1. A cross-sectional study on factors associated with secondary amenorrhoea among the students who attended Polyclinic Universiti Malaysia Sabah with irregular menstruation
- Author
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Win Win Than, M Tanveer Hossain Parash, Nathira binti Abdul Majeed, Khin Nyein Yin, Dg Marshitah binti Pg Baharuddin, Ehab Helmy Abdel Malek Fahmy, and Mohd Nazri bin Mohd Daud
- Abstract
Background The menstruation is considered as an indicator of women’s health. A woman who menstruates regularly (every 21–45 day) is considered to have secondary amenorrhea if she has not menstruated in 3 months or 6 months if she menstruates previously irregular. Hypothalamic amenorrhea (HA) and polycystic ovary syndrome (PCOS) are the two most common causes of secondary amenorrhoea, other than pregnancy. The changes in the female hormone levels are associated with health behaviours, obesity, and stress. High stress has been shown to affect the hypothalamic–pituitary–adrenal (HPA) axis activity, whereas high body mass index (BMI) has been demonstrated to influence the sex hormone-binding globulin (SHBG), free androgen index (FAI), testosterone, and insulin levels. Objectives The objective of the study is to study body mass index (BMI), stress score and hormonal levels on students from Universiti Malaysia Sabah (UMS) who attended Polyclinic UMS with irregular menstruation to detect the causes of irregular menstruation and to give specific treatment to improve their quality of life. Method Cross-sectional study was carried out during the period starting from 1st January 2021 until 31st December 2022 on UMS students with an age range of (19–35 years), both undergraduate and postgraduate, attended the Polyclinic UMS for irregular menstruation. The subjects who received hormonal treatment in the past six months, with organic lesions of the genital tract, with bleeding disorders, and with pregnancy, were excluded from the study. In this study total of 100 participants were included through stratified random sampling where 60 subjects were recruited who fulfilled the selection criteria, and the rest 40 subjects were recruited as matched controls. Result As the subjects were selected as matched pairs, both the groups had a similar frequency of different BMI grades. The p-value was higher than the level of significance, α = 0.05 and there was insufficient evidence to reject the null hypothesis. There were some apparent differences in the frequencies of depression, anxiety, and stress (DASS 21 score) between the two groups. The p-values for depression (0.004), anxiety (
- Published
- 2023
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