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33 results on '"Edwards, Angelina"'

5. Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease

Author

Tolani, Renuka, Sathiyaraj, Steffi, Lyu, David, Truong, Luan, Thurston, Theresa, El-Zaatari, Ziad M., Khan, Ali R., Edwards, Angelina, and Bobart, Shane A.

Abstract

Introduction:Concurrent atypical anti-glomerular basement membrane (anti-GBM) disease with membranous nephropathy is a rare occurrence. Compared to typical anti-GBM disease, atypical anti-GBM disease is often seronegative, with a mild disease presentation and course. We present a case of concomitant of PLA2R-associated membranous nephropathy and atypical anti-GBM disease in a patient with cholangiocarcinoma. Case Presentation:A 66-year-old male with type 2 diabetes, hypertension, hyperlipidemia, hepatitis C, cirrhosis, and cholangiocarcinoma presented with nephrotic range proteinuria and worsening bilateral lower extremity edema. Urine studies showed 3+ protein and 13 red blood cells per high power field and 24-h urine protein of 14 g (nephrotic range). Serum albumin was 2.1 g/dL and serum creatinine was 0.8 mg/dL (nephrotic syndrome). Serological work-up was negative for antinuclear antibody, anti-double stranded DNA antibody, anti-PLA2R, anti-neutrophil cytoplasmic antibody, rheumatoid factor, and anti-GBM. Complement (C3 and C4) levels were normal and no monoclonal gammopathy was detected. A kidney biopsy showed membranous nephropathy with typical light microscopic, immunofluorescence, and electron microscopic findings. In addition, there was atypical anti-GBM disease characterized by a non-circumferential cellular crescent in 1 out of 12 glomeruli 2–3+ linear staining for IgG along GBM. There was no tubular basement membrane staining for IgG and albumin staining was negative. The glomeruli demonstrated strong staining for PLA2R but were negative for THSD7A and NELL-1. The patient received rituximab infusion, dapagliflozin, and lisinopril, resulting in remission of proteinuria. Despite intense chemotherapy with cisplatin, gemcitabine, and immunotherapy, the patient’s cholangiocarcinoma progressed, and he transitioned to hospice care. Conclusion:For our patient, rituximab resulted in remission of proteinuria. The lack of temporal association with the malignancy is consistent with the biopsy findings of PLA2R-associated membranous nephropathy. While there is not an established guideline for atypical anti-GBM disease, our case demonstrates the utility of rituximab for the management of concurrent atypical anti-GBM disease with membranous nephropathy.

Published
2024
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13. Four influential horror films that address the nature of race relations in America

Author

Edwards, Angelina

Subjects
African Americans, Race relations, News, opinion and commentary, Sports and fitness
Abstract

Byline: Angelina Edwards With Halloween just around the corner, more people than usual are tuning into horror movies. While the genre consists of many Halloween favorites, horror movies have a [...]

Published
2020

21. Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012–2017)

Author

Al-Obaidi, Mohanad, primary, Hasbun, Rodrigo, additional, Vigil, Karen J, additional, Edwards, Angelina R, additional, Chavez, Violeta, additional, Hall, David R, additional, Dar, Wasim A, additional, De Golovine, Aleksandra, additional, Ostrosky-Zeichner, Luis, additional, Bynon, John S, additional, and Nigo, Masayuki, additional

Published
2019
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23. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID‐19 during the course of the pandemic

Author

Heldman, Madeleine R., Kates, Olivia S., Safa, Kassem, Kotton, Camille N., Georgia, Sarah J., Steinbrink, Julie M., Alexander, Barbara D., Hemmersbach‐Miller, Marion, Blumberg, Emily A., Multani, Ashrit, Haydel, Brandy, La Hoz, Ricardo M., Moni, Lisset, Condor, Yesabeli, Flores, Sandra, Munoz, Carlos G., Guitierrez, Juan, Diaz, Esther I., Diaz, Daniela, Vianna, Rodrigo, Guerra, Giselle, Loebe, Matthias, Rakita, Robert M., Malinis, Maricar, Azar, Marwan M., Hemmige, Vagish, McCort, Margaret E., Chaudhry, Zohra S., Singh, Pooja P., Hughes Kramer, Kailey, Velioglu, Arzu, Yabu, Julie M., Morillis, Jose A., Mehta, Sapna A., Tanna, Sajal D., Ison, Michael G., Derenge, Ariella C., Duin, David, Maximin, Adrienne, Gilbert, Carlene, Goldman, Jason D., Lease, Erika D., Fisher, Cynthia E., Limaye, Ajit P., De la Cruz, Oveimar, Besharatian, Behdad D., Crespo, Maria, Tomic, Rade, Sehgal, Sameep, Weisshaar, Dana, Girgis, Reda, Lawrence, Cameron, Nelson, Joanna, Bennett, William, Leandro, Jennifer, Sait, Afrah, Rumore, Amy, West, Patricia, Jeng, Amy, Bajrovic, Valida, Bilgili, Erin P., Anderson‐Haag, Tracy, Nastase, Abigail, Badami, Abbas, Alvarez‐Garcia, Jesus, Bowman‐Anger, Lyndsey, Julien, Lovelyn, Ortiz‐Bautista, Carlos, Friedman‐Morocco, Rachel, Gajurel, Kiran, Cahuayme‐Zuniga, Lizbeth, Wakefield, Mark, Fung, Monica, Theodoropoulos, Nicole, Chuang, Sally T., Bhandaram, Srividya, Veroux, Massimiliano, Chopra, Bhavna, Florescu, Diana, Witteck, Danielle, Diaz, Daniela, Ripley, Kathryn, Saharia, Kapil, Akkina, Sanjeev, McCarty, Todd P., Webb, Ally, Arya, Akanksha, Vedula, Giridhar, El‐Amm, Jose‐Marie, Katherine Dokus, M., Narayanan, Arun, Cilene Leon Bueno de Camargo, Priscila, Ouseph, Rosemary, Breuckner, Andrew, Luk, Alfred, Aujayeb, Avinash, Ganger, Daniel, Keith, Douglas S., Meloni, Federica, Haidar, Ghady, Zapernick, Lori, Moraels, Megan, Goyal, Nitender, Sharma, Tanvi, Malhotra, Uma, Kuo, Alexander, Rossi, Ana P., Edwards, Angelina, Keller, Brian, Beneri, Christy, Derringer, Darby, Dominguez, Edward, Carlson, Elise, Hashim, Faris, Murad, Haris, Wilkens, Heinrike, Neumann, Henry, Gani, Imran, Kahwaji, Joseph, Popoola, Joyce, Michaels, Marian, Jakharia, Niyati, Puing, Alfredo, Motallebzadeh, Reza, Velagapudi, Ravi, Kapoor, Rajan, Allam, Sridhar, Silveira, Fernanda, Vora, Surabhi, Kelly, Ursala M., Reddy, Uttam, Dharnidharka, Vikas, Wadei, Hani, and Zurabi, Lominadze

Abstract

Mortality among patients hospitalized for COVID‐19 has declined over the course of the pandemic. Mortality trends specifically in solid organ transplant recipients (SOTR) are unknown. Using data from a multicenter registry of SOTR hospitalized for COVID‐19, we compared 28‐day mortality between early 2020 (March 1, 2020–June 19, 2020) and late 2020 (June 20, 2020–December 31, 2020). Multivariable logistic regression was used to assess comorbidity‐adjusted mortality. Time period of diagnosis was available for 1435/1616 (88.8%) SOTR and 971/1435 (67.7%) were hospitalized: 571/753 (75.8%) in early 2020 and 402/682 (58.9%) in late 2020 (p < .001). Crude 28‐day mortality decreased between the early and late periods (112/571 [19.6%] vs. 55/402 [13.7%]) and remained lower in the late period even after adjusting for baseline comorbidities (aOR 0.67, 95% CI 0.46–0.98, p = .016). Between the early and late periods, the use of corticosteroids (≥6 mg dexamethasone/day) and remdesivir increased (62/571 [10.9%] vs. 243/402 [61.5%], p< .001 and 50/571 [8.8%] vs. 213/402 [52.2%], p < .001, respectively), and the use of hydroxychloroquine and IL‐6/IL‐6 receptor inhibitor decreased (329/571 [60.0%] vs. 4/492 [1.0%], p< .001 and 73/571 [12.8%] vs. 5/402 [1.2%], p< .001, respectively). Mortality among SOTR hospitalized for COVID‐19 declined between early and late 2020, consistent with trends reported in the general population. The mechanism(s) underlying improved survival require further study. Data from the pre‐vaccine era show declining mortality among solid organ transplant recipients hospitalized for COVID‐19 over the course of the pandemic. Kalil comments on page 12.

Published
2022
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27. Direct-Acting Antiviral Agents Successfully Treats Hepatitis C Virus Infection in Renal Transplant Recipients: A Single-Center Experience

Author

Mukherjee, Subhajit, primary, Edwards, Angelina, additional, Hall, David R., additional, Hobeika, Mark J., additional, De Golovine, Aleksandra, additional, Dar, Wasim A., additional, Bynon, Steve J., additional, Machicao, Victor I., additional, Fallon, Michael B, additional, and Rubin, Moises I. Nevah, additional

Published
2016
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28. The New Kidney Donor Allocation System and Implications for Anesthesiologists.

Author

Sridhar, Srikanth, Guzman-Reyes, Sara, Gumbert, Sam D., Ghebremichael, Semhar J., Edwards, Angelina R., Hobeika, Mark J., Dar, Wasim A., and Pivalizza, Evan G.

Abstract

Given potential disparity and limited allocation of deceased donor kidneys for transplantation, a new federal kidney allocation system was implemented in 2014. Donor organ function and estimated recipient survival in this system has implications for perioperative management of kidney transplant recipients. Early analysis suggests that many of the anticipated goals are being attained. For anesthesiologists, implications of increased dialysis duration and burdens of end-stage renal disease include increased cardiopulmonary disease, challenging fluid, hemodynamic management, and central vein access. With no recent evidence to guide anesthesia care within this new system, we describe the kidney allocation system, summarize initial data, and briefly review organ systems of interest to anesthesiologists. As additional invasive and echocardiographic monitoring may be indicated, one consideration may be development of a dedicated anesthesiology team experienced in management and monitoring of complex patients, in a similar manner as has been done for liver transplant recipients. [ABSTRACT FROM AUTHOR]

Published
2018
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