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This study aimed to determine the results of INR monitoring in patients on vitamin K antagonists (VKAs) and the time in therapeutic range (TTR) in 'real-world' settings.Retrospective analysis of 836,857 INR measurements performed in adults from February 2010 to August 2015 in two districts in the French Brittany region.Of the 836,857 INR measurements, 94.9% were ordered by general practitioners and 2.0% by cardiologists. The number of tests increased by 10-year age categories up to the age-group of 80-90 years. The number of INR measurements increased from 169,636 in 2011 to 176,184 in 2012, but then decreased slightly to 162,597 in 2013 and 164,427 in 2014. Mean coefficient of variation of INR was 19.0%, and mean TTR was 29.0%. TTR was higher in women than in men (31% vs. 18%), in older than in younger patients (19.1% at 40 years and 38.6% at 100 years) and in patients with arrhythmias than in those with deep vein thrombosis/pulmonary embolism (44.4% versus 19.4%) (p 10VKAs are still frequently prescribed in this era of direct oral anticoagulants. The low TTR cannot be explained by inadequate INR monitoring.

O objectivo deste estudo é conhecer a relação entre o exercício físico, a depressão e o índice de massa corporal (IMC). A amostra do estudo foi constituída por 175 participantes (43 do sexo masculino e 132 do sexo feminino) com idades compreendidas entre os 18 e 27 anos. Os instrumentos utilizados foram o Inventário de Depressão de Beck (BDI), numa versão adaptada e validada para a língua portuguesa, e uma adaptação da escala de exercício físico proposta por Prochaska, Sallis, e Long (2001). Os resultados apontam para um correlação negativa entre o exercício físico e a depressão, com significância estatística. O grupo que não atinge a prática de exercício físico recomendado apresenta valores médios de depressão superiores. Em conclusão, este estudo permitiu confirmar estudos prévios que evidenciaram os efeitos positivos do exercício físico sobre a depressão., Motricidade, Vol 5 No 1 (2009)

Background Bed rest is often recommended as part of the management of deep vein thrombosis (DVT) and pulmonary embolism (PE), though this recommendation is not clearly evidence-based. Methods Using the Cochrane Central Register of Controlled Trials, Medline, and Embase, this meta-analysis considered all randomized studies and prospective registries that compared the outcomes of patients with DVT, PE, or both, managed with bed rest versus early ambulation, in addition to anticoagulation. For each study, data regarding the incidence of new PE, new or progression of DVT, and death from all causes, were used to calculate relative risks (RR) and 95% confidence intervals (CI). Results The 5 studies retained in this analysis included a total of 3048 patients. When compared to bed rest, early ambulation was not associated with a higher incidence of a new PE (RR 1.03; 95% CI 0.65–1.63; p =0.90). Furthermore, early ambulation was associated with a trend toward a lower incidence of new PE and new or progression of DVT than bed rest (RR 0.79; 95% CI 0.55–1.14; p =0.21) and lower incidence of new PE and overall mortality (RR 0.79; 95% CI 0.402–1.56; p =0.50). Conclusions Compared with bed rest, early ambulation of patients with DVT, PE or both, was not associated with a higher risk of progression of DVT, new PE or death. This meta-analysis does not support the systematic recommendation of bed rest as part of the early management of patients presenting with DVT, PE of both.