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1. Doppler ultrasound, a noninvasive tool for the study of mesenteric arterial flow in systemic sclerosis: a cross-sectional study of a patient cohort with review and meta-analysis of the literature

Author

Bandini, Giulia, Monami, Matteo, Ciuti, Gabriele, Mercatelli, Paolo, Lo Cricchio, Anna, De Santis, Maria Cristina, Bonomi, Francesco, Bellando Randone, Silvia, Campochiaro, Corrado, El Aoufy, Khadija, Ruaro, Barbara, Giuggioli, Dilia, Hughes, Michael, McMahan, Zsuzsanna H., Benfaremo, Devis, Moroncini, Gianluca, Maconi, Giovanni, Accogli, Esterita, Dagna, Lorenzo, Matucci Cerinic, Marco, and Moggi Pignone, Alberto

Published
2024
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11. The Rising Challenge of Poor Health Literacy of Patients with Systemic Sclerosis: Preliminary Data Identify Important Unmet Needs in an Italian Cohort

Author

El Aoufy, Khadija, primary, Melis, Maria Ramona, additional, Iovino, Paolo, additional, Bambi, Stefano, additional, Lorini, Chiara, additional, Bonaccorsi, Guglielmo, additional, Galetti, Ilaria, additional, Garbagnati, Carla, additional, Canziani, Paola, additional, Tonolo, Silvia, additional, Mitola, Marco, additional, Guiducci, Serena, additional, Furst, Daniel E., additional, Matucci-Cerinic, Marco, additional, Rasero, Laura, additional, and Bellando-Randone, Silvia, additional

Published
2024
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12. Patients’ unmet needs and treatment preferences concerning digital ulcers in systemic sclerosis

Author

Bandini, Giulia, primary, Alunno, Alessia, additional, Alcacer-Pitarch, Begonya, additional, Ruaro, Barbara, additional, Galetti, Ilaria, additional, El-Aoufy, Khadija, additional, Pinheiro, Filipe, additional, Campanaro, Giulia, additional, Jade, Judith, additional, Donato, StefanoDi, additional, Muir, Lindsay, additional, Moggi Pignone, Alberto, additional, Bellando Randone, Silvia, additional, Del Galdo, Francesco, additional, McMahan, Zsuzsanna H, additional, Matucci-Cerinic, Marco, additional, and Hughes, Michael, additional

Published
2024
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17. The differential crosstalk of the skin-gut microbiome axis as a new emerging actor in systemic sclerosis

Author

Russo, Edda, primary, Bellando-Randone, Silvia, additional, Carboni, Davide, additional, Fioretto, Bianca Saveria, additional, Romano, Eloisa, additional, Baldi, Simone, additional, El Aoufy, Khadija, additional, Ramazzotti, Matteo, additional, Rosa, Irene, additional, Lepri, Gemma, additional, Di Gloria, Leandro, additional, Pallecchi, Marco, additional, Bruni, Cosimo, additional, Melchiorre, Daniela, additional, Guiducci, Serena, additional, Manetti, Mirko, additional, Bartolucci, Gian Luca, additional, Matucci-Cerinic, Marco, additional, and Amedei, Amedeo, additional

Published
2023
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18. Awake Prone Positioning in Nonintubated Patients With Acute Hypoxemic Respiratory Failure

Author

Fusi, C, Bulleri, E, Villa, M, Pisani, L, El Aoufy, K, Lucchini, A, Bambi, S, Fusi, Cristian, Bulleri, Enrico, Villa, Michele, Pisani, Luigi, El Aoufy, Khadija, Lucchini, Alberto, Bambi, Stefano, Fusi, C, Bulleri, E, Villa, M, Pisani, L, El Aoufy, K, Lucchini, A, Bambi, S, Fusi, Cristian, Bulleri, Enrico, Villa, Michele, Pisani, Luigi, El Aoufy, Khadija, Lucchini, Alberto, and Bambi, Stefano

Abstract

Background Awake prone positioning research focuses primarily on improving oxygenation and reducing intubation and mortality rates. Secondary outcomes concerning patient safety have been poorly addressed. Objective To summarize current evidence on the frequency of adverse events during awake prone positioning and the effects on patients’ safety, comfort, and tolerance. Methods This scoping review used the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews. MEDLINE/PubMed and CINAHL databases were the primary sources for the systematic search. Results The review included 19 original studies involving 949 patients who underwent awake prone positioning. No major complications such as death, severe respiratory compromise, or hemodynamic disease were reported. Ten studies reported the following secondary adverse events related to awake prone positioning: skin breakdown (1%-6% of patients), pain (12%-42%), discomfort (35%-43%), vomiting (2%-7%), intolerance (3%-47%), and vascular catheter dislodgment (5%). The duration of awake prone positioning sessions varied widely (0.3-19 hours). Seven studies reported that nurses helped patients during prone positioning maneuvers, including monitoring and surveillance, and 3 studies reported patients placing themselves in the prone position. In 6 studies light or moderate sedation was employed in the procedures. Conclusions Awake prone positioning was not related to cardiorespiratory consequences but was associated with pain, intolerance, discomfort, and patients’ refusal. Patients should receive education regarding awake prone positioning to improve their acceptance. Health care professionals should opti-mize pain control, communication, patient comfort, patient adherence, and correct positioning.

Published
2023

19. The dark side of the CPAP helmet: Why we need more monitoring systems

Author

Bambi, S, Manici, M, El Aoufy, K, Longobucco, Y, Lucchini, A, Bambi, Stefano, Manici, Matteo, El Aoufy, Khadija, Longobucco, Yari, Lucchini, Alberto, Bambi, S, Manici, M, El Aoufy, K, Longobucco, Y, Lucchini, A, Bambi, Stefano, Manici, Matteo, El Aoufy, Khadija, Longobucco, Yari, and Lucchini, Alberto

Published
2023

20. The Effectiveness of NIV and CPAP Training on the Job in COVID-19 Acute Care Wards: A Nurses' Self-Assessment of Skills

Author

Bambi, S, Parente, E, Bardacci, Y, Baldassini Rodriguez, S, Forciniti, C, Ballerini, L, Caruso, C, El Aoufy, K, Poggianti, M, Bonacaro, A, Rona, R, Rasero, L, Lucchini, A, Bambi, Stefano, Parente, Eustachio, Bardacci, Yari, Baldassini Rodriguez, Samuele, Forciniti, Carolina, Ballerini, Lorenzo, Caruso, Christian, El Aoufy, Khadija, Poggianti, Marta, Bonacaro, Antonio, Rona, Roberto, Rasero, Laura, Lucchini, Alberto, Bambi, S, Parente, E, Bardacci, Y, Baldassini Rodriguez, S, Forciniti, C, Ballerini, L, Caruso, C, El Aoufy, K, Poggianti, M, Bonacaro, A, Rona, R, Rasero, L, Lucchini, A, Bambi, Stefano, Parente, Eustachio, Bardacci, Yari, Baldassini Rodriguez, Samuele, Forciniti, Carolina, Ballerini, Lorenzo, Caruso, Christian, El Aoufy, Khadija, Poggianti, Marta, Bonacaro, Antonio, Rona, Roberto, Rasero, Laura, and Lucchini, Alberto

Abstract

Background: Noninvasive ventilation (NIV) in COVID-19 patients outside of intensive care unit (ICU) settings was a feasible support during the pandemic outbreak. The aim of this study was to assess the effectiveness of an “on the job” NIV training program provided to 66 nurses working in 3 COVID-19 wards in an Italian university hospital. Methods: A quasi-experimental longitudinal before–after study was designed. The NIV Team education program, provided by expert ICU nurses, included: 3 h sessions of training on the job during work-shifts about the management of helmet-continuous positive airway pressure (CPAP) Venturi systems, and NIV with oronasal and full-face masks. An eleven-item “brief skills self-report tool” was administered before and after the program to explore the perception of NIV education program attendees about their level of skills. Results: In total, 59 nurses responded to the questionnaire. There was an improvement in the skill levels of the management of Helmet-CPAP (median before training 2, inter-quartile range (IQR) 0–6; median after training 8, IQR 3–9; p < 0.0001), and mask-NIV (median before training 2, IQR 0–6; median after training 8, IQR 3–9; p < 0.0001). Conclusions: Training on the job performed by expert ICU nurses can be a valuable and fast means to implement new Helmet-CPAP and mask-NIV skills outside of ICUs.

Published
2023

22. Sleep Quality and Its Relationship to Anxiety and Hardiness in a Cohort of Frontline Italian Nurses during the First Wave of the COVID-19 Pandemic.

Author

Baldassini Rodriguez, Samuele, Bardacci, Yari, El Aoufy, Khadija, Bazzini, Marco, Caruso, Christian, Giusti, Gian Domenico, Mezzetti, Andrea, Lucchini, Alberto, Iozzo, Pasquale, Guazzini, Andrea, Magi, Camilla Elena, Iovino, Paolo, Longobucco, Yari, Rasero, Laura, Bambi, Stefano, and Gray, Richard

Subjects
MENTAL illness prevention, PSYCHOLOGICAL resilience, MENTAL health, QUESTIONNAIRES, ANXIETY, MULTIVARIATE analysis, DESCRIPTIVE statistics, SURVEYS, LONGITUDINAL method, STATE-Trait Anxiety Inventory, RESEARCH methodology, RESEARCH, SLEEP quality, CONFIDENCE intervals, DATA analysis software, COVID-19 pandemic
Abstract

Introduction: The COVID-19 pandemic has had a considerable impact on the psychological and psychopathological status of the population and health care workers in terms of insomnia, anxiety, depression, and post-traumatic stress disorder. The primary aim of this study was to describe and evaluate the impact of the pandemic on insomnia levels of a cohort of Italian nurses, particularly those involved in the care of COVID-19 patients. The secondary aim was to identify the interaction between insomnia and hardiness, anxiety, and sleep disturbances. Materials and Methods: A descriptive–exploratory study was conducted using an online survey during the first wave of the COVID-19 pandemic (March to July 2020). The questionnaire consisted of multiple-choice, open-ended, closed, and semi-closed questions. The psychometric tools administered were the Dispositional Resilience Scale (DRS-15), the State–Trait Anxiety Inventory (STAI-Y), and the Insomnia Severity Index (ISI). Results: a cohort of 1167 nurses fully completed the questionnaire (86.2% of total respondents). The insomnia scale survey showed an increase in post-pandemic scores compared to those before the pandemic, implying that insomnia levels increased after the first pandemic wave. Insomnia scores were directly correlated with anxiety levels (r = 0.571; p ≤ 0.05) and inversely correlated with hardiness levels (r = −0.324; p < 0.001). Multivariate analysis revealed the following protective factors: not having worked in COVID-19 wards, high levels of hardiness (commitment), and the presence of high pre-pandemic insomnia disorder. The main risk factor for insomnia reported in the analysis was a high anxiety score. Discussion and Conclusion: Anxiety represented the main risk factor for insomnia severity in our sample, while hardiness was confirmed as a protective factor. Thus, it is necessary to design further studies to identify additional risk factors for poor sleep quality and to develop educational courses and strategies aimed at enhancing rest and sleep quality, especially for frontline nurses. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Systemic Sclerosis Patients Experiencing Mindfulness-Based Stress Reduction Program: The Beneficial Effect on Their Psychological Status and Quality of Life

Author

El Aoufy, Khadija, primary, Pezzutto, Arianna, additional, Pollina, Alessandra, additional, Rasero, Laura, additional, Bambi, Stefano, additional, Bellando-Randone, Silvia, additional, Guiducci, Serena, additional, Maddali-Bongi, Susanna, additional, and Matucci Cerinic, Marco, additional

Published
2023
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27. The Effectiveness of NIV and CPAP Training on the Job in COVID-19 Acute Care Wards: A Nurses’ Self-Assessment of Skills

Author

Bambi, Stefano, primary, Parente, Eustachio, additional, Bardacci, Yari, additional, Baldassini Rodriguez, Samuele, additional, Forciniti, Carolina, additional, Ballerini, Lorenzo, additional, Caruso, Christian, additional, El Aoufy, Khadija, additional, Poggianti, Marta, additional, Bonacaro, Antonio, additional, Rona, Roberto, additional, Rasero, Laura, additional, and Lucchini, Alberto, additional

Published
2022
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28. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update

Author

Smolen, Josef S., Landewé, Robert B. M., Bergstra, Sytske Anne, Kerschbaumer, Andreas, Sepriano, Alexandre, Aletaha, Daniel, Caporali, Roberto, Edwards, Christopher John, Hyrich, Kimme L., Pope, Janet E., de Souza, Savia, Stamm, Tanja A., Takeuchi, Tsutomu, Verschueren, Patrick, Winthrop, Kevin L., Balsa, Alejandro, Bathon, Joan M., Buch, Maya H., Burmester, Gerd R., Buttgereit, Frank, Cardiel, Mario Humberto, Chatzidionysiou, Katerina, Codreanu, Catalin, Cutolo, Maurizio, den Broeder, Alfons A., el Aoufy, Khadija, Finckh, Axel, Fonseca, João Eurico, Gottenberg, Jacques-Eric, Haavardsholm, Espen A., Iagnocco, Annamaria, Lauper, Kim, Li, Zhanguo, McInnes, Iain B., Mysler, Eduardo F., Nash, Peter, Poor, Gyula, Ristic, Gorica G., Rivellese, Felice, Rubbert-Roth, Andrea, Schulze-Koops, Hendrik, Stoilov, Nikolay, Strangfeld, Anja, van der Helm-van Mil, Annette, van Duuren, Elsa, Vliet Vlieland, Theodora P. M., Westhovens, René, van der Heijde, D. sirée, Clinical Immunology and Rheumatology, and AII - Inflammatory diseases

Subjects
Arthritis, Rheumatoid, Biological Therapy, All institutes and research themes of the Radboud University Medical Center, Rheumatology, Arthritis, Rheumatoid, Antirheumatic Agents, Immunology, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

ObjectivesTo provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field.MethodsAn international task force was formed and solicited three systematic literature research activities on safety and efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The new evidence was discussed in light of the last update from 2019. A predefined voting process was applied to each overarching principle and recommendation. Levels of evidence and strengths of recommendation were assigned to and participants finally voted on the level of agreement with each item.ResultsThe task force agreed on 5 overarching principles and 11 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); GCs; biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab including biosimilars), abatacept, rituximab, tocilizumab, sarilumab and targeted synthetic (ts) DMARDs, namely the Janus kinase inhibitors tofacitinib, baricitinib, filgotinib, upadacitinib. Guidance on monotherapy, combination therapy, treatment strategies (treat-to-target) and tapering in sustained clinical remission is provided. Safety aspects, including risk of major cardiovascular events (MACEs) and malignancies, costs and sequencing of b/tsDMARDs were all considered. Initially, MTX plus GCs is recommended and on insufficient response to this therapy within 3–6 months, treatment should be based on stratification according to risk factors; With poor prognostic factors (presence of autoantibodies, high disease activity, early erosions or failure of two csDMARDs), any bDMARD should be added to the csDMARD; after careful consideration of risks of MACEs, malignancies and/or thromboembolic events tsDMARDs may also be considered in this phase. If the first bDMARD (or tsDMARD) fails, any other bDMARD (from another or the same class) or tsDMARD (considering risks) is recommended. With sustained remission, DMARDs may be tapered but should not be stopped. Levels of evidence and levels of agreement were high for most recommendations.ConclusionsThese updated EULAR recommendations provide consensus on RA management including safety, effectiveness and cost.

Published
2023

29. 2022 update

Author

Smolen, Josef S., Landewé, Robert B.M., Bergstra, Sytske Anne, Kerschbaumer, Andreas, Sepriano, Alexandre, Aletaha, Daniel, Caporali, Roberto, Edwards, Christopher John, Hyrich, Kimme L., Pope, Janet E., De Souza, Savia, Stamm, Tanja A., Takeuchi, Tsutomu, Verschueren, Patrick, Winthrop, Kevin L., Balsa, Alejandro, Bathon, Joan M., Buch, Maya H., Burmester, Gerd R., Buttgereit, Frank, Cardiel, Mario Humberto, Chatzidionysiou, Katerina, Codreanu, Catalin, Cutolo, Maurizio, Den Broeder, Alfons A., El Aoufy, Khadija, Finckh, Axel, Fonseca, João Eurico, Gottenberg, Jacques Eric, Haavardsholm, Espen A., Iagnocco, Annamaria, Lauper, Kim, Li, Zhanguo, McInnes, Iain B., Mysler, Eduardo F., Nash, Peter, Poor, Gyula, Ristic, Gorica G., Rivellese, Felice, Rubbert-Roth, Andrea, Schulze-Koops, Hendrik, Stoilov, Nikolay, Strangfeld, Anja, Van Der Helm-Van Mil, Annette, Van Duuren, Elsa, Vliet Vlieland, Theodora P.M., Westhovens, René, Van Der Heijde, Désirée, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Comprehensive Health Research Centre (CHRC) - pólo NMS

Subjects
Arthritis, Rheumatoid, Biological Therapy, Rheumatology, Biochemistry, Genetics and Molecular Biology(all), Antirheumatic Agents, Immunology, Immunology and Allergy
Abstract

Funding Information: This study was funded by European League Against Rheumatism. Publisher Copyright: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. Objectives: To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field. Methods: An international task force was formed and solicited three systematic literature research activities on safety and efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The new evidence was discussed in light of the last update from 2019. A predefined voting process was applied to each overarching principle and recommendation. Levels of evidence and strengths of recommendation were assigned to and participants finally voted on the level of agreement with each item. Results: The task force agreed on 5 overarching principles and 11 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); GCs; biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab including biosimilars), abatacept, rituximab, tocilizumab, sarilumab and targeted synthetic (ts) DMARDs, namely the Janus kinase inhibitors tofacitinib, baricitinib, filgotinib, upadacitinib. Guidance on monotherapy, combination therapy, treatment strategies (treat-to-target) and tapering in sustained clinical remission is provided. Safety aspects, including risk of major cardiovascular events (MACEs) and malignancies, costs and sequencing of b/tsDMARDs were all considered. Initially, MTX plus GCs is recommended and on insufficient response to this therapy within 3-6 months, treatment should be based on stratification according to risk factors; With poor prognostic factors (presence of autoantibodies, high disease activity, early erosions or failure of two csDMARDs), any bDMARD should be added to the csDMARD; after careful consideration of risks of MACEs, malignancies and/or thromboembolic events tsDMARDs may also be considered in this phase. If the first bDMARD (or tsDMARD) fails, any other bDMARD (from another or the same class) or tsDMARD (considering risks) is recommended. With sustained remission, DMARDs may be tapered but should not be stopped. Levels of evidence and levels of agreement were high for most recommendations. Conclusions: These updated EULAR recommendations provide consensus on RA management including safety, effectiveness and cost. publishersversion published

Published
2022

30. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update

Author

Smolen, Josef S, primary, Landewé, Robert B M, additional, Bergstra, Sytske Anne, additional, Kerschbaumer, Andreas, additional, Sepriano, Alexandre, additional, Aletaha, Daniel, additional, Caporali, Roberto, additional, Edwards, Christopher John, additional, Hyrich, Kimme L, additional, Pope, Janet E, additional, de Souza, Savia, additional, Stamm, Tanja A, additional, Takeuchi, Tsutomu, additional, Verschueren, Patrick, additional, Winthrop, Kevin L, additional, Balsa, Alejandro, additional, Bathon, Joan M, additional, Buch, Maya H, additional, Burmester, Gerd R, additional, Buttgereit, Frank, additional, Cardiel, Mario Humberto, additional, Chatzidionysiou, Katerina, additional, Codreanu, Catalin, additional, Cutolo, Maurizio, additional, den Broeder, Alfons A, additional, El Aoufy, Khadija, additional, Finckh, Axel, additional, Fonseca, João Eurico, additional, Gottenberg, Jacques-Eric, additional, Haavardsholm, Espen A, additional, Iagnocco, Annamaria, additional, Lauper, Kim, additional, Li, Zhanguo, additional, McInnes, Iain B, additional, Mysler, Eduardo F, additional, Nash, Peter, additional, Poor, Gyula, additional, Ristic, Gorica G, additional, Rivellese, Felice, additional, Rubbert-Roth, Andrea, additional, Schulze-Koops, Hendrik, additional, Stoilov, Nikolay, additional, Strangfeld, Anja, additional, van der Helm-van Mil, Annette, additional, van Duuren, Elsa, additional, Vliet Vlieland, Theodora P M, additional, Westhovens, René, additional, and van der Heijde, Désirée, additional

Published
2022
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32. Oral Care in Intensive Care Unit and Chlorhexidine: An Endless Story

Author

Bambi, S, El Aoufy, K, Iozzo, P, Negro, A, Bardacci, Y, Rodriguez, S, Giusti, G, Rasero, L, Lucchini, A, Bambi, Stefano, El Aoufy, Khadija, Iozzo, Pasquale, Negro, Alessandra, Bardacci, Yari, Rodriguez, Samuele Baldassini, Giusti, Giandomenico, Rasero, Laura, Lucchini, Alberto, Bambi, S, El Aoufy, K, Iozzo, P, Negro, A, Bardacci, Y, Rodriguez, S, Giusti, G, Rasero, L, Lucchini, A, Bambi, Stefano, El Aoufy, Khadija, Iozzo, Pasquale, Negro, Alessandra, Bardacci, Yari, Rodriguez, Samuele Baldassini, Giusti, Giandomenico, Rasero, Laura, and Lucchini, Alberto

Published
2022

33. The Effectiveness of NIV and CPAP Training on the Job in COVID-19 Acute Care Wards: A Nurses' Self-Assessment of Skills.

Author

Bambi, Stefano, Parente, Eustachio, Bardacci, Yari, Baldassini Rodriguez, Samuele, Forciniti, Carolina, Ballerini, Lorenzo, Caruso, Christian, El Aoufy, Khadija, Poggianti, Marta, Bonacaro, Antonio, Rona, Roberto, Rasero, Laura, and Lucchini, Alberto

Subjects
STATISTICS, INFERENTIAL statistics, KRUSKAL-Wallis Test, NURSING, COVID-19, ACADEMIC medical centers, CONTINUOUS positive airway pressure, SELF-evaluation, RESEARCH methodology, ARTIFICIAL respiration, CHI-squared test, DESCRIPTIVE statistics, CRITICAL care medicine, QUESTIONNAIRES, DATA analysis, DATA analysis software, EDUCATIONAL outcomes, LONGITUDINAL method
Abstract

Background: Noninvasive ventilation (NIV) in COVID-19 patients outside of intensive care unit (ICU) settings was a feasible support during the pandemic outbreak. The aim of this study was to assess the effectiveness of an "on the job" NIV training program provided to 66 nurses working in 3 COVID-19 wards in an Italian university hospital. Methods: A quasi-experimental longitudinal before–after study was designed. The NIV Team education program, provided by expert ICU nurses, included: 3 h sessions of training on the job during work-shifts about the management of helmet-continuous positive airway pressure (CPAP) Venturi systems, and NIV with oronasal and full-face masks. An eleven-item "brief skills self-report tool" was administered before and after the program to explore the perception of NIV education program attendees about their level of skills. Results: In total, 59 nurses responded to the questionnaire. There was an improvement in the skill levels of the management of Helmet-CPAP (median before training 2, inter-quartile range (IQR) 0–6; median after training 8, IQR 3–9; p < 0.0001), and mask-NIV (median before training 2, IQR 0–6; median after training 8, IQR 3–9; p < 0.0001). Conclusions: Training on the job performed by expert ICU nurses can be a valuable and fast means to implement new Helmet-CPAP and mask-NIV skills outside of ICUs. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Regional Citrate Anticoagulation and Systemic Anticoagulation during Pediatric Continuous Renal Replacement Therapy: A Systematic Literature Review

Author

Buccione, Emanuele, primary, Bambi, Stefano, additional, Rasero, Laura, additional, Tofani, Lorenzo, additional, Piazzini, Tessa, additional, Della Pelle, Carlo, additional, El Aoufy, Khadija, additional, Ricci, Zaccaria, additional, Romagnoli, Stefano, additional, and Villa, Gianluca, additional

Published
2022
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36. Menstruation-Related Disorders—Dysmenorrhea and Heavy Bleeding—as Significant Epiphenomena in Women With Rheumatic Diseases

Author

Orlandi, Martina, primary, Vannuccini, Silvia, additional, El Aoufy, Khadija, additional, Melis, Maria Ramona, additional, Lepri, Gemma, additional, Sambataro, Gianluca, additional, Bellando-Randone, Silvia, additional, Guiducci, Serena, additional, Cerinic, Marco Matucci, additional, and Petraglia, Felice, additional

Published
2022
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38. The positive side of the coin: Sars-Cov-2 pandemic has taught us how much Telemedicine is useful as standard of care procedure in real life

Author

El Aoufy, Khadija, primary, Melis, Maria Ramona, additional, Bellando Randone, Silvia, additional, Blagojevic, Jelena, additional, Bartoli, Francesca, additional, Fiori, Ginevra, additional, Nacci, Francesca, additional, Conforti, Maria Letizia, additional, Cometi, Laura, additional, Bruni, Cosimo, additional, Orlandi, Martina, additional, Moggi-Pignone, Alberto, additional, Rasero, Laura, additional, Guiducci, Serena, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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39. Lung ultrasound B-lines in systemic sclerosis: cut-off values and methodological indications for interstitial lung disease screening

Author

Gargani, Luna, primary, Romei, Chiara, additional, Bruni, Cosimo, additional, Lepri, Gemma, additional, El-Aoufy, Khadija, additional, Orlandi, Martina, additional, D’Errico, Luigia, additional, Bandini, Giulia, additional, D’Angelo, Gennaro, additional, Guiducci, Serena, additional, Dagna, Lorenzo, additional, Falaschi, Fabio, additional, Matucci-Cerinic, Marco, additional, and Moggi-Pignone, Alberto, additional

Published
2021
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40. Oral Lactobacillus Species in Systemic Sclerosis

Author

Melchiorre, Daniela, primary, Ceccherini, Maria Teresa, additional, Romano, Eloisa, additional, Cometi, Laura, additional, El-Aoufy, Khadija, additional, Bellando-Randone, Silvia, additional, Roccotelli, Angela, additional, Bruni, Cosimo, additional, Moggi-Pignone, Alberto, additional, Carboni, Davide, additional, Guiducci, Serena, additional, Lepri, Gemma, additional, Tofani, Lorenzo, additional, Pietramellara, Giacomo, additional, and Matucci-Cerinic, Marco, additional

Published
2021
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41. A Practical Approach to the Management of Digital Ulcers in Patients With Systemic Sclerosis A Narrative Review

Author

Hughes, Michael, Allanore, Yannick, El Aoufy, Khadija, Denton, Christopher P., Khanna, Dinesh, Krieg, Thomas, Matucci-Cerinic, Marco, Hughes, Michael, Allanore, Yannick, El Aoufy, Khadija, Denton, Christopher P., Khanna, Dinesh, Krieg, Thomas, and Matucci-Cerinic, Marco

Abstract

IMPORTANCE Digital ulcers (DUs) occurring on the fingers in patients with systemic sclerosis (SSc) are associated with substantial pain and disability and are often challenging to treat. However, careful clinical assessment and prompt intervention (wound bed management and systemic pharmacologic treatment) may modify the clinical course. OBJECTIVES To provide a practical approach to the assessment and management of SSc-DUs and highlight unmet needs and research priorities. EVIDENCE REVIEW A narrative review of the extant literature was undertaken to provide a broad overview of current knowledge and augmented by expert opinion. FINDINGS Half of the patients with SSc have a history of DUs, and there is a point of prevalence of approximately 10%. Digital ulcers are often very painful and affect all aspects of physical, social, and family life as well as occupation. Digital ulcers are associated with a severe disease course. Systemic sclerosis DUs, particularly those occurring on the fingertips, represent a vascular ischemic complication, although other etiopathogenic factors play an important role. To guide management, a structured clinical approach is required, including DU definition, classification, and categorization. Digital ulcers require a multidisciplinary approach with close cooperation between physicians and specialist nursing and other allied health professionals to guarantee the appropriate treatment and provide patient education. Local wound bed management is necessary for all DUs and is combined with systemic (pharmacologic) treatments. When treating a DU, the clinician should actively review the therapeutic strategy to prevent further DUs, including the level of systemic disease control, and monitor closely for the development of DU complications, including infection and progression to gangrene. Despite a wide available therapeutic armory, a number of unmet needs and challenges remain that that require resolution to optimize DU management. CONCLUSIONS AN

Published
2021

47. Lung ultrasound B-lines in systemic sclerosis: cut-off values and methodological indications for interstitial lung disease screening.

Author

Gargani, Luna, Romei, Chiara, Bruni, Cosimo, Lepri, Gemma, El-Aoufy, Khadija, Orlandi, Martina, D'Errico, Luigia, Bandini, Giulia, D'Angelo, Gennaro, Guiducci, Serena, Dagna, Lorenzo, Falaschi, Fabio, Matucci-Cerinic, Marco, and Moggi-Pignone, Alberto

Subjects
REFERENCE values, CYTOKINES, AUTOANTIBODIES, PREDICTIVE tests, INTERSTITIAL lung diseases, MEDICAL screening, SYSTEMIC scleroderma, DESCRIPTIVE statistics, COMPUTED tomography, SENSITIVITY & specificity (Statistics)
Abstract

Objectives Lung ultrasound (LUS), through assessment of B-lines and pleural line alterations, is able to evaluate interstitial lung disease (ILD), a frequent complication of SSc. Different scanning schemes and counting methods have been proposed but no clear cut-off values have been indicated for screening. We aimed to evaluate the accuracy of different LUS methodological approaches to detect ILD compared with high-resolution CT (HRCT) as the gold standard. Methods Sixty-nine SSc patients underwent LUS and chest HRCT on the same day. Both exams were scored by expert readers. The accuracy of different scanning schemes and counting methods was assessed and clinical and functional data were compared with imaging findings. Results B-lines were more numerous in patients with the diffuse skin subset and Scl70 autoantibody positivity. The number of B-lines correlated with the Scleroderma Lung Study (SLS) I HRCT score (R  = 0.754, P  < 0.0001). A total of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest showed 97% sensitivity for detecting even very early ILD signs (corresponding to an SLS I score of 1). Sensitivity increased to 100% when pleural line alterations were included in the analysis. Conclusions LUS has a very high sensitivity in detecting SSc-related ILD. A cut-off value of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest can be used for the screening of SSc-ILD. Assessing only the postero-basal chest seems to be mostly effective, combining high sensitivity with a less time-consuming approach. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Patient preferences for systemic sclerosis treatment: A descriptive study within an Italian cohort

Author

El Aoufy, Khadija, Bruni, Cosimo, Rasero, Laura, Matucci Cerinic, Marco, and Furst, Daniel Eric

Abstract

Objectives: The aim of this study is to ascertain systemic sclerosis patients’ preferences regarding the formulations of the medications they use.Methods: We undertook questionnaires and interviews aimed at understanding systemic sclerosis patients’ preferences with respect to the medications they used.Results: Among 160 systemic sclerosis patients, we found that the majority does not have difficulty taking their medication. However, preferences were identified (81.25% – 65/80 – preferred oral meds and 47.50% – 38/80 – disliked rectal/vaginal meds), as well as some systemic sclerosis patients have significant difficulties using their medications. In fact, factors such as swallowing and fine finger motion difficulties were frequent, while intravenous/intramuscular/subcutaneous medicines were usually not preferred because they are felt as inconvenient (intravenous = 33.4% and subcutaneous/intramuscular = 10%) or painful (intravenous = 37.50% and subcutaneous/intramuscular = 10%)Conclusion: Most systemic sclerosis patients are able to take their medication despite having some difficulties. However, as there were clear preferences, we could improve patients’ adherence to drug therapy if taking these preferences into account.

Published
2021
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50. Community health services in European literature: A systematic review of their features, outcomes, and nursing contribution to care.

Author

Caponnetto, Valeria, Dante, Angelo, El Aoufy, Khadija, Melis, Maria Ramona, Ottonello, Giulia, Napolitano, Francesca, Ferraiuolo, Fabio, Camero, Francesco, Cuoco, Angela, Erba, Ilaria, Rasero, Laura, Sasso, Loredana, Bagnasco, Annamaria, Alvaro, Rosaria, Manara, Duilio Fiorenzo, Rocco, Gennaro, Zega, Maurizio, Cicolini, Giancarlo, Mazzoleni, Beatrice, and Lancia, Loreto

Subjects
*COMMUNITY health services, *EUROPEAN literature, *POLICY discourse, *STRUCTURAL optimization, *PATIENT compliance, *NURSING interventions, *HEALTH policy
Abstract

Background Introduction Methods Results Discussion Conclusions and implications for health policy To meet the population's needs, community care should be customized and continuous, adequately equipped, and monitored.Considering their fragmented and heterogeneous nature, a summary of community healthcare services described in European literature is needed. The aim of this study was to summarize their organizational models, outcomes, nursing contribution to care, and nursing‐related determinants of outcomes.A systematic review was performed by searching PubMed, CINAHL, Scopus, and Embase in October 2022 and October 2023 (for updated results). Quantitative studies investigating the effects of community care, including nursing contribution, on patient outcomes were included and summarized. Reporting followed the PRISMA checklist. The review protocol was registered on PROSPERO (CRD42022383856).Twenty‐three studies describing six types of community care services were included, which are heterogeneous in terms of target population, country, interventions, organizational characteristics, and investigated outcomes. Heterogeneous services’ effects were observed for access to emergency services, satisfaction, and compliance with treatment. Services revealed a potential to reduce rehospitalizations of people with long‐term conditions, frail or older persons, children, and heart failure patients. Models are mainly multidisciplinary and, although staffing and workload may also have an impact on provided care, this was not enough investigated.Community health services described in European literature in the last decade are in line with population needs and suggest different suitable models and settings according to different care needs. Community care should be strengthened in health systems, although the influence of staffing, workload, and work environment on nursing care should be investigated by developing new management models.Community care models are heterogeneous across Europe, and the optimum organizational structure is not clear yet. Future policies should consider the impact of community care on both health and economic outcomes and enhance nursing contributions to care. [ABSTRACT FROM AUTHOR]

Published
2024
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