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2. Response to `attitudes of parents with children aged 12-18 to covid-19 vaccines for themselves and their children: vaccine hesitancy in türkiye`

Author

Şahin, Aslıhan, primary, Kara-Aksay, Ahu, additional, Aşcı, Bahri, additional, Ekemen-Keleş, Yıldız, additional, Üstundağ, Gülnihan, additional, Elvan-Tüz, Ayşegül, additional, Taşar, Selin, additional, Arslan-Maden, Aslıhan, additional, İnce, Gülberat, additional, Kanık, Ali, additional, Karadağ-Öncel, Eda, additional, Elmalı, Ferhan, additional, and Yılmaz, Dilek, additional

Published
2024
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3. Clinical Reflections of Acinetobacter Infections in Children in a Quaternary-Care Hospital: A Five-Year Single-Center Experience.

Author

Elvan-Tüz, Ayşegül, Tekin, Duygu, Ekemen-Keleş, Yıldız, Şahin, Aslıhan, Üstündağ, Gülnihan, Taşar, Selin, Kara-Aksay, Ahu, Karadağ-Öncel, Eda, and Yılmaz, Dilek

Subjects
INTENSIVE care units, ACINETOBACTER infections, URINARY tract infections, RETROSPECTIVE studies, ACQUISITION of data, RISK assessment, INFECTION, MEDICAL records, DESCRIPTIVE statistics, LONGITUDINAL method, DISEASE risk factors, CHILDREN
Abstract

Objective: This study aimed to determine the epidemiology of Acinetobacter species in the last 5 years, the clinical diseases caused by the pathogen, the possible risk factors for infection, and the resistance pattern of the microorganism in our quaternary-care hospital. Materials and Methods: In this retrospective cohort study, 67 pediatric cases infected with Acinetobacter species in our hospital between January 2017 and December 2021 were analyzed. Demographic characteristics and clinical and laboratory findings were analyzed. Results: In pediatric patients infected with Acinetobacter spp., the median age was 36 (7-114) months, and 64.2% (n = 43) were female. Acinetobacter baumannii was grown in the cultures of 31 (46.3%) cases. When the type of infection was examined, 31 (46.3%) cases were urinary tract infections, and 29 (43.3%) cases were bloodstream infections. Extensively drug-resistant, pandrug-resistant, and multidrug-resistant A. baumannii were found in 10 (14.9%), 3 (4.5%), and 2 (3%) cases, respectively. Health-care-associated infections were found to have a significant rate of Acinetobacter resistance (P = .002). Significant antimicrobial resistance was detected in Acinetobacter-infected cases with intensive care hospitalization within the last month and carbapenem use in the previous 3 months (P < .001, both). Conclusion: It is necessary to act in accordance with the infection prevention and control program to reduce the incidence of health-care-associated infections with Acinetobacter species and to prevent infection with highly resistant strains. Due to health-care-associated infections and factors contributing to the increase in Acinetobacter resistance, we believe this study will help clinicians to be more cautious in the use of carbapenems. [ABSTRACT FROM AUTHOR]

Published
2024
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4. COVID-19 Obez Çocuklarda Daha Ağır mı Seyrediyor?

Author

ARSLAN MADEN, Aslıhan, primary, EKEMEN KELEŞ, Yıldız, additional, KARADAG-ONCEL, Eda, additional, ÜSTÜNDAĞ, Gülnihan, additional, ŞAHİN, Aslıhan, additional, ELVAN TÜZ, Ayşegül, additional, TAŞAR, Selin, additional, MANYAS, Hayrullah, additional, KARA AKSAY, Ahu, additional, YILMAZ ÇİFTDOĞAN, Dilek, additional, and DÜNDAR, Bumin, additional

Published
2022
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6. Hydatid Disease in Children from Diagnosis to Treatment: A 10-year Single Center Experience

Author

Tüz, Ayşegül Elvan, primary, Ekemen Keleş, Yıldız, additional, Şahin, Aslıhan, additional, Üstündağ, Gülnihan, additional, Taşar, Selin, additional, Karadağ Öncel, Eda, additional, Kara Aksay, Ahu, additional, Öztan, Mustafa Onur, additional, Köylüoğlu, Gökhan, additional, Çapar, Ahmet Ergin, additional, and Yılmaz Çiftdoğan, Dilek, additional

Published
2022
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7. Evaluation of vaccination status of health care workers for recommended vaccines and their acceptance of SARS-CoV-2 vaccines

Author

Oygar, Pembe Derin, primary, Büyükçam, Ayşe, additional, Sahbudak Bal, Zumrut, additional, Dalgıç, Nazan, additional, Bozdemir, Şefika Elmas, additional, Karbuz, Adem, additional, Çetin, Benhur Şirvan, additional, Kara, Yalçın, additional, Çetin, Ceren, additional, Hatipoğlu, Nevin, additional, Uygun, Hatice, additional, Aygün, Fatma Deniz, additional, Hançerli Törün, Selda, additional, Şener Okur, Dicle, additional, Yılmaz Çiftdoğan, Dilek, additional, Tural Kara, Tuğçe, additional, Yahşi, Aysun, additional, Özer, Arife, additional, Öcal Demir, Sevliya, additional, Akkoç, Gülşen, additional, Turan, Cansu, additional, Salı, Enes, additional, Şen, Semra, additional, Erdeniz, Emine Hafize, additional, Kara, Soner Sertan, additional, Emiroğlu, Melike, additional, Erat, Tuğba, additional, Aktürk, Hacer, additional, Laçinel Gürlevik, Sibel, additional, Sütçü, Murat, additional, Gayretli Aydın, Zeynep Gökçe, additional, Yıldız Atikan, Başak, additional, Yeşil, Edanur, additional, Güner Özenen, Gizem, additional, Çelebi, Emel, additional, Efe, Kadir, additional, Kizmaz isancli, Didem, additional, Selver Durmuş, Habibe, additional, Tekeli, Seher, additional, Karaaslan, Ayşe, additional, Bülbül, Lida, additional, Almış, Habip, additional, Kaba, Özge, additional, Ekemen Keleş, Yıldız, additional, Yazıcıoğlu, Bahadır, additional, Bahtiyar Oğuz, Serife, additional, Ovalı, Hüsnü Fahri, additional, Doğan, Hazal Helin, additional, Çelebi, Solmaz, additional, Çakir, Deniz, additional, Karasulu, Burcugül, additional, Alkan, Gülsüm, additional, Yenidoğan, İrem, additional, Gül, Doruk, additional, Parıltan Kücükalioğlu, Burcu, additional, Avcu, Gülhadiye, additional, Kukul, Musa Gürel, additional, Bilen, Melis, additional, Yaşar, Belma, additional, Üstün, Tuğba, additional, Kılıç, Ömer, additional, Akın, Yasemin, additional, Oral Cebeci, Sinem, additional, Bucak, İbrahim Hakan, additional, Sarı Yanartaş, Mehpare, additional, Şahin, Aslıhan, additional, Arslanoglu, Sertaç, additional, Elevli, Murat, additional, Çoban, Rabia, additional, Tuter Öz, Sadiye Kübra, additional, Hatipoğlu, Halil, additional, Erkum, İlyas Tolga, additional, Turgut, Mehmet, additional, Demirbuğa, Asuman, additional, Özçelik, Taha, additional, Çiftçi, Diclehan, additional, Sarı, Emine Ergül, additional, Akkuş, Gökhan, additional, Hatipoğlu, Sadık Sami, additional, Dinleyici, Ener Cağrı, additional, Hacimustafaoğlu, Mustafa, additional, Özkınay, Ferda, additional, Kurugöl, Zafer, additional, Cengiz, Ali Bulent, additional, Somer, Ayper, additional, Tezer, Hasan, additional, and Kara, Ateş, additional

Published
2022
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10. Evaluation of Attitudes and Knowledge of Influenza Diagnosis, Treatment and Vaccination Among Pediatric Residents

Author

Garipçin, Pınar, primary, Ekemen Keleş, Yıldız, additional, Karadağ Öncel, Eda, additional, Kıymet, Elif, additional, Böncüoğlu, Elif, additional, Okumuş Özlü, Canan, additional, Karaoğlu Asrak, Hatice, additional, Güner Özenen, Gizem, additional, Ümit, Zuhal, additional, Kara, Soner Sertan, additional, Şen, Semra, additional, Kara Aksay, Ahu, additional, Şahbudak Bal, Zümrüt, additional, Devrim, İlker, additional, Belet, Nurşen, additional, and Yılmaz Çiftdoğan, Dilek, additional

Published
2021
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12. Multisystem Inflammatory Syndrome in Children

Author

EKEMEN KELEŞ, Yıldız and YILMAZ ÇİFTDOĞAN, Dilek

Subjects
COVID-19,child,SARS-CoV-2,multisystem inflammatorysyndrome,diagnose,treatment, Pediatri, Pediatrics, COVID-19,çocuk,SARS-CoV-2,çoklu sistemik inflamatuvarsendrom,tanı,tedavi
Abstract

An outbreak of pneumonia of unknown origin occurred in China in December 2019. The disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was named Coronavirus disease 2019 (COVID- 19). COVID-19, which is seen less frequently in children than adults, is known to have milder symptoms. However, at the end of April 2020 in Europe, it was observed that some children with SARS-CoV-2 infections developed fever, abdominal pain, shock, myocardial insufficiency, and the need for intensive care. This new disease has been called Multisystem Inflammatory Syndrome in Children (MIS-C). Although the pathogenesis of MIS-C is unclear, it progresses with signs of multi-organ involvement as a result of uncontrolled inflammation of the immune system and even causes death. Therefore, the diagnosis and treatment of patients with MIS-C should be managed quickly. In this review, the pathophysiology, clinical and laboratory findings, diagnostic methods, and treatment regimens of MIS-C were discussed., 2019 yılı Aralık ayında Çin’de nedeni bilinmeyen pnömoni salgını meydana geldi ve ciddi akut solunum yetmezliği sendromu koronavirüs 2’nin (SARSCoV- 2) neden olduğu hastalığa Koronavirüs hastalığı 2019 (COVID-19) adı verildi. Koronavirüs hastalığı 2019 çocuklarda erişkinlere kıyasla daha az sıklıkla görülmekte ve daha hafif bulgularla seyrettiği bilinmektedir. Fakat Avrupa’da Nisan 2020’nin sonlarında SARS-CoV-2 enfeksiyonu geçiren bazı çocuklarda ateş, karın ağrısı, şok, miyokardiyal yetmezlik ve yoğun bakımı ihtiyacı geliştiği görülmüştür. Bu yeni hastalığa Çoklu Sistemik İnflamatuvar Sendrom (MIS-C) adı verilmiştir. MIS-C’in patogenezi net olmamakla birlikte immün sistemin kontrolsüz inflamasyonu sonucunda çoklu organ tutulumuna ait bulgularla seyretmekte ve hatta ölüme neden olmaktadır. Bu nedenle MIS-C’li hastaların tanı ve tedavilerinin hızlıca yönetilmesi gerekmektedir. Bu derlemede MIS-C hastalığının patofizyolojisi, klinik ve laboratuvar bulguları, tanı yöntemleri ve tedavi rejimleri irdelenmiştir.

Published
2021

14. Education of Healthcare Personnel Working with Pediatric Patients During COVID-19 Pandemic within the Framework of Infection Control

Author

Oygar, Pembe Derin, primary, Büyükçam, Ayşe, additional, Şahbudak Bal, Zümrüt, additional, Dalgıç, Nazan, additional, Bozdemir, Şefika Elmas, additional, Karbuz, Adem, additional, Çetin, Benhur Şirvan, additional, Kara, Yalçın, additional, Çetin, Ceren, additional, Hatipoğlu, Nevin, additional, Uygun, Hatice, additional, Aygün, Fatma Deniz, additional, Hançerli Törün, Selda, additional, Şener Okur, Dicle, additional, Yılmaz Çiftdoğan, Dilek, additional, Tural Kara, Tuğçe, additional, Yahşi, Aysun, additional, Özer, Arife, additional, Öcal Demir, Sevliya, additional, Akkoç, Gülşen, additional, Turan, Cansu, additional, Salı, Enes, additional, Şen, Semra, additional, Erdeniz, Emine Hafize, additional, Kara, Soner Sertan, additional, Emiroğlu, Melike, additional, Erat, Tuğba, additional, Aktürk, Hacer, additional, Laçinel Gürlevik, Sibel, additional, Sütçü, Murat, additional, Gayretli Aydın, Zeynep Gökçe, additional, Atikan, Başak Yıldız, additional, Yeşil, Edanur, additional, Güner, Gizem, additional, Çelebi, Emel, additional, Efe, Kadir, additional, Kızmaz İşançlı, Didem, additional, Durmuş, Habibe Selver, additional, Tekeli, Seher, additional, Karaarslan, Ayşe, additional, Bülbül, Lida, additional, Almış, Habip, additional, Kaba, Özge, additional, Ekemen Keleş, Yıldız, additional, Yazıcıoğlu, Bahadır, additional, Bahtiyar Oğuz, Şerife, additional, Ovalı, Hüsnü Fahri, additional, Doğan, Hazal Helin, additional, Çelebi, Solmaz, additional, Çakır, Deniz, additional, Karasulu, Burcugül, additional, Alkan, Gülsüm, additional, Yenidoğan, İrem, additional, Gül, Doruk, additional, Parıltan Küçükalioğlu, Burcu, additional, Avcu, Gülhadiye, additional, Kukul, Musa Gürel, additional, Bilen, Melis, additional, Yaşar, Belma, additional, Üstün, Tuğba, additional, Kılıç, Ömer, additional, Akın, Yasemin, additional, Oral Cebeci, Sinem, additional, Turgut, Mehmet, additional, Sarı Yanartaş, Mehpare, additional, Şahin, Aslıhan, additional, Arslanoğlu, Sertaç, additional, Elevli, Murat, additional, Tüter Öz, Şadiye Kübra, additional, Hatipoğlu, Halil, additional, Erkum, İlyas Tolga, additional, Demirbuğa, Asuman, additional, Özçelik, Taha, additional, Ergül Sarı, Emine, additional, Akkuş, Gökhan, additional, Hatipoğlu, Sadık Sami, additional, Dinleyici, Ener Çağrı, additional, Hacımustafaoğlu, Mustafa, additional, Özkınay, Ferda, additional, Kurugöl, Zafer, additional, Cengiz, Ali Bülent, additional, Somer, Ayper, additional, Tezer, Hasan, additional, and Kara, Ateş, additional

Published
2020
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15. COVID-19 Pandemisinde Enfeksiyon Kontrol Çalışmaları Çerçevesinde Çocuk Hastalarla Çalışan Sağlık Personeli Eğitimi

Author

Oygar, Pembe Derin, primary, Büyükçam, Ayşe, additional, Şahbudak Bal, Zümrüt, additional, Dalgıç, Nazan, additional, Bozdemir, Şefika Elmas, additional, Karbuz, Adem, additional, Çetin, Benhur Şirvan, additional, Kara, Yalçın, additional, Çetin, Ceren, additional, Hatipoğlu, Nevin, additional, Uygun, Hatice, additional, Aygün, Fatma Deniz, additional, Hançerli Törün, Selda, additional, Şener Okur, Dicle, additional, Yılmaz Çiftdoğan, Dilek, additional, Tural Kara, Tuğçe, additional, Yahşi, Aysun, additional, Özer, Arife, additional, Öcal Demir, Sevliya, additional, Akkoç, Gülşen, additional, Turan, Cansu, additional, Salı, Enes, additional, Şen, Semra, additional, Erdeniz, Emine Hafize, additional, Kara, Soner Sertan, additional, Emiroğlu, Melike, additional, Erat, Tuğba, additional, Aktürk, Hacer, additional, Laçinel Gürlevik, Sibel, additional, Sütçü, Murat, additional, Gayretli Aydın, Zeynep Gökçe, additional, Atikan, Başak Yıldız, additional, Yeşil, Edanur, additional, Güner, Gizem, additional, Çelebi, Emel, additional, Efe, Kadir, additional, Kızmaz İşançlı, Didem, additional, Durmuş, Habibe Selver, additional, Tekeli, Seher, additional, Karaarslan, Ayşe, additional, Bülbül, Lida, additional, Almış, Habip, additional, Kaba, Özge, additional, Ekemen Keleş, Yıldız, additional, Yazıcıoğlu, Bahadır, additional, Bahtiyar Oğuz, Şerife, additional, Ovalı, Hüsnü Fahri, additional, Doğan, Hazal Helin, additional, Çelebi, Solmaz, additional, Çakır, Deniz, additional, Karasulu, Burcugül, additional, Alkan, Gülsüm, additional, Yenidoğan, İrem, additional, Gül, Doruk, additional, Parıltan Küçükalioğlu, Burcu, additional, Avcu, Gülhadiye, additional, Kukul, Musa Gürel, additional, Bilen, Melis, additional, Yaşar, Belma, additional, Üstün, Tuğba, additional, Kılıç, Ömer, additional, Akın, Yasemin, additional, Oral Cebeci, Sinem, additional, Bucak, İbrahim Hakan, additional, Turgut, Mehmet, additional, Sarı Yanartaş, Mehpare, additional, Şahin, Aslıhan, additional, Arslanoğlu, Sertaç, additional, Elevli, Murat, additional, Tüter Öz, Şadiye Kübra, additional, Hatipoğlu, Halil, additional, Erkum, İlyas Tolga, additional, Demirbuğa, Asuman, additional, Özçelik, Taha, additional, Ergül Sarı, Emine, additional, Akkuş, Gökhan, additional, Hatipoğlu, Sadık Sami, additional, Dinleyici, Ener Çağrı, additional, Hacımustafaoğlu, Mustafa, additional, Özkınay, Ferda, additional, Kurugöl, Zafer, additional, Cengiz, Ali Bülent, additional, Somer, Ayper, additional, Tezer, Hasan, additional, and Kara, Ateş, additional

Published
2020
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18. Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey

Author

Sadiye Kubra Tuteroz, Hatice Turk Dagi, Melike Emiroglu, Yalçın Kara, Gulnihan Ustundag, Dicle Sener Okur, Nimet Melis Bilen, Fevziye Coksuer, Yasemin Cosgun, Esra Çakmak Taşkın, Ceren Çetin, Tugba Erat, Zeynep Ergenc, Mehmet Köse, Enes Sali, Zafer Kurugol, Cansu Turan, Nurhayat Yakut, M Kemal Kanik, Fidan Khalilova, Gulser Esen Besli, Halil Özdemir, Erdal Ince, Yıldız Ekemen Keleş, Mine Cidem Senoglu, Murat Sutcu, Zümrüt Şahbudak Bal, Gül Arga, Burcu Selbest Demirtas, Mehpare Sarı Yanartaş, Emine H Erdeniz, Aydın Celikyurt, Orhan Kılıc, Göksel Vatansever, Ayşe Karaaslan, Birgul Cubukcu, Hüsnü Fahri Ovalı, Halil Ugur Hatipoglu, Serife Bahtiyar Oguz, Burcu Pariltan Kucukalioglu, Sabit Sahin, Muharrem Cicek, Ozlem Marti Akgun, S Elmas Bozdemir, Aysun Yahşi, Deniz Çakır, Hatice Nilgün Selçuk Duru, Aslıhan Şahin, Aysegul Sahiner, Zeynep Gökçe Gayretli Aydın, Özge Kaba, Solmaz Celebi, Tuğba Bedir Demirdağ, Manolya Kara, Mehmet Turgut, Tuğçe Tural Kara, Alkan Bal, Hacer Aktürk, Ferda Ozkinay, Hasan Tezer, Nevin Hatipoğlu, Arife Ozer, Bulent Karadag, Yasemin Gokdemir, Seval Özen, Esra Kockuzu, Adem Karbuz, Yasemin Akın, Ergin Çiftçi, Tahir Dalkiran, Hatice Kübra Konca, Murat Elevli, Gizem Guner Ozenen, Benhur Şirvan Çetin, Ahu Kara Aksay, Sevcan Saglam, Gülşen Akkoç, Omer Kilic, Selda Hançerli Törün, Dilek Yılmaz Çiftdoğan, Edanur Yeşil, Sare Ilbay, Semra Şen, Ateş Kara, Nazan Dalgic, Gulay Korukluoglu, Ayper Somer, Eda Kepenekli, Yeter Duzenli Kar, Zekiye Baydar, Recep Demirhan, Esra Şevketoğlu, Gulsum Iclal Bayhan, Gülsüm Alkan, Ela Erdem Eralp, Ayse Basak Altas, Ahmet Kağan Özkaya, Mevsim Demir Mis, Seher Tekeli, Hatice Uygun, Adem Dursun, Sevliya Öcal Demir, Mustafa Hacimustafaoglu, Songül Yılmaz, Remzi Sarikaya, F Deniz Aygun, Karbuz, Adem, Akkoc, Gulsen, Bedir Demirdag, Tugba, Yilmaz Ciftdogan, Dilek, Ozer, Arife, Cakir, Deniz, Hancerli Torun, Selda, Kepenekli, Eda, Erat, Tugba, Dalgic, Nazan, Ilbay, Sare, Karaaslan, Ayse, Erdeniz, Emine H., Aygun, F. Deniz, Bozdemir, S. Elmas, Hatipoglu, Nevin, Emiroglu, Melike, Sahbudak Bal, Zumrut, Ciftci, Ergin, Bayhan, Gulsum Iclal, Gayretli Aydin, Zeynep Gokce, Ocal Demir, Sevliya, Kilic, Omer, Hacimustafaoglu, Mustafa, Sener Okur, Dicle, Sen, Semra, Yahsi, Aysun, Akturk, Hacer, Cetin, Benhur, Sutcu, Murat, Kara, Manolya, Uygun, Hatice, Tural Kara, Tugce, Korukluoglu, Gulay, Akgun, Ozlem, ustundag, Gulnihan, Demir Mis, Mevsim, Sali, Enes, Kaba, Ozge, Yakut, Nurhayat, Kilic, Orhan, Kanik, M. Kemal, Cetin, Ceren, Dursun, Adem, Cicek, Muharrem, Kockuzu, Esra, Sevketoglu, Esra, Alkan, Gulsum, Guner Ozenen, Gizem, Ince, Erdal, Baydar, Zekiye, Ozkaya, Ahmet Kagan, Ovali, Husnu Fahri, Tekeli, Seher, Celebi, Solmaz, Cubukcu, Birgul, Bal, Alkan, Khalilova, Fidan, Kose, Mehmet, Hatipoglu, Halil Ugur, Dalkiran, Tahir, Turgut, Mehmet, Basak Altas, Ayse, Selcuk Duru, Hatice Nilgun, Aksay, Ahu, Saglam, Sevcan, Sari Yanartas, Mehpare, Ergenc, Zeynep, Akin, Yasemin, Duzenli Kar, Yeter, Sahin, Sabit, Tuteroz, Sadiye Kubra, Bilen, Nimet Melis, Ozdemir, Halil, Senoglu, Mine Cidem, Pariltan Kucukalioglu, Burcu, Besli, Gulser Esen, Kara, Yalcin, Turan, Cansu, Selbest Demirtas, Burcu, Celikyurt, Aydin, Cosgun, Yasemin, Elevli, Murat, Sahin, Aslihan, Bahtiyar Oguz, Serife, Somer, Ayper, Karadag, Bulent, Demirhan, Recep, Turk Dagi, Hatice, Kurugol, Zafer, Taskin, Esra Cakmak, Sahiner, Aysegul, Yesil, Edanur, Ekemen Keles, Yildiz, Sarikaya, Remzi, Erdem Eralp, Ela, Ozkinay, Ferda, Konca, Hatice Kubra, Yilmaz, Songul, Gokdemir, Yasemin, Arga, Gul, Ozen, Seval, Coksuer, Fevziye, Vatansever, Goksel, Tezer, Hasan, Kara, Ates, Aktürk, Hacer, Çelikyurt, Aydın, Akkoç, Gülşen, Bedir Demirdağ, Tuğba, Yılmaz Çiftdoğan, Dilek, Özer, Arife, Çakır, Deniz, Hançerli Törün, Selda, Erat, Tuğba, Dalgıç, Nazan, İlbay, Sare, Karaaslan, Ayşe, Aygün, F. Deniz, Hatipoğlu, Nevin, Emiroğlu, Melike, Şahbudak Bal, Zümrüt, Çiftçi, Ergin, Bayhan, Gülsüm İclal, Gayretli Aydın, Zeynep Gökçe, Öcal Demir, Sevliya, Kılıç, Ömer, Hacımustafaoğlu, Mustafa, Şener Okur, Dicle, Şen, Semra, Yahşi, Aysun, Çetin, Benhur, Sütçü, Murat, Tural Kara, Tuğçe, Korukluoğlu, Gülay, Akgün, Özlem, Üstündağ, Gülnihan, Salı, Enes, Kaba, Özge, Kılıç, Orhan, Kanık, M. Kemal, Çetin, Ceren, Çiçek, Muharrem, Koçkuzu, Esra, Şevketoğlu, Esra, Alkan, Gülsüm, Güner Özenen, Gizem, İnce, Erdal, Özkaya, Ahmet Kağan, Ovalı, Hüsnü Fahri, Çelebi, Solmaz, Çubukçu, Birgül, Köse, Mehmet, Hatipoğlu, Halil Uğur, Dalkıran, Tahir, Başak Altaş, Ayşe, Selçuk Duru, Hatice Nilgün, Sağlam, Sevcan, Sarı Yanartaş, Mehpare, Ergenç, Zeynep, Akın, Yasemin, Düzenli Kar, Yeter, Şahin, Sabit, Tüter Öz, Şadiye Kübra, Özdemir, Halil, Şenoglu, Mine Çiğdem, Parıltan Küçükalioğlu, Burcu, Besli, Gülser Esen, Kara, Yalçın, Selbest Demirtaş, Burcu, Coşgun, Yasemin, Şahin, Aslıhan, Bahtiyar Oğuz, Şerife, Karadağ, Bülent, Türk Dağı, Hatice, Kurugöl, Zafer, Taşkın, Esra Çakmak, Şahiner, Ayşegül, Yeşil, Edanur, Ekemen Keleş, Yıldız, Sarıkaya, Remzi, Özkınay, Ferda, Konca, Hatice Kübra, Yılmaz, Songül, Gökdemir, Yasemin, Arga, Gül, Özen, Seval, Çoksüer, Fevziye, Vatansever, Göksel, Kara, Ateş, Koç University Hospital, School of Medicine, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Murat Sütçü / 0000-0002-2078-9796, Halil Uğur Hatipoğlu / 0000-0002-7393-677X, Murat Sütçü / ABG-7336-2021, Halil Uğur Hatipoğlu / AAR-7056-2020, Murat Sütçü / 55499199300, and Halil Uğur Hatipoğlu / 56545443800

Subjects
myalgia, medicine.medical_specialty, 030204 cardiovascular system & hematology, Pediatrics, Asymptomatic, RJ1-570, COVID-19, Pediatric, Epidemiology, Laboratory findings, Disease severity, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Internal medicine, Sore throat, medicine, 030212 general & internal medicine, Original Research, Asthma, medicine.diagnostic_test, business.industry, Complete blood count, Retrospective cohort study, medicine.disease, CORONAVIRUS DISEASE, pediatric, laboratory findings, Pediatrics, Perinatology and Child Health, epidemiology, disease severity, medicine.symptom, business
Abstract

Objectives: the aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children.Methods: a retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: there were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% (n = 582) and females constituted 49.7% (n = 574). The median age of the confirmed cases was 10.75 years (4.5-14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1-3 years of age (9.3%), 148 were 3-6 years of age (12.8%), 298 were 6-12 years of age (25.8%), 233 were 12-15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) (n = 583) for a median of 2 days (IQR: 1-3 days). Fever was median at 38.4 degrees C (38.0-38.7 degrees C). The second most common symptom was cough (n = 543, 46.9%). The other common symptoms were sore throat (n = 143, 12.4%), myalgia (n = 141, 12.2%), dyspnea (n = 118, 10.2%), diarrhea (n = 112, 9.7%), stomachache (n = 71, 6.1%), and nasal discharge (n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition (p < 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have (p = 0.38), but the need for intensive care was higher in patients who had an underlying condition (p < 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: to the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution., NA

Published
2021

19. Can Serum 25-Hydroxy Vitamin D Levels Predict the Severity of Multisystem Inflammatory Syndrome in Children and COVID-19?

Author

Ekemen Keleş Y, Yılmaz D, Taşar S, Üstündağ G, Şahin A, Tuz AE, Arslan Maden A, Kara Aksay A, Çolak A, and Karadağ Öncel E

Subjects
Humans, Child, Vitamin D, Systemic Inflammatory Response Syndrome diagnosis, Vitamins, COVID-19, Vitamin D Deficiency
Abstract

Objective: To determine the clinical significance of serum 25-hydroxy (OH) vitamin D levels in pediatric patients with multisystem inflammatory syndrome in children (MIS-C) and compare the vitamin D levels of these patients with those patients with Coronavirus disease-2019 (COVID-19) and healthy controls., Methods: This study was designed for pediatric patients aged 1 month to 18 years and conducted between July 14 and December 25, 2021. Fifty-one patients with MIS-C, 57 who were hospitalized with COVID-19, and 60 controls were enrolled in the study. Vitamin D insufficiency was defined as a serum 25 (OH) vitamin D level of less than 20 ng/mL. Severe MIS-C was classified as necessitating intensive care due to cardiovascular instability, the necessity for non-invasive or invasive mechanical ventilation, and/or a diminishing Glasgow coma scale. World Health Organization definition criteria were used to describe the clinical stages of COVID-19 in children and patients were divided into four groups according to the clinical severity of COVID-19: asymptomatic, mild, moderate, and severe/critical., Results: The median serum 25 (OH) vitamin D was 14.6 ng/mL in patients with MIS-C, 16 ng/mL in patients with COVID-19, and 21.1 ng/mL in the control group (p<0.001). Vitamin D insufficiency was present in 74.5% (n=38) of patients with MIS-C, 66.7% (n=38) of patients with COVID-19, and 41.7% (n=25) of the controls (p=0.001). The percentage of four or more affected organ systems was 39.2% in patients with MIS-C. The correlation between the number of affected organ systems and serum 25 (OH) vitamin D levels was evaluated in patients with MIS-C and there was a moderate negative correlation (r=-0.310; p=0.027). A weak negative correlation was found between the severity of COVID-19 and serum 25 (OH) vitamin D (r=-0.320, p=0.015)., Conclusion: Vitamin D levels were insufficient in both the MIS-C and COVID groups. Furthermore, vitamin D levels correlated with the number of affected organ systems in MIS-C and the severity of COVID-19., (©Copyright 2023 by Turkish Society for Pediatric Endocrinology and Diabetes | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)

Published
2023
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21. Hydatid Disease in Children from Diagnosis to Treatment: A 10-year Single Center Experience

Author

Tüz AE, Ekemen Keleş Y, Şahin A, Üstündağ G, Taşar S, Karadağ Öncel E, Kara Aksay A, Öztan MO, Köylüoğlu G, Çapar AE, and Yılmaz Çiftdoğan D

Subjects
Albendazole therapeutic use, Animals, Child, Female, Humans, Male, Retrospective Studies, Cysts drug therapy, Echinococcosis diagnosis, Echinococcosis drug therapy, Echinococcosis epidemiology, Echinococcus granulosus
Abstract

Objective: Hydatid disease caused by Echinococcus granulosus is a parasitic zoonosis and is endemic in Turkey. Clinical manifestations vary and are related to the anatomical location. In this report, we shared the diagnosis, treatment and follow-up of hydatid disease in children with a 10-year experience., Methods: A total of fifty-seven children diagnosed with hydatid disease were analyzed retrospectively from hospital records. Diagnosis was based on clinical, serological and radiological findings. Treatment response was evaluated with clinical, radiological and serological findings., Results: The male/female ratio of 57 cases was 2.4:1 and the mean age was 113.6±45.9 months. The most common presenting complaint was abdominal pain (42.1%). While 22 (38.6%) of the cases had eosinophilia; indirect hemagglutination test positivity was detected in 27 cases (47.4%). Multiple organ involvement was present in 18 cases (31.6%). In patients with multiple organ involvement, the possibility of cysts being located in the abdomen was higher (p=0.005). Of the 50 cases (87.7%), 45 (78.9%) were operated with open surgery and 5 (8.8%) with percutaneous aspiration-injection-reaspiration method for treatment. There were 52 (91.2%) patients who were given albendazole in conservative treatment and the mean duration of treatment was 15.5±17.2 months. There were 10 cases (17.5%) who developed cyst rupture and the symptom duration was shorter than the cases without cyst rupture (p=0.017). Cyst rupture was more common in cases with dyspnea and fluid discharge from the mouth called rock water (p=0.001, p=0.005, respectively). Recurrence was observed in five cases (8.8%) during follow-up., Conclusion: In areas where the disease is endemic, despite prevention and control programs consisting of personal habits and health education, active transmission of hydatid disease is seen in children and continues to be an important public health problem. Hydatid disease should definitely be considered in the presence of suspicious radiological and clinical findings in endemic areas. Controlled clinical studies are required for diagnosis and treatment procedures.

Published
2022
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22. Seasonal coronaviruses infections in children: do they always cause mild illness?

Author

Tüz AE, Taşar S, Karadağ Öncel E, Ekemen Keleş Y, Şahin A, Üstündağ G, Demirçelik Y, Özkalay Yılmaz N, Kara Aksay A, and Yılmaz Çiftdoğan D

Subjects
Child, Humans, Hypoxia etiology, Infant, Oxygen, Retrospective Studies, Seasons, Coronavirus, Coronavirus Infections diagnosis, Coronavirus Infections epidemiology, Coronavirus Infections therapy, Respiratory Tract Infections epidemiology
Abstract

Background: Human coronaviruses (HCoVs) cause a comprehensive clinic ranging from asymptomatic course to pneumonia. We aimed to describe the HCoV infections in children to determine the clinical status and coinfection effects in a five-year retrospective surveillance study. The primary outcome was admission to the intensive care unit (ICU) and the secondary outcome was the need of high oxygen support., Methods: Between September 2015 and November 2020, all patients whose reverse transcription polymerase chain reaction (RT-PCR) tests were positive were determined and patients with HCoVs were included in the study. Demographical characteristics, underlying chronic diseases, clinical diagnosis, laboratory data, subtypes of HCoVs, radiological findings, treatments, hospitalization, and ICU admission were analyzed., Results: Of the 2606 children, the overall respiratory tract virus detection rate was 82.4%. Among these, 98 cases were HCoVs positive and of these 80 (81.6%) were under five years of age and most of the patients were admitted to the hospital in spring and 70% were a mixed infection with other respiratory viruses. Since lower respiratory tract infections are more common in HCoV coinfections, a significant difference was found in clinical diagnosis (p < 0.001). The presence of hypoxia (p=0.003) and underlying disease (p=0.004) were found to be significantly more common in patients admitted to the ICU. The presence of hypoxia, infiltration on chest X-ray, and elevated C-reactive protein levels were more frequently determined in patients who received high oxygen support (p=0.001, p=0.036, p=0.004, respectively)., Conclusions: Clinical findings may be more severe if HCoVs, which generally cause mild respiratory disease, are coinfected with another viral agent.

Published
2022
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