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5. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

Van den Berg, M, primary, Cattley, R, additional, Cherrie, J W, additional, Dorman, D C, additional, Dunnick, J K, additional, Gohlke, J M, additional, Jinot, J, additional, Käfferlein, H U, additional, Kopylev, L, additional, Matsumoto, M, additional, Nomiyama, T, additional, Ogawa, K, additional, Perbellini, L, additional, Sone, H, additional, Grosse, Y, additional, Guyton, K Z, additional, Schubauer-Berigan, M K, additional, El Ghissassi, F, additional, Bouvard, V, additional, Benbrahim-Tallaa, L, additional, Hall, A, additional, Paul, A, additional, Mattock, H, additional, and Straif, K, additional

Published
2018
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6. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, Cattley, R, One Health Toxicologie, dIRAS RA-1, One Health Toxicologie, and dIRAS RA-1

Subjects
03 medical and health sciences, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Environmental chemistry, Medicine, Chemical industry, business, 030210 environmental & occupational health, Carcinogen
Published
2018

7. Carcinogenicity of some nitrobenzenes and other industrial chemicals

Author

One Health Toxicologie, dIRAS RA-1, Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, Cattley, R, One Health Toxicologie, dIRAS RA-1, Dunnick, J K, Schubauer-Berigan, M K, Grosse, Y, Straif, K, Jinot, J, Van den Berg, M, Perbellini, L, Nomiyama, T, Gohlke, J M, Bouvard, V, Sone, H, Paul, A, Matsumoto, M, Dorman, D C, Kopylev, L, Cherrie, J W, Benbrahim-Tallaa, L, Ogawa, K, El Ghissassi, F, Mattock, H, Käfferlein, H U, Hall, A, Guyton, K Z, and Cattley, R

Published
2018

8. Carcinogenicity of diesel-engine and gasoline-engine exhausts and some nitroarenes

Author

Benbrahim-Tallaa, L., Baan, R.A., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., Guha, N., Loomis, D., Straif, K., Portier, C.J., Karman, D., White, P., Heinrich, U., Zeeb, H., Shimada, T., Tsuda, H., Scheepers, P.T., and Vermeulen, R.

Subjects
Molecular epidemiology [NCEBP 1], Oncology, Waste management, business.industry, Medicine, Carcinogenicity Test, Diesel engine, business, Petrol engine
Abstract

Benbrahim-Tallaa, Lamia Baan, Robert A Grosse, Yann Lauby-Secretan, Beatrice El Ghissassi, Fatiha Bouvard, Veronique Guha, Neela Loomis, Dana Straif, Kurt News England Lancet Oncol. 2012 Jul;13(7):663-4.

Published
2012

9. Carcinogenicity of malaria and of some polyomaviruses

Author

Bouvard, V, Baan, Ra, Grosse, Y, Lauby Secretan, B, El Ghissassi, F, Benbrahim Tallaa, L, Guha, N, Straif, K, Newton, R, Coursaget, P, Becker, J, Pawlita, M, Sarid, R, Sumba, Po, zur Hausen, A, de Sanjosé, S, Bejarano, Mt, Dalianis, T, Troye Blomberg, M, Wahlgren, M, Darnton, A, Butel, Js, Engels, E, Goel, A, Gordon, J, Mbulaiteye, Sm, Rochford, R, Rollison, De, Shah, Kv, Viscidi, R, Tognon, Mauro, Buck, Cb, and Chang, Y.

Subjects
biology, business.industry, polyomavirus, cancer, Association, Plasmodium falciparum, medicine.disease, biology.organism_classification, Virology, Oncology, medicine, business, Epstein–Barr virus infection, Carcinogen, Malaria
Published
2012

10. A review of human carcinogens--part C: metals, arsenic, dusts, and fibres

Author

Straif, K, Benbrahim Tallaa, L, Baan, R, Grosse, Y, Secretan, B, El Ghissassi, F, Bouvard, V, Guha, N, Freeman, C, Galichet, L, Cogliano, V, WHO International Agency for Research on Cancer Monograph Working Group: Collaborators Heinrich, U, Samet, J, Demers, Pa, Gérin, M, Siemiatycki, J, Grandjean, P, Aitio, A, Kauppinen, T, Goldberg, M, Hartwig, A, Muhle, H, Fubini, Bice, Merletti, Franco, Ikeda, M, Attfield, Md, Cantor, Kp, Fowler, Ba, Henderson, R, Infante, Pf, Kane, Ab, Landrigan, Pj, Lunn, R, Rossman, Tg, Stayner, L, Waalkes, Mp, Ward, Em, and Ward, J. M.

Published
2009

11. A review of human carcinogens--Part B: biological agents

Author

Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V, and Who, International Agency For Research On Cancer Monograph Working Group

Subjects
Biology – Resources and Infrastructure
Published
2008

12. IARC monographs programme on the evaluation of carcinogenic risks to humans

Author

Anderson, GL, Autier, P, Beral, V, Bosland, MC, Fernández, E, Haslam, SZ, Kaufman, DG, La Vecchia, C, Molinolo, AA, Newcomb, PA, Parl, FF, Peto, J, Rosano, G, Roy, D, Stanczyk, FZ, Thomas, DB, Vatten, L, Junghans, T, Olin, S, Shapiro, S, Stafford, RS, Jameson, CW, Meyer, JU, Baan, R, Berthiller, J, Cogliano, VJ, Dresler, C, El Ghissassi, F, Franceschi, S, Gonçalves, M-AG, Grosse, Y, Guha, N, Marron, M, Mitchell, J, Napalkov, N, Secretan, B, Straif, K, Ullrich, A, Egraz, S, Kajo, B, Lézère, M, and Lorenzen-Augros, H

Published
2007

13. Combined estrogen-progestogen menopausal therapy

Author

Anderson, GL, Autier, P, Beral, V, Bosland, MC, Fernández, E, Haslam, SZ, Kaufman, DG, La Vecchia, C, Molinolo, AA, Newcomb, PA, Parl, FF, Peto, J, Rosano, G, Roy, D, Stanczyk, FZ, Thomas, DB, Vatten, L, Junghans, T, Olin, S, Shapiro, S, Stafford, RS, Jameson, CW, Meyer, JU, Baan, R, Berthiller, J, Cogliano, VJ, Dresler, C, El Ghissassi, F, Franceschi, S, Gonçalves, M-AG, Grosse, Y, Guha, N, Marron, M, Mitchell, J, Napalkov, N, Secretan, B, Straif, K, Ullrich, A, Egraz, S, Kajo, B, Lézère, M, and Lorenzen-Augros, H

Published
2007

14. Combined estrogen-progestogen contraceptives

Author

Anderson, GL, Autier, P, Beral, V, Bosland, MC, Fernández, E, Haslam, SZ, Kaufman, DG, La Vecchia, C, Molinolo, AA, Newcomb, PA, Parl, FF, Peto, J, Rosano, G, Roy, D, Stanczyk, FZ, Thomas, DB, Vatten, L, Junghans, T, Olin, S, Shapiro, S, Stafford, RS, Jameson, CW, Meyer, JU, Baan, R, Berthiller, J, Cogliano, VJ, Dresler, C, El Ghissassi, F, Franceschi, S, Gonçalves, M-AG, Grosse, Y, Guha, N, Marron, M, Mitchell, J, Napalkov, N, Secretan, B, Straif, K, Ullrich, A, Egraz, S, Kajo, B, Lézère, M, and Lorenzen-Augros, H

Published
2007

16. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites

Author

Guha, N., Loomis, D., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Baan, R., Mattock, H., Straif, K., International Agency for Research on CAncer Monograph Working Group, Fritschi, Lin, Guha, N., Loomis, D., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., Baan, R., Mattock, H., Straif, K., International Agency for Research on CAncer Monograph Working Group, and Fritschi, Lin

Published
2012

17. Preventable Exposures Associated With Human Cancers

Author

Cogliano, V. J., primary, Baan, R., additional, Straif, K., additional, Grosse, Y., additional, Lauby-Secretan, B., additional, El Ghissassi, F., additional, Bouvard, V., additional, Benbrahim-Tallaa, L., additional, Guha, N., additional, Freeman, C., additional, Galichet, L., additional, and Wild, C. P., additional

Published
2011
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18. Exposure to N-nitrosamines and other risk factors for gastric cancer in Costa Rican children

Author

Sierra Ramos, Rafaela, Ohshima, Hiroshi, Muñoz Calero, Nubia, Teuchmann, Sibylle, Peña, Salvador, Malaveille, Christian, Pignatelli, Brigitte, Chinnock Mc'Neil, Anne Eliza, El Ghissassi, F., Chen, C., Hautefeuille, A., Gamboa Cerda, Cecilia, and Bartsch, Helmut

Subjects
Costa Rica, Salud pública, salud infantil, Cáncer gástrico, Desarrollo del niño
Abstract

Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1991 The hypothesis that endogenous chemical nitrosation in the normal stomach in early life could play a crucial role in inducing chronic atrophic gastritis/intestinal metaplasia in later life was tested by applying the N-nitrosoproline (NPRO) test to 12-h urine samples from about 50 children (aged 8-14 years) living in high- and low-risk areas for stomach cancer. The median values of NPRO and the sum of four nitrosamino acids analysed were 0.28-0.84 ag/12 h and 0.75-1.75 tig/12 h, respectively. The NPRO level after proline intake was significantly higher in children from a high-risk area than in those from a low-risk area (p < 0.04), and markedly reduced after ingestion of ascorbic acid and proline (p < 0.05). Urinary nitrate level was lower than that of adults. NPRO levels on the day of proline intake, however, correlated well with nitrate levels (p < 0.001), indicating that children in a high-risk area in Costa Rica have high endogenous nitrosation potential. Blood samples were also collected from about 300 children (aged 7-20 years) and analysed for antibodies against Campylabacter pylori, a suspected gastritis-causing bacteria. About 71% of children in both high- and low-risk areas for stomach cancer had antibodies. In addition, raw and cooked beans, which are consumed very frequently in Costa Rica, were collected from families in both areas and analysed for levels of nitrite/nitrate, total N-nitroso compounds and genotoxicity in the SOS chromotest. Mean levels of total N-nitroso compounds in an aqueous extract (pH 2) of cooked bean samples from high- and low-incidence areas were similar (0.4-0.6 nmol/g of cooked beans). Acid-catalysed nitrosation of the same aqueous extracts produced levels up to 2.4 pmol/g of cooked beans. There was no difference in mean levels of nitrosation-dependent total N-nitroso compounds between samples from the two areas. Only two out of 11 extracts from the low-incidence area and two out of 14 from the high-incidence area showed weak direct genotoxicity. After acid-catalysed nitrosation, all samples were genotoxic at similar levels Universidad de Costa Rica. Instituto de Investigaciones en Salud. UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)

Published
1991

19. The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

Author

North, S, El-Ghissassi, F, Pluquet, O, Verhaegh, G, and Hainaut, P

Subjects
*CELL cycle, *THIOLS, *CYCLIN-dependent kinases
Abstract

The phosphoaminothiol WR1065, the active metabolite of the pro-drug amifostine (WR2721), protects cultured cells and tissues against cytotoxic exposure to radiation or chemotherapeutic agents. We show here that WR1065 and the pro-drug WR2721 activate the p53 tumor suppressor protein and induce the expression of the cyclin-dependent kinase inhibitor p21waf-1 in the breast cancer cell line MCF-7, and in the mouse fibroblast cell line balb/c 3T3. Using two MCF-7 derived cell lines, MN1 and MDD2, we show that induction of p21waf-1 is detectable in MN1 (expressing a functional p53) but not in MDD2 (p53 disabled). These effects are observed at concentrations of WR1065 (0.5 to 1 mM) identical to those required to protect against cytotoxicity by hydrogen peroxide. Induction of p53 is not prevented by addition of aminoguanidine, an inhibitor of Cu-dependent amine-oxidases which blocks the extra-cellular degradation of WR1065 into toxic metabolites. Moreover, spermidine, a natural polyamine structurally related to amifostine, does not activate p53. Induction of p53 by WR1065 results in a delay in the G1/S transition in MCF-7 and MN-1 cells, but not in the p53 disabled cells MDD2. These data indicate that WR1065, a polyamine analog with thiol anti-oxidant properties, activates a cell cycle check-point involving p53. Oncogene (2000) 19, 1206–1214. [ABSTRACT FROM AUTHOR]

Published
2000
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20. Formation and accumulation of DNA ethenobases in adult Sprague-Dawley rats exposed to vinyl chloride.

Author

Guichard, Y, el Ghissassi, F, Nair, J, Bartsch, H, and Barbin, A

Abstract

DNA ethenobases are promutagenic lesions formed by carcinogens such as vinyl chloride (VC). Their formation was investigated in 6-week old, male Sprague-Dawley rats exposed to 500 p.p.m. VC by inhalation (4 h/day, 5 days/ week) for 1, 2, 4 or 8 weeks and in 7- and 14-week old, matched control animals. 1,N6-Ethenoadenine (epsilon A) and 3, N4-ethenocytosine (epsilon C) deoxyribonucleotides were analysed by immunoaffinity purification and 32P-postlabelling. This postlabelling method was compared with a radio-immunoassay method, which yielded similar results. Background levels of ethenobases were found in DNA from the liver, lungs, kidneys and circulating lymphocytes of unexposed, control rats. In the liver, the following background molar ratios of ethenobase to parent base in DNA were detected (mean values x 10(-8)): epsilon A/A, 0.04-0.05; epsilon C/C, 0.06-0.07. In the lungs, kidneys and circulating lymphocytes, background levels of epsilon A and epsilon C ranged from 1.7 to 4.2 x 10(-8) and from 4.8 to 11.2 x 10(-8), respectively. Following a 5-day exposure to VC, a significant increase of epsilon A and epsilon C was measured in hepatic DNA from rats sacrificed immediately after treatment. Further, a dose-dependent increase of both etheno adducts was observed in liver DNA of VC-treated rats. Compared to the 5-day exposure, approximately 4-fold higher levels of epsilon A and epsilon C were observed in the liver of animals after 8 weeks of exposure. In contrast, there was an accumulation of epsilon C but not of epsilon A in lungs and kidneys. In circulating lymphocytes, no significant increase of ethenobase levels above control values was observed after 2 months of exposure to VC. Both etheno adducts were found to be persistent in liver DNA, after 2 months following the termination of VC exposure. These results further support the notion that DNA etheno-bases are critical lesions in VC-induced carcinogenesis. The possible contribution of lipid peroxidation products that also yield ethenobases, on the formation and persistence of these DNA adducts, remains to be clarified.

Published
1996
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21. Human papillomaviruses

Author

Arbyn, M., Bosch, X., Cuzick, J., Denny, L., Galloway, D., Giuliano, A. R., Herrero, R., Lambert, P., Lawson, H., Meijer, C. J. L. M., Palefsky, J., Pawlita, M., Qiao, Y. -L, Schiffman, M., Shin, H. -R, Sideri, M., Strickler, H. D., Ballegooijen, M., Villa, L. L., Wong, M., Zur Hausen, H., Campo, M. S., Franco, E. L., Iftner, T., Pfister, H., Gruber, J., Baan, R. A., Boulch, D., Bouvard, V., Clifford, G., Cogliano, V. J., Dai, M., Dikshit, R., Dresler, C., El Ghissassi, F., silvia franceschi, Goncalves, M. A., Grosse, Y., Guha, N., Hasan, U., Hsu, C., Kreimer, A., Krutovskikh, V., Mitchell, J., Napalkov, N., Uhe, S. P., Plummer, M., Secretan, B., Straif, K., Sylla, B., Tommasino, M., Vaccarella, S., Egraz, S., Javin, M., Kajo, B., Lézère, M., Mollon, G., and Perez, E.

22. IARC monographs programme on the evaluation of carcinogenic risks to humans

Author

Anderson, G. L., Autier, P., Beral, V., Bosland, M. C., Fernández, E., Haslam, S. Z., Kaufman, D. G., La Vecchia, C., Molinolo, A. A., Newcomb, P. A., Parl, F. F., Peto, J., Rosano, G., Roy, D., Stanczyk, F. Z., Thomas, D. B., Vatten, L., Junghans, T., Olin, S., Shapiro, S., Stafford, R. S., Jameson, C. W., Meyer, J. U., Baan, R., Berthiller, J., Cogliano, V. J., Dresler, C., El Ghissassi, F., silvia franceschi, Gonçalves, M. -A G., Grosse, Y., Guha, N., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Ullrich, A., Egraz, S., Kajo, B., Lézère, M., and Lorenzen-Augros, H.

24. Painting, firefighting, and shiftwork

Author

Blair, A., Blask, D., Bråtveit, M., Brock, T., Burgess, J. L., Costa, G., Davis, S., Demers, P. A., Hansen, J., Haus, E., Landrigan, P. J., Lemasters, G. K., Lévi, F., Merletti, F., Christopher Portier, Pukkala, E., Schernhammer, E., Steenland, K., Stevens, R., Vermeulen, R., Zheng, T., Zhu, Y., Arendt, J., Austin, C., Cherrie, J., Huici-Montagud, A., Mundt, K., Altieri, A., Baan, R., Bouvard, V., James Cogliano, V., Giannandrea, F., El Ghissassi, F., Grosse, Y., Heck, J., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Freeman, C., Guha, N., Galichet, L., Hameau, A. -S, Moutinho, S., and Russell, D.

25. Alcohol consumption and ethyl carbamate

Author

Allen, N., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S. -I, Crabb, D. W., Eriksson, P., Gapstur, S. M., Gmel, G., Griciute, L. -L, Kono, S., Lachenmeier, D. W., La Vecchia, C., M. Matilde Marques, Miller, A. B., Rehm, J., Rehn-Mendoza, N., Rusyn, I., Seitz, H. K., Weiderpass, E., Willett, W. C., Yokoyama, A., Zhang, Z. -F, Huici-Montagud, A., Altieri, A., Baan, R., Balbo, S., Berthiller, J., Bouvard, V., Brennan, P., Cogliano, V. J., El Ghissassi, F., Ferrari, P., Franceschi, S., Gaudin, N., Grosse, Y., Hashibe, M., Islami, F., Lee, Y. -C A., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Tong, W. -M, Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Benbrahim-Tallaa, L., Freeman, C., Guha, N., Galichet, L., Hameau, A. -S, Moutinho, S., and Russell, D.

26. IARC Monographs programme on the evaluation of carcinogenic risks to humans

Author

Arbyn, M., Bosch, X., Cuzick, J., Denny, L., Galloway, D., Giuliano, A. R., Herrero, R., Lambert, P., Lawson, H., Meijer, C. J. L. M., Palefsky, J., Pawlita, M., Qiao, Y. -L, Schiffman, M., Shin, H. -R, Sideri, M., Strickler, H. D., Ballegooijen, M., Luisa Lina Villa, Wong, M., Zur Hausen, H., Campo, M. S., Franco, E. L., Iftner, T., Pfister, H., Gruber, J., Baan, R. A., Boulch, D., Bouvard, V., Clifford, G., Cogliano, V. J., Dai, M., Dikshit, R., Dresler, C., El Ghissassi, F., Franceschi, S., Goncalves, M. A., Grosse, Y., Guha, N., Hasan, U., Hsu, C., Kreimer, A., Krutovskikh, V., Mitchell, J., Napalkov, N., Uhe, S. P., Plummer, M., Secretan, B., Straif, K., Sylla, B., Tommasino, M., Vaccarella, S., Egraz, S., Javin, M., Kajo, B., Lézère, M., Mollon, G., and Perez, E.

27. Alcohol consumption and ethyl carbamate

Author

Allen, N., Anderson, L. M., Frederick Beland, Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S. -I, Crabb, D. W., Eriksson, P., Gapstur, S. M., Gmel, G., Griciute, L. -L, Kono, S., Lachenmeier, D. W., La Vecchia, C., Marques, M. M., Miller, A. B., Rehm, J., Rehn-Mendoza, N., Rusyn, I., Seitz, H. K., Weiderpass, E., Willett, W. C., Yokoyama, A., Zhang, Z. -F, Huici-Montagud, A., Altieri, A., Baan, R., Balbo, S., Berthiller, J., Bouvard, V., Brennan, P., Cogliano, V. J., El Ghissassi, F., Ferrari, P., Franceschi, S., Gaudin, N., Grosse, Y., Hashibe, M., Islami, F., Lee, Y. -C A., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Tong, W. -M, Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Benbrahim-Tallaa, L., Freeman, C., Guha, N., Galichet, L., Hameau, A. -S, Moutinho, S., and Russell, D.

28. Combined estrogen-progestogen contraceptives

Author

Anderson, G. L., Autier, P., Beral, V., Bosland, M. C., Fernández, E., Haslam, S. Z., Kaufman, D. G., La Vecchia, C., Molinolo, A. A., Newcomb, P. A., Parl, F. F., Peto, J., Rosano, G., Roy, D., Stanczyk, F. Z., Thomas, D. B., Vatten, L., Junghans, T., Olin, S., Shapiro, S., Stafford, R. S., Jameson, C. W., Meyer, J. U., Baan, R., Berthiller, J., Cogliano, V. J., Dresler, C., El Ghissassi, F., silvia franceschi, Gonçalves, M. -A G., Grosse, Y., Guha, N., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Ullrich, A., Egraz, S., Kajo, B., Lézère, M., and Lorenzen-Augros, H.

29. Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide

Author

Altamirano-Lozano, M., Beyersmann, D., Carter, D. E., Fowler, B. A., Bice Fubini, Kielhorn, J., Kirsch-Volders, M., Kucera, J., Kusaka, Y., Lasfargues, G., Lison, D., Mangelsdor, I., Mcelvenny, D., Nemery, B., Roycroft, J., Svartengren, M., Junghans, T., Olin, S., Renne, R., Longfellow, D. G., Ziegler-Skylakakis, K., Baan, R., Cogliano, V., El Ghissassi, F., Fletcher, T., Friesen, M., Grosse, Y., Napalkov, N., Secretan, B., Straif, K., Wang, Z. -Q, and Williams, R.

30. Carcinogenicity of polycyclic aromatic hydrocarbons.

Author

Straif K, Baan R, Secretan B, El Ghissassi F, Cogliano V, Straif, Kurt, Baan, Robert, Grosse, Yann, Secretan, Béatrice, El Ghissassi, Fatiha, Cogliano, Vincent, and WHO International Agency for Research on Cancer Monograph Working Group

Published
2005
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32. Advice on formaldehyde and glycol ethers.

Author

Cogliano V, Grosse Y, Baan R, Straif K, Secretan B, El Ghissassi F, WHO International Agency for Research on Cancer, Cogliano, Vincent, Grosse, Yann, Baan, Robert, Straif, Kurt, Secretan, Béatrice, and El Ghissassi, Fatiha

Published
2004
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33. Carcinogenicity of aspartame, methyleugenol, and isoeugenol.

Author

Riboli E, Beland FA, Lachenmeier DW, Marques MM, Phillips DH, Schernhammer E, Afghan A, Assunção R, Caderni G, Corton JC, de Aragão Umbuzeiro G, de Jong D, Deschasaux-Tanguy M, Hodge A, Ishihara J, Levy DD, Mandrioli D, McCullough ML, McNaughton SA, Morita T, Nugent AP, Ogawa K, Pandiri AR, Sergi CM, Touvier M, Zhang L, Benbrahim-Tallaa L, Chittiboyina S, Cuomo D, DeBono NL, Debras C, de Conti A, El Ghissassi F, Fontvieille E, Harewood R, Kaldor J, Mattock H, Pasqual E, Rigutto G, Simba H, Suonio E, Viegas S, Wedekind R, Schubauer-Berigan MK, and Madia F

Subjects
Humans, Carcinogenicity Tests, Aspartame adverse effects, Eugenol
Published
2023
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34. Carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite.

Author

Cattley RC, Kromhout H, Sun M, Tokar EJ, Abdallah MA, Bauer AK, Broadwater KR, Campo L, Corsini E, Houck KA, Ichihara G, Matsumoto M, Morais S, Mráz J, Nomiyama T, Ryan K, Shen H, Toyoda T, Vähäkangas K, Yakubovskaya MG, Yu IJ, DeBono NL, de Conti A, El Ghissassi F, Madia F, Mattock H, Pasqual E, Suonio E, Wedekind R, Benbrahim-Tallaa L, and Schubauer-Berigan MK

Subjects
Humans, Anthracenes, Organophosphonates
Published
2023
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35. Carcinogenicity of occupational exposure as a firefighter.

Author

Demers PA, DeMarini DM, Fent KW, Glass DC, Hansen J, Adetona O, Andersen MH, Freeman LEB, Caban-Martinez AJ, Daniels RD, Driscoll TR, Goodrich JM, Graber JM, Kirkham TL, Kjaerheim K, Kriebel D, Long AS, Main LC, Oliveira M, Peters S, Teras LR, Watkins ER, Burgess JL, Stec AA, White PA, DeBono NL, Benbrahim-Tallaa L, de Conti A, El Ghissassi F, Grosse Y, Stayner LT, Suonio E, Viegas S, Wedekind R, Boucheron P, Hosseini B, Kim J, Zahed H, Mattock H, Madia F, and Schubauer-Berigan MK

Subjects
Humans, Firefighters, Occupational Exposure adverse effects
Published
2022
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36. kc-hits: a tool to aid in the evaluation and classification of chemical carcinogens.

Author

Reisfeld B, de Conti A, El Ghissassi F, Benbrahim-Tallaa L, Gwinn W, Grosse Y, and Schubauer-Berigan M

Subjects
Automation, Workflow, Carcinogens toxicity, Software
Abstract

Motivation: The evaluation of chemicals for their carcinogenic hazard requires the analysis of a wide range of data and the characterization of these results relative to the key characteristics of carcinogens. The workflow used historically requires many manual steps that are labor-intensive and can introduce errors, bias and inconsistencies., Results: The automation of parts of the evaluation workflow using the kc-hits software has led to significant improvements in process efficiency, as well as more consistent and comprehensive results., Availability and Implementation: https://gitlab.com/i1650/kc-hits.git., Supplementary Information: Supplementary data are available at Bioinformatics online., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2022
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37. Carcinogenicity of cobalt, antimony compounds, and weapons-grade tungsten alloy.

Author

Karagas MR, Wang A, Dorman DC, Hall AL, Pi J, Sergi CM, Symanski E, Ward EM, Arrandale VH, Azuma K, Brambila E, Calaf GM, Fritz JM, Fukushima S, Gaitens JM, Grimsrud TK, Guo L, Lynge E, Marinho-Reis AP, McDiarmid MA, Middleton DRS, Ong TP, Polya DA, Quintanilla-Vega B, Roberts GK, Santonen T, Sauni R, Silva MJ, Wild P, Zhang CW, Zhang Q, Grosse Y, Benbrahim-Tallaa L, de Conti A, DeBono NL, El Ghissassi F, Madia F, Reisfeld B, Stayner LT, Suonio E, Viegas S, Wedekind R, Ahmadi S, Mattock H, Gwinn WM, and Schubauer-Berigan MK

Subjects
Alloys toxicity, Antimony toxicity, Humans, Cobalt toxicity, Tungsten toxicity
Published
2022
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38. The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification.

Author

Samet JM, Chiu WA, Cogliano V, Jinot J, Kriebel D, Lunn RM, Beland FA, Bero L, Browne P, Fritschi L, Kanno J, Lachenmeier DW, Lan Q, Lasfargues G, Le Curieux F, Peters S, Shubat P, Sone H, White MC, Williamson J, Yakubovskaya M, Siemiatycki J, White PA, Guyton KZ, Schubauer-Berigan MK, Hall AL, Grosse Y, Bouvard V, Benbrahim-Tallaa L, El Ghissassi F, Lauby-Secretan B, Armstrong B, Saracci R, Zavadil J, Straif K, and Wild CP

Subjects
Animals, Humans, International Agencies organization & administration, Motivation, Program Evaluation, Public Health Surveillance, Carcinogens antagonists & inhibitors, Neoplasms prevention & control
Abstract

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs program. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating, and integrating evidence to identify causes of human cancer. The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention., (© The Author(s) 2019. Published by Oxford University Press.)

Published
2020
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39. Carcinogenicity of isobutyl nitrite, β-picoline, and some acrylates.

Author

Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, and Straif K

Subjects
Animals, Humans, Acrylates adverse effects, Carcinogens toxicity, Nitrites adverse effects, Picolines adverse effects
Published
2018
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40. Carcinogenicity of benzene.

Author

Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Vilahur N, Mattock H, and Straif K

Subjects
Animals, Benzene administration & dosage, Carcinogenicity Tests, Consensus, Disease Models, Animal, Female, France, Hematologic Neoplasms epidemiology, Hematologic Neoplasms physiopathology, Humans, Incidence, Internationality, Leukemia, Myeloid, Acute physiopathology, Male, Occupational Exposure adverse effects, Random Allocation, Rats, Risk Assessment, Survival Rate, Benzene toxicity, Carcinogenesis chemically induced, Carcinogens, Environmental toxicity, Hematologic Neoplasms chemically induced, Leukemia, Myeloid, Acute chemically induced
Published
2017
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42. Carcinogenicity of welding, molybdenum trioxide, and indium tin oxide.

Author

Guha N, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Vilahur N, Muller K, and Straif K

Subjects
Animals, Carcinogens, Environmental classification, Humans, Molybdenum classification, Neoplasms diagnosis, Neoplasms epidemiology, Oxides classification, Risk Assessment, Tin Compounds classification, Carcinogens, Environmental adverse effects, Molybdenum adverse effects, Neoplasms chemically induced, Occupational Exposure adverse effects, Occupational Health, Oxides adverse effects, Tin Compounds adverse effects, Welding
Published
2017
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43. Carcinogenicity of pentachlorophenol and some related compounds.

Author

Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Mattock H, and Straif K

Subjects
Animals, Carcinogenicity Tests, Humans, Neoplasms metabolism, Neoplasms pathology, Risk Assessment, Environmental Pollutants adverse effects, Insecticides adverse effects, Neoplasms chemically induced, Pentachlorophenol adverse effects
Published
2016
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44. Carcinogenicity of drinking coffee, mate, and very hot beverages.

Author

Loomis D, Guyton KZ, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Mattock H, and Straif K

Subjects
Esophageal Neoplasms chemically induced, Humans, Beverages adverse effects, Carcinogens toxicity, Coffee adverse effects, Esophageal Neoplasms epidemiology
Published
2016
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45. Carcinogenicity of some industrial chemicals.

Author

Grosse Y, Loomis D, Guyton KZ, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Mattock H, and Straif K

Subjects
Humans, Carcinogens, Industry, Neoplasms chemically induced, Occupational Diseases chemically induced
Published
2016
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46. Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds.

Author

Lauby-Secretan B, Loomis D, Baan R, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Grosse Y, and Straif K

Subjects
Animals, Carcinogens chemistry, Humans, Polychlorinated Biphenyls chemistry, Toxicology standards, Carcinogens toxicity, Neoplasms etiology, Polychlorinated Biphenyls toxicity, Toxicology organization & administration
Abstract

The IARC Monographs are a series of scientific reviews that identify environmental factors that can increase the risk of cancer in humans. In its first part, the principles and procedures of the IARC Monographs evaluations are summarized. In a second part, we present the most recent IARC evaluation of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs), performed in February 2013: PCBs and dioxin-like PCBs were both classified into group 1 "carcinogens," while PBBs were evaluated as "probably carcinogenic to humans" (group 2A). Noteworthy is that the relative contributions of different PCB congeners to the carcinogenicity of PCB mixtures are not known. The use of mechanistic data for the classification into a higher category is discussed in the context of the history of the consecutive evaluations of several related polychlorinated compounds.

Published
2016
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47. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate.

Author

Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, and Straif K

Subjects
Diazinon toxicity, Glycine analogs & derivatives, Glycine toxicity, Humans, Malathion toxicity, Neoplasms pathology, Parathion toxicity, Pesticides toxicity, Tetrachlorvinphos toxicity, Glyphosate, Carcinogenesis, Neoplasms chemically induced, Neoplasms epidemiology
Published
2015
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48. Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes.

Author

Grosse Y, Loomis D, Guyton KZ, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, and Straif K

Subjects
Biocompatible Materials adverse effects, Cell Transformation, Neoplastic pathology, Humans, Neoplasms pathology, Asbestos, Amphibole adverse effects, Carbon Compounds, Inorganic adverse effects, Cell Transformation, Neoplastic chemically induced, Nanotubes, Carbon adverse effects, Neoplasms chemically induced, Silicon Compounds adverse effects
Published
2014
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49. Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone.

Author

Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, and Straif K

Subjects
Caprylates chemistry, Carcinogens toxicity, Education, Fluorocarbons chemistry, Humans, International Cooperation, Methylene Chloride chemistry, Occupational Exposure adverse effects, Occupational Health, Propane adverse effects, Propane chemistry, Risk Assessment, Thiophenes chemistry, Caprylates adverse effects, Carcinogenesis chemically induced, Fluorocarbons adverse effects, Methylene Chloride adverse effects, Propane analogs & derivatives, Thiophenes adverse effects
Published
2014
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50. The carcinogenicity of outdoor air pollution.

Author

Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, and Straif K

Subjects
Air Pollutants analysis, Air Pollution analysis, Environmental Exposure adverse effects, Humans, Neoplasms epidemiology, Neoplasms genetics, Particulate Matter analysis, Particulate Matter toxicity, Risk Factors, Vehicle Emissions analysis, Vehicle Emissions toxicity, Air Pollutants toxicity, Air Pollution adverse effects, Neoplasms etiology
Published
2013
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