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Your search keyword '"Eickhardt‐Dalbøge, Christina Schjellerup"' showing total 16 results
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16 results on '"Eickhardt‐Dalbøge, Christina Schjellerup"'

1. Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms—a Danish longitudinal study

Author

Larsen, Morten Kranker, Skov, Vibe, Kjær, Lasse, Eickhardt-Dalbøge, Christina Schjellerup, Knudsen, Trine Alma, Kristiansen, Marie Hvelplund, Sørensen, Anders Lindholm, Wienecke, Troels, Andersen, Morten, Ottesen, Johnny T., Gudmand-Høyer, Johanne, Snyder, Jordan Andrew, Andersen, Mikkel Porsborg, Torp-Pedersen, Christian, Poulsen, Henrik Enghusen, Stiehl, Thomas, Hasselbalch, Hans Carl, and Ellervik, Christina

Published
2024
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2. The gut microbiota in patients with polycythemia vera is distinct from that of healthy controls and varies by treatment

Author

Eickhardt-Dalbøge, Christina Schjellerup, Ingham, Anna Cäcilia, Andersen, Lee O'Brien, Nielsen, Henrik V., Fuursted, Kurt, Stensvold, Christen Rune, Larsen, Morten Kranker, Kjær, Lasse, Christensen, Sarah Friis, Knudsen, Trine Alma, Skov, Vibe, Ellervik, Christina, Olsen, Lars Rønn, Hasselbalch, Hans Carl, Nielsen, Xiaohui Chen, and Christensen, Jens Jørgen Elmer

Published
2023
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3. Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms

Author

Boklund, Tobias Idor, primary, Snyder, Jordan, additional, Gudmand-Hoeyer, Johanne, additional, Larsen, Morten Kranker, additional, Knudsen, Trine Alma, additional, Eickhardt-Dalbøge, Christina Schjellerup, additional, Skov, Vibe, additional, Kjær, Lasse, additional, Hasselbalch, Hans C., additional, Andersen, Morten, additional, Ottesen, Johnny T., additional, and Stiehl, Thomas, additional

Published
2024
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4. JAK2V617F drives gut microbiota differences in patients with myeloproliferative neoplasms

Author

Eickhardt‐Dalbøge, Christina Schjellerup, primary, Nielsen, Henrik V., additional, Fuursted, Kurt, additional, Stensvold, Christen Rune, additional, Andersen, Lee O' Brien, additional, Lilje, Berit, additional, Larsen, Morten Kranker, additional, Kjær, Lasse, additional, Christensen, Sarah Friis, additional, Knudsen, Trine Alma, additional, Skov, Vibe, additional, Sørensen, Anders Lindholm, additional, Ellervik, Christina, additional, Olsen, Lars Rønn, additional, Christensen, Jens Jørgen Elmer, additional, Nielsen, Xiaohui Chen, additional, Hasselbalch, Hans Carl, additional, and Ingham, Anna Cäcilia, additional

Published
2024
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5. Pronounced gut microbiota signatures in patients with JAK2V617F- positive essential thrombocythemia

Author

Eickhardt-Dalbøge, Christina Schjellerup, primary, Ingham, Anna Cäcilia, additional, Nielsen, Henrik V., additional, Fuursted, Kurt, additional, Stensvold, Christen Rune, additional, Andersen, Lee O'Brien, additional, Larsen, Morten Kranker, additional, Kjær, Lasse, additional, Christensen, Sarah Friis, additional, Knudsen, Trine Alma, additional, Skov, Vibe, additional, Ellervik, Christina, additional, Olsen, Lars Rønn, additional, Hasselbalch, Hans Carl, additional, Elmer Christensen, Jens Jørgen, additional, and Nielsen, Xiaohui Chen, additional

Published
2023
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6. Quality of Life and Symptom Burden of Patients with MPN during Treatment with Hydroxyurea or Pegylated Interferon-alpha2: Results from a Randomized Controlled Trial

Author

Knudsen, Trine A., Hansen, Dennis Lund, Ocias, Lukas Frans, Bjerrum, Ole Weis, Brabrand, Mette, Christensen, Sarah F., Eickhardt-Dalbøge, Christina Schjellerup S., Ellervik, Christina, El Fassi, Daniel, Frederiksen, Mikael, Kjær, Lasse, Kristensen, Thomas Kielsgaard, Kruse, Torben A., Larsen, Morten Kranker, Mourits-Andersen, Torben, Overgaard, Ulrik Malthe, Severinsen, Marianne Tang, Skov, Vibe, Sørensen, Anders Lindholm, Stentoft, Jesper, Starklint, Jørn, de Stricker, Karin, Thomassen, Mads, Larsen, Thomas S., and Hasselbalch, Hans Carl

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

7. Combination Therapy with Ruxolitinib and Interferon in Newly Diagnosed Patients with Polycythemia Vera

Author

Sørensen, Anders Lindholm Lindholm, primary, Skov, Vibe, additional, Kjær, Lasse, additional, Eickhardt-Dalbøge, Christina Schjellerup Schjellerup, additional, Larsen, Morten Kranker, additional, Nielsen, Claus, additional, Thomsen, Carsten, additional, Gjerdrum, Lise Mette Rahbek, additional, Knudsen, Trine Alma, additional, Ellervik, Christina, additional, Overgaard, Ulrik Malthe, additional, Andersen, Christen Lykkegaard, additional, Bjørn, Mads Emil, additional, and Hasselbalch, Hans Carl, additional

Published
2022
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8. Patients with Essential Thrombocythemia Have a Gut Microbiota That Differs from Healthy Controls

Author

Eickhardt-Dalbøge, Christina Schjellerup Schjellerup, primary, Ingham, Anna Cäcilia, additional, Andersen, Lee O'Brien, additional, Nielsen, Henrik V, additional, Fuursted, Kurt, additional, Stensvold, Christen Rune, additional, Larsen, Morten Kranker, additional, Kjær, Lasse, additional, Christensen, Sarah F., additional, Knudsen, Trine A., additional, Skov, Vibe, additional, Ellervik, Christina, additional, Olsen, Lars Rønn, additional, Hasselbalch, Hans Carl, additional, Nielsen, Xiaohui Chen, additional, and Christensen, Jens Jørgen Elmer, additional

Published
2022
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9. The Gut Microbiota in Patients with Polycythemia Vera is Distinct from that of Healthy Controls and Varies by Treatment

Author

Eickhardt-Dalbøge, Christina Schjellerup, primary, Ingham, Anna Cäcilia, additional, Andersen, Lee O'Brien, additional, Nielsen, Henrik Vedel, additional, Fuursted, Kurt, additional, Stensvold, Christen Rune, additional, Larsen, Morten Kranker, additional, Kjær, Lasse, additional, Christensen, Sarah Friis, additional, Knudsen, Trine Alma, additional, Skov, Vibe, additional, Ellervik, Christina, additional, Olsen, Lars Rønn, additional, Hasselbalch, Hans Carl, additional, Nielsen, Xiaohui Chen, additional, and Christensen, Jens Jørgen Elmer, additional

Published
2022
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10. Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow‐up

Author

Larsen, Morten K., primary, Skov, Vibe, additional, Kjær, Lasse, additional, Møller‐Palacino, Natascha A., additional, Pedersen, Rasmus K., additional, Andersen, Morten, additional, Ottesen, Johnny T., additional, Cordua, Sabrina, additional, Poulsen, Henrik E., additional, Dahl, Morten, additional, Knudsen, Trine A., additional, Eickhardt‐Dalbøge, Christina Schjellerup, additional, Koschmieder, Steffen, additional, Pedersen, Kasper M., additional, Çolak, Yunus, additional, Bojesen, Stig E., additional, Nordestgaard, Børge G., additional, Stiehl, Thomas, additional, Hasselbalch, Hans C., additional, and Ellervik, Christina, additional

Published
2022
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11. Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis.

Author

Kjær, Lasse, Skov, Vibe, Larsen, Morten Kranker, Boklund, Tobias Idor, Andersen, Morten, Kefala, Maria, Knudsen, Trine A., Eickhardt-Dalbøge, Christina Schjellerup, Stiehl, Thomas, Gudmand-Høyer, Johanne, Snyder, Jordan, Holmström, Morten, Andersen, Mads H., Ottesen, Johnny T., Ellervik, Christina, and Hasselbalch, Hans C.

Subjects
MYELOFIBROSIS, HEMATOPOIESIS, BLOOD cell count, THROMBOPOIETIN receptors, MYELOPROLIFERATIVE neoplasms, SYMPTOMS
Abstract

Initial diagnosis of overt myeloproliferative neoplasms (MPNs) represents the juncture during clonal evolution when symptoms or complications prompt an afflicted individual to seek medical attention. In 30-40% of the MPN subgroups essential thrombocythemia (ET) and myelofibrosis (MF), somatic mutations in the calreticulin gene (CALR) are drivers of the disease resulting in constitutive activation of the thrombopoietin receptor (MPL). In the current study, we describe a healthy CALR mutated individual during a 12 year follow-up from initial identification of CALR clonal hematopoiesis of indeterminate potential (CHIP) to the diagnosis of pre-MF. The pre-diagnostic exponential development dynamics of the malignant clone demonstrated close correlation with the platelet counts, neutrophil-to-lymphocyte (NLR) ratio, and inversely correlated to hemoglobin and erythrocyte counts. Backward extrapolation of the growth rate indicated the potential for discovery of the malignant clone many years prior to presentation of overt disease, opening a window of opportunity for early treatment intervention. We did not find any additional mutations associated with MPNs and the current case report provides novel information regarding the development of a driver mutation and the association with blood cell counts prior to clinical manifestation of symptoms suggesting that pre-diagnostic dynamics may supplement future diagnostic criteria for early diagnosis and intervention in MPN patients. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Clonal haematopoiesis of indeterminate potential and impaired kidney function - A Danish general population study with 11 years follow-up

Author

Larsen, Morten K., Skov, Vibe, Knudsen, Trine A., Eickhardt-Dalbøge, Christina Schjellerup, Koschmieder, Steffen, Pedersen, Kasper M., Çolak, Yunus, Bojesen, Stig E., Nordestgaard, Børge G., Stiehl, Thomas, Hasselbalch, Hans C., Ellervik, Christina, Kjaer, Lasse, Møller-Palacino, Natascha A., Pedersen, Rasmus K., Andersen, Morten, Ottesen, Johnny T., Cordua, Sabrina, Poulsen, Henrik E., and Dahl, Morten

Published
2022

13. Forhøjede blodcelletal og vaskulær sygdom med de myeloproliferative neoplasier som modelsygdomme

Author

Hasselbalch, Hans Carl, Knudsen, Trine Alma, Sørensen, Anders Lindholm, Friis Christensen, Sarah, Kranker Larsen, Morten, Bak, Marie, El Fassi, Daniel, Cordua, Sabrina, Brabrand, Mette, Thomsen, Gitte, Stentoft, Jesper, Starklint, Jørn, Ellervik, Christina, Wienecke, Troels, Bruun, Niels Eske, Eickhardt-Dalbøge, Christina Schjellerup, Kjær, Lasse, and Skov, Vibe

Subjects
food and beverages
Abstract

Recent studies have shown the Philadelphia-negative myeloproliferative neoplasms (MPN) to be massively underdiagnosed and often preceded by a long pre-diagnostic phase of several years, in which many patients suffer serious vascular events. In this review, we focus on the urgent need for earlier diagnosis and treatment of MPN. Such efforts are foreseen to decrease morbidity and mortality for the individual patients and potentially reduce costs for health and social care systems.

Published
2021

14. The Impact of Somatic Mutations upon the Response to Combination Therapy with Ruxolitinib and Interferon in MPN Patients

Author

Skov, Vibe, primary, Sørensen, Anders Lindholm, additional, Knudsen, Trine Alma, additional, Bjørn, Mads Emil, additional, Ellervik, Christina, additional, Kranker Larsen, Morten, additional, Eickhardt-Dalbøge, Christina Schjellerup Schjellerup, additional, Christensen, Sarah Friis, additional, Thomassen, Mads, additional, Kruse, Torben A, additional, and Hasselbalch, Hans C., additional

Published
2021
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15. The Gut Microbiota in Patients with Polycythemia Vera: Novel Vs. Conventional Treatments

Author

Eickhardt-Dalbøge, Christina Schjellerup Schjellerup, primary, Ingham, Anna Cäcilia, additional, Andersen, Lee O'Brien, additional, Nielsen, Henrik V, additional, Fuursted, Kurt, additional, Larsen, Morten Kranker, additional, Kjær, Lasse, additional, Christensen, Sarah Friis, additional, Knudsen, Trine Alma, additional, Skov, Vibe, additional, Ellervik, Christina, additional, Hasselbalch, Hans C., additional, Christensen, Jens Jørgen Elmer, additional, and Nielsen, Xiaohui Chen, additional

Published
2021
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16. Final Analysis of the Daliah Trial: A Randomized Phase III Trial of Interferon-α Versus Hydroxyurea in Patients with MPN

Author

Knudsen, Trine Alma, Hansen, Dennis Lund, Ocias, Lukas Frans, Bjerrum, Ole, Brabrand, Mette, Christensen, Sarah Friis, Eickhardt-Dalbøge, Christina Schjellerup, Ellervik, Christina, El Fassi, Daniel, Frederiksen, Mikael, Kjær, Lasse, Kristensen, Thomas Kielsgaard, Kruse, Torben A., Larsen, Morten Kranker, Mourits-Andersen, Torben, Möller, Sören, Overgaard, Ulrik Malthe, Severinsen, Marianne Tang, Skov, Vibe, Sørensen, Anders Lindholm, Stentoft, Jesper, Starklint, Jørn, de Stricker, Karin, Thomassen, Mads, Larsen, Thomas S., and Hasselbalch, Hans C.

Abstract

Background:Hydroxyurea (HU) is the most commonly used first-line cytoreductive treatment option for patients with myeloproliferative neoplasms (MPN) worldwide. However, increasing evidence on the efficacy and safety of pegylated interferon-alpha2 (IFNα) is emerging, and optimal first-line treatment is to be established.

Published
2023
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