Search

Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are two diseases that are frequently codiagnosed and present many similarities, such as poor tolerance to physical exercise. Although exercise is recommended in their daily routine to improve quality of life, little is known about how CFS codiagnosis affects that. Using scientifically validated questionnaires, we evaluated the psychological state and quality of life of patients with FM (n = 70) and how habitual physical exercise (HPE) reported by patients with only FM (FM-only n = 38) or codiagnosed with CFS (FM + CFS, n = 32) influences those aspects. An age-matched reference group of “healthy” women without FM (RG, n = 70) was used. The FM-only group presented a worse psychological state and quality of life compared to RG, with no influence of CFS codiagnosis. The patients of the FM-only and FM + CFS groups who perform HPE presented better levels of stress and state anxiety, but with no differences between them. Depression and trait anxiety improved only in women with just FM. CFS codiagnosis does not worsen the psychological and quality of life impairment of FM patients and does not have a great influence on the positive effect of HPE.

Background Tension band wiring and plates are the most widely used treatments for transverse displaced fractures of olecranon despite high rates of hardware complications, subsequent implant removal, and associated costs. The purpose of this study was to report the outcomes of displaced transverse olecranon fractures treated with intramedullary screw and suture tension band. Methods We performed an observational, retrospective, consecutive, monocentric, continuous multioperator study. We reviewed 31 Mayo type IIA displaced olecranon fractures treated in our institution with intramedullary 6.5 mm AO cancellous screw and high-strength suture tension band (No. 2 FiberWire®) from 2016 to 2018. Inclusion was limited to functionally independent patients with Mayo type IIA fractures and minimum 24-month follow-up for implant removal. We assessed clinical outcomes including range of motion; QuickDASH score; and Mayo Elbow Performance Score. Categorical data were analyzed with Fisher's exact test when appropriate. Continuous data were analyzed with the Student t-test or Mann-Whitney U test after assessment for normality. Statistical analysis was performed with STATA 16 software. Results Twenty-seven patients with a mean follow-up period of 38.4 ± 6.2 months (range, 24.1-50 months) were included in the study. The average flexion was 134.5° ± 14.8° (range, 70°-140°) and the mean extension was −5.9° ± 7.0° (range, −20°-0°). Mean pronation and supination were 85.8° ± 11.9° (range, 45°-90°) and 86.9° ± 14.3° (range, 20°-90°), respectively. The mean Mayo Elbow Performance Score was 90.8 ± 9.6 (range, 70-100) with 92.3% good and excellent results. The mean QuickDASH score was 17.1 ± 16 (range, 0-54.5). There were 3 hardware-related removals (11.1%). The overall removal rate was 18.5%. Univariate analysis of the factors associated with implant removal were pain in relation to the implant (60% vs. 11%, P = 0.0482), proximal screw migration (3.7 mm vs. 1.7 mm, P = 0.05), articular angle (22.5° vs. 27.7°, P = 0.0353), and olecranon width (22.2 mm vs. 24.4 mm, P = 0.0166). In total, 26.1% of the cases presented some degree of proximal migration of the implant (2.7 ± 1.8 mm of migration; range, 1.5-6.2 mm). Univariate analysis of the factors associated with implant proximal migration were proximal ulnar dorsal angulation (1.7° vs. 6.4°, P = 0.0179), anteroposterior endomedullary canal (7.3 mm vs. 6.0 mm, P = 0.0369), and lateral endomedullary canal (7.2 mm vs. 5.0 mm, P = 0.0219). Conclusion The functional outcomes of simple transverse olecranon fractures treated with an intramedullary cancellous screw and a suture tension band are excellent, associated with a low rate of complications and material removal.

Summary Background The maxillary lateral incisor is one of the teeth most likely to suffer agenesis, resulting in spacing between the central incisor and the canine. Objective To compare maxillary lateral incisor agenesis with space closure treatment versus non-treatment based on measurements of the self-perceived oral-health-related quality of life (OHRQoL) and self-esteem of the participants. Subjects and methods A total of 44 people, aged 17–49 years, with missing lateral incisors were randomly assigned to two groups (n = 22 in each)—a treated group in which the space was orthodontically closed (TG) and a control group that remained untreated (CG). Randomization was performed by a researcher who was not involved in the clinical part of the study. The outcomes were assessed using the Oral Health Impact Profile and Rosenberg’s Self-Esteem Scale, which were applied before (phase 1) and after (phase 2) the orthodontic treatment in the TG, and at baseline (phase 1) and 12 months after (phase 2) in the CG. All the data were blindly evaluated, supporting the single-blinded design of the study. Results All participants finished the randomized controlled trial, and the demographic characteristics were similar between the groups. In phase 1, the levels of self-esteem and OHRQoL at baseline were similar (P = 0.079, P = 0.693, respectively). In phase 2, the self-esteem scores of the CG decreased and the OHRQoL increased (P = 0.005, P < 0.001, respectively), while self-esteem increased in the TG and the OHRQoL decreased (P < 0.001). The CG had lower scores than the TG for self-esteem, but the opposite was observed for OHRQoL (P < 0.001). Limitations Information bias may have occurred. Since the questionnaires could not have been applied at the same time in both groups, the time difference between the two assessments may have led to random and systematic error. Conclusions The spacing resulting from missing maxillary lateral incisors had a negative impact on the OHRQoL and self-esteem of the participants, while orthodontically closing those spaces had a positive impact on those aspects. Clinical trial registration This study was not registered. Protocol The protocol was not published before trial commencement.

Introduction The purpose of this study was to use cone-beam computed tomography (CBCT) to determine bone thickness in the mandibular buccal shelf (MBS) and the infrazygomatic crest (IC) in individuals with different vertical facial heights for ultimate placement of miniscrews. Methods The sample consisted of 100 individuals aged at least 16 years, of whom 58 were women, and 42 were men. The mean age was 19.18 years (± 5.5 standard deviation). The patients' facial height was determined by the gonial angle. Cross-sectional slices of the MBS and IC were obtained with CBCT to evaluate bone thickness for the insertion of miniscrews in these extra-alveolar sites. Spearman's nonparametric test was used to correlate the gonial angle with MBS and IC thickness. The level of significance was 5%. Results The gonial angle ranged from 102.4° to 143.2°. Bone thickness in the MBS increased posteriorly, whereas bone thickness in the IC decreased posteriorly. There was an inversely proportional correlation between the gonial angle and the MBS. There was no correlation between the IC and the gonial angle. Conclusions Short-faced individuals had higher bone thickness values in the MBS than long-faced ones. There was no correlation between the patients' vertical face height and the bone width in the IC. The best site to install miniscrews in the MBS is buccal to the second molar distal root, whereas in the IC, it is buccal to the first molar mesiobuccal root. CBCT may be necessary to install extra-alveolar miniscrews correctly, especially in the IC.

Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are two medical conditions in which pain, fatigue, immune/inflammatory dysregulation, as well as various mental health disorders predominate in the diagnosis, without evidence of a clear consensus on the treatment of FM and CFS. The main aim of this research was to analyse the possible effects of a synbiotic (Synbiotic, Gasteel Plus® (Heel España S.A.U.), through the study of pro-inflammatory/anti-inflammatory cytokines (IL-8/IL-10) and neuroendocrine biomarkers (cortisol and DHEA), in order to evaluate the interaction between inflammatory and stress responses mediated by the cytokine-HPA (hypothalamic-pituitary-adrenal) axis, as well as mental and physical health using body composition analysis, accelerometry and previously validated questionnaires. The participants were women diagnosed with FM with or without a diagnostic of CFS. Each participant was evaluated at baseline and after the intervention, which lasted one month. Synbiotic intervention decreased levels of perceived stress, anxiety and depression, as well as improved quality of life during daily activities. In addition, the synbiotic generated an activation of HPA axis (physiological cortisol release) that can compensate the increased inflammatory status (elevated IL-8) observed at baseline in FM patients. There were no detrimental changes in body composition or sleep parameters, as well as in the most of the activity/sedentarism-related parameters studied by accelerometry. It is concluded that synbiotic nutritional supplements can improve the dysregulated immunoneuroendocrine interaction involving inflammatory and stress responses in women diagnosed with FM, particularly in those without a previous CFS diagnostic; as well as their perceived of levels stress, anxiety, depression and quality of life.

Obesity is characterized by low-grade inflammation and more susceptibility to infection, particularly viral infections, as clearly demonstrated in COVID-19. In this context, immunometabolism and metabolic flexibility of macrophages play an important role. Since inflammation is an inherent part of the innate response, strategies for decreasing the inflammatory response must avoid immunocompromise the innate defenses against pathogen challenges. The concept “bioregulation of inflammatory/innate responses” was coined in the context of the effects of exercise on these responses, implying a reduction in excessive inflammatory response, together with the preservation or stimulation of the innate response, with good transitions between pro- and anti-inflammatory macrophages adapted to each individual’s inflammatory set-point in inflammatory diseases, particularly in obesity. The question now is whether these responses can be obtained in the context of weight loss by dietary interventions (low-fat diet or abandonment of the high-fat diet) in the absence of exercise, which can be especially relevant for obese individuals with difficulties exercising such as those suffering from persistent COVID-19. Results from recent studies are controversial and do not point to a clear anti-inflammatory effect of these dietary interventions, particularly in the adipose tissue. Further research focusing on the innate response is also necessary.

Objectives To systematically review existing literature regarding clinical parameters comparing surgical laser and conventional surgery with scalpel for soft tissue adjunctive periodontal procedures in orthodontic patients. Methods and Materials MEDLINE, Scopus, Web of Science, The Cochrane Library, LILACS, Bibliografia Brasileira de Odontologia (Brazilian Dental Literature - BBO), Embase, Open Grey, Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Coordination for the Improvement of Higher Education Personnel - CAPES), and Google Scholar were searched up to December 2020 without language restriction. Clinical trials comparing clinical parameters from surgical laser and conventional surgery with scalpel for soft tissue adjunctive periodontal procedures in orthodontic patients were selected. Risk of bias (RoB) assessments were performed using the Cochrane RoB2 tool. Narrative syntheses were performed, and the certainty of evidence was determined using the GRADE tool. Results Five randomized clinical trials were included. One study was rated as low RoB, whereas others presented some concerns or high RoB. The studies were highly heterogeneous in relation to the procedure performed, laser protocol, outcomes evaluated, and follow-up periods. In general, regardless of the procedure and laser protocol used, the studies did not show significant differences between laser and scalpel for the outcomes of probing pocket depth, clinical crown length, gingival index, and relapse rate. Pain and bleeding were significantly lower with the use of laser compared with the scalpel. The certainty of evidence ranged from moderate to very low. Conclusions The existing literature on the subject is scarce and very heterogeneous and has methodological limitations. Based on the available evidence, it is not possible to draw definitive conclusions about the beneficial effect of laser use in orthodontic patients.

Idiopathic hyperckemia has been described as persistent serum creatine kinase elevation at least 1.5 times the upper limit of normal in individuals with otherwise normal laboratory findings and neurological examination. This type of hyperckemia encompasses both sporadic and familial cases, which have been found to be asymptomatic or subclinical, presenting with mild symptoms, such as myalgias or cramps. Genetic causes of hyperckemia have been rarely described. The authors aim to describe a benign autosomal dominant condition caused by a rare mutation in the caveolin gene. Caveolin gene encodes for structural membrane proteins in muscle. The purpose of this article was to discuss the presentation, pathophysiology, and diagnosis of familial hyperckemia secondary to a relatively unknown mutation in caveolin-3 gene.

The purpose of this study was to evaluate whether the presence of orthodontic brackets influences the accuracy of digital models generated by intraoral and extraoral scanning from the same patients.Eighteen orthodontic patients in permanent dentition underwent full-arch intraoral scanning with a CEREC Omnicam scanner (Dentsply Sirona, York, Pa). Alginate impressions from each patient's arch were taken, and plaster models were made and scanned. Intermolar, intercanine, and mesiodistal width of the incisors were measured on 2 digital and 1 plaster models. Analysis of variance or Friedman's test was used, with differences between pairs verified by the Bonferroni test or Wilcoxon test, respectively. Both digital models were superimposed using surface-based registration.Lin's lowest coefficient of agreement was 0.960 (95% confidence interval, 0.900-0.984), which was clinically adequate. No statistically significant differences between the 3 types of model measurements were observed, except for the mandibular left lateral incisor in which scanned intraoral digital models presented Δmedium of 0.05 mm, which was higher than the plaster model. The superimposition of the extraoral and intraoral digital models revealed a minimum difference between models with a mean of means of 0.12 ± 0.03 mm.Brackets bonded to teeth affected intraoral scanning; however, the intraoral digital models are clinically comparable and present fewer distortions than plaster models. Moreover, measurements on intraoral and extraoral digital models are excellent in terms of trueness and precision and can be used clinically and in plaster models.

Resumen La toxoplasmosis congénita en embarazos gemelares es infrecuente. Presentamos el caso de un embarazo gemelar monocigótico, monocorial con una infección materna por toxoplasmosis diagnosticada a las 33 semanas de gestación mediante detección de IgM e IgG reactivas y test de baja avidez de IgG. No pudo realizarse la detección del parásito en líquido amniótico debido a que no se hizo amniocentesis. Las recién nacidas (RN) de término presentaron calcificaciones cerebrales y coriorretinitis activa bilateral, sin otras manifestaciones clínicas asociadas. Tuvieron IgG e IgM reactiva para toxoplasmosis. No se realizó RPC para Toxoplasma gondii en placenta ni en sangre de cordón. Recibieron tratamiento durante el primer año de vida con pirimetamina, sulfadiazina y ácido folínico, sin eventos adversos asociados a la terapia. La metodología diagnóstica y el tratamiento no difieren de los embarazos con feto único. Uno o ambos RN pueden estar comprometidos. Es fundamental el seguimiento multidisciplinario para la detección precoz de reactivaciones o progresión de las lesiones.

Sacroiliac joint (SIJ) pain is an important cause of lower back problems. Multiple SIJ injection techniques have been proposed over the years to help in the diagnosis and treatment of this condition. However, the SIJ innervation is complex and variable, and truly intra-articular injections are sometimes difficult to obtain. Different sacroiliac joint injections have shown to provide pain relief in patients suffering this ailment. Various techniques for intraarticular injections, sacral branch blocks and radiofrequency ablation, both fluoroscopy guided and ultrasound guided are discussed in this paper. Less common techniques like prolotherapy, platelet rich plasma injections and botulism toxin injections are also discussed.

Congenital toxoplasmosis in twin pregnancies is infrequent. We present the case of a monozygotic and monocorial twin pregnancy with maternal toxoplasmosis infection diagnosed at 33 weeks gestation by detecting reactive IgM and IgG and low avidity test for IgG. The detection of the parasite in amniotic fluid could not be performed because the amniocentesis was not done. The term newborns presented cerebral calcifications and bilateral active chorioretinitis without other associated clinical manifestations. They had IgG and IgM reactive for toxoplasmosis. The detection of Toxoplasma gondii was not performed by placental PCR or cord blood. They received treatment during the first year of life with pyrimethamine, sulfadiazine and folinic acid. They had no adverse events associated with the therapy. The diagnostic assessment and treatment does not differ from pregnancies with a single fetus. One or both newborns may be compromised. Multidisciplinary monitoring is essential for the early detection of reactivations or progression of lesions.

Estudio y edición crítica de la obra del presbítero hispano Juvenco "Evangeliorum libri IV"

Goldbloom syndrome is a rare clinical entity, of unknown etiology that happens almost exclusively in pediatric population. It is a prolonged febrile syndrome with periosteal hyperostosis and dysproteinemia, and often simulates an hematooncology or lymphoproliferative disease. The diagnosis is to rule out the different causes of bone pain associated with hypergammaglobulinemia, hypoalbuminemia, high erythrocyte sedimentation rate and periostitis at the radiographies. Symptomatology, radiology and laboratory parameters refer in a variable time, usually from 3 to 12 months. We report the case of a six-year-old boy with diffuse bone pain, prolonged febrile syndrome (of 8 months of evolution), weight loss and elevated acute phase reactants with dysproteinemia (hypergammaglobulinemia and hypoalbuminemia). Goldbloom syndrome should be considered in patients with prolonged febrile syndrome and cortical hyperostosis after the exclusion of infectious, lymphoproliferative or inflammatory disease.

Goldbloom syndrome is a rare clinical entity, of unknown etiology that happens almost exclusively in pediatric population. It is a prolonged febrile syndrome with periosteal hyperostosis and dysproteinemia, and often simulates an hematooncology or lymphoproliferative disease. The diagnosis is to rule out the different causes of bone pain associated with hypergammaglobulinemia, hypoalbuminemia, high erythrocyte sedimentation rate and periostitis at the radiographies. Symptomatology, radiology and laboratory parameters refer in a variable time, usually from 3 to 12 months. We report the case of a six-year-old boy with diffuse bone pain, prolonged febrile syndrome (of 8 months of evolution), weight loss and elevated acute phase reactants with dysproteinemia (hypergammaglobulinemia and hypoalbuminemia). Goldbloom syndrome should be considered in patients with prolonged febrile syndrome and cortical hyperostosis after the exclusion of infectious, lymphoproliferative or inflammatory disease.El síndrome de Goldbloom es una rara entidad clínica de etiología desconocida que ocurre casi exclusivamente en pediatría. Consiste en un síndrome febril prolongado con hiperostosis perióstica y disproteinemia, que, con frecuencia, simula una patología hematooncológica o linfoproliferativa. El diagnóstico se hace por exclusión de las diferentes causas de dolor de los huesos y se asocia a hipergammaglobulinemia, hipoalbuminemia, eritrosedimentación acelerada e imágenes radiológicas de periostitis. La sintomatología, la radiología y los parámetros de laboratorio remiten en un tiempo variable, que va, habitualmente, de los 3 a los 12 meses. Se presenta a un paciente de 6 años con dolores óseos difusos, hiperostosis perióstica, síndrome febril prolongado de 8 meses de evolución, pérdida de peso y reactantes de fase aguda elevados con disproteinemia (hipergammaglobulinemia e hipoalbuminemia). Debe considerarse el síndrome de Goldbloom en un paciente con las manifestaciones descritas luego de la exclusión de la patología infecciosa, hematooncológica e inflamatoria de otra causa.

Objective The Primekote® (TP) polymer was incorporated to the of Orthodontic Bracket mesh base to improve bond strength and make it more efficient. The purpose of this study was to assess the shear bond strength and adhesive remnant index (ARI) of these brackets. Material and method The test sample consisted of thirty bovine incisors divided into 2 groups: with a group with TP® brackets (n=15), and a control group with Morelli® brackets (n=15) without Primekote® technology. The TransbondTM XT was used as adhesive system in both groups, following the same protocol and manufacturer’s instructions. Specimens were stored in distilled water for 24 hours and then submitted to shear bond strength test in a universal testing machine (EMIC DL2000). The assessment of ARI was performed under stereomicroscope by two calibrated examiners. Result No significant differences (p>0.05) in shear bond strength were found between the two groups according to the independent t-test. The Wilcoxon test was used to assess ARI data and statistical difference was found between Morelli® and TP® Nu-Edge brackets; the last one left less remaining adhesive on tooth surface. Conclusion TP® brackets had higher adherence to the adhesive system as shown by lower ARI scores, but this does not improve its clinical performance. Resumo Objetivo Avaliar a resistência ao cisalhamento e o índice de remanescente adesivo (IRA) dos bráquetes que tiveram o polímero Primekote® incorporado a suas bases. Material e método Foram confeccionados trinta corpos de prova com incisivos bovinos, divididos em dois grupos: o colado com bráquete TP® Nu-Edge(n=15) e grupo controle com bráquetes Morelli® (n=15) sem tratamento na base. O sistema adesivo TransbondTM XT foi utilizado nos dois grupos seguindo o mesmo protocolo de colagem e respeitando as instruções do fabricante. Os corpos de prova foram armazenados em água destilada por 24 horas, e posteriormente submetidos ao teste de cisalhamento na máquina de ensaios universais (EMIC-DL2000). O IRA foi avaliado por dois examinadores calibrados utilizando lupa estereoscópica com aumento de 20 vezes. Resultado Na resistência ao cisalhamento o teste T-independente mostrou não haver diferença estatisticamente significante entre os grupos (p>0,05), ambos tiveram desempenho semelhante. O teste Wilcoxon foi utilizado nos valores obtidos no IRA revelando diferença estatística, sendo que os bráquetes TP® deixaram menos remanescente adesivo na superfície dental que os bráquetes Morelli®. Conclusão Bráquetes TP® apresentaram maior adesão ao sistema adesivo pois foi encontrado menor IRA nos mesmos, porém esta característica não reflete em melhora no desempenho clínico.

Introducción: en los últimos años hemos sido testigos en el país de un proceso de institucionalización y formalización del área cultural, a través de la aprobación de los derechos culturales, la consolidación de legislación cultural, la conformación del Ministerio y secretarías de cultura, entre otros. Al mismo tiempo, hemos sido testigos de transformaciones importantes a nivel discursivo, como la noción de desarrollo cultural y de pluralidad cultural promovidos centralmente por la unesco. Metodología: describir el contexto nacional e internacional de políticas sobre lo cultural, examinar el marco general de las políticas culturales en el departamento de Santander (Colombia), detallar los diferentes programas que componen las líneas estratégicas culturales y analizar los indicadores de cada una de las líneas estratégicas. Resultado: fialmente hemos evidenciado transformaciones en el campo de las comunicaciones y de la economía, en la cual la cultura empieza a adquirir un rol central en el pib, sin que esto tenga importancia signifiativa aún en la política de nuestros gobiernos. Conclusiones: la difiultad de aprehender la dimensión cultural, que vacila entre lo artístico y lo antropológico, colabora a la indefiición de los programas y a la difiultad en la concepción de la vinculación entre la cultura, el desarrollo y la democracia.

Object The aim of this study was to describe the pelvic parameters in a sample of healthy Mexican volunteers and to compare them with previously reported data for Caucasian and Asian populations. Methods This was a transversal study that included a sample population of healthy Mexican volunteers. Age, sex, and lateral radiographs of the lumbosacral region with the individual standing to obtain the pelvic parameters of pelvic tilt (PT), sacral slope (SS), pelvic incidence (PI), and lumbar lordosis (LL) were recorded in each volunteer. The data were compared with those previously published for Caucasian and Asian individuals. Results In total, 202 Mexican individuals (81 men and 121 women; mean age 46.5 years, range 18–85 years) were included. There were statistically significant differences between the Mexican and Caucasian control group with respect to PT (11.9° vs 15.78°, respectively) and PI (51.91° vs 56.68°, respectively). Comparison with the Asian population showed statistically significant differences in relation to the Mexican group in terms of the PT (11.5° vs 15.78°), PI (47.8° vs 56.68°), and SS (36.3° vs 40.89°). The mean LL was 60.17° for the Mexican group, 52.3° for the Asian group, and 61.3° for the Caucasian group. A significant difference in LL was found between the Mexican and Asian populations (p < 0.0001). Conclusions A comparison of the values for pelvic parameters and lumbar lordosis across the different population samples revealed statistically significant differences, which can be attributed to the ethnic origin of the individuals.