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41 results on '"Eichbaum, Christine"'

15. Learning Breech Birth in an Upright Position Is Influenced by Preexisting Experience—A FRABAT Prospective Cohort Study

Author

Jennewein, Lukas, Brüggmann, Dörthe, Fischer, Kyra, Raimann, Florian J., Pfeifenberger, Hemma Roswitha, Agel, Lena, Zander, Nadja, Eichbaum, Christine, and Louwen, Frank

Subjects
delivery mode, Medicine, ddc:610, Article, reproductive and urinary physiology, female genital diseases and pregnancy complications, vaginal breech, clinical teaching
Abstract

Background: Vaginal breech delivery is becoming an extinct art although national guidelines underline its safety and vaginal breech delivery in an upright position has been shown to be a safe birth mode option. In order to spread clinical knowledge and be able to implement vaginal breech delivery into obstetricians’ daily practice, we need to gather knowledge from facilities who teach specialized obstetrical management. Methods: We performed a prospective cohort study on 140 vaginal deliveries out of breech presentation solely-managed by seven newly-trained physicians and compared fetal outcome as well as rates of manual assistance in respect to preexisting experience. Results: Fetal morbidity rate measured with a modified PREMODA score was not significantly different in three sub-cohorts sorted by preexisting expertise levels of managing obstetricians (experience groups EG, EG0: 2, 5%, EG1: 3, 7.5%, EG2: 1, 1.7%, p = 0.357). Manual assistance rate was significantly higher in EG1 (low experience level in breech delivery and only in dorsal position) compared to EG0 and EG2 (EG1 28, 70%, EG0: 14, 25%, EG2: 21, 35%, p = 0.0008). Conclusions: Our study shows that vaginal breech delivery with newly-trained obstetricians is a safe option whether or not they have advanced preexisting expertise in breech delivery. These data should encourage implementing vaginal breech delivery in clinical routine.

Published
2021

19. Differences in biometric fetal weight estimation accuracy and doppler examination results in uncomplicated term singleton pregnancies between vertex and breech presentation

Author

Jennewein, Lukas, Theissen, Simon, Pfeifenberger, Hemma Roswitha, Zander, Nadja, Fischer, Kyra, Eichbaum, Christine, Louwen, Frank, Jennewein, Lukas, Theissen, Simon, Pfeifenberger, Hemma Roswitha, Zander, Nadja, Fischer, Kyra, Eichbaum, Christine, and Louwen, Frank

Abstract

Doppler examination of the umbilical artery and the fetal middle cerebral artery is evaluated predominantly in pregnancies with fetuses in cephalic presentation and never has been elucidated in breech presentation. Evidence on the accuracy of fetal weight estimation in dependence of the fetal presentation is controversial. Nevertheless, clinical decisions including recommendations for a cesarean section or labor induction based on these examinations are applied to pregnancies with fetuses in breech presentation. The objective of this study was to investigate the influence of the fetal presentation on fetal weight estimation accuracy, umbilical artery and middle cerebral artery resistance indices (RI) in a prospective case control study. Ultrasound examinations in 305 uncomplicated term pregnancies (153 vertex presentations, 152 breech) were investigated. Non-parametric variables were compared using Pearson’s chi2 test and Wilcoxon chi2 test, depending on variable scaling. Fetal weight estimation accuracy was not significantly different between vertex presentation group (VP) (6.97%) and breech presentation group (BP) (7.96%, p = 0.099). Fetal head circumference measurements were significantly larger in BP (350 mm vs. 341 mm in VB, p > 0.0001) while abdominal circumferences were significantly smaller (VP: 338 mm, BP: 331 mm, p = 0.0039) and weight estimation was not significantly different. Umbilical artery RIs were not significantly different between VP (54.5) and BP (55.3, p = 0.354). Fetal middle cerebral artery RIs also showed no significant differences (VP: 71.2, BP: 70.7, p = 0.335). Our study shows that fetal Doppler (RI) and weight estimation ultrasound originally calibrated in cephalic pregnancies are applicable to pregnancies with fetuses in breech presentation.

Published
2021

20. Obesity epidemic - the underestimated risk of endometrial cancer

Author

Kiesel, Ludwig, Eichbaum, Christine, Baumeier, Ariane, and Eichbaum, Michael

Subjects
ddc:610
Abstract

Simple Summary Endometrial cancer is the most frequent gynecologic tumor in developed countries. Obesity is an established risk factor for this disease. This work provides an overview of pathophysiological interactions and pathways in obese women initiating tumorigenesis. Furthermore, the clinical impact of adiposity on the treatment of endometrial cancer is discussed as well therapeutic and preventive options. Abstract Endometrial cancer (EC) is the most frequently observed malignant gynecologic disease in developed countries. There is a strong association between the established risk factor obesity and the incidence of EC. Furthermore, the rate of women with a body mass index (BMI) > 30 kg/m2 is increasing worldwide, correspondingly leading to a higher prevalence of EC. Understanding the adipose tissue as an endocrine organ, elementary pathophysiological pathways of tumorigenesis have been revealed. This includes the fundamental role of hyperglycemia, insulin resistance, and hyperestrogenemia, as well as interactions with a chronic proinflammatory microenvironment. Therapeutic options potentially include metformin or bariatric surgery. Moreover, changes in individual lifestyle such as weight reduction, physical activity, and an awareness of healthy nutrition are effective in preventing the disease.

Published
2020

40. [Biologics - nomenclature and classification].

Author

Eichbaum C and Haefeli WE

Subjects
Antibodies, Monoclonal classification, Antibodies, Monoclonal therapeutic use, Humans, Oncogene Proteins, Fusion classification, Oncogene Proteins, Fusion therapeutic use, Recombinant Proteins classification, Recombinant Proteins therapeutic use, World Health Organization, Biological Products classification, Biological Products therapeutic use, Biosimilar Pharmaceuticals classification, Biosimilar Pharmaceuticals therapeutic use, Terminology as Topic
Abstract

Biological medicines are a heterogeneous group of drugs that are produced by living organisms using genetic or biological technology. Unlike chemically derived small molecules biologics are structurally complex making characterization and manufacturing difficult. Moreover, biological medicines show a great variety concerning their clinical use. To appropriately consider these particularities, there are other standards and guidelines for approval of similar derivatives of biologics, the so-called biosimilars or follow-on biologics. In contrast to a generic medicinal product containing a chemically identical active ingredient, a biosimilar is only expected to be similar to the innovator drug. Nowadays, monoclonal antibodies, fragments of antibodies, and fusion proteins manufactured by recombinant procedures play an important role. They have been used in many specialties for diagnostic and therapeutic purposes and are subject to continuous further development and improvement. Their nomenclature is based on a classification by the WHO which allows drawing conclusions for class of substance, origin, and pharmacological target.

Published
2011
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41. Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis.

Author

Eichbaum C, Meyer AS, Wang N, Bischofs E, Steinborn A, Bruckner T, Brodt P, Sohn C, and Eichbaum MH

Subjects
Animals, Antibodies, Monoclonal pharmacology, Cell Adhesion drug effects, Cell Line, Tumor, Cimetidine pharmacology, E-Selectin immunology, Endothelial Cells cytology, Endothelial Cells drug effects, Endothelial Cells metabolism, Female, Humans, Macrophages drug effects, Macrophages metabolism, Mice, Solubility drug effects, Subcellular Fractions drug effects, Subcellular Fractions metabolism, Tumor Necrosis Factor-alpha biosynthesis, Umbilical Veins cytology, Up-Regulation drug effects, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cytokines metabolism, Macrophages pathology, Neoplasm Metastasis pathology
Abstract

Background: Liver metastasis is associated with a proinflammatory microenvironment and up-regulation of cell adhesion molecules expressed by endothelial cells. The aim of this study was to characterize the interrelations between breast cancer cell-secreted cytokines, macrophages and E-selectin-mediated cancer cell adhesion and their role in metastasis of breast cancer., Materials and Methods: Three metastatic breast cancer cell lines (1590, KM22, ZE) were studied. Cell culture supernatants were screened for cytokines and the potential for cytokines to increase tumor-necrosis factor-α (TNF-α) production by ANA-1-macrophages was analyzed. E-Selectin-mediated tumor cell adhesion of fluorescence labelled tumor cells was evaluated by measurement of fluorescence intensity with and without E-selectin-blocking strategies (monoclonal antibodies, cimetidine)., Results: Tumor-specific cytokine secretion patterns were revealed. TNF-α secretion from cultured macrophages increased after incubation with tumor supernatants. Tumor cell adhesion was significantly inhibited by cimetidine and monoclonal antibodies against E-selectin (KM22 with cimetidine, p<0.05)., Conclusion: Breast cancer cell-secreted cytokines stimulate macrophages to produce TNF-α, a known up-regulator of E-selectin expression, and therefore cell adherence to endothelium. Inhibition of this mechanism could be an attractive therapeutic option for the prevention of breast cnacer metastasis.

Published
2011

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