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Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.

A well-documented trend in family demography is that young adults from disadvantaged backgrounds tend to enter their first partnership earlier and forego marriage more often than their advantaged counterparts. Yet, limited research has explored whether there is also an association between parental background and expectations for partnership formation, which are considered important precursors of behaviours. Further, few studies have explored the potential mechanisms mediating these differences. This paper uses data from the British Household Panel Survey and Understanding Society to analyse the relationships between parental socioeconomic status and young Britons' expectations for marriage, cohabitation, and attitudes towards ideal age at marriage. Using the KHB decomposition as a mediation method, we verify whether these relationships are explained by two mechanisms measured during the young adults' adolescence: family structure socialisation and academic socialisation. We find that marriage expectations are socially stratified in the UK. Those from the least advantaged backgrounds have significantly lower expectations for marriage than the most advantaged, but this difference does not hold for cohabitation. Those from the least advantaged backgrounds are also more uncertain about their ideal age at marriage. Academic socialisation mediates these relationships to a limited extent. Family structure socialisation mediates a greater percentage, especially living with a single parent, rather than married parents, during adolescence. • We analyse the link between parental SES and young Britons' partnership expectations, or attitudes toward marriage age. • KHB decomposition quantified mediation of these links via family structure or educational aspirations during adolescence. • Those from the least advantaged backgrounds have, on average, lower marriage expectations than their well-off counterparts. • No socioeconomic differences were found in the cohabitation expectations. • Further, low-SES young adults are more uncertain regarding their age at marriage or whether to marry at all. • Experiencing a lone-parent family rather than one with married parents mediates the highest percentage of these differences. • Mediation is, however, still partial. [ABSTRACT FROM AUTHOR]

Urbanization is Globally increasing at a rapid rate but its consequences for mental health, including cognitive functioning, are not well understood. In particular, little is known about the effects of different morphological features associated with urban development, such as variations in the densities of urban fabric (i.e., degrees of ground sealing). We investigated associations of episodic memory, working memory, and fluid intelligence with different densities of urban fabric, obtained from the European Urban Atlas, in a structural equation model framework. We used data on 1053 healthy participants aged 61–88 years (mean age 70.33; SD = 3.75; 51% female) drawn from the Berlin Aging Study II. All participants were living within the city of Berlin, Germany. Our data include the precise geographical coordinates of every household, thereby permitting the calculation of the share of each density type of urban fabric within a 1-km radius around the household. We found these types to be significantly related to working memory and fluid intelligence. No significant association emerged for episodic memory. All results were robust against the inclusion of a set of covariates known to be related to cognitive performance. We discuss the idea of enrichment effects due to morphological features of urban development as one possible mechanism. • Morphological features of urban spaces impact cognition (1 km radius around house). • Higher percentage of soil sealed is positively associated with working memory. • Higher percentage of soil sealed is positively associated with fluid intelligence. • Different gradations of urbanicity are differentially related to cognition. [ABSTRACT FROM AUTHOR]

Biological processes have provided new insights into diverging labour market trajectories. This paper uses population variation in testosterone levels to explain transition probabilities into and out of unemployment. We examine labour market transitions for 2004 initially employed and 111 initially unemployed British men from the UK Household Longitudinal Study ("Understanding Society") between 2011 and 2013. We address the endogeneity of testosterone levels by using genetic variation as instrumental variables (Mendelian Randomization). We find that for both initially unemployed men as well as initially employed men, higher testosterone levels reduce the risk of unemployment. Based on previous studies and descriptive evidence, we argue that these effects are likely driven by differences in cognitive and non-cognitive skills as well as job search behaviour of men with higher testosterone levels. Our findings suggest that latent biological processes can affect job search behaviour and labour market outcomes without necessarily relating to illness and disability. • We examine the impact of testosterone on labour market transitions of British men. • We link UK Household Longitudinal Study with the Health and biomarkers Survey. • We estimate probit regression models adjusting for known confounders. • We use genetic variants as instruments in a Mendelian Randomisation analysis. • Higher testosterone levels reduce the risk of becoming or staying unemployed. [ABSTRACT FROM AUTHOR]

This paper examines the causal impact of retirement on preventive care use by focusing on breast cancer screening. It contributes to a better understanding of the puzzling results in the literature reporting mixed effects on health care consumption at retirement. We use five waves of data from the Eurobarometer surveys conducted between 1996 and 2006, covering 25 different European countries. We address the endogeneity of retirement by using age thresholds for pension eligibility as instrumental variables in a bivariate probit model. We find that retirement reduces mammography use and other secondary preventive care use. Our results suggest that health status, income, and knowledge on cancer prevention and treatment contribute little to our understanding of the effects of retirement. Instead, our evidence suggests important effect heterogeneity based on the generosity of the social health insurance system and organized screening programs. • Retirement reduces mammography use among European women. • We also find reductions in other types of women's secondary preventive care use. • Changes in health, income and health beliefs do not seem to be relevant mechanisms. • Effects occur mainly in countries without organized screening programs. • Effects are larger in countries with less generous social health insurance. [ABSTRACT FROM AUTHOR]

• We investigated the association between brain and Urban Fabric and Green in old age. • Urban Fabric is negatively, Urban Green positively associated with p/sACC grey matter. • Neither Urban Fabric (UF), Green (UG) nor p/sACC is related to mental health measures. • But a resting-state measure in p/sACC showed a negative association with UF. • Although UF is often seen as the opposite of UG additional variance in p/sACC structure is explained. The relationship between urbanization, the brain, and human mental health is subject to intensive debate in the current scientific literature. Particularly, since mood and anxiety disorders as well as schizophrenia are known to be more frequent in urban compared to rural regions. Here, we investigated the association between cerebral signatures, mental health and land use indicators (Urban Fabric and Urban Green) within a 1 km radius around the home address of 207 well-characterized older adults. We observed a negative association between Urban Fabric coverage and a positive association between Urban Green coverage and grey matter volume in perigenual/subgenual anterior cingulate cortex (p/sACC). Although p/sACC has repeatedly been associated with depressive symptoms, neither brain structure nor land use categories were related to measures of mental health. However, resting-state measure in p/sACC showed a negative association with Urban Fabric in our healthy sample, reminiscent of previous reports on major depression where p/sACC is often found to be reduced in activation. Interestingly, hierarchical regression analyses showed that Urban Green accounted for additional variance in brain structure beyond Urban Fabric. We take this finding as an exploratory result that hints at potentially salutogenic elements of green spaces (e.g. terpenes, nature sounds) that go beyond the absence of the detrimental elements of urban contexts (e.g. traffic noise, air pollution), which may inform the future search of environmental factors affecting mental health and disease. [ABSTRACT FROM AUTHOR]

The effects of retirement on health, risk factors and its pathways are not entirely understood. Regular retirement marks a smooth transition with positive effects on subjective physical health. Early retirement is related to increased physical activity but also increasing BMI and WHR. Female and low-educated early retirees are especially concerned by negative effects Retirement is a major life event potentially associated with changes in relevant risk factors for cardiovascular and metabolic conditions. This study analyzes the effect of retirement on behavioral and biomedical risk factors for chronic disease, together with subjective health parameters using Southern German epidemiological data. We used panel data from the KORA cohort study, consisting of 11,168 observations for individuals 45–80 years old. Outcomes included health behavior (alcohol, smoking, physical activity), biomedical risk factors (body-mass-index (BMI), waist-to-hip ratio (WHR), glycosylated hemoglobin (HbA1c), total cholesterol/HDL quotient, systolic/diastolic blood pressure), and subjective health (SF12 mental and physical scales, self-rated health). We applied a parametric regression discontinuity design based on age thresholds for pension eligibility. Robust results after p-value corrections for multiple testing showed an increase in BMI in early retirees (at the age of 60) [β = 1.11, corrected p-val. < 0.05] and an increase in CHO/HDL in regular retirees (age 65) [β = 0.47, corrected p-val. < 0.05]. Stratified analyses indicate that the increase in BMI might be driven by women and low educated individuals retiring early, despite increasing physical activity. The increase in CHO/HDL might be driven by men retiring regularly, alongside an increase in subjective physical health. Blood pressure also increased, but the effect differs by retirement timing and sex and is not always robust to sensitivity analysis checks. Our study indicates that retirement has an impact on different risk factors for chronic disease, depending on timing, sex and education. Regular male, early female, and low educated retirees should be further investigated as potential high-risk groups for worsening risk factors after retirement. Future research should investigate if and how these results are linked: in fact, especially in the last two groups, the increase in leisure time physical activity might not be enough to compensate for the loss of work-related physical activity, leading thus to an increase in BMI. [ABSTRACT FROM AUTHOR]

To check claims of a "loneliness epidemic," we examined whether current cohorts of older adults report higher levels and/or steeper age-related increases in loneliness than earlier-born peers. Specifically, we used 1,068 age-matched longitudinal reports (M age observations = 79 years, 49% women) of loneliness provided by independent samples recruited in the German city of Berlin in 1990 and 2010, n = 257 participants in the Berlin Aging Study (BASE) and n = 383 participants in Berlin Aging Study II (BASE-II). Using multilevel models that orthogonalize between-person and within-person age effects, we examined how responses to items from the UCLA Loneliness Scale provided by observation-matched cohorts differed with age and across cohorts, and if those differences might be explained by a variety of individual factors. Results revealed that at age 79, the later-born BASE-II cohort reported substantially lower levels of loneliness than the earlier-born BASE cohort (d = -0.84), with cohort differences accounting for more than 14% of the variance in loneliness. Age trajectories, however, were parallel without evidence of cohort differences in rates of within-person age-related changes in loneliness. Differences in gender, education, cognitive functioning, and external control beliefs accounted for the lion's share of cohort-related differences in levels of loneliness. Results show that loneliness among older adults has shifted to markedly lower levels today, but the rate at which loneliness increases with age proceeds similarly as 2 decades ago. Future studies should investigate how psychosocial functioning across the life course is progressing in different sociohistorical contexts and in other age groups, such as younger and middle-aged adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

This study uses prospective data spanning 27 years (1991-2018) to explore the relationship between economic precariousness and transitions to first co-residential partnership among Britons aged 18-34 across three dimensions: age, historical time, and sex. Economic precariousness is measured using eight objective and subjective indicators, including income, employment, housing, and financial perceptions. Our results show that economic precariousness has a strong negative relationship with entering the first co-residential partnership among those aged 20-30, but the pattern is less clear among the youngest and oldest. Objective measures are easier to interpret than subjective measures. Historical analyses suggest that not being employed decreases the probability of union formation more in recessionary periods than in non-recessionary ones. Among working women, low labour income started to be a predictor of union formation in the most recent periods. Labour income is the only indicator presenting trends in line with our hypotheses across all dimensions.

History-graded increases in older adults' levels of cognitive performance are well documented, but little is known about historical shifts in within-person change: cognitive decline and onset of decline. We combined harmonized perceptual-motor speed data from independent samples recruited in 1990 and 2010 to obtain 2,008 age-matched longitudinal observations ( M = 78 years, 50% women) from 228 participants in the Berlin Aging Study (BASE) and 583 participants in the Berlin Aging Study II (BASE-II). We used nonlinear growth models that orthogonalized within- and between-person age effects and controlled for retest effects. At age 78, the later-born BASE-II cohort substantially outperformed the earlier-born BASE cohort ( d = 1.20; 25 years of age difference). Age trajectories, however, were parallel, and there was no evidence of cohort differences in the amount or rate of decline and the onset of decline. Cognitive functioning has shifted to higher levels, but cognitive decline in old age appears to proceed similarly as it did two decades ago.

A large body of empirical evidence has accumulated showing that the experience of old age is "younger," more "agentic," and "happier" than ever before. However, it is not yet known whether historical improvements in well-being, control beliefs, cognitive functioning, and other outcomes generalize to individuals' views on their own aging process. To examine historical changes in such views on aging, we compared matched cohorts of older adults within two independent studies that assessed differences across a two-decade interval, the Berlin Aging Studies (BASE; 1990/1993 vs. 2017/2018, each n = 256, M age = 77) and the Midlife in the United States Study (MIDUS; 1995/1996 vs. 2013/14, each n = 848, M age = 67). Consistent across four different dimensions of individuals' subjective views on aging (age felt, age appeared, desired age, and attitudes toward own aging) in the BASE and corroborated with subjective age felt and subjective age desired in the MIDUS, there was no evidence whatsoever that older adults of today have more favorable views on how they age than older adults did two decades ago. Further, heterogeneity in views on aging increased across two decades in the MIDUS but decreased in BASE. Also consistent across studies, associations of views on aging with sociodemographic, health, cognitive, and psychosocial correlates did not change across historical times. We discuss possible reasons for our findings, including the possibility that individual age views may have become increasingly decoupled from societal age views. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Introduction: Control beliefs can protect against age-related declines in functioning. It is unclear whether neighborhood characteristics shape how much control people perceive over their life. This article studies associations of neighborhood characteristics with control beliefs of residents of a diverse metropolitan area (Berlin, Germany)., Methods: We combine self-report data about perceptions of control obtained from participants in the Berlin Aging Study II (N = 507, 60-87 years, 51% women) with multisource geo-referenced indicators of neighborhood characteristics using linear regression models., Results: Findings indicate that objective neighborhood characteristics (i.e., unemployment rate) are indeed tied to perceptions of control, in particular, how much control participants feel others have over their lives. Including neighborhood characteristics in part doubled the amount of explained variance compared with a reference model covarying for demographic characteristics only (from R2 = 0.017 to R2 = 0.030 for internal control beliefs; R2 = 0.056 to R2 = 0.102 for external control beliefs in chance; R2 = 0.006 to R2 = 0.030 for external control beliefs in powerful others)., Discussion/conclusion: Findings highlight the importance of access to neighborhood resources for control beliefs across old age and can inform interventions to build up neighborhood characteristics which might be especially helpful in residential areas with high unemployment., (© 2021 The Author(s) Published by S. Karger AG, Basel.)

Many public health interventions aim to provide individuals with health information on the consequences of behaviours such as smoking, alcohol consumption or preventive care use, with the intention of changing health behaviour through better health knowledge. This paper examines whether the provision of health information in organised breast cancer screening programs affects mammography utilisation via changes in health knowledge. We use unique data on 10,610 European women from the Eurobarometer survey collected in 1997/1998, and we exploit variation in the availability and coverage of organised breast cancer screening programs for causal identification in a difference-in-differences design. We find that health information provision improves health knowledge. Yet, these changes in health knowledge had little to no effects on mammography utilisation in the overall population. Our findings imply that health information provision contributes little to health behaviour change. Although screening programs are effective at increasing preventive care use, their effect can be attributed almost entirely to factors other than health knowledge., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Objectives: To estimate the relationship between patient characteristics and referral decisions made by musculoskeletal hubs, and to assess the possible impact of an evidence-based referral tool., Design: Retrospective analysis of medical records and decision tree model evaluating policy changes using local and national data., Setting: One musculoskeletal interface clinic (hub) in England., Participants: 922 adults aged ≥50 years referred by general practitioners with symptoms of knee or hip osteoarthritis., Interventions: We assessed the current frequency and determinants of referrals from one hub and the change in referrals that would occur at this centre and nationally if evidence-based thresholds for referral (Oxford Knee and Hip Scores, OKS/OHS) were introduced., Main Outcome Measure: OKS/OHS, referrals for surgical assessment, referrals for arthroplasty, costs and quality-adjusted life years., Results: Of 110 patients with knee symptoms attending face-to-face hub consultations, 49 (45%) were referred for surgical assessment; the mean OKS for these 49 patients was 18 (range: 1-41). Of 101 hip patients, 36 (36%) were referred for surgical assessment (mean OHS: 21, range: 5-44). No patients referred for surgical assessment were above previously reported economic thresholds for OKS (43) or OHS (45). Setting thresholds of OKS ≤31 and OHS ≤35 might have resulted in an additional 22 knee referrals and 26 hip referrals in our cohort. Extrapolating hub results across England suggests a possible increase in referrals nationally, of around 13 000 additional knee replacements and 4500 additional hip replacements each year., Conclusions: Musculoskeletal hubs currently consider OKS/OHS and other factors when making decisions about referral to secondary care for joint replacement. Those referred typically have low OHS/OKS, and introducing evidence-based OKS/OHS thresholds would prevent few inappropriate (high-functioning, low-pain) referrals. However, our findings suggest that some patients not currently referred could benefit from arthroplasty based on OKS/OHS. More research is required to explore other important patient characteristics currently influencing hub decisions., Competing Interests: Competing interests: HAD reports personal fees from Halyard Health, outside the submitted work. DB reports grants from Zimmer Biomet, outside the submitted work. AJP reports personal fees from Zimmer Biomet and DePuy, outside the submitted work. All declare that there are no other relationships or activities that could appear to have influenced the submitted work. The other authors declare that there are no relevant conflicts of interests or funding besides the NIHR grant that supports the current work., (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.)

Life Span theory posits that sociohistorical contexts shape individual development. In line with this proposition, cohort differences favoring later-born cohorts have been widely documented for cognition and health. However, little is known about historical change in how key resources of psychosocial functioning such as control beliefs develop in old age. We pooled data from 3 independent samples: Berlin Aging Study (6 waves, N = 414); Interdisciplinary Longitudinal Study of Adult Development (4 waves, N = 925); and Berlin Aging Study II (4 waves, N = 1,111) to construct overlapping multiyear longitudinal data from ages 61 through 85 years for cohorts born 1905 to 1953 and examine historical changes in within-person trajectories of internal and external control beliefs. Results revealed that earlier-born cohorts exhibit age-related declines in internal control beliefs regarding both desirable and undesirable outcomes, whereas later-born cohorts perceive higher internal control and maintain this advantage into old age. Earlier-born cohorts also experience steep age-related increases in external control beliefs regarding both powerful others and chance, whereas later-born cohorts perceive lower external control and were stable across old age. Education and gender disparities in control beliefs narrowed over historical time. Sociodemographic, physical health, cognitive, and social factors explained some of the differences in control beliefs, and accounted for sizable portions of cohort effects. Our results indicate that current generations of older adults perceive more and better maintained internal control and fewer external constraints. We discuss potential underlying mechanisms and consider conceptual and societal implications of our findings. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Research on close relationships in later life has received increased attention over the past decade. However, little is known about sexuality and intimacy in old age. Using cross-sectional data from the Berlin Aging Study II (BASE-II; Mage = 68 years, SD = 3.68; 50% women; N = 1,514), we examine age differences in behavioral (sexual activity), cognitive (sexual thoughts), and emotional (intimacy) facets of sexuality and investigate associations with physical health and psychosocial resources for successful aging. Older age was associated with less sexual activity and fewer sexual thoughts, but not with differences in intimacy. Relative to a reference sample of 22- to 36-year-olds within BASE-II (N = 475), the average older adult reported considerably fewer sexual activity and thoughts (ds > .60), but only slightly lower intimacy (d = .20). Substantial heterogeneity existed among older adults, with almost one third of the 60- to 82-year-olds reporting more sexual activity and thoughts than the average younger adult. Examining correlates of sexuality among older adults revealed that, covarying for diagnosed illnesses and performance-based grip strength, psychosocial factors (e.g., partnered, relationship satisfaction) accounted for considerable shares of variance in sexual activity and intimacy, whereas age and gender explained more of the variance in sexual thoughts. Some psychosocial factors exhibited similar-sized associations with all sexuality facets, whereas other factors operated in more facet-specific ways. To illustrate, participants reporting more loneliness also reported less sexual activity and less intimacy, but not fewer sexual thoughts. We discuss implications of our findings for theories of successful aging. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

As antibiotic consumption grows, bacteria are becoming increasingly resistant to treatment. Antibiotic resistance undermines much of modern health care, which relies on access to effective antibiotics to prevent and treat infections associated with routine medical procedures. The resulting challenges have much in common with those posed by climate change, which economists have responded to with research that has informed and shaped public policy. Drawing on economic concepts such as externalities and the principal-agent relationship, we suggest how economics can help to solve the challenges arising from increasing resistance to antibiotics. We discuss solutions to the key economic issues, from incentivizing the development of effective new antibiotics to improving antibiotic stewardship through financial mechanisms and regulation., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

Objectives: To assess how costs and quality of life (measured by EuroQoL-5 Dimensions (EQ-5D)) before and after total hip replacement (THR) and total knee replacement (TKR) vary with age, gender and preoperative Oxford hip score (OHS) and Oxford knee score (OKS)., Design: Regression analyses using prospectively collected data from clinical trials, cohort studies and administrative data bases., Setting: UK secondary care., Participants: Men and women undergoing primary THR or TKR. The Hospital Episode Statistics data linked to patient-reported outcome measures included 602 176 patients undergoing hip or knee replacement who were followed up for up to 6 years. The Knee Arthroplasty Trial included 2217 patients undergoing TKR who were followed up for 12 years. The Clinical Outcomes in Arthroplasty Study cohort included 806 patients undergoing THR and 484 patients undergoing TKR who were observed for 1 year., Outcome Measures: EQ-5D-3L quality of life before and after surgery, costs of primary arthroplasty, costs of revision arthroplasty and the costs of hospital readmissions and ambulatory costs in the year before and up to 12 years after joint replacement., Results: Average postoperative utility for patients at the 5th percentile of the OHS/OKS distribution was 0.61/0.5 for THR/TKR and 0.89/0.85 for patients at the 95th percentile. The difference between postoperative and preoperative EQ-5D utility was highest for patients with preoperative OHS/OKS lower than 10. However, postoperative EQ-5D utility was higher than preoperative utility for all patients with OHS≤46 and those with OKS≤44. In contrast, costs were generally higher for patients with low preoperative OHS/OKS than those with high OHS/OKS. For example, costs of hospital readmissions within 12 months after primary THR/TKR were £740/£888 for patients at the 5th percentile compared with £314/£404 at the 95th percentile of the OHS/OKS distribution., Conclusions: Our findings suggest that costs and quality of life associated with total joint replacement vary systematically with preoperative symptoms measured by OHS/OKS., Competing Interests: Competing interests: HAD reports personal fees from Halyard Health, outside the submitted work. NKA reports grants from Bioiberica, personal fees from Bioventus, personal fees from ESCEO, personal fees from Flexion, personal fees from Freshfields Bruckhaus Deringer, personal fees from Merck, personal fees from Regeneron, outside the submitted work., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Background: The last decades have seen great advances in the understanding, treatment, and prevention of cardiovascular disease (CVD). Although mortality rates due to CVD have declined significantly in the last decades, the burden of CVD is still high, particularly in older adults. This raises the question whether contemporary populations of older adults are experiencing better or worse objective as well as subjective health than earlier-born cohorts. The aim of this study was to examine differences in modifiable indicators of cardiovascular health (CVH), comparing data obtained 20 years apart in the Berlin Aging Study (BASE, 1990-93) and the Berlin Aging Study II (BASE-II, 2009-2014)., Methods: Serial cross-sectional analysis of 242 propensity-score-matched participants of BASE (born 1907-1922) and BASE-II (born 1925-1942). Body mass index (BMI), blood pressure, total cholesterol, glycated hemoglobin (HbA1c), diet, smoking and physical activity were operationalized according to the "Life's simple 7"(LS7) criteria of the American Heart Association., Results: 121 matched pairs were identified based on age, sex, and education. In the later-born BASE-II sample, the mean LS7 score was significantly higher than in the earlier-born sample (7.8±1.8 vs. 6.4±2.1, p<0.001), indicating better CVH. In detail, diet, physical activity, smoking, cholesterol, and HbA1c were more favorable, whereas blood pressure was significantly higher in individuals from the later-born cohort. BMI did not differ significantly between the two matched samples. Notably, despite better CVH, later-born individuals (BASE-II) reported lower self-rated health, presumably because of higher health expectations., Conclusions: Overall, cardiovascular health was significantly better in the later-born cohort, but several notable exceptions exist.

Enriched environments elicit brain plasticity in animals. In humans it is unclear which environment is enriching. Living in a city has been associated with increased amygdala activity in a stress paradigm, and being brought up in a city with increased pregenual anterior cingulate cortex (pACC) activity. We set out to identify geographical characteristics that constitute an enriched environment affecting the human brain. We used structural equation modelling on 341 older adults to establish three latent brain factors (amygdala, pACC and dorsolateral prefrontal cortex (DLPFC)) to test the effects of forest, urban green, water and wasteland around the home address. Our results reveal a significant positive association between the coverage of forest and amygdala integrity. We conclude that forests may have salutogenic effects on the integrity of the amygdala. Since cross-sectional data does not allow causal inference it could also be that individuals with high structural integrity choose to live closer to forest.

Background: Excessive loss of muscle mass in advanced age is a major risk factor for decreased physical ability and falls. Physical activity and exercise training are typically recommended to maintain muscle mass and prevent weakness. How exercise in different stages of life relates to muscle mass, grip strength, and risk for weakness in later life is not well understood., Methods: Baseline data on 891 participants at least 60 years old from the Berlin Aging Study II (BASE-II) were analyzed. Linear and logistic regressions of self-reported exercise in early adulthood, old age, or both on appendicular lean mass (ALM), grip strength, and a risk indicator for weakness (ALM/ body mass index cutoff) were calculated. In addition, treatment bounds are analyzed to address potential confounding using a method proposed by Oster., Results: Analyses indicate that for men only, continuous exercise is significantly associated with higher muscle mass (SD = 0.24, p < .001), grip strength (SD = 0.18, p < .05), and lower risk for clinically relevant low muscle mass (odds ratio = 0.36, p < .01). Exercise in early adulthood alone is not significantly associated with muscle mass or strength. No significant associations were observed for women., Conclusions: The results of the current study underscore the importance of health programs to promote physical activity with a focus on young adults, a group known to be affected from environmentally associated decline of physical activity, and to promote the continuation of physical exercise from early adulthood into later life in general., (© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Background: Lifespan psychological and life course sociological perspectives indicate that individual development is shaped by social and historical circumstances. Increases in fluid cognitive performance over the last century are well documented and researchers have begun examining historical trends in personality and subjective well-being in old age. Relatively less is known about secular changes in other key components of psychosocial function among older adults., Objective: In the present study, we examined cohort differences in key components of psychosocial function, including subjective age, control beliefs, and perceived social integration, as indicated by loneliness and availability of very close others., Methods: We compared data obtained 20 years apart in the Berlin Aging Study (in 1990-1993) and the Berlin Aging Study II (in 2013-2014) and identified case-matched cohort groups based on age, gender, cohort-normed education, and marital or partner status (n = 153 in each cohort, mean age = 75 years). In follow-up analyses, we controlled for having lived in former East versus West Germany, physical diseases, cohort-normed household income, cognitive performance, and the presence of a religious affiliation., Results: Consistently across analyses, we found that, relative to the earlier-born BASE cohort (year of birth: mean = 1916; SD = 3.38 years; range = 1901-1922), participants in the BASE-II sample (year of birth: mean = 1939; SD = 3.22 years; range = 1925-1949) reported lower levels of external control beliefs (d = -1.01) and loneliness (d = -0.63). Cohorts did not differ in subjective age, availability of very close others, and internal control beliefs., Conclusion: Taken together, our findings suggest that some aspects of psychosocial function of older adults have improved across the two recent decades. We discuss the possible role of sociocultural factors that might have led to the observed set of cohort differences., (© 2016 S. Karger AG, Basel.)

Background: Neighborhood characteristics are important determinants of individual health and well-being. For example, characteristics such as noise and pollution affect health directly, while other characteristics affect health and well-being by either providing resources (e.g. social capital in the neighborhood), which individuals can use to cope with health problems, or limiting the use thereof (e.g. crime). This also suggests that there might be age differentials in the impact of these characteristics, since individuals at different stages of life might need different resources. However, there is a lack of empirical evidence on age differentials in associations between well-being, health, and neighborhood characteristics., Objective: This paper studies associations between a wide range of neighborhood characteristics with the health and well-being of residents of the greater Berlin area. In particular, we focus on differences in the effects between younger (aged 20-35) and older (aged 60+) residents., Methods: We used data from the Berlin Aging Study II (312 younger and 993 older residents of the Berlin metropolitan area in Germany). We used survey data on health and well-being, combined these with subjective perceptions of the neighborhood, and geo-referenced indicators on the neighborhood, e.g. amenities (public transport, physicians, and hospitals)., Results: The results show that access to public transportation is associated with better outcomes on all measures of health and well-being, and social support is associated with higher life satisfaction and better mental health. There are considerable differences between both age groups: while the associations between access to public transport and health and well-being are similar for both age groups, neighborhood social capital shows stronger associations for older residents. However, the difference is not always statistically significant., Conclusion: Having access to services is associated with better health and well-being regardless of age. Local policy makers should focus on lowering barriers to mobility in order to improve the health and well-being of the population. Since the social capital of a neighborhood is associated with better health and well-being among older residents, investments that increase social capital (e.g. community centers) might be warranted in neighborhoods with higher shares of older residents., (© 2016 S. Karger AG, Basel.)