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1. Targeting argininosuccinate synthetase-deficient advanced solid tumors in a phase I trial of ADI-PEG20 plus cisplatin

Author

Funda Meric-Bernstam, Naiyi Shi, Siqing Fu, Eevy Nguyen, John S. Bomalaski, Sarina Anne Piha-Paul, Patrick Hwu, Apostolia Maria Tsimberidou, Jennifer J. Wheler, Sapna Pradyuman Patel, David S. Hong, Ralph Zinner, Vivek Subbiah, Filip Janku, and Gerald S. Falchook

Subjects
Cisplatin, Cancer Research, Arginine, biology, business.industry, Argininosuccinate synthase, Autophagy, Oncology, Apoptosis, Cancer cell, biology.protein, Cancer research, Medicine, business, medicine.drug
Abstract

2563 Background: Besides its selective activity to induce autophagy and caspase-independent apoptosis in argininosuccinate synthetase (ASS)-deficient cancer cells, ADI-PEG20 (pegylated arginine dei...

Published
2014

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