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2. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Author

Huggins, Ashley A, Baird, C Lexi, Briggs, Melvin, Laskowitz, Sarah, Hussain, Ahmed, Fouda, Samar, Haswell, Courtney, Sun, Delin, Salminen, Lauren E, Jahanshad, Neda, Thomopoulos, Sophia I, Veltman, Dick J, Frijling, Jessie L, Olff, Miranda, van Zuiden, Mirjam, Koch, Saskia BJ, Nawjin, Laura, Wang, Li, Zhu, Ye, Li, Gen, Stein, Dan J, Ipser, Jonathan, Seedat, Soraya, du Plessis, Stefan, van den Heuvel, Leigh L, Suarez-Jimenez, Benjamin, Zhu, Xi, Kim, Yoojean, He, Xiaofu, Zilcha-Mano, Sigal, Lazarov, Amit, Neria, Yuval, Stevens, Jennifer S, Ressler, Kerry J, Jovanovic, Tanja, van Rooij, Sanne JH, Fani, Negar, Hudson, Anna R, Mueller, Sven C, Sierk, Anika, Manthey, Antje, Walter, Henrik, Daniels, Judith K, Schmahl, Christian, Herzog, Julia I, Říha, Pavel, Rektor, Ivan, Lebois, Lauren AM, Kaufman, Milissa L, Olson, Elizabeth A, Baker, Justin T, Rosso, Isabelle M, King, Anthony P, Liberzon, Isreal, Angstadt, Mike, Davenport, Nicholas D, Sponheim, Scott R, Disner, Seth G, Straube, Thomas, Hofmann, David, Qi, Rongfeng, Lu, Guang Ming, Baugh, Lee A, Forster, Gina L, Simons, Raluca M, Simons, Jeffrey S, Magnotta, Vincent A, Fercho, Kelene A, Maron-Katz, Adi, Etkin, Amit, Cotton, Andrew S, O’Leary, Erin N, Xie, Hong, Wang, Xin, Quidé, Yann, El-Hage, Wissam, Lissek, Shmuel, Berg, Hannah, Bruce, Steven, Cisler, Josh, Ross, Marisa, Herringa, Ryan J, Grupe, Daniel W, Nitschke, Jack B, Davidson, Richard J, Larson, Christine L, deRoon-Cassini, Terri A, Tomas, Carissa W, Fitzgerald, Jacklynn M, Blackford, Jennifer Urbano, Olatunji, Bunmi O, Kremen, William S, Lyons, Michael J, Franz, Carol E, Gordon, Evan M, May, Geoffrey, Nelson, Steven M, Abdallah, Chadi G, Levy, Ifat, and Harpaz-Rotem, Ilan

Subjects
Clinical and Health Psychology, Psychology, Mind and Body, Mental Illness, Anxiety Disorders, Neurosciences, Brain Disorders, Post-Traumatic Stress Disorder (PTSD), Behavioral and Social Science, Mental Health, Mental health, Humans, Stress Disorders, Post-Traumatic, Cerebellum, Female, Male, Adult, Magnetic Resonance Imaging, Middle Aged, White Matter, Gray Matter, Organ Size, Deep Learning, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p-FDR

Published
2024

3. Internal consistency of the Mental Health Professional Culture Inventory: A pilot study in Romanian population

Author

Denis Frédéric, Kane Hélène, Baumgart Jade Gourret, Rusch Emmanuel, Deloyer Jocelyn, Fuenzalida Claudio, Kelemen Gabriela, Gavrila-Ardelean Mihaela, Krzystanek Marek, Marazziti Donatella, Moraitou Margarita, Reunanen Merja, Shyhrete Rexhaj, El Hage Wissam, Thome Johannes, Verwaest Wim, Rude Nathalie, Laruppe Charline, and Fond-Harmant Laurence

Subjects
psychometric, psychiatry, romania, mental health, professional culture, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: The objective of this study (registered under number 2020 006) was to assess the internal consistency of the revised Mental Health Professional Culture Inventory (MHPCI) scale, which comprises 15 items, among mental health service workers in Romania.

Published
2024
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4. Adherence to clinical practice guidelines for using electroconvulsive therapy in elderly depressive patients

Author

Yrondi, Antoine, Blanc, Olivier, Anguill, Loic, Arbus, Christophe, Boudieu, Ludivine, Patoz, Marie-Camille, Arnould, Adeline, Charpeaud, Thomas, Genty, Jean-Baptiste, Abidine, Racan, Redon, Maximilien, Rey, Romain, Aouizerate, Bruno, Bennabi, Djamila, El-Hage, Wissam, Etain, Bruno, Holtzmann, Jérôme, Leboyer, Marion, Molière, Fanny, Richieri, Raphaelle Marie, Stéphan, Florian, Vaiva, Guillaume, Sauvaget, Anne, Poulet, Emmanuel, Haffen, Emmanuel, Courtet, Philippe, Fossati, Philippe, Llorca, Pierre-Michel, and Samalin, Ludovic

Published
2024
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5. Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study

Author

Kalfon, Pierre, El-Hage, Wissam, Geantot, Marie-Agnès, Favier, Constance, Bodet-Contentin, Laetitia, Kuteifan, Khaldoun, Olivier, Pierre-Yves, Thévenin, Didier, Pottecher, Julien, Crozon-Clauzel, Jullien, Mauchien, Bénédicte, Galbois, Arnaud, de Varax, Roland, Valera, Sabine, Estagnasie, Philippe, Berric, Audrey, Nyunga, Martine, Revel, Nathalie, Simon, Georges, Kowalski, Benjamin, Sossou, Achille, Signouret, Thomas, Leone, Marc, Delalé, Charles, Seemann, Aurélien, Lasocki, Sigismond, Quenot, Jean-Pierre, Monsel, Antoine, Michel, Olivier, Page, Mathieu, Patrigeon, René-Gilles, Nicola, Walid, Thille, Arnaud W., Hekimian, Guillaume, Auquier, Pascal, and Baumstarck, Karine

Published
2024
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14. Cerebral Metabolic Signature of Chronic Benzodiazepine Use in Nondemented Older Adults: An FDG-PET Study in the MEMENTO Cohort

Author

Gallet, Quentin, Bouteloup, Vincent, Locatelli, Maxime, Habert, Marie-Odile, Chupin, Marie, Campion, Jacques-Yves, Michels, Pierre-Emmanuel, Delrieu, Julien, Lebouvier, Thibaud, Balageas, Anna-Chloé, Surget, Alexandre, Belzung, Catherine, Arlicot, Nicolas, Ribeiro, Maria-Joao Santiago, Gissot, Valérie, El-Hage, Wissam, Camus, Vincent, Gohier, Bénédicte, and Desmidt, Thomas

Published
2024
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15. Changes in cerebral connectivity and brain tissue pulsations with the antidepressant response to an equimolar mixture of oxygen and nitrous oxide: an MRI and ultrasound study

Author

Desmidt, Thomas, Dujardin, Paul-Armand, Andersson, Frédéric, Brizard, Bruno, Réméniéras, Jean-Pierre, Gissot, Valérie, Arlicot, Nicolas, Barantin, Laurent, Espitalier, Fabien, Belzung, Catherine, Tanti, Arnaud, Robert, Gabriel, Bulteau, Samuel, Gallet, Quentin, Kazour, François, Cognet, Sandrine, Camus, Vincent, El-Hage, Wissam, Poupin, Pierre, and Karim, Helmet T.

Published
2023
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17. Indirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: A FACE-DR study

Author

Salles, Juliette, Stephan, Florian, Molière, Fanny, Bennabi, Djamila, Haffen, Emmanuel, Bouvard, Alexandra, Walter, Michel, Allauze, Etienne, Llorca, Pierre Michel, Genty, Jean Baptiste, Leboyer, Marion, Holtzmann, Jérôme, Nguon, Anne Sophie, D'Amato, Thierry, Rey, Romain, Horn, Mathilde, Vaiva, Guillaume, Fond, Guillaume, Richieri, Raphaelle, Hennion, Vincent, Etain, Bruno, El-Hage, Wissam, Camus, Vincent, Courtet, Philippe, Aouizerate, Bruno, and Yrondi, Antoine

Published
2024
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19. Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium

Author

Suarez-Jimenez, Benjamin, Lazarov, Amit, Zhu, Xi, Zilcha-Mano, Sigal, Kim, Yoojean, Marino, Claire E., Rjabtsenkov, Pavel, Bavdekar, Shreya Y., Pine, Daniel S., Bar-Haim, Yair, Larson, Christine L., Huggins, Ashley A., Terri deRoon-Cassini, Tomas, Carissa, Fitzgerald, Jacklynn, Kennis, Mitzy, Varkevisser, Tim, Geuze, Elbert, Quidé, Yann, El Hage, Wissam, Wang, Xin, O’Leary, Erin N., Cotton, Andrew S., Xie, Hong, Shih, Chiahao, Disner, Seth G., Davenport, Nicholas D., Sponheim, Scott R., Koch, Saskia B.J., Frijling, Jessie L., Nawijn, Laura, van Zuiden, Mirjam, Olff, Miranda, Veltman, Dick J., Gordon, Evan M., May, Geoffery, Nelson, Steven M., Jia-Richards, Meilin, Neria, Yuval, and Morey, Rajendra A.

Published
2024
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22. Development of the PREMIUM computerized adaptive testing for measuring the access and care coordination for patients with severe mental illness

Author

Boyer, Laurent, Fernandes, Sara, Brousse, Yann, Zendjidjian, Xavier, Cano, Delphine, Riedberger, Jeremie, Llorca, Pierre-Michel, Samalin, Ludovic, Dassa, Daniel, Trichard, Christian, Laprevote, Vincent, Sauvaget, Anne, Abbar, Mocrane, Misdrahi, David, Berna, Fabrice, Lancon, Christophe, Coulon, Nathalie, El-Hage, Wissam, Rozier, Pierre-Emmanuel, Benoit, Michel, Giordana, Bruno, Caqueo-Urizar, Alejandra, Yon, Dong Keon, Tran, Bach, Auquier, Pascal, and Fond, Guillaume

Published
2023
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24. Long-term benzodiazepine prescription in treatment-resistant depression: A national FACE-TRD prospective study

Author

Fond, Guillaume, Faugere, Mélanie, Boyer, Laurent, Peri, Pauline, Stephan, Florian, Moliere, Fanny, Anguill, Loic, Bennabi, Djamila, Haffen, Emmanuel, Bouvard, Alexandra, Walter, Michel, Samalin, Ludovic, Llorca, Pierre Michel, Genty, Jean Baptiste, Leboyer, Marion, Holtzmann, Jérôme, Nguon, Anne Sophie, Rey, Romain, Horn, Mathilde, Vaiva, Guillaume, Hennion, Vincent, Etain, Bruno, El-Hage, Wissam, Camus, Vincent, Courtet, Philippe, Aouizerate, Bruno, Yrondi, Antoine, Lancon, Christophe, and Richieri, Raphaelle

Published
2023
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30. Group Dissociation-Focused Cognitive Behavioral Therapy (DF-CBT) in Patients Suffering from a Dissociative Subtype of PTSD: An Exploratory Study.

Author

Vancappel, Alexis, Chavigny, Claudie, Chami, Lyna, Kazour, François, and El-Hage, Wissam

Subjects
TREATMENT of post-traumatic stress disorder, ANXIETY prevention, PREVENTION of mental depression, EMOTION regulation, ACADEMIC medical centers, HEALTH attitudes, MINDFULNESS, QUESTIONNAIRES, GROUP psychotherapy, TREATMENT effectiveness, EMOTIONS, ANXIETY, DISSOCIATIVE disorders, TRAUMA centers, RESEARCH, COGNITIVE therapy, GROUP process, MENTAL depression
Abstract

Dissociation is a widespread difficulty among patients suffering from Posttraumatic Stress Disorder (PTSD). However, there is no gold standard treatment for dissociative symptoms. Recent studies propose a cognitive and behavioral conceptualization for dissociation. The aim of this study was to explore the efficacy of a group program of Dissociation-Focused Cognitive Behavior Therapy (DF-CBT) on dissociative symptoms. We recruited 27 patients suffering from a dissociative subtype of PTSD in a university hospital trauma center. Participants completed questionnaires evaluating dissociation, PTSD, mindfulness abilities, beliefs about emotions, beliefs about dissociation, emotion regulation difficulties, anxiety and depression. Following an initial evaluation, participants undertook 7 sessions of DF-CBT, and were reevaluated after the last session using the same questionnaires. We found a significant reduction of dissociative, PTSD, anxiety, and depression symptoms following DF-CBT. The effect size was noticeable for all variables (.61

Published
2025
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32. Benzodiazepine use and neuroimaging markers of Alzheimer’s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort

Author

Gallet, Quentin, Bouteloup, Vincent, Locatelli, Maxime, Habert, Marie-Odile, Chupin, Marie, Delrieu, Julien, Lebouvier, Thibaud, Robert, Gabriel, David, Renaud, Bulteau, Samuel, Balageas, Anna-Chloé, Surget, Alexandre, Belzung, Catherine, Arlicot, Nicolas, Ribeiro, Maria-Joao, Barantin, Laurent, Andersson, Frédéric, Cottier, Jean-Philippe, Gissot, Valérie, El-Hage, Wissam, Camus, Vincent, Gohier, Bénédicte, and Desmidt, Thomas

Published
2022
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33. Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the real-world FACE-TRD national cohort

Author

Korchia, Théo, Faugere, Mélanie, Suc, Nicolas, Garosi, Alexandra, Andrieu-Haller, Christelle, Breyton, Martin, Godin, Ophélia, Aouizerate, Bruno, Arbus, Christophe, Bennabi, Djamila, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Courtet, Philippe, Doumy, Olivier, El-Hage, Wissam, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérome, Horn, Mathilde, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Moliere, Fanny, Petrucci, Jean, Rey, Romain, Samalin, Ludovic, Stephan, Florian, Vaiva, Guillaume, Walter, Michel, Yrondi, Antoine, Boyer, Laurent, Lancon, Christophe, Richieri, Raphaelle, and Fond, Guillaume

Published
2022
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36. Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

Author

Aouizerate, B., Bennabi, D., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Laouamri, H., Souryis, Karmene, Mallet, L., Yon, L., Petrucci, J., Genty, J.B., Yrondi, A., Pierre, D., Schmitt, L., Sarrail, M., Bennabi, Djamila, Ryff, I., Beuchet, E., Tio, G., Cappe, C., Clerc, E., Garnier, M., Honciuc, R.M., Allauze, E., Blanc, O., Bellivier, F., Allaili, N., Nieto, I., Meheust, J., Sunthavy, Y., Maruani, J., Bougerol, T., Polosan, M., Courvoisier, P., Holtzmann, J., Fredembach, B., Foubert-Andreani, S., Camus, V., El Hage, W., D’Amato, T., Haesebaert, F., Dubien, C., Lefebvre, M., Meznad, A., Brunelin, J., Moirand, R., Doumy, O., Lancon, C., Richieri, R., Peri, P., Faugere, M., Faget-Agius, C., Courtet, P., Boulenger, J.P., Moliere, F., Stephan, F., Walter, M., Mesmeur, C., Vaiva, G., Horn, M., Yrondi, Antoine, Vaiva, Guillaume, Walter, Michel, D Amato, Thierry, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Doumy, Olivier, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérôme, Horn, Mathilde, Lançon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Molière, Fanny, Petrucci, Jean, Richieri, Raphaelle, Samalin, Ludovic, Schmitt, Laurent, Stephan, Florian, Courtet, Philippe, El-Hage, Wissam, and Aouizerate, Bruno

Published
2021
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40. Cognitive distortions, anxiety, and depression in individuals suffering from PTSD.

Author

Ouhmad, Nawal, Deperrois, Romain, El Hage, Wissam, and Combalbert, Nicolas

Subjects
COGNITION disorder risk factors, POST-traumatic stress disorder, MENTAL depression risk factors, RISK assessment, STATISTICAL correlation, ACADEMIC medical centers, T-test (Statistics), MENTAL illness, ANXIETY, DESCRIPTIVE statistics, EMOTIONAL trauma, ANALYSIS of variance, COMPARATIVE studies, DATA analysis software, SOCIAL support, PSYCHOLOGICAL tests, WELL-being
Abstract

Cognitive distortions are an essential factor in the development and maintenance of post-traumatic stress disorder (PTSD). The aim of the study is to investigate the link between the production of cognitive distortions and PTSD by measuring levels of anxiety and depression. Our sample comprised 183 participants divided into three groups: 59 trauma-exposed with PTSD, 61 trauma-exposed without PTSD, and 63 non-trauma-exposed non-PTSD (controls). All participants were assessed on the following dimensions: PTSD (PCL-5), cognitive distortions (EDC-A), anxiety and depression (HADS). The main results highlight a production of cognitive distortions in people with PTSD, who had significantly more positive than negative cognitive distortions compared to the group exposed to trauma without PTSD. In addition, the PTSD group had higher anxiety and depression scores than the other two groups. Findings indicate that people with PTSD show more positive cognitive distortions than those without PTSD, and that this is not related to levels of anxiety and depression. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder:a mega-analysis by the ENIGMA-PGC PTSD workgroup

Author

Huggins, Ashley A., Baird, C. Lexi, Briggs, Melvin, Laskowitz, Sarah, Hussain, Ahmed, Fouda, Samar, Haswell, Courtney, Sun, Delin, Salminen, Lauren E., Jahanshad, Neda, Thomopoulos, Sophia I., Veltman, Dick J., Frijling, Jessie L., Olff, Miranda, van Zuiden, Mirjam, Koch, Saskia B.J., Nawjin, Laura, Wang, Li, Zhu, Ye, Li, Gen, Stein, Dan J., Ipser, Jonathan, Seedat, Soraya, du Plessis, Stefan, van den Heuvel, Leigh L., Suarez-Jimenez, Benjamin, Zhu, Xi, Kim, Yoojean, He, Xiaofu, Zilcha-Mano, Sigal, Lazarov, Amit, Neria, Yuval, Stevens, Jennifer S., Ressler, Kerry J., Jovanovic, Tanja, van Rooij, Sanne J.H., Fani, Negar, Hudson, Anna R., Mueller, Sven C., Sierk, Anika, Manthey, Antje, Walter, Henrik, Daniels, Judith K., Schmahl, Christian, Herzog, Julia I., Říha, Pavel, Rektor, Ivan, Lebois, Lauren A.M., Kaufman, Milissa L., Olson, Elizabeth A., Baker, Justin T., Rosso, Isabelle M., King, Anthony P., Liberzon, Isreal, Angstadt, Mike, Davenport, Nicholas D., Sponheim, Scott R., Disner, Seth G., Straube, Thomas, Hofmann, David, Qi, Rongfeng, Lu, Guang Ming, Baugh, Lee A., Forster, Gina L., Simons, Raluca M., Simons, Jeffrey S., Magnotta, Vincent A., Fercho, Kelene A., Maron-Katz, Adi, Etkin, Amit, Cotton, Andrew S., O’Leary, Erin N., Xie, Hong, Wang, Xin, Quidé, Yann, El-Hage, Wissam, Lissek, Shmuel, Berg, Hannah, Bruce, Steven, Cisler, Josh, Ross, Marisa, Herringa, Ryan J., Grupe, Daniel W., Nitschke, Jack B., Davidson, Richard J., Larson, Christine L., deRoon-Cassini, Terri A., Tomas, Carissa W., Fitzgerald, Jacklynn M., Blackford, Jennifer Urbano, Olatunji, Bunmi O., Kremen, William S., Lyons, Michael J., Franz, Carol E., Gordon, Evan M., May, Geoffrey, Nelson, Steven M., Abdallah, Chadi G., Levy, Ifat, Harpaz-Rotem, Ilan, Krystal, John H., Dennis, Emily L., Tate, David F., Cifu, David X., Walker, William C., Wilde, Elizabeth A., Harding, Ian H., Kerestes, Rebecca, Thompson, Paul M., Morey, Rajendra, Huggins, Ashley A., Baird, C. Lexi, Briggs, Melvin, Laskowitz, Sarah, Hussain, Ahmed, Fouda, Samar, Haswell, Courtney, Sun, Delin, Salminen, Lauren E., Jahanshad, Neda, Thomopoulos, Sophia I., Veltman, Dick J., Frijling, Jessie L., Olff, Miranda, van Zuiden, Mirjam, Koch, Saskia B.J., Nawjin, Laura, Wang, Li, Zhu, Ye, Li, Gen, Stein, Dan J., Ipser, Jonathan, Seedat, Soraya, du Plessis, Stefan, van den Heuvel, Leigh L., Suarez-Jimenez, Benjamin, Zhu, Xi, Kim, Yoojean, He, Xiaofu, Zilcha-Mano, Sigal, Lazarov, Amit, Neria, Yuval, Stevens, Jennifer S., Ressler, Kerry J., Jovanovic, Tanja, van Rooij, Sanne J.H., Fani, Negar, Hudson, Anna R., Mueller, Sven C., Sierk, Anika, Manthey, Antje, Walter, Henrik, Daniels, Judith K., Schmahl, Christian, Herzog, Julia I., Říha, Pavel, Rektor, Ivan, Lebois, Lauren A.M., Kaufman, Milissa L., Olson, Elizabeth A., Baker, Justin T., Rosso, Isabelle M., King, Anthony P., Liberzon, Isreal, Angstadt, Mike, Davenport, Nicholas D., Sponheim, Scott R., Disner, Seth G., Straube, Thomas, Hofmann, David, Qi, Rongfeng, Lu, Guang Ming, Baugh, Lee A., Forster, Gina L., Simons, Raluca M., Simons, Jeffrey S., Magnotta, Vincent A., Fercho, Kelene A., Maron-Katz, Adi, Etkin, Amit, Cotton, Andrew S., O’Leary, Erin N., Xie, Hong, Wang, Xin, Quidé, Yann, El-Hage, Wissam, Lissek, Shmuel, Berg, Hannah, Bruce, Steven, Cisler, Josh, Ross, Marisa, Herringa, Ryan J., Grupe, Daniel W., Nitschke, Jack B., Davidson, Richard J., Larson, Christine L., deRoon-Cassini, Terri A., Tomas, Carissa W., Fitzgerald, Jacklynn M., Blackford, Jennifer Urbano, Olatunji, Bunmi O., Kremen, William S., Lyons, Michael J., Franz, Carol E., Gordon, Evan M., May, Geoffrey, Nelson, Steven M., Abdallah, Chadi G., Levy, Ifat, Harpaz-Rotem, Ilan, Krystal, John H., Dennis, Emily L., Tate, David F., Cifu, David X., Walker, William C., Wilde, Elizabeth A., Harding, Ian H., Kerestes, Rebecca, Thompson, Paul M., and Morey, Rajendra

Abstract

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p -FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.

Published
2024

50. Intrusive Traumatic Re-Experiencing Domain: Functional Connectivity Feature Classification by the ENIGMA PTSD Consortium

Author

MGGZ, Brain, Suarez-Jimenez, Benjamin, Lazarov, Amit, Zhu, Xi, Zilcha-Mano, Sigal, Kim, Yoojean, Marino, Claire E., Rjabtsenkov, Pavel, Bavdekar, Shreya Y., Pine, Daniel S., Bar-Haim, Yair, Larson, Christine L., Huggins, Ashley A., Terri deRoon-Cassini, deRoon-Cassini, Tomas, Carissa, Fitzgerald, Jacklynn, Kennis, Mitzy, Varkevisser, Tim, Geuze, Elbert, Quidé, Yann, El Hage, Wissam, Wang, Xin, O'Leary, Erin N., Cotton, Andrew S., Xie, Hong, Shih, Chiahao, Disner, Seth G., Davenport, Nicholas D., Sponheim, Scott R., Koch, Saskia B.J., Frijling, Jessie L., Nawijn, Laura, van Zuiden, Mirjam, Olff, Miranda, Veltman, Dick J., Gordon, Evan M., May, Geoffery, Nelson, Steven M., Jia-Richards, Meilin, Neria, Yuval, Morey, Rajendra A., MGGZ, Brain, Suarez-Jimenez, Benjamin, Lazarov, Amit, Zhu, Xi, Zilcha-Mano, Sigal, Kim, Yoojean, Marino, Claire E., Rjabtsenkov, Pavel, Bavdekar, Shreya Y., Pine, Daniel S., Bar-Haim, Yair, Larson, Christine L., Huggins, Ashley A., Terri deRoon-Cassini, deRoon-Cassini, Tomas, Carissa, Fitzgerald, Jacklynn, Kennis, Mitzy, Varkevisser, Tim, Geuze, Elbert, Quidé, Yann, El Hage, Wissam, Wang, Xin, O'Leary, Erin N., Cotton, Andrew S., Xie, Hong, Shih, Chiahao, Disner, Seth G., Davenport, Nicholas D., Sponheim, Scott R., Koch, Saskia B.J., Frijling, Jessie L., Nawijn, Laura, van Zuiden, Mirjam, Olff, Miranda, Veltman, Dick J., Gordon, Evan M., May, Geoffery, Nelson, Steven M., Jia-Richards, Meilin, Neria, Yuval, and Morey, Rajendra A.

Published
2024

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