiatives. There was recognition that the current medication error reporting processes and systems were suboptimal, with suggested enhancements in themes of promoting a fair blame culture and open communication. Conclusion: These positive and negative aspects of organisational culture can inform the development of theory-based interventions to promote patient safety. Central to these will be the further development and sustainment of a “fair” blame culture in Qatar and beyond. The authors wish to acknowledge the contributions of all interviewees, as well as support departments at Hamad Medical Corporation, Doha, Qatar. The study was supported by NPRP grant NPRP 7‐388‐3‐095 from Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors. The publication of this article was funded by the Qatar National Library.

Background Medication errors are a major public health concern that negatively impact patient safety and health outcomes. Effective and efficient medication error reporting systems and practices are imperative in reducing error incidence and severity. Objective The objectives were to quantify the incidence, nature and severity of medication errors, and to explore potential causality using a theoretical framework. Setting The study was conducted at Hamad Medical Corporation, the largest public funded academic healthcare center in the state of Qatar. Methods A retrospective review of medication error reports submitted to the Hamad Medical Corporation incident reporting system during 2015 to 2017. Data related to number of reports, reporter, medication, severity and outcomes were extracted. Reason’s Accident Causation Model was used as a theoretical framework for identifying potential causality. Two researchers independently categorized errors as: active failures (e.g. forgetting to administer medication at scheduled time); error provoking conditions (e.g. medication prescribed by an unauthorized physician and administered to the patient); and latent failures (e.g. organizational factors, lack of resources). Main outcome measures Incidence, classes of medications, reporter, error severity and outcomes, potential causality. Results A total of 5103 reports provided sufficient information to be included in the study giving an estimated error incidence of 0.044% of prescribed medication items. Most of the reports (91.5%, n = 4667) were submitted by pharmacists and majority (87.9%, n = 4485) were prescribing errors. The most commonly reported medications were anti-infectives for systemic use (22.0%, n = 1123) followed by medications to treat nervous system disorders (17.2%, n = 876). Only three errors reported to have caused temporary harm requiring intervention while one contributed to or resulted in temporary harm requiring initial or prolonged hospitalization. In terms of potential causality of medication errors, the majority (91.5%, n = 4671) were classified as active failures. Conclusion Almost all reports were submitted by pharmacists, indicating likely under-reporting affecting the actual incidence. Effort is required to increase the effectiveness and efficiency of the reporting system. The use of the theoretical framework allowed identification of potential causality, largely in relation to active failures, which can inform the basis of interventions to improve medication safety.Other Information Published in: International Journal of Clinical Pharmacy License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1007/s11096-020-01108-y

Binny Thomas,1-3 Mahmoud Mohamed,1,3,4 Moza Al Hail,1-3Fatma Alzahra Y Awwad,1 Ramy M Wahba,1 Sabir B Hassan,1 Khalid Omar,1 Wessam El Kassem,1 Palivalappila Abdul Rouf1 1Hamad Medical Corporation, Doha, Qatar; 2Robert Gordon University, Aberdeen, Scotland, UK; 3Qatar University, Doha, 4Weill Cornell Medical College, Ar-Rayyan, Qatar Abstract: We report a case of 22-year-old primigravida presented to Women’s Hospital – Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as “probably”. Keywords: hyperemesis, drug-induced liver injury, esomeprazole, adverse drug reaction, ADR, proton pump inhibitor