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Your search keyword '"Ekambaram, Hemavathy"' showing total 6 results
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6 results on '"Ekambaram, Hemavathy"'

4. Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf.

Author

Dey, Swarna Kamal, Middha, Sushil Kumar, Usha, Talambedu, Foudah, Ahmed Ibrahim, Ekambaram, Hemavathy, Kamala, Arunagiri, Samuel, Rosa J., Yusufoglu, Hasan Soliman, and Goyal, Arvind Kumar

Subjects
BAMBUSA, METHANOL, BAMBOO, SUPEROXIDE dismutase, PHARMACOLOGY
Abstract

Bambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be 6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81%) and glutathione peroxidase (31.60%) with a decline in malondialdehyde levels (21.90%) when compared to untreated alloxan-induced diabetic control rats. The histopathological assessment of pancreas also showed an increase in ß-cells, though not at a significant level. Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B. tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its exact mechanism of action against diabetes. [ABSTRACT FROM AUTHOR]

Published
2021
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5. Hepatoprotective activity of the ethanolic extract of Morus indicaroots from Indian Bodo tribes

Author

Boro, Hankhray, Usha, Talambedu, Babu, Dinesh, Chandana, Prakashmurthy, Goyal, Arvind Kumar, Ekambaram, Hemavathy, Yusufoglu, Hasan Soliman, Das, Sandeep, and Middha, Sushil Kumar

Abstract

The roots of Morusspecies are well described in the Pharmacopoeia of the People's Republic of China (ChP) for its traditional use in treating liver fibrosis due to its hepatoprotective property. However, little is known about the hepatoprotective effect of the roots of Morus indicaL. (RoMi), and the pharmacological mechanism(s) are uncertain due to its intricacy. Therefore, this study evaluates the hepatoprotective activity of the ethanolic extract of RoMi (eRoMi) against the CCl4-induced in-vivoanimal model at different dosages (100 and 200 mg/kg BW) in comparison with silymarin as a positive control. The hepatoprotective activity of eRoMi was evaluated by measuring the levels of serum biomarkers, hepatic antioxidant enzymes and was verified by histological studies. Interestingly, 1,2-bis(trimethylsilyl) benzene, 1,4-phenylenebis (trimethylsilane), 2,4,6-cycloheptatriene-1-one, 3,5-bis-trimethylsilyl and α-amyrin were the active components found in eRoMi as detected by GC–MS. Oral administration of eRoMi (200 mg/kg BW) to rats significantly protected serum biochemical parameters (increased ALT, AST, LDH, bilirubin and GGT as well as depletion of antioxidant enzymes and hepatic GSH) and elevation in hepatic lipid peroxidation as compared to CCl4-treated rats. The hematological indices such as erythrocytes, hemoglobin, monocytes and lymphocytes were also normal in eRoMi-treated rats. The histopathological evaluation indicated a significant restoration of liver structure as compared to silymarin. This study is the first scientific validation for the traditional use of eRoMi to understand its hepatoprotective activity.

Published
2022
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6. Microbiomics and cloud-based analytics advance sustainable soil management.

Author

Das AJ, Ravinath R, Shilpa BR, Rohith BS, Goyal AK, Shilpa NR, Prasannakumar MK, Prasannakumar HE, Ekambaram H, Usha T, and Middha SK

Subjects
Ecosystem, Cloud Computing, Microbiota, Soil Microbiology
Abstract

Soil constitutes a major component of the agro-ecosystem. Unrestrained uses of chemical pesticides and increased human activities have contributed to unprecedented changes in soil microflora affecting productivity. Modern microbiomics has proven to be an indispensable tool to understand the adaptations underlying complex soil microbial communities and their beneficial applications. In this review, we seek to emphasize the scope of microbiomics in enhancing soil productivity by providing an overview of the various sequencing platforms considering key parameters such as the accuracy, read lengths, reads per run, time involved and weighing out their pros and cons. The advances in modern ultra-high-throughput microbiomics platforms in combination with cloud-based analytics for in-depth exploration of soil-microbe associations can help achieve sustainable soil management contributing to better plant yield and productivity.

Published
2021
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