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22. a Treatment cost of invasive fungal disease (Ifd) in patients with acute myelogenous leukaemia (Aml) or myelodysplastic syndrome (Mds) in German hospitals

Author

Rieger, C. T., Cornely, O. A., Hoppe-Tichy, T., Kiehl, M., Knoth, H., Thalheimer, M., Schuler, U., Ullmann, A. J., Ehlken, B., Ostermann, H., Rieger, C. T., Cornely, O. A., Hoppe-Tichy, T., Kiehl, M., Knoth, H., Thalheimer, M., Schuler, U., Ullmann, A. J., Ehlken, B., and Ostermann, H.

Abstract

Invasive fungal disease (IFD) causes increasing morbidity and mortality in haematological cancer patients. Reliable cost data for treating IFD in German hospitals is not available. Objective of the study was to determine the institutional cost of treating the IFD. Data were obtained by retrospective chart review in German hospitals. Patients had either newly diagnosed or relapsed acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS). Direct medical cost was calculated from hospital providers perspective. A total of 108 patients were enrolled at 5 tertiary care hospitals, 36 IFD patients and 72 controls. The vast majority of IFD patients (74%) were diagnosed with invasive aspergillosis. On average, the hospital stay for IFD patients was 12 days longer than in control patients. All patients in the IFD group and 89% of patients in the control group received antifungal drugs. Mean direct costs per patient were 51 pound 517 in the IFD group and 30 pound 454 in the control group. Incremental costs of 21 pound 063 were dominated by cost for antifungal drugs (36%), hospital stay (32%) and blood products (23%). From the perspective of hospitals in Germany the economic burden of IFD in patients with AML or MDS is substantial. Therefore, prevention of IFD is necessary with respect to both clinical and economic reasons.

Published
2012

25. Rotavirus-Gastroenteritis im Säunglings- und Kleinkindes Alter : Ergebnisse einer prospektiven Erfassung in den Regionen Genf und Basel 1997/1998 (RoMoS)

Author

Laubereau, B, Gateau, S, Ehlken, B, Huber, K, Rohwedder, A, Gervaix, Alain, Heininger, Ulrich, and Schaad, UB

Subjects
Diarrhea, Male, ddc:618, Dehydration, Vomiting, viruses, virus diseases, Infant, Polymerase Chain Reaction, Gastroenteritis/physiopathology/virology, Rotavirus Infections/physiopathology, Child, Preschool, Humans, Female, Prospective Studies, Rotavirus/isolation & purification, Switzerland, Feces/virology
Abstract

In Europe information is scarce about the impact of rotavirus, probably the most important cause of acute gastroenteritis in children up to the age of 4 years. The aim of this study was to collect data on the frequency and symptoms of community-acquired rotavirus-positive acute gastroenteritis in Switzerland.

Published
1999

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