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15 results on '"Eduardo Rame J"'

1. P63: Preemptive Temporary Right Ventricular Assist Device Implantation For Severe Biventricular Heart Failure: A Case Series

Author

Miyamoto, Takuma, primary, Ahmad, Danial, additional, Wood, Chelsey T., additional, Marek-Iannucci, Stefanie, additional, Brailovsky, Yevgeniy, additional, Rajapreyar, Indranee, additional, Eduardo Rame, J, additional, Alvarez, Rene, additional, Entwistle, John W., additional, Tchantchaleishvili, Vakhtang, additional, and Massey, Howard T., additional

Published
2023
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4. Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

Author

Trefely, Sophie, primary, Huber, Katharina, additional, Liu, Joyce, additional, Noji, Michael, additional, Stransky, Stephanie, additional, Singh, Jay, additional, Doan, Mary T., additional, Lovell, Claudia D., additional, von Krusenstiern, Eliana, additional, Jiang, Helen, additional, Bostwick, Anna, additional, Pepper, Hannah L., additional, Izzo, Luke, additional, Zhao, Steven, additional, Xu, Jimmy P., additional, Bedi, Kenneth C., additional, Eduardo Rame, J., additional, Bogner-Strauss, Juliane G., additional, Mesaros, Clementina, additional, Sidoli, Simone, additional, Wellen, Kathryn E., additional, and Snyder, Nathaniel W., additional

Published
2020
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7. The NHLBI REVIVE-IT study: Understanding its discontinuation in the context of current left ventricular assist device therapy

Author

Pagani, Francis D., primary, Aaronson, Keith D., additional, Kormos, Robert, additional, Mann, Douglas L., additional, Spino, Cathie, additional, Jeffries, Neal, additional, Taddei-Peters, Wendy C., additional, Mancini, Donna M., additional, McNamara, Dennis M., additional, Grady, Kathleen L., additional, Gorcsan, John, additional, Petrucci, Ralph, additional, Anderson, Allen S., additional, Glick, Henry A., additional, Acker, Michael A., additional, Eduardo Rame, J., additional, Goldstein, Daniel J., additional, Pamboukian, Salpy V., additional, Miller, Marissa A., additional, and Timothy Baldwin, J., additional

Published
2016
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11. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: Executive summary

Author

Feldman, David, primary, Pamboukian, Salpy V., additional, Teuteberg, Jeffrey J., additional, Birks, Emma, additional, Lietz, Katherine, additional, Moore, Stephanie A., additional, Morgan, Jeffrey A., additional, Arabia, Francisco, additional, Bauman, Mary E., additional, Buchholz, Hoger W., additional, Deng, Mario, additional, Dickstein, Marc L., additional, El-Banayosy, Aly, additional, Elliot, Tonya, additional, Goldstein, Daniel J., additional, Grady, Kathleen L., additional, Jones, Kylie, additional, Hryniewicz, Katarzyna, additional, John, Ranjit, additional, Kaan, Annemarie, additional, Kusne, Shimon, additional, Loebe, Matthias, additional, Massicotte, M. Patricia, additional, Moazami, Nader, additional, Mohacsi, Paul, additional, Mooney, Martha, additional, Nelson, Thomas, additional, Pagani, Francis, additional, Perry, William, additional, Potapov, Evgenij V., additional, Eduardo Rame, J., additional, Russell, Stuart D., additional, Sorensen, Erik N., additional, Sun, Benjamin, additional, Strueber, Martin, additional, Mangi, Abeel A., additional, Petty, Michael G., additional, and Rogers, Joseph, additional

Published
2013
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15. Microcurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration.

Author

Bachamanda Somesh D, Jürchott K, Giesel T, Töllner T, Prehn A, Richters JP, Kosevic D, Eduardo Rame J, Göttel P, and Müller J

Subjects
Rats, Animals, Myocardium metabolism, Fibroblasts metabolism, Heart physiology, Cell Differentiation, Fibrosis, Myofibroblasts metabolism, Cardiomyopathies metabolism
Abstract

Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care. This study therefore sought to investigate the effects of microcurrent therapy on cardiac myofibroblasts, aiming to unravel its potential as a treatment for cardiac fibrosis and heart failure. The experimental design involved the differentiation of primary rat cardiac fibroblasts into myofibroblasts. Subsequently, these cells were subjected to microcurrent (MC) treatment at 1 and 2 µA/cm 2 DC with and without polarity reversal. We then investigated the impact of microcurrent treatment on myofibroblast cell behavior, including protein and gene expression, by performing various assays and analyses comparing them to untreated myofibroblasts and cardiac fibroblasts. The application of microcurrents resulted in distinct transcriptional signatures and improved cellular processes. Gene expression analysis showed alterations in myofibroblast markers, extracellular matrix components, and pro-inflammatory cytokines. These observations show signs of microcurrent-mediated reversal of myofibroblast phenotype, possibly reducing cardiac fibrosis, and providing insights for cardiac tissue repair.

Published
2024
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