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19. HLA-DPB1 mismatch reduce relapse and improve survival in T-cell replete unrelated donor allogeneic stem cell transplantation

Author

Grønvold, B., primary, Ali, M. M., additional, Remberger, M., additional, Mattsson, J., additional, Egeland, T., additional, Lundin, K. U., additional, Myhre, A. E., additional, Abrahamsen, I. W., additional, Heldal, D., additional, Dybedal, I., additional, Tjønnfjord, G. E., additional, Fløisand, Y., additional, and Gedde-Dahl, T., additional

Published
2020
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21. Comment

Author

Selmer, K. K., Egeland, T., Solaas, M. H., Nakken, K. O., Kjeldsen, M. J., Friis, M. L., Brandal, K., Corey, L. A., and Undlien, D. E.

Published
2008

34. Editorial Acknowledgment

Author

Aarvak, T., Abedi-Valugerdi, M., Abrahamsen, T., Akdis, C., Akuffo, H.O., Alarcon-Riquelme, M., Andersen, P., Arstila, P., Austgulen, R., Baecker-Allan, C., Baggiolini, M., Baker, B.S., Bakke, O., Bakken, V., Barclay, A.N., Bemark, M., Benestad, H.B., Berzins, K., Bjerkvik, R., Bjørge, L., Bland, P., Bolstad, A.I., Born, W., Bowman, S., Brinchmann, J., Britton, S., Brokstad, K.A., Brunet, L.R., Bruserud, Ø., Cardona, P.J., Ceyppens, J.L., Cirino, G., Cohn, M., Cox, R.J., Cunliffe, J., Dahlgren, U., Dellacasagrande, J., Ditzel, H., Dobryszycka, E., Dyrhol-Riise, A.M., Edwards, J.C., Egeland, T., Elsayed, S., Eray, M., Erb, K.J., Esch, T., Eugen-Olsen, J., Everse, L.A., Fagerhol, M., Farstad, I., Feldmann, M., Fernandez, C., Fleck, M., Franksson, R., Freitas, A., Garred, P., Gidlund, M., Gilhus, N.E., Goldbach-Mansky, R., Gordon, J., Gordon, T., Grandien, A., Gregerson, P., Grewal, H., Hakulinen, J., Halstensen, T., Haneberg, B., Hanej, S.H.E., Hansen, T., Harley, J.B., Haukenes, G., Hengartner, H., Henz, B.M., Holen, E., Hurme, M., Husby, G., Husby, S., Hörnqvist-Hultgren, E., Haaheim, L.R., Isenberg, D., Jahnson, F., Jakobsen, H., James, J.A., Jansson, J.O., Jarva, H., Jeansson, S., Johannessen, A.C., Johansen, F.E., Julkunen, I., Kalland, K.H., Kaye, J., Kazatchkine, M., Kihlström, E., Kohler, L., Konttinen, Y., Kotenko, S., Koutzov, S., Krammer, P., Kristoffersen, E., Kunzendorf, U., Lachmann, P., Langman, R., Langner, J., Lanzavecchia, L., Lappalainen, M., Laskay, T., Lea, T., Lefvert, A.K., Lehmann, A.C., Louka, A, Lúdviksson, B.R., Mariette, X., Marion, T., Marker-Herrmann, E., Mattsson, R., McAdam, S., Mellbye, O.J., Mellgren, G., Mellgren, S.I., Mestecky, J., Michaelsen, T., Michalek, S., Miettinen, A., Moestrup, S.K., Moretta, A., Moser, M., Mountz, J., Moutsopoulos, H., Munthe, L.A., Mustafa, T., Myrmel, H., Nannemark, G., Netea, M.G., Nilsen, R., Notarangelo, L.D., Ögmundsdóttir, H., Olsson, I., Olweus, J., Osland, A., Paludan, S.R., Parsons, K.R., Patarroyo, M., Paul, W.E., Perlman, P., Pollock, J.M., Puolakkainen, M., Quale, A., Rajewsky, K., Raman, C., Reichlin, M., Renkonen, R., Rese Shadidi, K., Ricciardi-Castagnoli, P., Rickinson, A.B., Ringdén, O., Risto, R., Rodinov, D., Rosenkrands, I., Rottenberg, M., Russel, M., Rygaard, J., Rødahl, E., Röllinghof, M., Sandberg, M., Schenk, K., Seppälä, I., Shevach, E., Shortman, K., Siegrist, C.A., Sigurdardóttir, S., Silvennoinen, O., Sinigaglia, F., Sistonen, L., Skarstein, K., Skogh, T., Smith, E., Spurkland, A., Stendahl, O., Sugden, B., Suri-Payer, E., Svennerholm, A.M., Szodoray, P., Theofilopoulos, A., Thorley-Lawson, D.A., Timonen, T., Trowsdale, J., Tuomo, T., Ulmer, A.J., Ulvestad, E., Ulvik, R., Vaerman, J.P., van, der Merwe J.P., van Eden, W., Vedeler, C., Vintermyr, O.K., Vyse, J., Wahlgren, M., Wahren-Herlenius, M., Walsh, L.J., Weetman, A.P., Westermark, P., Wiker, H., Yang, J., Yewdell, J.W., Youinou, P., and Zouali, M.

Published
2002

41. AMINOETHYL-ISOTHIOUREA INHIBITS THE INCREASE IN PLASMA ENDOTHELIN-1 CAUSED BY SEROGROUP A STREPTOCOCCI AND PROLONGS SURVIVAL IN RAT PERITONEAL SEPSIS

Author

G. Lermark, E. A. Hoiby, T. Saetre, Torstein Lyberg, T. Aspelin, Aud Svindland, and Egeland T

Subjects
Endothelin Receptor Antagonists, Male, Time Factors, Streptococcus pyogenes, medicine.drug_class, Nitric Oxide Synthase Type II, Blood Pressure, Pharmacology, Biology, Critical Care and Intensive Care Medicine, Nitric oxide, Rats, Sprague-Dawley, chemistry.chemical_compound, Streptococcal Infections, Intensive care, medicine, Animals, Enzyme Inhibitors, Antihypertensive Agents, chemistry.chemical_classification, Sulfonamides, Reactive oxygen species, Endothelin-1, Thiourea, Bosentan, Receptor, Endothelin A, Receptor antagonist, Shock, Septic, Endothelin 1, Rats, Survival Rate, Nitric oxide synthase, chemistry, Biochemistry, Mechanism of action, Emergency Medicine, biology.protein, Nitric Oxide Synthase, medicine.symptom, medicine.drug
Abstract

To elucidate the possible roles of nitric oxide (NO), endothelin-1 (ET-1), and reactive oxygen species (ROS) in the pathophysiology of serogroup A streptococcal (GAS) peritoneal sepsis, we investigated the effects of aminoethylisothiourea (AE-ITU), an inducible NO synthase (iNOS) inhibitor, and a ROS scavenger, and the ET-1 receptor antagonist bosentan. In rats, live GAS inocula, 3 x 10(8) and 1 x 10(9) cfu/kg, entailed a 24-h mortality of 10% and 90%, respectively. GAS caused increases in tissue iNOS activity (9 h), in serum nitrite/nitrate (9-24 h), and in intracellular leukocyte ROS levels (3-6 h). These changes were all prevented by the pre-treatment with AE-ITU. A novel finding was that AE-ITU also prevented the GAS-induced marked increase in plasma ET-1 at 6 h. Short-term (7-h) survival was improved by both AE-ITU and by bosentan. The mechanism(s) for the beneficial effects of AE-ITU may possibly be a combined mode of action; iNOS inhibition, ROS scavenging, and inhibition of the increase in plasma ET-1 caused by GAS.

Published
2001

42. Aminoethyl-isothiourea, a nitric oxide synthase inhibitor and oxygen radical scavenger, improves survival and counteracts hemodynamic deterioration in a porcine model of streptococcal shock

Author

G. Lermark, E. A. Hoiby, Torstein Lyberg, Egeland T, T. Saetre, and T. Aspelin

Subjects
Male, Streptococcus pyogenes, Swine, Radical, Pharmacology, Nitric Oxide, Critical Care and Intensive Care Medicine, medicine.disease_cause, Nitric oxide, Sepsis, Random Allocation, chemistry.chemical_compound, Streptococcal Infections, Animals, Medicine, biology, business.industry, Hemodynamics, Thiourea, Oxygen transport, medicine.disease, Shock, Septic, Survival Rate, Nitric oxide synthase, Disease Models, Animal, Biochemistry, chemistry, Enzyme inhibitor, Shock (circulatory), biology.protein, Female, medicine.symptom, business, Isothiuronium
Abstract

To test the effect of a continuous infusion of the nitric oxide (NO) synthase (S) inhibitor aminoethyl-isothiourea (AE-ITU) on survival time, hemodynamics, and oxygen transport in a porcine model of live group A streptococcal (GAS) sepsis. Furthermore, to examine the role of endothelin-1, histamine, and reactive oxygen species (ROS) in streptococcal shock.Prospective, randomized trial.Laboratory at a university hospital.Twenty-eight pigs with an average weight of 25 kg.Sixteen animals received a continuous infusion of live Streptococcus pyogenes 1.3 x 10(10) colony forming units/hr: eight received fluids only, and the other eight received an intravenous infusion of AE-ITU 10 mg/kg/hr starting 30 mins before the GAS challenge. Six control pigs received AE-ITU 10 mg/kg/hr iv for 5 hrs. Another six animals received half the dose of GAS over 5 hrs.GAS infusion caused a rapid increase in pulmonary, hepatic, and systemic vascular resistance, followed by hypotension with a 90% lethality at 4 hrs. Treatment with AE-ITU increased 4-hr survival in septic animals from 1/8 to 8/8 and 5-hr survival from 0/8 to 5/8, prevented hypotension, and increased urine output. AE-ITU attenuated the decrease in cardiac output, liver blood flow, and oxygen delivery, and hepatic arterial blood flow as a fraction of cardiac output increased (all p.05). Plasma nitrate/nitrite levels decreased in all animals. Inducible NOS and endothelial constitutive NOS activities in liver, gut, and lung were not increased during sepsis, nor were they decreased after AE-ITU. Plasma levels of endothelin-1 and methylhistamine increased in all septic animals and were not modified by AE-ITU. AE-ITU prevented the increase in monocyte ROS production caused by GAS. In control animals, AE-ITU caused an increase in mean arterial pressure, liver blood flow, and oxygen delivery.In this model of porcine GAS-induced septic shock, which was not associated with enhanced NO production, infusion of the NOS inhibitor AE-ITU prolonged survival, prevented hypotension, and improved cardiac contractility, organ perfusion, and tissue oxygenation. These beneficial effects of AE-ITU might be a result of the combined effect of ROS scavenging and modulation of local NO production, thus improving the balance of vasodilator and vasoconstrictor forces and reducing oxidative stress.

Published
2000

46. Eular workshop on Rheumatology Research: Noordwijkerhout February 1982

Author

Bjelle, A., Cedergren, B., Wählby, L., Boerbooms, A. P. Th., Geerdink, P. J., van de Putte, L. B. A., Ouweland, F. A. M., Buchanan, R. R. C., Morgan, A., Staines, N. A., Venables, P. J. W., Maini, R. N., Bucknall, R. C., Bacon, P. A., Jones, J. Verrier, Leirisalo, M., Laitinen, O., Bühring, M., Rosak, C., Stöckle, W., Magnet, W., Catogio, L. J., Bernstein, R. M., Black, C. M., Hughes, G. R. V., Maddison, P. J., Charles P. J., Venables P. J. W., Tung Yi., Buchanan R. C., Maini R. N., Deicher, H., Weißbarth, E., Zeller, J., Baruth, B., Delbarre, F., de Gery, A., Kahan, A., de Vries, E., van der Veen, C. J. P., van der Weij, J. P., Klein, F., de Bruijn, A. M., Cats, A., Dreher, R., Coworkers, Duclos, M., Peter, H., Zeidler, H., Rieber, P., Pichler, J., Limany, W., Dunn, N., Hurst, N. P., Denholm, E., Nuki, G., Ebringer, A., Hayes, J., Cowling, P., Ebringer, R., Egeland, T., Forre, Ø., Festen, J. J. M., Kuipers, F. H., Schaars, A. H., Førre, Ø., Waalen, K., Mellbye, O. J., Froebel, K., Lewis, D., Sturrock, R. D., Goldschmeding, R., Limburg, P. C., Pastoor, G. W., Houtman, P. M., Kallenberg, C. G. M., Halberg, P., Lorenzen, I., Bennedsen, J., Rhodes, J. M., Hall, N. D., Eales, L. -J., Blake, D. R., Hunneyball, I. M., Helmke, K., Boeder, T., Teuber, J., Hermanns, P., Veys, E. M., Verbruggen, G., Horsfall, A. C., Mumford, P. A., Schrieber, L., Huber, O., Kluin-Nelemans, H., Vernooy, J., Meyling, F. Gmelig, Derksen, R., Kater, L., Hurst N. P., Nuki G., Husby, G., Gran, J. T., Thorsby, E., Johnson, G. D., Bainbridge, D. R., Holborow, E. J., Bubel, M., Goddard, D. H., Jonsson, J., Norberg, R., Schilling, W., Kalden, R., Leitner, O., Manger, B., Beck, A., Koch, B., de Jong, M. C. J. M., Walstra, T., van der Meulen, J., Kávai, M., Bányai, A., Zsindely, A., Sonkoly, I., Szegedi, Gy., Klareskog, L., Forsum, U., Scheynius, A., Kabelitz, D., Wigzell, H., Koivuranta, P., Repo, H., Kiistala, U., Österman, P., Konttinen, Y., Friman, C., Tolvanen, E., Johansson, E., Konttinen, Y. T., Reitamo, S., Seppä, A., Malmström, M., Lindström, F., Hellquist, H., Olofsson, J., Maddison, PJ., Black, CM., Jayson, MIV, Batchelor, J. R., Walsh, Kl., Bernstein, RM, Catoggio, LJ., Holland, CD., Hughes, GRV, Mbuyi, J. M., Dequeker, J., Förre Ö, Johnsen, W., Meijer, C. J. L. M., de Graaf-Reitsma, C., Lafeber, G. J. M., Meyer, O., Borda-Oriarte, O., Haïm, T., Ryckewaert, A., Mielants, H., Van Steenkiste, M., De Langhe, J., Buchanan, R. C., Moutsopoulos, M., Hooks, J., Mumford, P., Patel, V., Panayi, G. S., Piatier-Tonneau, D., Mach, P. S., Plater-Zyberk, C., Clarke, M., Raeman, F., De Cock, W., Leempoels, J., De Cree, J., Verhaegen, H., Ranki, A., Paavonen, T., Kankaanpää, U., Nilsson, E., Biberfeld, G., Room, G., Saal, J. G., Frank, F., Rauteenstrauch, H., Hadam, M., Fritz, P., Laschner, W., Scheper, R. J., von Blomberg-van der Flier, B. M. E., Boerrigter, G. H., van Bruynzeel, D., van Dinther-Janssen, A. C. H. M., Simon, K. H., Schmidt, R. E., Erhardt, C. C., Melsom, R. D., McCarthy, J., Smeenk, R., Van der Lelij, G., Aarden, L., Staite, N. D., Stierle, H. E., Brown, K. A., Perry, J. D., Swaak, A. J. G., Groenwold, J., Smeenk, R. J. T., Toenes, G. H., Edel, H. H., Eggert, K., Held, E., Hübner, F. K., Schattenkirchner, M., Wegelius, O., Tron, F., Jacob, L., Bach, J. F., Lens, J. W., van den Berg, W. B., van Rijswijk, M. H., van Leeuwen, M. A., van der Giessen, M., The, T. H., van Venrooij, W. J., van Eekelen, C. A. G., Habets, W. J. A., Salden, M. H. L., de Rooij, D. J., Van Wanghe, P., Hermanns, Ph., Van Bruwaene, Ph., De Brabanter, G., De Landsheere, D., Immesoete, C., Walravens, M. J. F., Stevens, E., Warnatz, H., Lemm, G., Wiik, A., Petersen, J., Permin, H., Wollheim, F. A., Carlsson, J., Forsgren, A., Pettersson, H., Youinou, P., Miossec, P., and Le Goff, P.

Published
1982
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48. The quest for a donor: probability based methods offer help

Author

Mostad, P. F., Egeland, T., Cowell, R., Bosnes, V., and Braaten, O.

Subjects
HG
Abstract

When a patient in need of a stem cell transplant has no compatible donor within his or her closest family, and no matched unrelated donor can be found, a remaining option is to search within the patient’s extended family. This situation often arises when the patient is of an ethnic minority, originating from a country that lacks a well-developed stem cell donor program, and has HLA haplotypes that are rare in his or her country of residence. Searching within the extended family may be time-consuming and expensive, and tools to calculate the probability of a match within groups of untested relatives would facilitate the search. We present a general approach to calculating the probability of a match in a given relative, or group of relatives, based on the pedigree, and on knowledge of the genotypes of some of the individuals. The method extends previous approaches by allowing the pedigrees to be consanguineous and arbitrarily complex, with deviations from Hardy-Weinberg equilibrium. We show how this extension has a considerable effect on results, in particular for rare haplotypes. The methods are exemplified using freeware programs to solve a case of practical importance.

Published
2005

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