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1. Contributors

Author

Aggarwal, Geeta, primary, Andukuri, Venkata, additional, Arnold, Susan LaFollette, additional, Arriaga, Alexander F., additional, Bader, Angela M., additional, Balfour, Angie, additional, Berger, Elizabeth R., additional, Berlin, Nicholas L., additional, Blitz, Jeanna D., additional, Booth, Alexander, additional, Botwinick, Laura K., additional, Bozic, Kevin, additional, Buehler, Kate, additional, Chappell, Desiree, additional, Chen, Yun-Yun K., additional, Chereshneva, Maria, additional, Clapp, Justin T., additional, Cloyd, Benjamin H., additional, Cruikshanks, Claire, additional, Dauw, Casey A., additional, Dhesi, Jugdeep, additional, DiBianco, John Michael, additional, Dixon-Woods, Mary, additional, Duffy, Caoimhe C., additional, Edwards, Angela F., additional, Edwards, Kylie-Ellen, additional, El-Ghazali, Sally, additional, Englesbe, Michael, additional, Esper, Stephen A., additional, Falk, Scott, additional, Fischer, Chelsea P., additional, Fleisher, Lee A., additional, Fogerty, Robert L., additional, Fowler, Aidan, additional, Franz, Amber, additional, Ghani, Khurshid R., additional, Grocott, Michael P.W., additional, Gulotta, Lawrence V., additional, Hallway, Alexander, additional, Harpe-Bates, Jennifer, additional, Healey, Frances, additional, Azad, Kaveh Houshmand, additional, Howard, Ryan, additional, Incorvia, Joseph, additional, Jackiewicz, Thomas E., additional, Janda, Allison, additional, Johnson, Emily H., additional, Johnston, Carolyn, additional, Jordan, Lesley, additional, Kelz, Rachel R., additional, Khan, Maria, additional, Kheterpal, Sachin, additional, King, Christopher J., additional, Ko, Clifford Y., additional, Lane-Fall, Meghan B., additional, Lee, Thomas H., additional, Levett, Denny Z.H., additional, Lin, Della M., additional, Lloyd, Robert, additional, Lockett, Mark, additional, Low, Daniel, additional, Mahajan, Aman, additional, Mainey, Chris, additional, Manning, Michael W., additional, Martin, Graham P., additional, Martin, Lynn D., additional, Mathis, Michael, additional, McCulloch, Peter, additional, Moonesinghe, S. Ramani, additional, Murray, Dave, additional, Myles, Paul S., additional, Mythen, Monty G., additional, Odell, Wendy, additional, Offodile, Anaeze C., additional, Parry, Gareth, additional, Partridge, Judith, additional, Peden, Carol J., additional, Quiney, Nial, additional, Ragheb, Jacqueline W., additional, Raper, Steven E., additional, Rogerson, Andrew, additional, Rooney, Kevin, additional, Roper, Madeleine, additional, Santhirapala, Ramai, additional, Scott, Michael, additional, Shah, Nirav, additional, Singleton, Georgina F., additional, Soar, Harry, additional, Spencer, Paula, additional, Stephens, Timothy J., additional, Stevens, Emma, additional, Sweitzer, BobbieJean, additional, Tong, Jason, additional, Tung, Alan, additional, Vetter, Thomas R., additional, Vlisides, Phillip E., additional, Wain, Hester, additional, Wick, Elizabeth C., additional, Wu, Christopher L., additional, Wyatt, Ronald, additional, and YaDeau, Jacques T., additional

Published
2023
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3. Delivery of drinking, eating and mobilising (DrEaMing) and its association with length of hospital stay after major noncardiac surgery: observational cohort study

Author

Oliver, Charles M., Warnakulasuriya, Samantha, McGuckin, Dermot, Singleton, Georgina, Martin, Peter, Santos, Cristel, Bedford, James, Wagstaff, Duncan, Sahni, Arun, Gilhooly, David, Wilson, Jonathan, Edwards, Kylie, Baumber, Rachel, Vindrola-Padros, Cecilia, Dorey, Jenny, Leeman, Irene, Boyd-Carson, Hannah, Vohra, Ravi, Singh, Pritam, Bedford, Matthew, Vallance, Abigail, Aresu, Giuseppe, Tucker, Olga, Swart, Michael, Mythen, Monty G., and Moonesinghe, Suneetha R.

Published
2022
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4. The Perioperative Quality Improvement Programme (PQIP patient study): protocol for a UK multicentre, prospective cohort study to measure quality of care and outcomes after major surgery

Author

Moonesinghe, S. Ramani, McGuckin, Dermot, Martin, Peter, Bedford, James, Wagstaff, Duncan, Gilhooly, David, Santos, Cristel, Wilson, Jonathan, Dorey, Jenny, Leeman, Irene, Smith, Helena, Vindrola-Padros, Cecilia, Edwards, Kylie, Singleton, Georgina, Swart, Michael, Baumber, Rachel, Sahni, Arun, Warnakulasuriya, Samantha, Vohra, Ravi, Ellicott, Helen, Bougeard, Anne-Marie, Chazapis, Maria, Ignacka, Aleksandra, Cripps, Martin, Brent, Alexandra, Drake, Sharon, Goodwin, James, Martinez, Dorian, Williams, Karen, Singh, Pritam, Bedford, Matthew, Vallance, Abigail E., Samuel, Katie, Lourtie, Jose, Olive, Dominic, Taylor, Christine, Tucker, Olga, Aresu, Giuseppe, Swift, Andrew, Fulop, Naomi, and Grocott, Mike

Published
2022
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5. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

A'Court, Alicja, Abdel-Gadir, Dina, Abdu, Ayman, Abisogun, Caroline, Aboud, Zainab, Abrams, Judith, Ackerman, Andrea, Adamso, Christine, Addison, Rachel, Adeyeye, Adedayo, Adler, Rachel, Aduse-Poku, Maame, Adyanthaya, Siddharth, Ahmad, Najmiah, Ahmed, Dabeeruddeen, Ahmed, Atif, Akindele, Bucky, Akindele, Olubukola, Akrimi, Sonia, Al-Rawi, Samar, Ali, Yousif, Allam, Jo, Allana, Alisha, Allen, Kellie, Allen, Orlanda, Amaradasa, Natasha, Amarasekara, Lareina, Amoakwa-adu, Freda, Anandageetha, Padmanabhan, Anandakrishnan, Suresh, Anandanadesan, Rathai, Anderson, Michelle, Apps, Simon, Aquilina, Audrey, Arbane, Gill, Arch, Alice, Armstrong, Sarah, Arya, Rita, Ashiru, Gloria, Ashpole, Keri, Atkinson, Claire, Atkinson, Francesca, Auer, Elizabeth, Avery, Ben, Babio-Galan, Maite, Bader, Hareth, Badham, George, Bagchi, Subha, Bailey, Sarah, Baird, Yolanda, Balaka, Cristina, Baldwin, Melissa, Balfour, Paul, Bali, Shreya, Banks, Samantha, Barclay, Philip, Barnes, Lucy, Barnes, Thomas, Barot, Niraj, Barrett, Stephen, Barrett, Venetia, Barrett, Kate, Bates, Louise, Batte, Katherine, Baytug, Beki, Behravesh, Mona, Bell, Suzanne, Benloch, Raul, Bentley, Richard, Berg, Jennifer, Berwick, Charlotte, Berwick, Richard, Bhadange, Rashmi, Bhattacharyya, Sanjoy, Bielskute, Egidija, Birch, Sian, Bird, Scott, Bird, Ruth, Birts, William, Black, Becky, Blagova, Tatyana, Blake, Holly, Blightman, Oliver, Blunden, Susara, Bolton, Richard, Borkett-Jones, Caroline, Boselli, John, Bowen, Manuella, Bowen, Ruth, Bowye, James, Boyle, Henry, Brar, Zameen, Bray, Jo, Brayshaw, Samantha, Bressington, Catherine, Brewer, Alison, Brice, Naomi, Bridge, Laura, Briscoe, James, Brocklesby, Sonia, Brown, Harry, Brown, Sarah, Brunnen, Derek, Burijintichenna, Keshavareddy, Burnard, Sara, Burtt, Agnieszka, Buswell, Victoria, Bykar, Hannah, Cairney, Matthew, Calvert, Clare, Camarasa, Laura, Campbell, Natasha, Campbell-Jones, Frederick, Cantliffe, Jane, Carrol, William, Carvalho, Joanna, Cashell, Catherine, Cassie, Sarah, Cassim, Kadu, Chandler, Marika, Chapman, Rachel, Charles, Robert, Chen, Ping, Cheyne, Deanne, Chima, Kiran, Chin, Floju, Chirvasuta, Radu, Shao Chong, Martin, Choudhury, Sadia, Chowdhury, Priyakam, Christmas, Tracey, Chughwani, Shilpa, Ciechanowicz, Sarah, Clarey, Emma, Coe, Rob, Cohen, Jolyon, Coker, Nicholas, Collins, Karen, Collis, Lauren, Comar, Jasna, Conroy, Marianne, Constantin, Kathy, Corfe, Jeremy, Coulborn, Elaine, Cowie, Vanessa, Crone, Rachel, Cronin, James, Crooks, Jennifer, Crowther, Nicola, Crowther, Elizabeth, Cruz, Carina, Curtis, Alexa, Curtis, Sarah, Curtis, Sam, Dabrowicz, Adrian, Daines, Nick, Dalal, Viral, Dannatt, Peter, Das, Dinesh, Dash, Jennifer, Davidson, Katherine, Davies, Sarah, Davis, Yvette, Dawson, James, Dean, Jonathan, Dean, Caroline, Denman, Jane, Desai, Neel, Dewan, Preeti, Dimont, Sarah, Donovan, Clare, Doraiswami, Mano, Doughty, Kate, Douglass, Jamie, Dower, Michelle, Downing, Samantha, Duberry, Wendy, Duckham, Emily, Dudgeon, Lucy, Dukes, Stephanie, Dunn, Leigh, Duraiswamy, Venkat, O' Dwyer, Anthony, Dyer, Kristyn, Eapen, Suresh, Earl, Mark, Eason, Sally, Edwards, Kylie-Ellen, Edwards, Zara, Egole, Osinachi, Ekpa, John, El-Amin, Olivia, El-Boghdadly, Kariem, Elbasir, Okba, Eldridge, James, Elgie, Laura, Ellington, Matt, Elliott, Katharine, Elliott, Justine, Elmi, Mohamed, Elnoumeir, Ramy, Emeakaraoha, Eunice, Evans, Matt, Everett, Mary, Fabb, Philippa, Farooq, Hadia, Farrimond, Rohan, Faulds, Fiona, Fawcett, Erik, Feneley, Andrew, Fernando, Dinushi, Ferns, Janis, Finlay, Claire, Fitzgerald, Simon, O'Flaherty, Doireann, Fleet, Mark, Fletcher, Lydia, Fludder, Vanessa, Follet, Terri, Forbes, Jane, Forth, Mark, Foster, Greg, Francis, John, Fraser, Kate, Friedman, Lauren, Fruggeri, Luca, Fulton, Laura, Funnell, Sam, Gadre, Amit, Gandhi, Ajay, Gardiner, Harriet, Garner, Zoe, Garvey, Gráinne, Gately, Tom, George, Richard, Gillespie, Siobhan, Glover, Stephanie, Goddard, Jennifer, Goodman, Ben, Gopal, Tarikere, Graham, George, Green, David, Griffin, Denise, Griffith, Jessica, Grigsby, Stephanie, Grindey, Julie, Griffiths, Huw, Groome, Jonathan, Grother, Christine, Grounds, Gabrielle, Groves, Alice, Guha, Abhik, Gunawardhana, Amila, Gupta, Aman, Gupta, Rekha, Gutsell, James, Haddon, Richard, Hadi, Dina, Hadjipavlou, Nicola, Hammerbeck, Henry, Hammon, Laura, Hammond, Sarah, Hampanna, Hampesh, Hancock, Holly, Handapangoda, Hemantha, Haroon-Mowahed, Yumna, Harpham, Dawn, Harris, Grant, Harrison, Abigail, Harshan, Divya, Hartopp, Andrew, Harty, Eoin, Haslam, Nick, Hawkins, Gemma, Hawkins, Edith, Hawksey, Sarah, Hays, Carole, Hazelton, Tracy, Heavyside, Andrew, Hemeson, Chibuzo, Henderson, Katrina, Henry, Oliver, Herbert, Lara, Higgins, Nikki, Hilton, James, Hindmoor, Claire, Hitchcock, Rachael, Hobbs, Laura, Homsy, Michele, Honeywell, Cassandra, Hoque, Nazima, House, Kirsty, Howle, Ryan, Tiller, Amanda, Huniak, Matthew, Hunte, Jeremy, Husain, Tauqeer, Huson, Coralie, Hussain, Catriona, Hussain, Tawhida, Hussein, Zainab, Hyams, Jeremy, Hyde, Eleanor, Iaverdino, Marina, Ignacka, Alex, Innes, Erin, Ioannidis, Stefanos, Iqbal, Rehana, Ismail, Fahja, Jackson, Jenny, Jackson, Michael, Jackson, Guy, Jacobs, Robyn, Jadhav, Poonam, Jalaly, Aisha, James, Lorraine, James, Monica, Jani, Surekha, Jeganathan, Chandran, Joannides, Claire, Johnson, Robert, Johnson, Thosa, Johnston, Carolyn, Jones, Reeanne, Jones, Tom, Kadr, Miran, Kainth, Rasmeet, Kane, Jenna, Kanji, Rafiq, Kannanparambil, Sunil, Kar, Girish, Kasianandan, Theanalli, Kaskos, Husam, Kavanagh, Lisa, Kaye, Richard, Kelliher, Leith, Kelliot, Serena, Kelly, Jemma, Kelly, Jenna, Kenyon, Carol, Kessack, Laura, Kestner, Samuel, Khaku, Mohammed, Khaleeq, Sophia, Khan, Pervaz, Khan, Sabeen, Kidwai, Usamah, King, Christopher, King, Helen, Kingston, Elizabeth, Kok, Waisun, Konig, Rebekka, Konstantinova, Zheyna, Krishnan, Priya, Kua, Justin, Kuntumalla, Kavitha, Kursumovic, Emira, Kurzatkowski, Krzysztof, Kuttambakam, Hariprasad, Lane, Katherine, Lane, Sophie, Langton, Andrew, Latif, Hamad, Lau, Norlan, Laxman, Shyam, Laycock, Helen, Lee, Rachel, Leonardi, Silvia, Light, Karen, Lightfoot, Heidi, Liu, Shuang, Liyanage, Sanduni, Lowe, Jessica, Lucas, Nuala, Lungu, Miyoba, Lunn, Marianne, Lynes, Heather, Machavarapu, Kishore, Mackenzie, Matthew, Major, Jonathan, Male, Victoria, Malik, Zain, Manso, Katarina, Maquinana, Myrna, Marciniak, Katarzyna, Maronge, Lizzie, Marsh, Chris, Martella, Carmela, Martin, Nicki, Martins, Nicole, Marway, Jaspreet, Mason, Louisa, Mason, Lucy, Masood, Nadia, Masters, James, Maton-Howarth, Matthew, Mazzola, Francesca, McAllister, Tamsin, McCarthy, Rachel, McCormick, Claire, McCready, Sharon, McDougall, Steffan, Mcewan, Lorna, McGarry, Jon, McKevitt, Helen, Mckinley, Stephanie, Mckskeane, Anna, McMaster, Eloise, McMonagle, Martina, McNamara, Helen, McPhee, Hannah, McRae, Laura, Mead, Dee, Meadows, Emma, Mehta, Madhur, Meikle, Joanne, Metodiev, Yavor, Michael, Chloe, Millar, Victoria, Miller, Sarah, Miller, Gregg, Milne, Sezanne, Miltsios, Kostas, Misquita, Lucia, Misquita, Simone, Mittal, Manasi, Mohamed, Mohamed, Powell Monaghan, Katherine, Monk, Joanna, Monkhouse, Alexandra, Monks, David, Montague, Laura, Moon, Angela, Moran, Jennifer, Moreton, Annette, Morgan, Endaf, Morgan, Oliver, Morland, Danny, Morosan, Monica, Morris, Kimberley, Morris, Andrea, Moser, Clare, Mount, Manulella, Muir, Carol, Mupudzi, McDonald, Murali, Mayur, Murdoch, Iona, Murray, Heather, Murray, Theresa, Murrell, Karen, Narasimha Murthy, Girish, Neeley, Diana, Nei, Hannah, Neil, Kerry, Nejim, Tara, Nel, Mark, Nicholson, Anne, Nicklin, Angela, Nolan, Catherine, Nolan, Tracey, Nurmi, Eveliina, O'Neill, Bridie, Oakes, Christie, Oakes, Neil, Ochoa-Ferraro, Maria, Odeleye, Nike, Oliver, Katy, Oliver, Mark, Onslow, Julie, Onwochei, Desire, Oommen, Thomas, Orr, Tim, Osagie, Osato, Osborn, Hannah, Overend, Jennie, Owston, Hazel, Pack, Emma, Padhi, Pulak, Palani, Prabvathy, Pandey, Rajesh, Pandya, Dhruti, Panesar, Navjot, Papageorgiou, Con, Papanastasiou, Georgios, Papoutsos, Costas, Pararajasingham, Suji, Parry, James, Patel, Hasita, Patel, Jaishel, Patel, Jiten, Patel, Kaumudi, Patel, Kiran, Patel, Mitul, Patel, Reshma, Patel, Ruchira, Patel, Nimisha, Pathak, Sangeeta, Pearson, Fiona, Peciulene, Viktorija, Peers, Beth, Peirce, Benjamin, Pepper, Stacey, Perinpanayagam, Jasmina, Perry, Hollie, Petrova, Nadya, Phillips, Trudie, Phillips, Sioned, Phylactides, Leonidas, Pilkington, Felicity, Plumb, James, Poimenidi, Evangelia, Sau Kuk Poon, Anna, Potter, Thomas, Poultney, Una, Powell, Lucy, Prenter, Andrew, Preston, Katie, Price, Anna, Pritchard, Naomi, Pullen, Jenny, Purohit, Manishi, Quamina, Charlotte, Qureshi, Jibran, Rajput, Zahra, Ramage, Stephen, Ramanathan, Tamilselvi, Ranasinghe, Upeka, Ranatunga, Kalum, Rand, Abby, Randive, Seema, Rangarajan, Desikan, Rao, Chandana, Rao Pelluri, Sambasiva, Ratnasingham, Antony, Razzaque, Jamil, Reddy, Anuvidya, Redington, Katie, Reel, Emma, Remeta, Peter, Ricco, Francesca, Riccoboni, Anna, Rice, Polly, Rich, Mel, Richards, Nicole, Riches, Joanne, Ripoll, Simon, Roberts, Fleur, Roberts, Kitty, Robins, Kay, Robinson, Susie, Roche, Samantha, Rojo, Maria, Carmela Romano, Milena, Rosser, Hilary, Roughley, Lindsay, Routley, Catriona, Rowley, Christine, Rudra, Pallab, Russell, Robin, Ryan, Christine, Saad, Chloe, Sadeghi, Abtin, Salberg, Armorel, Samuel, Matt, Samuels, Rebecca, Sanapala, Suresh, Sanusi, Seliat, Sarao, Sarbpreet, Sathyabhama, Sathyabhama, Saunders, Zoe, Sawarzynska-ryszka, Bernadetta, Sceales, Panagiota, Sceales, Penny, Schumacher, Natasha, Schwartz, Nuala, Sellers, Claudia, Sellers, Heather, Sellick, Jessica, Sen, Soumen, Senaratne, Dhaneesha, Senbeto, Sarah, Seneviratna, Dineth, Setty, Thunga, Shah, Raj, Shah, Sonia, Shambly, James, Sharafudeen. Imran Sharieff, Saju, Sharifi, Laurence, Sharpe, Lisa, Shaw, Michael, Sheldrake, Ian, Shinde, Priya, Shonfeld. Jonathon Short, Adam, Siah, Julian, Sibug. Omar Siddique, Sheena, Siew, Sara, Simpson, Matthew, Singleton, Georgina, Sinha, Kathryn, Sinha, Aneeta, Sinnott, Matthew, Sivadhas, Harry, Sivakumar, Sivanth, Sivarajan, Boopathi, Sivarajan, Sinduja, Skeoch, Chris, Slade, Samuel, Slater, Paul, Smith, Camilla, Smith, Carys, Smith, Christopher, Smith, James, Smith, Lorraine, Smith, Annika, Smith, Edward, Smith, Ruth, Smith, Sue, Smith, Tim, Smithers, Helen, Smolen, Sue, Smyth, Claire, Snel, Toni, Snipe, Carol, Soltanifar, Sam, Sonawane, Nilesh, Soundararaja, Andal, Spence, Emily, Spiliopoulos, Mark, Srivastava, Chhavi, Stacey, Karen, Stafford, Helena, Staines, Nikki, Stead, Richard, Stevens, Emma, Stilwell, Alex, Stocks, Gary, Stokes, Aaron, Stone, Christopher, Straughan, Ben, Subbarathnam, Vanitha, Sudunagunta, Srinath, Sultan, Pervez, Suppiah, Puvan, Surve, Priyanka, Sutherland, Angus, Swanton, Rob, Swarbrick, Claire, Swinson, Amy, Syrrakou, Eleni, Tadbiri, Shahrzad, Tamhane, Preetam, Tamilselvan, Perumal, Tan, Andrew, Tanna, Shamil, Tarft, Hayley, Tarry, Laura, Taylor, Ian, Taylor, Suzanne, Tebbot, Julie, Theron, Svetlana, Thomas, Megan, Todd, Sarah, Tolliday, Hermione, Topham, Charlotte, Tovell, Nicholas, Traves, Martyn, Trodd, Dawn, Tufchi, Aseem, Turley, Katie, Turnbull, Marc, Turnbull, Chris, Turner, Oliver, Turner, William, Turney, Sharon, Tyagi, Eleanor, Uncles, David, Unsworth, Vanessa, Vadnere, Pradnya, Varadan, Rama, Vasishta, Vik, Veal, Andrew, Vedham, Lalitha, Venkaya, Jessica, Verghese, Miriam, Veronica, Icel, Vidanagamage, Dinesh, Vincent, Rachel, Vyapury, Vinodhan, Wain, Harris, Walbridge, Fiona, Walker, Elaine, Walsh, Pete, Walshe, Eleanor, Walters, Michelle, Wan, Yize, Wang, Cherry, Wankhade, Kavita, Waters, Gareth, Watts, Christopher, Webber, Alex, Wedgwood, Tom, Wee, Michael, Wellstead, Susan, White, Alison, Whitear, Michael, Whitefield, Lucy, Wilkinson, Sarah, Williams, Lauren, Williams, Rhys, Wilson, Dawn, Wilson, Samantha, Wimble, Katie, Winkley, Elaine, Winslow, Luke, Winwright, Paul, Wloch, Karolina, Wong, Gideon, Wong, Hannah, Man Wong, Jan, Wood, Tim, Wray, Sarah, Wrench, Ian, Wu, James, Wynn, Kynn, Yap, Yeng, Kuan Yeow, Chia, Young, Emily, Yusaf, Alex, Uz Zafar, Saeed, Zeinali, Darius, Zhang, Sheldon, Zope, Sarvesh, Zucco, Liana, Anwar, Sibtain, Blunt, Nadia, Cronin, John, Grover, Vimal, Grailey, Kate, Grey, Martin, Highton, David, Hopkins, Phil, Kemp, Harriet, Lo, Queenie, Martin, Daniel, Morkane, Clare, O'Carroll, James, Oliver, Charles, Post, Benjamin, Visram, Anil, Wickham, Alex, Odor, P.M., Bampoe, S., Lucas, D.N., Moonesinghe, S.R., Andrade, J., and Pandit, J.J.

Published
2020
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9. Predicting severe pain after major surgery: a secondary analysis of the Peri‐operative Quality Improvement Programme (PQIP) dataset.

Author

Armstrong, R. A., Fayaz, A., Manning, G. L. P., Moonesinghe, S. R., Oliver, C. M., Moonesinghe, S. Ramani, Wagstaff, Duncan, Bedford, James, Sahni, Arun, McGuckin, Dermot, Gilhooly, David, Santos, Cristel, Wilson, Jonathan, Martin, Peter, Singleton, Georgina, Edwards, Kylie, Vindrola‐Padros, Cecilia, Warnakulasuriya, Samantha, Dorey, Jenny, and Leemans, Irene

Subjects
SECONDARY analysis, TYPE 1 diabetes, POSTOPERATIVE pain, PSYCHOLOGICAL well-being, SURGERY, CANCER pain, ANALGESIA
Abstract

Summary: Acute postoperative pain is common, distressing and associated with increased morbidity. Targeted interventions can prevent its development. We aimed to develop and internally validate a predictive tool to pre‐emptively identify patients at risk of severe pain following major surgery. We analysed data from the UK Peri‐operative Quality Improvement Programme to develop and validate a logistic regression model to predict severe pain on the first postoperative day using pre‐operative variables. Secondary analyses included the use of peri‐operative variables. Data from 17,079 patients undergoing major surgery were included. Severe pain was reported by 3140 (18.4%) patients; this was more prevalent in females, patients with cancer or insulin‐dependent diabetes, current smokers and in those taking baseline opioids. Our final model included 25 pre‐operative predictors with an optimism‐corrected c‐statistic of 0.66 and good calibration (mean absolute error 0.005, p = 0.35). Decision‐curve analysis suggested an optimal cut‐off value of 20–30% predicted risk to identify high‐risk individuals. Potentially modifiable risk factors included smoking status and patient‐reported measures of psychological well‐being. Non‐modifiable factors included demographic and surgical factors. Discrimination was improved by the addition of intra‐operative variables (likelihood ratio χ2 496.5, p < 0.001) but not by the addition of baseline opioid data. On internal validation, our pre‐operative prediction model was well calibrated but discrimination was moderate. Performance was improved with the inclusion of peri‐operative covariates suggesting pre‐operative variables alone are not sufficient to adequately predict postoperative pain. [ABSTRACT FROM AUTHOR]

Published
2023
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14. The Perioperative Quality Improvement Programme (PQIP Patient Study): Protocol for a UK Multicentre, Prospective Cohort Study to Measure, Report and Improve Quality and Outcomes of Major Surgery

Author

Moonesinghe, S. Ramani, primary, McGuckin, Dermot, additional, Martin, Peter, additional, Bedford, James, additional, Wagstaff, Duncan, additional, Vindrola-Padros, Cecilia, additional, Sahni, Arun, additional, Edwards, Kylie, additional, Singleton, Georgina, additional, Singh, Pritam, additional, Wilson, R.Jonathan T., additional, Gilhooly, David Anthony, additional, Baumber, Rachel, additional, Bougeard, Anne-Marie, additional, Samuel, Katie, additional, Brent, Alexandra, additional, Chazapis, Maria, additional, Cripps, Martin, additional, Dorey, Jenny, additional, Leeman, Irene, additional, Smith, Helena, additional, Swart, Michael, additional, Drake, Sharon, additional, Goodwin, James, additional, Lourtie, Jose, additional, Martinez, Dorian, additional, Olive, Dominic, additional, Taylor, Christine, additional, Williams, Karen, additional, Santos, Cristel, additional, Ellicott, Helen, additional, Warnakulasuriya, Samantha, additional, Ignacka, Aleksandra, additional, Bedford, Matthew, additional, Aresu, Giuseppe, additional, Tucker, Olga, additional, Vallance, Abigail E, additional, Vohra, Ravinder, additional, Swift, Andrew, additional, Fulop, Naomi J, additional, and Grocott, Michael PW, additional

Published
2021
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16. Protocol for direct reporting of awareness in maternity patients (DREAMY): a prospective, multicentre cohort study of accidental awareness during general anaesthesia

Author

Odor, P.M., primary, Bampoe, S., additional, Lucas, D.N., additional, Moonesinghe, S.R., additional, Andrade, J., additional, Pandit, J.J., additional, A'Court, Alicja, additional, Abdel-Gadir, Dina, additional, Abdu, Ayman, additional, Abisogun, Caroline, additional, Aboud, Zainab, additional, Abrams, Judith, additional, Ackerman, Andrea, additional, Adamso, Christine, additional, Addison, Rachel, additional, Adeyeye, Adedayo, additional, Adler, Rachel, additional, Aduse-Poku, Maame, additional, Adyanthaya, Siddharth, additional, Ahmad, Najmiah, additional, Ahmed, Dabeeruddeen, additional, Ahmed, Atif, additional, Akindele, Bucky, additional, Akindele, Olubukola, additional, Akrimi, Sonia, additional, Al-Rawi, Samar, additional, Ali, Yousif, additional, Allam, Jo, additional, Allana, Alisha, additional, Allen, Kellie, additional, Allen, Orlanda, additional, Amaradasa, Natasha, additional, Amarasekara, Lareina, additional, Amoakwa-adu, Freda, additional, Anandageetha, Padmanabhan, additional, Anandakrishnan, Suresh, additional, Anandanadesan, Rathai, additional, Anderson, Michelle, additional, Apps, Simon, additional, Aquilina, Audrey, additional, Arbane, Gill, additional, Arch, Alice, additional, Armstrong, Sarah, additional, Arya, Rita, additional, Ashiru, Gloria, additional, Ashpole, Keri, additional, Atkinson, Claire, additional, Atkinson, Francesca, additional, Auer, Elizabeth, additional, Avery, Ben, additional, Babio-Galan, Maite, additional, Bader, Hareth, additional, Badham, George, additional, Bagchi, Subha, additional, Bailey, Sarah, additional, Baird, Yolanda, additional, Balaka, Cristina, additional, Baldwin, Melissa, additional, Balfour, Paul, additional, Bali, Shreya, additional, Banks, Samantha, additional, Barclay, Philip, additional, Barnes, Lucy, additional, Barnes, Thomas, additional, Barot, Niraj, additional, Barrett, Stephen, additional, Barrett, Venetia, additional, Barrett, Kate, additional, Bates, Louise, additional, Batte, Katherine, additional, Baytug, Beki, additional, Behravesh, Mona, additional, Bell, Suzanne, additional, Benloch, Raul, additional, Bentley, Richard, additional, Berg, Jennifer, additional, Berwick, Charlotte, additional, Berwick, Richard, additional, Bhadange, Rashmi, additional, Bhattacharyya, Sanjoy, additional, Bielskute, Egidija, additional, Birch, Sian, additional, Bird, Scott, additional, Bird, Ruth, additional, Birts, William, additional, Black, Becky, additional, Blagova, Tatyana, additional, Blake, Holly, additional, Blightman, Oliver, additional, Blunden, Susara, additional, Bolton, Richard, additional, Borkett-Jones, Caroline, additional, Boselli, John, additional, Bowen, Manuella, additional, Bowen, Ruth, additional, Bowye, James, additional, Boyle, Henry, additional, Brar, Zameen, additional, Bray, Jo, additional, Brayshaw, Samantha, additional, Bressington, Catherine, additional, Brewer, Alison, additional, Brice, Naomi, additional, Bridge, Laura, additional, Briscoe, James, additional, Brocklesby, Sonia, additional, Brown, Harry, additional, Brown, Sarah, additional, Brunnen, Derek, additional, Burijintichenna, Keshavareddy, additional, Burnard, Sara, additional, Burtt, Agnieszka, additional, Buswell, Victoria, additional, Bykar, Hannah, additional, Cairney, Matthew, additional, Calvert, Clare, additional, Camarasa, Laura, additional, Campbell, Natasha, additional, Campbell-Jones, Frederick, additional, Cantliffe, Jane, additional, Carrol, William, additional, Carvalho, Joanna, additional, Cashell, Catherine, additional, Cassie, Sarah, additional, Cassim, Kadu, additional, Chandler, Marika, additional, Chapman, Rachel, additional, Charles, Robert, additional, Chen, Ping, additional, Cheyne, Deanne, additional, Chima, Kiran, additional, Chin, Floju, additional, Chirvasuta, Radu, additional, Shao Chong, Martin, additional, Choudhury, Sadia, additional, Chowdhury, Priyakam, additional, Christmas, Tracey, additional, Chughwani, Shilpa, additional, 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additional, Dewan, Preeti, additional, Dimont, Sarah, additional, Donovan, Clare, additional, Doraiswami, Mano, additional, Doughty, Kate, additional, Douglass, Jamie, additional, Dower, Michelle, additional, Downing, Samantha, additional, Duberry, Wendy, additional, Duckham, Emily, additional, Dudgeon, Lucy, additional, Dukes, Stephanie, additional, Dunn, Leigh, additional, Duraiswamy, Venkat, additional, O' Dwyer, Anthony, additional, Dyer, Kristyn, additional, Eapen, Suresh, additional, Earl, Mark, additional, Eason, Sally, additional, Edwards, Kylie-Ellen, additional, Edwards, Zara, additional, Egole, Osinachi, additional, Ekpa, John, additional, El-Amin, Olivia, additional, El-Boghdadly, Kariem, additional, Elbasir, Okba, additional, Eldridge, James, additional, Elgie, Laura, additional, Ellington, Matt, additional, Elliott, Katharine, additional, Elliott, Justine, additional, Elmi, Mohamed, additional, Elnoumeir, Ramy, additional, Emeakaraoha, Eunice, additional, Evans, Matt, 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additional, Hawkins, Gemma, additional, Hawkins, Edith, additional, Hawksey, Sarah, additional, Hays, Carole, additional, Hazelton, Tracy, additional, Heavyside, Andrew, additional, Hemeson, Chibuzo, additional, Henderson, Katrina, additional, Henry, Oliver, additional, Herbert, Lara, additional, Higgins, Nikki, additional, Hilton, James, additional, Hindmoor, Claire, additional, Hitchcock, Rachael, additional, Hobbs, Laura, additional, Homsy, Michele, additional, Honeywell, Cassandra, additional, Hoque, Nazima, additional, House, Kirsty, additional, Howle, Ryan, additional, Tiller, Amanda, additional, Huniak, Matthew, additional, Hunte, Jeremy, additional, Husain, Tauqeer, additional, Huson, Coralie, additional, Hussain, Catriona, additional, Hussain, Tawhida, additional, Hussein, Zainab, additional, Hyams, Jeremy, additional, Hyde, Eleanor, additional, Iaverdino, Marina, additional, Ignacka, Alex, additional, Innes, Erin, additional, Ioannidis, Stefanos, additional, Iqbal, Rehana, additional, Ismail, Fahja, additional, Jackson, Jenny, additional, Jackson, Michael, additional, Jackson, Guy, additional, Jacobs, Robyn, additional, Jadhav, Poonam, additional, Jalaly, Aisha, additional, James, Lorraine, additional, James, Monica, additional, Jani, Surekha, additional, Jeganathan, Chandran, additional, Joannides, Claire, additional, Johnson, Robert, additional, Johnson, Thosa, additional, Johnston, Carolyn, additional, Jones, Reeanne, additional, Jones, Tom, additional, Kadr, Miran, additional, Kainth, Rasmeet, additional, Kane, Jenna, additional, Kanji, Rafiq, additional, Kannanparambil, Sunil, additional, Kar, Girish, additional, Kasianandan, Theanalli, additional, Kaskos, Husam, additional, Kavanagh, Lisa, additional, Kaye, Richard, additional, Kelliher, Leith, additional, Kelliot, Serena, additional, Kelly, Jemma, additional, Kelly, Jenna, additional, Kenyon, Carol, additional, Kessack, Laura, additional, Kestner, Samuel, additional, Khaku, Mohammed, additional, Khaleeq, Sophia, additional, Khan, Pervaz, additional, Khan, Sabeen, additional, Kidwai, Usamah, additional, King, Christopher, additional, King, Helen, additional, Kingston, Elizabeth, additional, Kok, Waisun, additional, Konig, Rebekka, additional, Konstantinova, Zheyna, additional, Krishnan, Priya, additional, Kua, Justin, additional, Kuntumalla, Kavitha, additional, Kursumovic, Emira, additional, Kurzatkowski, Krzysztof, additional, Kuttambakam, Hariprasad, additional, Lane, Katherine, additional, Lane, Sophie, additional, Langton, Andrew, additional, Latif, Hamad, additional, Lau, Norlan, additional, Laxman, Shyam, additional, Laycock, Helen, additional, Lee, Rachel, additional, Leonardi, Silvia, additional, Light, Karen, additional, Lightfoot, Heidi, additional, Liu, Shuang, additional, Liyanage, Sanduni, additional, Lowe, Jessica, additional, Lucas, Nuala, additional, Lungu, Miyoba, additional, Lunn, Marianne, additional, Lynes, Heather, additional, Machavarapu, Kishore, additional, Mackenzie, Matthew, additional, Major, Jonathan, additional, Male, Victoria, additional, Malik, Zain, additional, Manso, Katarina, additional, Maquinana, Myrna, additional, Marciniak, Katarzyna, additional, Maronge, Lizzie, additional, Marsh, Chris, additional, Martella, Carmela, additional, Martin, Nicki, additional, Martins, Nicole, additional, Marway, Jaspreet, additional, Mason, Louisa, additional, Mason, Lucy, additional, Masood, Nadia, additional, Masters, James, additional, Maton-Howarth, Matthew, additional, Mazzola, Francesca, additional, McAllister, Tamsin, additional, McCarthy, Rachel, additional, McCormick, Claire, additional, McCready, Sharon, additional, McDougall, Steffan, additional, Mcewan, Lorna, additional, McGarry, Jon, additional, McKevitt, Helen, additional, Mckinley, Stephanie, additional, Mckskeane, Anna, additional, McMaster, Eloise, additional, McMonagle, Martina, additional, McNamara, Helen, additional, McPhee, Hannah, additional, McRae, Laura, additional, Mead, Dee, additional, Meadows, Emma, additional, Mehta, Madhur, additional, Meikle, Joanne, additional, Metodiev, Yavor, additional, Michael, Chloe, additional, Millar, Victoria, additional, Miller, Sarah, additional, Miller, Gregg, additional, Milne, Sezanne, additional, Miltsios, Kostas, additional, Misquita, Lucia, additional, Misquita, Simone, additional, Mittal, Manasi, additional, Mohamed, Mohamed, additional, Powell Monaghan, Katherine, additional, Monk, Joanna, additional, Monkhouse, Alexandra, additional, Monks, David, additional, Montague, Laura, additional, Moon, Angela, additional, Moran, Jennifer, additional, Moreton, Annette, additional, Morgan, Endaf, additional, Morgan, Oliver, additional, Morland, Danny, additional, Morosan, Monica, additional, Morris, Kimberley, additional, Morris, Andrea, additional, Moser, Clare, additional, Mount, Manulella, additional, Muir, Carol, additional, Mupudzi, McDonald, additional, Murali, Mayur, additional, Murdoch, Iona, additional, Murray, Heather, additional, Murray, Theresa, additional, Murrell, Karen, additional, Narasimha Murthy, Girish, additional, Neeley, Diana, additional, Nei, Hannah, additional, Neil, Kerry, additional, Nejim, Tara, additional, Nel, Mark, additional, Nicholson, Anne, additional, Nicklin, Angela, additional, Nolan, Catherine, additional, Nolan, Tracey, additional, Nurmi, Eveliina, additional, O'Neill, Bridie, additional, Oakes, Christie, additional, Oakes, Neil, additional, Ochoa-Ferraro, Maria, additional, Odeleye, Nike, additional, Oliver, Katy, additional, Oliver, Mark, additional, Onslow, Julie, additional, Onwochei, Desire, additional, Oommen, Thomas, additional, Orr, Tim, additional, Osagie, Osato, additional, Osborn, Hannah, additional, Overend, Jennie, additional, Owston, Hazel, additional, Pack, Emma, additional, Padhi, Pulak, additional, Palani, Prabvathy, additional, Pandey, Rajesh, additional, Pandya, Dhruti, additional, Panesar, Navjot, additional, Papageorgiou, Con, additional, Papanastasiou, Georgios, additional, Papoutsos, Costas, additional, Pararajasingham, Suji, additional, Parry, James, additional, Patel, Hasita, additional, Patel, Jaishel, additional, Patel, Jiten, additional, Patel, Kaumudi, additional, Patel, Kiran, additional, Patel, Mitul, additional, Patel, Reshma, additional, Patel, Ruchira, additional, Patel, Nimisha, additional, Pathak, Sangeeta, additional, Pearson, Fiona, additional, Peciulene, Viktorija, additional, Peers, Beth, additional, Peirce, Benjamin, additional, Pepper, Stacey, additional, Perinpanayagam, Jasmina, additional, Perry, Hollie, additional, Petrova, Nadya, additional, Phillips, Trudie, additional, Phillips, Sioned, additional, Phylactides, Leonidas, additional, Pilkington, Felicity, additional, Plumb, James, additional, Poimenidi, Evangelia, additional, Sau Kuk Poon, Anna, additional, Potter, Thomas, additional, Poultney, Una, additional, Powell, Lucy, additional, Prenter, Andrew, additional, Preston, Katie, additional, Price, Anna, additional, Pritchard, Naomi, additional, Pullen, Jenny, additional, Purohit, Manishi, additional, Quamina, Charlotte, additional, Qureshi, Jibran, additional, Rajput, Zahra, additional, Ramage, Stephen, additional, Ramanathan, Tamilselvi, additional, Ranasinghe, Upeka, additional, Ranatunga, Kalum, additional, Rand, Abby, additional, Randive, Seema, additional, Rangarajan, Desikan, additional, Rao, Chandana, additional, Rao Pelluri, Sambasiva, additional, Ratnasingham, Antony, additional, Razzaque, Jamil, additional, Reddy, Anuvidya, additional, Redington, Katie, additional, Reel, Emma, additional, Remeta, Peter, additional, Ricco, Francesca, additional, Riccoboni, Anna, additional, Rice, Polly, additional, Rich, Mel, additional, Richards, Nicole, additional, Riches, Joanne, additional, Ripoll, Simon, additional, Roberts, Fleur, additional, Roberts, Kitty, additional, Robins, Kay, additional, Robinson, Susie, additional, Roche, Samantha, additional, Rojo, Maria, additional, Carmela Romano, Milena, additional, Rosser, Hilary, additional, Roughley, Lindsay, additional, Routley, Catriona, additional, Rowley, Christine, additional, Rudra, Pallab, additional, Russell, Robin, additional, Ryan, Christine, additional, Saad, Chloe, additional, Sadeghi, Abtin, additional, Salberg, Armorel, additional, Samuel, Matt, additional, Samuels, Rebecca, additional, Sanapala, Suresh, additional, Sanusi, Seliat, additional, Sarao, Sarbpreet, additional, Sathyabhama, Sathyabhama, additional, Saunders, Zoe, additional, Sawarzynska-ryszka, Bernadetta, additional, Sceales, Panagiota, additional, Sceales, Penny, additional, Schumacher, Natasha, additional, Schwartz, Nuala, additional, Sellers, Claudia, additional, Sellers, Heather, additional, Sellick, Jessica, additional, Sen, Soumen, additional, Senaratne, Dhaneesha, additional, Senbeto, Sarah, additional, Seneviratna, Dineth, additional, Setty, Thunga, additional, Shah, Raj, additional, Shah, Sonia, additional, Shambly, James, additional, Sharafudeen. Imran Sharieff, Saju, additional, Sharifi, Laurence, additional, Sharpe, Lisa, additional, Shaw, Michael, additional, Sheldrake, Ian, additional, Shinde, Priya, additional, Shonfeld. Jonathon Short, Adam, additional, Siah, Julian, additional, Sibug. Omar Siddique, Sheena, additional, Siew, Sara, additional, Simpson, Matthew, additional, Singleton, Georgina, additional, Sinha, Kathryn, additional, Sinha, Aneeta, additional, Sinnott, Matthew, additional, Sivadhas, Harry, additional, Sivakumar, Sivanth, additional, Sivarajan, Boopathi, additional, Sivarajan, Sinduja, additional, Skeoch, Chris, additional, Slade, Samuel, additional, Slater, Paul, additional, Smith, Camilla, additional, Smith, Carys, additional, Smith, Christopher, additional, Smith, James, additional, Smith, Lorraine, additional, Smith, Annika, additional, Smith, Edward, additional, Smith, Ruth, additional, Smith, Sue, additional, Smith, Tim, additional, Smithers, Helen, additional, Smolen, Sue, additional, Smyth, Claire, additional, Snel, Toni, additional, Snipe, Carol, additional, Soltanifar, Sam, additional, Sonawane, Nilesh, additional, Soundararaja, Andal, additional, Spence, Emily, additional, Spiliopoulos, Mark, additional, Srivastava, Chhavi, additional, Stacey, Karen, additional, Stafford, Helena, additional, Staines, Nikki, additional, Stead, Richard, additional, Stevens, Emma, additional, Stilwell, Alex, additional, Stocks, Gary, additional, Stokes, Aaron, additional, Stone, Christopher, additional, Straughan, Ben, additional, Subbarathnam, Vanitha, additional, Sudunagunta, Srinath, additional, Sultan, Pervez, additional, Suppiah, Puvan, additional, Surve, Priyanka, additional, Sutherland, Angus, additional, Swanton, Rob, additional, Swarbrick, Claire, additional, Swinson, Amy, additional, Syrrakou, Eleni, additional, Tadbiri, Shahrzad, additional, Tamhane, Preetam, additional, Tamilselvan, Perumal, additional, Tan, Andrew, additional, Tanna, Shamil, additional, Tarft, Hayley, additional, Tarry, Laura, additional, Taylor, Ian, additional, Taylor, Suzanne, additional, Tebbot, Julie, additional, Theron, Svetlana, additional, Thomas, Megan, additional, Todd, Sarah, additional, Tolliday, Hermione, additional, Topham, Charlotte, additional, Tovell, Nicholas, additional, Traves, Martyn, additional, Trodd, Dawn, additional, Tufchi, Aseem, additional, Turley, Katie, additional, Turnbull, Marc, additional, Turnbull, Chris, additional, Turner, Oliver, additional, Turner, William, additional, Turney, Sharon, additional, Tyagi, Eleanor, additional, Uncles, David, additional, Unsworth, Vanessa, additional, Vadnere, Pradnya, additional, Varadan, Rama, additional, Vasishta, Vik, additional, Veal, Andrew, additional, Vedham, Lalitha, additional, Venkaya, Jessica, additional, Verghese, Miriam, additional, Veronica, Icel, additional, Vidanagamage, Dinesh, additional, Vincent, Rachel, additional, Vyapury, Vinodhan, additional, Wain, Harris, additional, Walbridge, Fiona, additional, Walker, Elaine, additional, Walsh, Pete, additional, Walshe, Eleanor, additional, Walters, Michelle, additional, Wan, Yize, additional, Wang, Cherry, additional, Wankhade, Kavita, additional, Waters, Gareth, additional, Watts, Christopher, additional, Webber, Alex, additional, Wedgwood, Tom, additional, Wee, Michael, additional, Wellstead, Susan, additional, White, Alison, additional, Whitear, Michael, additional, Whitefield, Lucy, additional, Wilkinson, Sarah, additional, Williams, Lauren, additional, Williams, Rhys, additional, Wilson, Dawn, additional, Wilson, Samantha, additional, Wimble, Katie, additional, Winkley, Elaine, additional, Winslow, Luke, additional, Winwright, Paul, additional, Wloch, Karolina, additional, Wong, Gideon, additional, Wong, Hannah, additional, Man Wong, Jan, additional, Wood, Tim, additional, Wray, Sarah, additional, Wrench, Ian, additional, Wu, James, additional, Wynn, Kynn, additional, Yap, Yeng, additional, Kuan Yeow, Chia, additional, Young, Emily, additional, Yusaf, Alex, additional, Uz Zafar, Saeed, additional, Zeinali, Darius, additional, Zhang, Sheldon, additional, Zope, Sarvesh, additional, Zucco, Liana, additional, Anwar, Sibtain, additional, Blunt, Nadia, additional, Cronin, John, additional, Grover, Vimal, additional, Grailey, Kate, additional, Grey, Martin, additional, Highton, David, additional, Hopkins, Phil, additional, Kemp, Harriet, additional, Lo, Queenie, additional, Martin, Daniel, additional, Morkane, Clare, additional, O'Carroll, James, additional, Oliver, Charles, additional, Post, Benjamin, additional, Visram, Anil, additional, and Wickham, Alex, additional

Published
2020
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21. Retesting the Hypothesis of a Clinical Randomized Controlled Trial in a Simulation Environment to Validate Anesthesia Simulation in Error Research (the VASER Study).

Author

Merry, AF, Torrie, J, Weller, JM, Hannam, Jacqueline A, Webster, Craig S, Edwards, Kylie-Ellen, Frampton, Chris, Wheeler, Daniel W, Gupta, Arun K, Mahajan, Ravi P, Evley, Rachel, Merry, AF, Torrie, J, Weller, JM, Hannam, Jacqueline A, Webster, Craig S, Edwards, Kylie-Ellen, Frampton, Chris, Wheeler, Daniel W, Gupta, Arun K, Mahajan, Ravi P, and Evley, Rachel

Abstract

Simulation has been used to investigate clinical questions in anesthesia, surgery, and related disciplines, but there are few data demonstrating that results apply to clinical settings. We asked "would results of a simulation-based study justify the same principal conclusions as those of a larger clinical study?" We compared results from a randomized controlled trial in a simulated environment involving 80 cases at three centers with those from a randomized controlled trial in a clinical environment involving 1,075 cases. In both studies, we compared conventional methods of anesthetic management with the use of a multimodal system (SAFERsleep; Safer Sleep LLC, Nashville, Tennessee) designed to reduce drug administration errors. Forty anesthesiologists each managed two simulated scenarios randomized to conventional methods or the new system. We compared the rate of error in drug administration or recording for the new system versus conventional methods in this simulated randomized controlled trial with that in the clinical randomized controlled trial (primary endpoint). Six experts were asked to indicate a clinically relevant effect size. In this simulated randomized controlled trial, mean (95% CI) rates of error per 100 administrations for the new system versus conventional groups were 6.0 (3.8 to 8.3) versus 11.6 (9.3 to 13.8; P = 0.001) compared with 9.1 (6.9 to 11.4) versus 11.6 (9.3 to 13.9) in the clinical randomized controlled trial (P = 0.045). A 10 to 30% change was considered clinically relevant. The mean (95% CI) difference in effect size was 27.0% (-7.6 to 61.6%). The results of our simulated randomized controlled trial justified the same primary conclusion as those of our larger clinical randomized controlled trial, but not a finding of equivalence in effect size.

Published
2017

22. Precocious floral initiation and identification of exact timing of embryo physiological maturity facilitate germination of immature seeds to truncate the lifecycle of pea

Author

Ribalta, Federico M., primary, Pazos-Navarro, Maria, additional, Nelson, Karen, additional, Edwards, Kylie, additional, Ross, John J., additional, Bennett, Richard G., additional, Munday, Christine, additional, Erskine, William, additional, Ochatt, Sergio J., additional, and Croser, Janine S., additional

Published
2016
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25. Multimodal system designed to reduce errors in recording and administration of drugs in anaesthesia: prospective randomised clinical evaluation.

Author

Merry AF, Webster CS, Hannam J, Mitchell SJ, Henderson R, Reid P, Edwards KE, Jardim A, Pak N, Cooper J, Hopley L, Frampton C, and Short TG

Subjects
Adult, Aged, Clinical Protocols, Female, Guideline Adherence, Humans, Male, Medical Records, Middle Aged, Prospective Studies, Workload, Anesthesia, Forms and Records Control organization & administration, Medication Errors prevention & control, Pharmacy Service, Hospital organization & administration
Abstract

Objective: To clinically evaluate a new patented multimodal system (SAFERSleep) designed to reduce errors in the recording and administration of drugs in anaesthesia., Design: Prospective randomised open label clinical trial., Setting: Five designated operating theatres in a major tertiary referral hospital., Participants: Eighty nine consenting anaesthetists managing 1075 cases in which there were 10,764 drug administrations., Intervention: Use of the new system (which includes customised drug trays and purpose designed drug trolley drawers to promote a well organised anaesthetic workspace and aseptic technique; pre-filled syringes for commonly used anaesthetic drugs; large legible colour coded drug labels; a barcode reader linked to a computer, speakers, and touch screen to provide automatic auditory and visual verification of selected drugs immediately before each administration; automatic compilation of an anaesthetic record; an on-screen and audible warning if an antibiotic has not been administered within 15 minutes of the start of anaesthesia; and certain procedural rules-notably, scanning the label before each drug administration) versus conventional practice in drug administration with a manually compiled anaesthetic record., Main Outcome Measures: Primary: composite of errors in the recording and administration of intravenous drugs detected by direct observation and by detailed reconciliation of the contents of used drug vials against recorded administrations; and lapses in responding to an intermittent visual stimulus (vigilance latency task). Secondary: outcomes in patients; analyses of anaesthetists' tasks and assessments of workload; evaluation of the legibility of anaesthetic records; evaluation of compliance with the procedural rules of the new system; and questionnaire based ratings of the respective systems by participants., Results: The overall mean rate of drug errors per 100 administrations was 9.1 (95% confidence interval 6.9 to 11.4) with the new system (one in 11 administrations) and 11.6 (9.3 to 13.9) with conventional methods (one in nine administrations) (P = 0.045 for difference). Most were recording errors, and, though fewer drug administration errors occurred with the new system, the comparison with conventional methods did not reach significance. Rates of errors in drug administration were lower when anaesthetists consistently applied two key principles of the new system (scanning the drug barcode before administering each drug and keeping the voice prompt active) than when they did not: mean 6.0 (3.1 to 8.8) errors per 100 administrations v 9.7 (8.4 to 11.1) respectively (P = 0.004). Lapses in the vigilance latency task occurred in 12% (58/471) of cases with the new system and 9% (40/473) with conventional methods (P = 0.052). The records generated by the new system were more legible, and anaesthetists preferred the new system, particularly in relation to long, complex, and emergency cases. There were no differences between new and conventional systems in respect of outcomes in patients or anaesthetists' workload., Conclusions: The new system was associated with a reduction in errors in the recording and administration of drugs in anaesthesia, attributable mainly to a reduction in recording errors. Automatic compilation of the anaesthetic record increased legibility but also increased lapses in a vigilance latency task and decreased time spent watching monitors. Trial registration Australian New Zealand Clinical Trials Registry No 12608000068369.

Published
2011
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