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170 results on '"Ehterami, Arian"'

27. Combining Cell Technologies With Biomimetic Tissue Engineering Applications: A New Paradigm for Translational Cardiovascular Therapies

Author

Motta, Sarah E; https://orcid.org/0000-0001-9056-3365, Martin, Marcy; https://orcid.org/0000-0003-0035-0185, Gähwiler, Eric K N, Visser, Valery L, Zaytseva, Polina, Ehterami, Arian, Hoerstrup, Simon P; https://orcid.org/0000-0003-4755-8776, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, Motta, Sarah E; https://orcid.org/0000-0001-9056-3365, Martin, Marcy; https://orcid.org/0000-0003-0035-0185, Gähwiler, Eric K N, Visser, Valery L, Zaytseva, Polina, Ehterami, Arian, Hoerstrup, Simon P; https://orcid.org/0000-0003-4755-8776, and Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716

Abstract

Cardiovascular disease is a major cause of morbidity and mortality worldwide and, to date, the clinically available prostheses still present several limitations. The design of next-generation regenerative replacements either based on cellular or extracellular matrix technologies can address these shortcomings. Therefore, tissue engineered constructs could potentially become a promising alterative to the current therapeutic options for patients with cardiovascular diseases. In this review, we selectively present an overview of the current tissue engineering tools such as induced pluripotent stem cells, biomimetic materials, computational modeling, and additive manufacturing technologies, with a focus on their application to translational cardiovascular therapies. We discuss how these advanced technologies can help the development of biomimetic tissue engineered constructs and we finally summarize the latest clinical evidence for their use, and their potential therapeutic outcome.

Published
2023

28. Xenogeneic Serum‐Free Human Cell‐Derived Tissue Engineered Matrices for the Development of Clinical‐Grade Biomimetic Cardiovascular Devices

Author

Zaytseva, Polina, Visser, Valery L, Ehterami, Arian, Hoerstrup, Simon P, Motta, Sarah E; https://orcid.org/0000-0001-9056-3365, Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716, Zaytseva, Polina, Visser, Valery L, Ehterami, Arian, Hoerstrup, Simon P, Motta, Sarah E; https://orcid.org/0000-0001-9056-3365, and Emmert, Maximilian Y; https://orcid.org/0000-0002-8837-1716

Abstract

The development of next‐generation biomimetic cardiovascular implants using tissue engineering concepts can address the existing shortcomings of the clinically available prostheses, offering the possibility to generate life‐long, native‐analogous constructs with self‐remodeling and regenerative capacities. Scaffolds for tissue‐engineered cardiovascular prostheses can be obtained from allogenic cell sources, that can then produce human tissue‐engineered matrices (hTEMs) in vitro. Traditionally, fetal bovine serum (FBS) is used as a universal cell growth supplement. However, concerns regarding its biosafety remain a challenge for clinical translation. The aim of this study is to develop a novel xenogeneic serum‐free approach for the manufacturing of clinical grade hTEMs. To achieve this, decellularized hTEMs are generated under xenogeneic serum‐free conditions and have subsequently demonstrated hTEMs perform similarly to the FBS‐supplemented control group in terms of extracellular matrix (ECM) composition, hemocompatibility, thrombogenicity, and calcification potential. Finally, the xenogeneic serum‐free protocol is successfully adapted to the development of hTEM‐based tissue‐engineered heart valves for the systemic circulation, showing proof‐of‐concept functionality in vitro. Overall, the data suggest the effectiveness of xenogeneic serum‐free culture method as a valid alternative to FBS for the production of hTEM for cardiovascular applications.

Published
2023

29. A promising wound dressing based on alginate hydrogels containing vitamin D3 cross-linked by calcium carbonate/d-glucono-δ-lactone

Author

Ehterami, Arian, Salehi, Majid, Farzamfar, Saeed, Samadian, Hadi, Vaez, Ahmad, Sahrapeyma, Hamed, and Ghorbani, Sadegh

Abstract

In the present study, we fabricated vitamin D3-loaded alginate hydrogel and assessed its wound healing capability in the animal model. The various concentrations of vitamin D3 were added to the pre-dissolved sodium alginate in deionized water and cross-linked by calcium carbonate in combination with d-glucono-δ-lactone. The microstructure, swelling behavior, weight loss, hemo- and cytocompatibility of the fabricated hydrogels were evaluated. In the last stage, the therapeutic efficacy of the prepared hydrogels was evaluated in the full-thickness dermal wound model. The scanning electron microscopy images showed that the prepared hydrogel was highly porous with the porosity of 89.2 ± 12.5% and contained the interconnected pores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about 89% in 14 days. The results showed that the prepared hydrogels were hemo- and cytocompatible. The animal study results implied that alginate hydrogel/3000 IU vitamin D3group exhibited the highest wound closure present which was statistically significant than the control group (p< 0.05). Moreover, the histological examinations revealed that hydrogel containing 3000 IU vitamin D3 had the best performance and induced the highest re-epithelialization and granular tissue formation. All in all, this study suggests that alginate hydrogels with 3000 IU vitamin D3can be exploited as a potential wound dressing in skin tissue engineering.

Published
2024
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30. Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model

Author

Salehi, Majid, Ehterami, Arian, Farzamfar, Saeed, Vaez, Ahmad, and Ebrahimi-Barough, Somayeh

Abstract

Wounds have always been considered as one of the most common physical damages. Therefore, various researches have been conducted to find an appropriate method to improve wound healing process. Among various materials, since hydrogels have appropriate properties for wound healing, they are widely used for this purpose. In this study, to develop a potential wound dressing, different concentrations of naringenin (0%, 1%, 10% and 20%) were incorporated in alginate hydrogel followed by evaluating its characters such as morphology, swelling properties, weight loss, antibacterial activity, releasing profile of the naringenin, hemo-, and cytocompatibility. Finally, to evaluate the effect of developed hydrogels on wound healing, the full-thickness dermal wound model in rat was used. Our results provided that the prepared hydrogels have appropriate porosity (86.7 ± 5.3%) with the interconnected pores. Moreover, weight loss assessment confirmed that fabricated hydrogels have suitable biodegradability (about 89% after 14 days). MTT assay also revealed the positive effect of hydrogels on cell viabilities, and they have no toxicity effect on cells. In vivo study indicated that the prepared hydrogels had better wound closure than the gauze-treated wound (the control), and alginate/20% naringenin group had the best wound closure among other groups. All in all, this study concluded that alginate/naringenin hydrogel has positive effect on wound healing process, and it can be used to treat skin injuries in the clinic.

Published
2024
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39. Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

Author

Salehi, Majid, primary, Shahporzadeh, Keyvan, additional, Ehterami, Arian, additional, Yeganehfard, Hodays, additional, Ziaei, Heliya, additional, Azizi, Mohammad Moein, additional, Farzamfar, Saeed, additional, Tahersoltani, Amirreza, additional, Goodarzi, Arash, additional, Ai, Jafar, additional, and Ahmadi, Akbar, additional

Published
2020
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45. Bone tissue engineering using 3‐D polycaprolactone/gelatin nanofibrous scaffold containing berberine: In vivo and in vitro study.

Author

Ehterami, Arian, Abbaszadeh‐Goudarzi, Ghasem, Haghi‐Daredeh, Saeed, Niyakan, Maryam, Alizadeh, Morteza, JafariSani, Moslem, Atashgahi, Mahboubeh, and Salehi, Majid

Subjects
POLYCAPROLACTONE, BERBERINE, TISSUE engineering, GELATIN, BONE cells, IN vitro studies, IN vivo studies
Abstract

A solid structure similar to an extracellular matrix network is needed for bone cells attachment and starting healing of bone damages. Different biomaterials and fabrication techniques are used for scaffold fabrication to prepare a supportive structure in bone tissue engineering. In the current study, a 3‐D polycaprolactone (PCL)/gelatin scaffold was developed by blending electrospinning and freeze‐drying techniques to make an appropriate structure for bone healing. In addition, different concentrations of berberine that have a positive effect on bone healing were loaded to enhance the healing process. Fabricated scaffolds were characterized by different tests like surface morphology, water contact angle, degradation rate, compressive strength, porosity, and Fourier transform infrared. Their interactions with blood and cells were evaluated by hemolysis, and MTT test, and the healing process was also evaluated by implanting scaffolds in the rat calvaria defect model. Based on the results, the average porosity of scaffolds was about 80% and by adding berberine, mechanical strength decreased while due to its hydrophilic properties, degradation rate increased. In vivo and in vitro tests showed better cell proliferation and bone healing in PCL/gelatin/berberine 0.1%‐treated group. These results showed the positive effect of fabricated scaffold on osteogenesis and bone healing and the possibility of using it in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Evaluating effect of alginate/chitosan hydrogel containing 4-Methylcatechol on peripheral nerve regeneration in rat model.

Author

Abbaszadeh-Goudarzi, Ghasem, Haghi-Daredeh, Saeed, Ehterami, Arian, Rahmati, Majid, Nazarnezhad, Simin, Hashemi, Seyedeh Fatemeh, Niyakan, Maryam, Vaez, Ahmad, and Salehi, Majid

Subjects
NERVOUS system regeneration, ALGINATES, PERIPHERAL nervous system, ANIMAL disease models, PERIPHERAL nerve injuries, ALGINIC acid, SODIUM alginate
Abstract

Some of the trauma patients (about 3%) suffer from peripheral nerve injuries and unfortunately, it is still a significant clinical problem to regenerate and functional recovery of them. These days, peripheral nerve damages have been treated with various methods and materials. The goal of the present study is to evaluate the effect of various amounts of 4-Methylcatechol (4-MC) on peripheral nerve regeneration. For this target, alginate/chitosan hydrogel was used to deliver different percentages (0.1%, 1%, and 10% (w/v)) of 4-MC to the sciatic nerve-injured sites in a rat model. Before that, the properties of hydrogels were assessed and after injecting, different functional analyses were used to evaluate the efficacy of fabricated hydrogels on peripheral nerve regeneration. Our results exhibited that the pore size of hydrogels was appropriate for cell proliferation (26–42 µm). Biodegradability of hydrogels was about 70% after 7 days and hemocompatibility of hydrogels was also confirmed. The MTT assay showed that the hydrogels not only do not have toxicity effects but also can improve the proliferation rate of PC12 cells. The functional results showed that 4-MC especially the group contained 10% of 4-MC enhance sciatic nerve regeneration. It could be concluded that fabricated hydrogels can use as suitable materials for peripheral nerve regeneration. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Porous electrospun poly(ε-caprolactone)/gelatin nanofibrous mat containing cinnamon for wound healing application: in vitro and in vivo study

Author

Salehi, Majid, primary, Niyakan, Maryam, additional, Ehterami, Arian, additional, Haghi-Daredeh, Saeed, additional, Nazarnezhad, Simin, additional, Abbaszadeh-Goudarzi, Ghasem, additional, Vaez, Ahmad, additional, Hashemi, Seyedeh Fatemeh, additional, Rezaei, Nariman, additional, and Mousavi, Seyed Reza, additional

Published
2019
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