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Uppsatsens syfte är att undersöka hur relationen mellan människa och djur framställs i den samtida realistiska litteraturen för att diskutera motsägelsefulla etiska aspekter av djursynen i den industrialiserade delen av världen. Genom att i analysen av romanen Vi är alla helt utom oss av Karen Joy Fowler utgå från djurstudier är ambitionen att synliggöra och ifrågasätta rådande normer kring djursyn. Fowler illustrerar hur en nära relation till ett annat djur kan skapa medkänsla för andra levande varelser, påverka livsval och förändra sättet vi agerar på. Genom att minska distanseringen arterna emellan och leva med andra djur kan människan få en mer empatisk djursyn och förlegade idéer om att utnyttja djur kan ifrågasättas. Fowlers roman visar att olikheterna mellan arter snarare handlar om uppträdande än om beteckning, vilket öppnar för en diskussion kring multiarter. Det framgår också att språket saknar förmågan att spegla verklighetens rikedom och komplexitet när det rör sig om identitet., The purpose of the thesis is to examine how the relation between human and animal is depicted in the contemporary realistic literature and to discuss contradictory ethical aspects of the Western view of animals. Using Animal Studies, the analysis of the novel We Are All Completely Beside Ourselves by Karen Joy Fowler questions the prevailing norms around the view of animals in our society. Fowler’s novel illustrates how a close relationship with another animal can create compassion for other living beings, influence the choices we make and may change the way we act. By reducing the distance between species, humans can develop a stronger understanding for animals and start to question norms and outdated ideas about exploiting animals. Fowler’s novel shows that the differences between species concerns behavior rather than designation, which opens up for a discussion about multi-species. It is clear that language lacks the ability to reflect the richness and complexity of reality when it comes to identity.

Objective. Macrophage activation syndrome (MAS) constitutes 1 subtype of the hyperinflammatory syndrome hemophagocytic lymphohistiocytosis (HLH), and the term MAS-HLH was recently proposed for HLH with underlying autoimmune/autoinflammatory conditions. The mortality of MAS-HLH has been estimated at 5-10%. Here we report our experiences with moderately dosed etoposide in severe MAS-HLH; the objective was to effectively reduce severe hyperinflammatory activity with limited side effects. Methods. In addition to conventional antiinflammatory treatment, moderately dosed etoposide was administered to 7 children affected by rapidly progressing MAS-HLH with central nervous system (n = 5) and/ or pulmonary (n = 5) involvement. Three had underlying systemic juvenile idiopathic arthritis (sJIA), 2 had atypical sJIA (no arthritis at diagnosis), and 2 had systemic lupus erythematosus. We performed lymphocyte cytotoxicity analyses in all 7 and genetic analyses in 6. Results. All children promptly responded to moderately dosed etoposide (50-100 mg/m(2Y) once weekly), added to conventional MAS-HLH treatment that was considered insufficient. The mean accumulated etoposide dose was 671 mg/m(2) (range 300-1050 mg/m(2)) as compared to 1500 mg/m(2) recommended in the first 8 weeks of the HLH-94/HLH-2004 protocols. One child developed neutropenic fever and another neutropenic sepsis (neutrophils 0.3 x 10(9)/L at therapy onset). Five of 7 children had low percentages (< 5%) of circulating natural killer (NK) cells prior to or in association with diagnosis; NK cell activity was pathologically low in 2 of 5 children studied. Disease-causing variants in HLH-associated genes were not found. All children were alive at latest follow-up (2-9 yrs after onset); neurological symptoms had normalized in 4 of 5 affected children. Conclusion. Moderately dosed etoposide may be beneficial in severe and/or refractory MAS-HLH.

Purpose: To assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA). Design: Population-based, multicenter, prospective JIA cohort, with a cross-sectional assessment of JIA-associated uveitis (JIA-U) 18 years after the onset of JIA. Participants: A total of 434 patients with JIA, of whom 96 had uveitis, from defined geographic areas of Denmark, Finland, Norway, and Sweden. Methods: Patients with onset of JIA between January 1997 and June 2000 were prospectively followed for 18 years. Pediatric rheumatologists and ophthalmologists collected clinical and laboratory data. Main Outcome Measures: Cumulative incidence of uveitis and clinical characteristics, JIA and uveitis disease activity, ocular complications, visual outcome, and risk factors associated with the development of uveitis-related complications. Results: Uveitis developed in 96 (22.1%) of 434 patients with JIA. In 12 patients (2.8%), uveitis was diagnosed between 8 and 18 years of follow-up. Systemic immunosuppressive medication was more common among patients with uveitis (47/96 [49.0%]) compared with patients without uveitis (78/338 [23.1 %]). Active uveitis was present in 19 of 78 patients (24.4%) at the 18-year visit. Ocular complications occurred in 31 of 80 patients (38.8%). Short duration between the onset of JIA and the diagnosis of uveitis was a risk factor for developing ocular complications (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1-1.8). Patients with a diagnosis of uveitis before the onset of JIA all developed cataract and had an OR for development of glaucoma of 31.5 (95% CI, 3.6-274). Presence of antinuclear antibodies (ANAs) was also a risk factor for developing 1 or more ocular complications (OR, 3.0; 95% CI, 1.2-7.7). Decreased visual acuity (VA) <6/12 was found in 12 of 135 eyes (8.9%) with uveitis, and 4 of 80 patients (5.0%) with JIA-U had binocular decreased VA <6/12. Conclusions: Our results suggest that uveitis screening should start immediat

Objective: To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset. Methods: Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ involvement. The followup visit included demographic data, a standardized clinical orofacial examination, and full-face cone-beam computed tomography (CBCT). For comparison, 200 age-matched healthy controls were used. Results: Of 420 eligible participants with JIA, 265 (63%) were included (mean age 23.5 +/- 4.2 yrs) and completed a standardized clinical orofacial examination. Of these, 245 had a full-face CBCT performed. At least 1 orofacial symptom was reported by 33%. Compared to controls, the JIA group significantly more often reported TMJ pain, TMJ morning stiffness, and limitation on chewing. Further, among participants reporting complaints, the number of symptoms was also higher in JIA. The mean maximal incisal opening was lower in the JIA group (p < 0.001), and TMJ pain on palpation was more frequent. Condylar deformities and/or erosions were observed in 61% as assessed by CBCT, showing bilateral changes in about 70%. Risk factors of condylar deformities were orofacial dysfunction or biologic treatment; enthesitis-related arthritis was protective. Conclusion: This study of the longterm consequences of TMJ involvement in a population-based JIA cohort reports persistence of comprehensive symptoms, dysfunctions, and damage of the TMJ into adulthood. We suggest interdisciplinary followup of JIA patients also in adulthood.

Objective: The present study was undertaken to assess the long-term course, remission rate, and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population-based setting from the early biologic era. Methods: A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden, and Finland were prospectively included in this 18-year cohort study. At the follow-up visit, patient-reported demographic and clinical data were collected. Results: The study included 434 (85%) of the 510 eligible JIA participants. The mean +/- SD age was 24.0 +/- 4.4 years. The median juvenile arthritis disease activity score in 71 joints (JADAS-71) was 1.5 (interquartile range [IQR] 0-5), with the enthesitis-related arthritis (ERA) category of JIA having the highest median score (4.5 [IQR 1.5-8.5], P = 0.003). In this cohort, 46% of patients still had active disease, and 66 (15%) were treated with synthetic disease-modifying antirheumatic drugs and 84 (19%) with biologics. Inactive disease indicated by a JADAS-71 score of <1 was seen in 48% of participants. Clinical remission off medication (CR) was documented in 33% of the participants with high variability among the JIA categories. CR was most often seen in persistent oligoarticular and systemic arthritis and least often in ERA (P < 0.001). Conclusion: A substantial proportion of the JIA cohort did not achieve CR despite new treatment options during the study period. The ERA category showed the worst outcomes, and in general there is still a high burden of disease in adulthood for JIA.

OBJECTIVE: To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.METHODS: Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997-2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ involvement. The follow-up visit included demographic data, a standardized clinical orofacial examination, and fullface cone-beam computed tomography (CBCT). For comparison, 200 age-matched healthy controls were used.RESULTS: Of 420 eligible participants with JIA, 265 (63%) were included (mean age 23.5 ± 4.2 years) and completed a standardized clinical orofacial examination. Of these, 245 had a full-face CBCT performed. At least one orofacial symptom was reported by 33%. Compared to controls, the JIA group significantly more often reported TMJ pain, TMJ morning stiffness, and limitation on chewing. Furthermore, among participants reporting complaints, the number of symptoms was also higher in the JIA. The mean maximal incisal opening was lower in the JIA group (p<0.001), and TMJ pain on palpation was more frequent. Condylar deformities and/or erosions were observed in 61% as assessed by CBCT, showing bilateral changes in about 70%. Risk factors of condylar deformities were orofacial dysfunction or biologic treatment; enthesitis-related arthritis was protective.CONCLUSION: This first study on long-term consequences of TMJ involvement in a population-based JIA cohort reports persistence of comprehensive symptoms, dysfunctions, and damage of the TMJ into adulthood. We suggest interdisciplinary follow-up of JIA patients also in adulthood.

Background To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from a population-based Nordic juvenile idiopathic arthritis (JIA) cohort. Additionally, to assess the predictive value of lectin pathway proteins with respect to remission status. Methods A population-based cohort study of consecutive cases of JIA with a disease onset from 1997 to 2000 from defined geographical areas of Finland, Sweden, Norway and Denmark with 17 years of follow-up was performed. Clinical characteristics were registered and H-ficolin, M-ficolin, MASP-1, MASP-3, MBL and CL-K1 levels in serum were analyzed. Results In total, 293 patients with JIA were included (mean age 23.7 ± 4.4 years; mean follow-up 17.2 ± 1.7 years). Concentrations of the lectin protein levels in serum were higher at baseline compared to the levels 17 years after disease onset (p ≤ 0.006, n = 164). At baseline, the highest level of M-ficolin was observed in systemic JIA. Further, high M-ficolin levels at baseline and at 17-year follow-up were correlated to high levels of ESR. In contrast, high MASP-1 and MASP-3 tended to correlate to low ESR. CL-K1 showed a negative correlation to JADAS71 at baseline. None of the protein levels had prognostic abilities for remission status 17 years after disease onset. Conclusion We hypothesize that increased serum M-ficolin levels are associated with higher disease activity in JIA and further, the results indicate that MASP-1, MASP-3 and CL-K1 are markers of inflammation.

Objective To study self-reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as a predictor of long-term disease outcomes. Methods Consecutive cases of JIA with disease onset from 1997 to 2000 from defined geographical areas of Norway, Sweden, Finland, and Denmark were prospectively enrolled in this population-based cohort study. Self-reported, disease-related pain was measured on a 10-cm visual analog scale (VAS pain). Inclusion criteria were a baseline visit with a pain score 6 months after disease onset, followed by an 8-year study visit. Remission was defined according to Wallace et al (2004) preliminary criteria. Functional disability was measured by the Childhood Health Assessment Questionnaire and the Child Health Questionnaire Parent Form if the child was age <18 years and by the Health Assessment Questionnaire if age >= 18 years. Damage was scored using the Juvenile Arthritis Damage Index. Results The final study cohort consisted of 243 participants, and 120 participants (49%) had oligoarticular onset. At baseline, 76% reported a VAS pain score >0 compared to 57% reporting at 8 years. Half of those who reported baseline pain also reported pain at 8 years but at a lower intensity. Compared to no pain, higher pain intensity at baseline predicted more pain at 8 years, more functional disability, more damage, and less remission without medication. Baseline pain predicted more use of disease-modifying antirheumatic drugs/biologics during the disease course. Participants with oligoarticular JIA reporting pain at baseline were more likely to develop extended oligoarticular JIA or other JIA categories with an unfavorable prognosis. Conclusion Early self-reported, disease-related pain among children and adolescents with JIA is common and seems to predict persistent pain and unfavorable long-term disease outcomes.

An increased access to information and knowledge through the development of information- and communication technology, Internet and social media has led to changes in perceptions of what the public library is and what role it has in contemporary society. In addition, the use of smartphones has contributed to an easy and economic way to market an institution and to build relationships with users through visual communication. In the context of adapting both to the influences of a global market and stated cultural policies on a national, regional and municipal level, the public library aims to serve a target group that includes all citizens. The question at issue states: How does the public libraries in Jönköping use Instagram to market their activity and in what way is different library roles expressed through the images? During 2016 – 2017, 302 images were posted on Instagram by the municipality of Jönköping. These images where studied using content analysis. The four spaces model, as explained by Jochumsen, Hvenegaard Rasmussen and Skot- Hansen (2012), was used to analyze the result. The result shows that the public libraries use Instagram to legitimize the librarys existence towards users and decision-makers, to build relationships with users and to market activities, for instance. he majority of the studied images could be related to the inspiration space.

Background: The aim of the study was to describe school attendance and participation in physical education in school among children with juvenile idiopathic arthritis (JIA). Methods: Consecutive cases of JIA from defined geographical areas of Finland, Sweden and Norway with disease onset in 1997 to 2000 were followed for 8 years in a multi-center cohort study, aimed to be as close to population-based as possible. Clinical characteristics and information on school attendance and participation in physical education (PE) were registered. Results: Participation in school and in PE was lowest initially and increased during the disease course. Eight years after disease onset 228/274 (83.2%) of the children reported no school absence due to JIA, while 16.8% reported absence during the last 2 months due to JIA. Full participation in PE was reported by 194/242 (80.2%), partly by 16.9%, and none by 2.9%. Lowest participation in PE was found among children with ERA and the undifferentiated categories. Absence in school and PE was associated with higher disease activity measures at the 8-year visit. School absence > 1 day at baseline predicted use of disease-modifying anti-rheumatic drugs, including biologics (DMARDs) (OR 1.2 (1.1-1.5)), and non-remission off medication (OR 1.4 (1.1-1.7) 8 years after disease onset. Conclusion: School absence at baseline predicted adverse long-term outcome. In children and adolescents with JIA participation in school activities is mostly high after 8 years of disease. For the minority with low participation, special attention is warranted to promote their full potential of social interaction and improve long-term outcome.

The aim of this study was to examine how professionals on residential care for unaccompanied children worked with the youths needs. Due to the increase of refugees coming to Sweden and specially unaccompanied children it has become one of our present time most important political questions. In order to examine how the professionals are working with the unaccompanied children’s needs we believed that a qualitative study was necessary, and therefore we conducted six interviews. The theory of professional approach (Holm, 1995, 2001) was used to examined which approach the professionals used in their work with the youths, which need the professionals saw was the most important and if the personal put the youths needs before theirs. Our result showed that the needs the professionals saw were the most important with the youths, was the need of a safe relationship, being a participated in the decisions that involved them and the need of learning how to cope with their anxiety. Our result also showed that in their work with the youths needs the professionals had different approaches, an approach that was influenced by rules, an approach that saw the youths as responsible adults and an last approach there the professionals acted as a role model. We could also see that the professionals had an aptitude to see the youths need as a group and not as individual. The respondent expressed that achieving an individual work was hard when the youths all had different needs and different takes at what is important.

Two cables with chlorosulfonated polyethylene jackets and EPDM core insulations, but having different designs and geometries, were aged at 140 degrees C for different periods of time mimicking ageing at 50 degrees C for an exposure time of more than one hundred years. The cable samples were aged in dry air and dry nitrogen. The cable samples were studied with indenter modulus measurements, tensile tests, infrared spectroscopy and line resonance analysis (LIRA). The main question was whether universal correlations could be established between the two classical methods (indenter and tensile testing) and LIRA. The global ageing indicator (CBAC2) obtained by LIRA showed good correlation with the indenter modulus of the jacketing and with the mechanical properties of the core insulation. Almost universal CBAC2 values were obtained for samples reaching a critical state; the latter being defined according to a criterion based on LOCA test data. Infrared spectroscopy showed that the core insulation degraded by an essentially oxygen-free mechanism, with a gradual increase in the concentration of vinyl and vinylene groups. (C) 2010 Elsevier Ltd. All rights reserved., QC 20110307

Problem: Såväl upplevelsebranschen som fenomenet varumärkesutvidgning växer allt mer. Tidigare forskning kring varumärkesutvidgning har dock i första hand fokuserat på produkter och i andra hand på tjänster. Uppsatsen vill därför, genom en fallundersökning på evenemangsorganisationen Vasaloppet, bidra till forskningsfältet genom att undersöka vad inom tidigare forskning som är tillämpbart på en evenemangsorganisation. Dessutom har uppsatsen som ambition att finna angränsande forskningsfält som kan utvidga den tidigare forskningen för att i större utsträckning spegla uppsatsens empiriska resultat och bidra till forskningen om varumärkesutvidgning i stort. Syfte: Att öka kunskapen kring hur ledningar i svenska evenemangsorganisationer, som tillhandahåller upplevelseorienterade tjänster, kan arbeta med varumärkesutvidgning. Metod: Genom dokumentstudier och djupintervjuer med Vasaloppets ledning har en god förståelse för organisationens arbete med varumärkesutvidgning skapats. Det empiriska materialet har jämförts med tidigare forskning som finns kring varumärkesutvidgning. Därefter har uppsatsen kompletterats med forskning kring ett antal angränsande forskningsfält i de fall empirin inte har förklarats av tidigare forskning på området. Resultat: Uppsatsen har funnit att tidigare forskning är tillämpbar på Vasaloppet vad gäller centrala faktorer så som image, överensstämmelse och kvalitet. Däremot är forskningen om risker kring varumärkesutvidgning inte lika central, då organisationen menar att fokus bör vara att göra ”rätt” varumärkesutvidgningar så att riskerna inte uppkommer. De forskningsfält som föreslås komplettera varumärkesutvidgningsforskningen är forskning om upplevelseorganisationer, organisationsförändring och organisatoriskt lärande.

The migration of di(2-ethylhexyl)phthalate (DEHP) from poly(vinyl chloride) (PVC) to a surrounding gas phase at temperatures below 120 degrees C kinetically is controlled by evaporation. The effects on the DEHP loss rate of nitrogen flow rate, relative humidity and degradation of the plasticizer at 100 degrees C was assessed. The sample mass decreased linearly with time for both pristine DEHP and plasticized PVC at comparable rates, suggesting that a thin film of DEHP was present on the jacketing insulation during desorption. The latter hypothesis was supported by infrared spectroscopy and by the fact that DEHP is an amphiphilic molecule that will tend to aggregate at the surface with the hydrophobic 2-ethylhexyl units at the air interface. The effect on the migration rate of moisture present in the gas phase was negligible. The DEHP loss rate increased in a retarding non-linear fashion with increasing gas flow rate. In one of the experiments, DEHP was accidently degraded as revealed by discoloration, the presence of low molar mass degradation products (liquid chromatography) containing additional carbonyl groups (infrared spectroscopy) and an increase in the evaporation rate at temperatures between 100 and 130 degrees C. (C) 2010 Elsevier Ltd. All rights reserved., QC 20101209

Two different approaches for lifetime prediction are presented. The underlying lifetime limiting processes have been identified in two cases. Mathematical expressions of chemical/physical relevance were used for the lifetime predictions for PE hot-water pipes and cables insulated with plasticized PVC. Accelerated testing, extrapolation and validation of the extrapolation by assessment of the remaining lifetime of objects aged during service conditions for 25 years were successfully applied to cables insulated with chlorosulfonated polyethylene. Polyolefin pipes exposed to chlorinated water showed a very complex deterioration scenario and it was only possible to find a method suitable for predicting the time for the depletion of the stabilizer system., QC 20110408