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Background: chronic gastritis is one of the most prevalent pathological entities in gastroenterology and digestive endoscopy conflicting patients' morbidity. This cohort study aims to study the role of upper gastro-intestinal tract (Upper GIT) endoscopy and histopathology in diagnosis, follow up and analyze the correlation between the endoscopic and histopathologic findings of chronic gastritis. Methods: In this cohort study, 85 patients of chronic gastritis were studied and followed up endoscopically and histopathologically within 3 to 6 months after treatment between January 2017 and January 2020. Six biopsies were taken from different areas of the stomach and comparing the endoscopic (modified Lanza score) with histopathologic findings according to Sydney System. Results: The longest duration of symptoms of chronic gastritis was (1 up to < 2 years), the most common cause was NSAIDS (65.9%) and H. Pylori induced gastritis by (50.6%). There was significant weak direct correlation between degree of gastritis (endoscope) and degree of gastritis (histopathology) before treatment (p-Value is 0.026) and after treatment (p-Value is 0.007) Also, there was highly significant (HS) improvement after treatment in degree and extent of chronic gastritis endoscopically and histopathologically as p-value <0.001 (HS). Conclusions: Chronic gastritis is a common disease that affects different age groups. NSAIDS induced chronic gastritis is the most common cause of chronic gastritis. H Pylori is the second most common cause of chronic gastritis so preventive measures and treatment regimens should be applied to eradicate H. Pylori. [ABSTRACT FROM AUTHOR]