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4. Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium

Author

Erausquin, Gabriel A, Snyder, Heather, Brugha, Traolach S, Seshadri, Sudha, Carrillo, Maria, Sagar, Rajesh, Huang, Yueqin, Newton, Charles, Tartaglia, Carmela, Teunissen, Charlotte, Håkanson, Krister, Akinyemi, Rufus, Prasad, Kameshwar, D'Avossa, Giovanni, Gonzalez‐Aleman, Gabriela, Hosseini, Akram, Vavougios, George D, Sachdev, Perminder, Bankart, John, Mors, Niels Peter Ole, Lipton, Richard, Katz, Mindy, Fox, Peter T, Katshu, Mohammad Zia, Iyengar, M Sriram, Weinstein, Galit, Sohrabi, Hamid R, Jenkins, Rachel, Stein, Dan J, Hugon, Jacques, Mavreas, Venetsanos, Blangero, John, Cruchaga, Carlos, Krishna, Murali, Wadoo, Ovais, Becerra, Rodrigo, Zwir, Igor, Longstreth, William T, Kroenenberg, Golo, Edison, Paul, Mukaetova‐Ladinska, Elizabeta, Staufenberg, Ekkehart, Figueredo‐Aguiar, Mariana, Yécora, Agustín, Vaca, Fabiana, Zamponi, Hernan P, Re, Vincenzina Lo, Majid, Abdul, Sundarakumar, Jonas, Gonzalez, Hector M, Geerlings, Mirjam I, Skoog, Ingmar, Salmoiraghi, Alberto, Boneschi, Filippo Martinelli, Patel, Vibuthi N, Santos, Juan M, Arroyo, Guillermo Rivera, Moreno, Antonio Caballero, Felix, Pascal, Gallo, Carla, Arai, Hidenori, Yamada, Masahito, Iwatsubo, Takeshi, Sharma, Malveeka, Chakraborty, Nandini, Ferreccio, Catterina, Akena, Dickens, Brayne, Carol, Maestre, Gladys, Blangero, Sarah Williams, Brusco, Luis I, Siddarth, Prabha, Hughes, Timothy M, Zuñiga, Alfredo Ramírez, Kambeitz, Joseph, Laza, Agustin Ruiz, Allen, Norrina, Panos, Stella, Merrill, David, Ibáñez, Agustín, Tsuang, Debby, Valishvili, Nino, Shrestha, Srishti, Wang, Sophia, Padma, Vasantha, Anstey, Kaarin J, Ravindrdanath, Vijayalakshmi, Blennow, Kaj, Mullins, Paul, Łojek, Emilia, Pria, Anand, Mosley, Thomas H, Gowland, Penny, Girard, Timothy D, Bowtell, Richard, and Vahidy, Farhaan S

Subjects
Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Alzheimer's Disease, Infectious Diseases, Emerging Infectious Diseases, Clinical Research, Dementia, Neurodegenerative, Prevention, Acquired Cognitive Impairment, Aging, Aetiology, 2.1 Biological and endogenous factors, Neurological, Good Health and Well Being, cognitive impairment, dementia, neuropsychiatric sequelae, predictors, SARS-CoV-2, SARS‐CoV‐2
Abstract

IntroductionCoronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term.MethodsThis article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions.ResultsSuccessful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe.DiscussionThe Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection.Key pointsThe following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility.The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease.We provide a framework for current and future studies to be carried out within the Consortium. and offers a "green paper" to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic.The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.

Published
2022

8. Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Author

Livingston, Nicholas R., Calsolaro, Valeria, Hinz, Rainer, Nowell, Joseph, Raza, Sanara, Gentleman, Steve, Tyacke, Robin J., Myers, Jim, Venkataraman, Ashwin V., Perneczky, Robert, Gunn, Roger N., Rabiner, Eugenii A., Parker, Christine A., Murphy, Philip S., Wren, Paul B., Nutt, David J., Matthews, Paul M., and Edison, Paul

Published
2022
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9. Incretin Mimetics as Potential Disease Modifying Treatment for Alzheimer's Disease.

Author

Crook, Harry and Edison, Paul

Subjects
*DISEASE risk factors, *TYPE 2 diabetes, *ALZHEIMER'S disease, *GASTRIC inhibitory polypeptide, *PATHOLOGY
Abstract

Alzheimer's disease is a devastating neurodegenerative condition that exerts a significant global burden. Despite recent efforts, disease modifying therapies remain extremely limited, with a tremendous proportion of patients having to rely on symptomatic treatment only. Epidemiological and pathological overlaps exist between Alzheimer's disease and diabetes mellitus type 2, with people with diabetes mellitus type 2 at a significantly increased risk of developing Alzheimer's disease in the future. Incretin mimetics, also known as GLP-1/GIP receptor agonists, are useful tools licensed for the treatment of diabetes mellitus type 2 which have recently been the subject of news coverage for their off-label use as weight loss medications. Emerging evidence highlights the possible neuroprotective function of incretin mimetics in models of Alzheimer's disease as well as in clinical studies. This review details the pre-clinical and clinical studies that have explored the effectiveness of incretin mimetics to alleviate Alzheimer's disease associated pathology and cognitive impairment, while also highlighting the progress made to examine the effectiveness of these molecules in Parkinson's disease. Should clinical trials prove effective, incretin mimetics may be able to be repurposed and become useful novel tools as disease-modifying treatments for Alzheimer's disease and other neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Do Tau Deposition and Glucose Metabolism Dissociate in Alzheimer's Disease Trajectory?

Author

Nowell, Joseph, Raza, Sanara, Livingston, Nicholas R., Sivanathan, Shayndhan, Gentleman, Steve, and Edison, Paul

Subjects
ALZHEIMER'S disease, TAU proteins, GLUCOSE metabolism, MILD cognitive impairment, FLUORODEOXYGLUCOSE F18
Abstract

Background: Tau aggregation demonstrates close associations with hypometabolism in Alzheimer's disease (AD), although differing pathophysiological processes may underlie their development. Objective: To establish whether tau deposition and glucose metabolism have different trajectories in AD progression and evaluate the utility of global measures of these pathological hallmarks in predicting cognitive deficits. Methods: 279 participants with amyloid-β (Aβ) status, and T1-weighted MRI scans, were selected from the Alzheimer's Disease Neuroimaging Initiative (). We created the standard uptake value ratio images using Statistical Parametric Mapping 12 for [18F]AV1451-PET (tau) and [18F]FDG-PET (glucose metabolism) scans. Voxel-wise group and single-subject level SPM analysis evaluated the relationship between global [18F]FDG-PET and [18F]AV1451-PET depending on the Aβ status. Linear models assessed whether tau deposition or glucose metabolism better predicted clinical progression. Results: There was a dissociation between global cerebral glucose hypometabolism and global tau load in amyloid-positive AD and amyloid-negative mild cognitive impairment (MCI) (p > 0.05). Global hypometabolism was only associated with global cortical tau in amyloid-positive MCI. Voxel-level single subject tau load better predicted neuropsychological performance, Alzheimer's disease assessment scale-cognitive (ADAS-Cog) 13 score, and one-year change compared with regional and global hypometabolism. Conclusions: A dissociation between tau pathology and glucose metabolism at a global level in AD could imply that other pathological processes influence glucose metabolism. Furthermore, as tau is a better predictor of clinical progression, these processes may have independent trajectories and require independent consideration in the context of therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Impact of serum leptin and adiponectin levels on brain infarcts in patients with mild cognitive impairment and Alzheimer’s disease: a longitudinal analysis

Author

Carbone, Giovanni, primary, Bencivenga, Leonardo, additional, Santoro, Maria Angela, additional, De Lucia, Natascia, additional, Palaia, Maria Emiliana, additional, Ercolano, Erica, additional, Scognamiglio, Francesco, additional, Edison, Paul, additional, Ferrara, Nicola, additional, Vitale, Dino Franco, additional, Rengo, Giuseppe, additional, and Femminella, Grazia Daniela, additional

Published
2024
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14. Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

Author

Calsolaro, Valeria, Matthews, Paul M., Donat, Cornelius K., Livingston, Nicholas R., Femminella, Grazia D., Guedes, Sandra Silva, Myers, Jim, Fan, Zhen, Tyacke, Robin J., Venkataraman, Ashwin V., Perneczky, Robert, Gunn, Roger, Rabiner, Eugenii A., Gentleman, Steve, Parker, Christine A., Murphy, Philip S., Wren, Paul B., Hinz, Rainer, Sastre, Magdalena, Nutt, David J., and Edison, Paul

Published
2021
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15. Microglial activation and tau propagate jointly across Braak stages

Author

Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2021
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17. Sources of Administrative Law in public management

Author

Barba Tamayo, Edison Paul, Rodríguez Aunqui, Hernán Rómulo, Castro Solis, Paula Nicole, Barba Tamayo, Edison Paul, Rodríguez Aunqui, Hernán Rómulo, and Castro Solis, Paula Nicole

Abstract

Within Administrative Law as such, there are several legal figures that are of vital importance for public administration in general, but it is essential to recognize the sources of Administrative Law in order to exercise a public management aligned to a constitutional State of rights; these sources are extremely important for the administration. The present work, through a serious bibliographic review, characterizes these sources and allows us to conclude that these sources, due to their special characteristics, allow us to achieve not only a conceptual and epistemological basis for the exercise of power, but also provide the State with a broader, more orderly vision, where both the rights and guarantees of citizens and public servants are respected, thus allowing a transparent, efficient, equitable and solid public management, working together with the various public-private institutions, guided in this way in each of the laws, jurisprudence, regulations and especially in the Constitution., En el campo jurídico administrativo, existen varias figuras jurídicas que son de vital importancia para la administración pública en general, pero es fundamental reconocer las fuentes del Derecho Administrativo con el fin de ejercer una gestión pública alineada a un Estado constitucional de derechos; estas fuentes son sumamente importantes para la administración. El presente trabajo, a través de una revisión bibliográfica seria, caracteriza estas fuentes y permite colegir que estas fuentes debido a  sus características especiales permiten lograr no solamente una base conceptual y epistemológica del ejercicio del poder, sino también otorga al Estado una visión más amplia, ordenada, donde se respeten tanto los derechos como las garantías de los ciudadanos y de los servidores públicos, permitiendo de esta forma una gestión pública transparente, eficiente, equitativa y sólida, que trabaje en conjunto con las diversas instituciones públicas-privadas, guiándose de esta manera en cada una de las leyes, jurisprudencia, reglamentos y sobre todo en la Constitución.

Published
2024

19. Combined Neuroinflammation and Amyloid PET Markers in Predicting Disease Progression in Cognitively Impaired Subjects.

Author

Leng, Fangda, Hinz, Rainer, Gentleman, Steve, Dani, Melanie, Brooks, David J., and Edison, Paul

Subjects
POSITRON emission tomography, MILD cognitive impairment, ALZHEIMER'S disease, PROGNOSIS, DISEASE progression
Abstract

Background: Neuroinflammation in Alzheimer's disease is known as an important process in the disease, yet how microglial activation affects disease progression remains unclear. Objective: The current study aims to interrogate the predictive value of neuroinflammation biomarker (11C-PBR28 PET), together with A/T/N imaging markers on disease deterioration in a cognitively impaired patient cohort. Methods: The study included 6 AD and 27 MCI patients, who had MRI, 11C-PBR28, 18F-flutemetamol (amyloid marker), 18F-AV1451 (tau marker) PET scans, and were followed up with multiple neuropsychological assessments for at least one year (1.6 and 2.8 years on average for AD and MCI). The predictive values of imaging biomarkers on baseline and longitudinal cognition were interrogated using linear regression to identify the biomarkers that could explain disease progression. Results: Linear mixed models found the average intercepts (baseline) MMSE were 23.5 for AD and 28.2 for MCI patients, and the slope of MMSE (annual change) were –0.74 for AD and –0.52 for MCI patients. White matter microstructural integrity was predictive of baseline cognition, while PET markers of amyloid, tau and neuroinflammation were predictive of longitudinal cognitive decline. Both amyloid and neuroinflammation PET markers were predictors independent of each other. And a sub-group analysis showed the predictive effect of neuroinflammation on cognitive decline is independent of amyloid and tau. Conclusions: Our study highlights the prognostic value of disease specific markers (amyloid, tau and neuroinflammation) in clinically diagnosed AD and MCI patients and suggests that the effects of these molecular markers are mediated by structural damage to the brain. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Dysfunctional cerebral glucose transport in Alzheimer’s Disease

Author

Nowell, Joseph, primary, Femminella, Grazia Daniela, additional, Ritchie, Craig W, additional, Holmes, Clive, additional, Walker, Zuzana, additional, Ridha, Basil H, additional, Lawrence, Robert M, additional, McFarlane, Brady, additional, Archer, Hilary, additional, Coulthard, Elizabeth, additional, Underwood, Benjamin, additional, Koranteng, Paul, additional, Karim, Salman, additional, Prasanna, Aparna, additional, Junaid, Kehinde, additional, McGuinness, Bernadette, additional, Nilforooshan, Ramin, additional, Thacker, Simon, additional, Russell, Gregor, additional, Malik, Naghma, additional, Mate, Vandana, additional, Knight, Lucy, additional, Kshemendran, Sajeev, additional, Holscher, Christian, additional, Harrison, John E, additional, Hinz, Rainer, additional, Tadros, George, additional, Passmore, Anthony Peter, additional, Ballard, Clive G, additional, and Edison, Paul, additional

Published
2023
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26. MRI CHANGES FOLLOWING TREATMENT OF GLP‐1 ANALOGUE, LIRAGLUTIDE IN ALZHEIMER’S DISEASE

Author

Edison, Paul, primary, Femminella, Grazia Daniela, additional, Ritchie, Craig, additional, Nowell, Joseph, additional, Holmes, Clive, additional, Walker, Zuzana, additional, Ridha, Basil H, additional, Williams, Gareth, additional, Lawrence, Robert M, additional, McFarlane, Brady, additional, Archer, Hilary, additional, Coulthard, Elizabeth, additional, Underwood, Benjamin, additional, Koranteng, Paul, additional, Karim, Salman, additional, Perneczky, Robert, additional, Prasanna, Aparna, additional, Junaid, Kehinde, additional, McGuinness, Bernadette, additional, Nilforooshan, Ramin, additional, Donaldson, Andrew, additional, Thacker, Simon, additional, Russell, Gregor, additional, Mate, Vandana, additional, Knight, Lucy, additional, Kshemendran, Sajeev, additional, Holscher, Christian, additional, Mansouri, Anita, additional, Chester‐Jones, Mae, additional, Holmes, Jane, additional, Harrison, John E, additional, Tadros, George, additional, Passmore, Anthony Peter, additional, and Ballard, Clive G, additional

Published
2023
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27. AMYPAD: Correlation of Amyloid PET results with anxiety and depressive symptoms in SCD+, MCI and dementia patients

Author

Zeyen, Philip, primary, Sannemann, Lena, additional, Escher, Claus, additional, Maier, Franziska, additional, Rostamzadeh, Ayda, additional, Drzezga, Alexander, additional, Giehl, Kathrin, additional, Bischof, Gerard N, additional, Hönig, Merle C., additional, Altomare, Daniele, additional, Garibotto, Valentina, additional, Barkhof, Frederik, additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, Collij, Lyduine E., additional, Molinuevo, Jose Luis, additional, Grau‐Rivera, Oriol, additional, Gispert, Juan Domingo, additional, Delrieu, Julien, additional, Payoux, Pierre, additional, Nordberg, Agneta K, additional, Savitcheva, Irina, additional, Walker, Zuzana, additional, Edison, Paul, additional, Demonet, Jean‐François, additional, Stephens, Andrew W., additional, Gismondi, Rossella, additional, Farrar, Gill, additional, Frisoni, Giovanni B, additional, and Jessen, Frank, additional

Published
2023
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31. Magnetic Resonance Spectroscopy metabolites as biomarkers of Alzheimer’s Disease

Author

Nowell, Joseph, primary, Young, Megan, additional, Femminella, Grazia Daniela, additional, Ritchie, Craig W, additional, Holmes, Clive, additional, Walker, Zuzana, additional, Ridha, Basil H, additional, Lawrence, Robert M, additional, McFarlane, Brady, additional, Archer, Hilary, additional, Coulthard, Elizabeth, additional, Underwood, Benjamin, additional, Koranteng, Paul, additional, Karim, Salman, additional, Prasanna, Aparna, additional, Junaid, Kehinde, additional, McGuinness, Bernadette, additional, Nilforooshan, Ramin, additional, Thacker, Simon, additional, Russell, Gregor, additional, Malik, Naghma, additional, Mate, Vandana, additional, Knight, Lucy, additional, Kshemendran, Sajeev, additional, Holscher, Christian, additional, Harrison, John E, additional, Hinz, Rainer, additional, Tadros, George, additional, Passmore, Anthony Peter, additional, Ballard, Clive G, additional, and Edison, Paul, additional

Published
2023
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32. Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

Author

Femminella, Grazia Daniela, Livingston, Nicholas R., Raza, Sanara, van der Doef, Thalia, Frangou, Eleni, Love, Sharon, Busza, Gail, Calsolaro, Valeria, Carver, Stefan, Holmes, Clive, Ritchie, Craig W., Lawrence, Robert M., McFarlane, Brady, Tadros, George, Ridha, Basil H., Bannister, Carol, Walker, Zuzana, Archer, Hilary, Coulthard, Elizabeth, Underwood, Ben, Prasanna, Aparna, Koranteng, Paul, Karim, Salman, Junaid, Kehinde, McGuinness, Bernadette, Passmore, Anthony Peter, Nilforooshan, Ramin, Macharouthu, Ajayverma, Donaldson, Andrew, Thacker, Simon, Russell, Gregor, Malik, Naghma, Mate, Vandana, Knight, Lucy, Kshemendran, Sajeev, Tan, Tricia, Holscher, Christian, Harrison, John, Brooks, David J., Ballard, Clive, and Edison, Paul

Published
2021
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33. A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

Author

Bottlaender, Michel, Brooks, David, Carroll, Michael A., Chalon, Sylvie, Gee, Anthony, Gerhard, Alexander, Halldin, Christer, Herholz, Karl, Herth, Matthias M., Hinz, Rainer, Knudsen, Gitte M., Kuhnast, Bertrand, López-Picón, Francisco, Moresco, Rosa Maria, Pappata, Sabina, Rinne, Juha O., Rodriguez-Vieitez, Elena, Santiago-Ribeiro, Marie Joao, Turkheimer, Federico E., Van Laere, Koen, Varrone, Andrea, Vercouillie, Johnny, Winkeler, Alexandra, Perani, Daniela, Iaccarino, Leonardo, Lammertsma, Adriaan A., Windhorst, Albert D., Edison, Paul, Boellaard, Ronald, Hansson, Oskar, Nordberg, Agneta, and Jacobs, Andreas H.

Published
2019
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37. Publisher Correction: Microglial activation and tau propagate jointly across Braak stages

Author

Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2021
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39. Brief Overview of Vote Advisors (Proxy Advisors) in Peru

Author

Edison Paul Tabra Ochoa

Subjects
proxy advisors, activism, corporate governance, insti-tutional investor, responsibility., Law in general. Comparative and uniform law. Jurisprudence, K1-7720
Abstract

This article makes a short introduction about Peruvian legal situation in case Proxy Advisers starts operations. The research works Peruvian Securities Act, Pension Funds Law, and local corporate governance practices. The main idea is to propose Peruvian market needs a minimum rule to protect interests of institutional meanwhile is necessary the creation of group of corporate governance practices to make work of proxy advisers more transparent and responsible.

Published
2017
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40. Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)

Author

Femminella, Grazia Daniela, Frangou, Eleni, Love, Sharon B., Busza, Gail, Holmes, Clive, Ritchie, Craig, Lawrence, Robert, McFarlane, Brady, Tadros, George, Ridha, Basil H., Bannister, Carol, Walker, Zuzana, Archer, Hilary, Coulthard, Elizabeth, Underwood, Ben R., Prasanna, Aparna, Koranteng, Paul, Karim, Salman, Junaid, Kehinde, McGuinness, Bernadette, Nilforooshan, Ramin, Macharouthu, Ajay, Donaldson, Andrew, Thacker, Simon, Russell, Gregor, Malik, Naghma, Mate, Vandana, Knight, Lucy, Kshemendran, Sajeev, Harrison, John, Hölscher, Christian, Brooks, David J., Passmore, Anthony Peter, Ballard, Clive, and Edison, Paul

Published
2020
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41. Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

Author

Caprioglio, Camilla, Ribaldi, Federica, Visser, Leonie N. C., Minguillon, Carolina, Collij, Lyduine E., Grau-Rivera, Oriol, Zeyen, Philip, Molinuevo, José Luis, Gispert, Juan Domingo, Garibotto, Valentina, Moro, Christian, Walker, Zuzana, Edison, Paul, Demonet, Jean-François, Barkhof, Frederik, Scheltens, Philip, Alves, Isadora Lopes, Gismondi, Rossella, Farrar, Gill, Stephens, Andrew W., Jessen, Frank, Frisoni, Giovanni B., Altomare, Daniele, Abdelnour, Carla, Aguilera, Nuria, Aksman, Leon, Alarcón-Martín, Emilio, Alegret, Montse, Alonso-Lana, Silvia, Andersen, Pia, Arab, Majd, Aspö, Malin, Bader, Ilona, Bader, Ilse, Banton, Nigel, Barnes, Rodrigo, Barrie, Dawn, Battle, Mark, Belén Collado, Ana, Bellet, Julie, Berkhof, Johannes, Biger, Marine, Birck, Cindy, Bischof, Gerard, Boada, Mercè, Boellaard, Ronald, Bogdanovic, Nenad, Bollack, Ariane, Bombois, Stéphanie, Borg, Stefan, Borjesson-Hanson, Anne, Boskov, Vladimir, Boutantin, Justine, Boutoleau-Bretonniere, Claire, Bouwman, Femke, Breuilh, Laetitia, Bringman, Eva, Brunel, Baptiste, Bucci, Marco, Buckley, Chris, Buendía, Mar, Bullich, Santi, Calvet, Anna, Cañada, Laia, Cañada, Marta, Cardoso, Jorge, Carlier, Jasmine, Carre, Elise, Carrie, Isabelle, Cassagnaud, Pascaline, Cassol, Emmanuelle, Castilla-Martí, Miguel, Cazalon, Elodie, Chaarriau, Tiphaine, Chaigeau, Rachel, Chalmers, Taylor, Clerc, Marie-Thérèse, Clerigue, Montserrat, Cognat, Emmanuel, Coll, Nina, Collij, Lyduine E, Connely, Peter, Cordier, Elodie, Costes, Corine, Coulange, Camille, Courtemanche, Hélène, Creisson, Eric, Crinquette, Charlotte, Cuevas, Rosario, Cufi, Marie-Noëlle, Dardenne, Sophie, de Arriba, Maria, de Costa Luis, Casper, de Gier, Yvonne, de Verbizier Lonjon, Delphine, Dekker, Veronique, Dekyndt, Bérengère, Delbeuck, Xavier, Delrieu, Julien, Deramecourt, Vincent, Desclaux, Françoise, Diaz, Carlos, Diego, Susana, Djafar, Mehdi, Dölle, Britta, Doull, Laura, Dricot, Laurence, Drzezga, Alexander, Dubois, Bruno, Dumont, Julien, Dumur, Jean, Dumurgier, Julien, Dvorak, Martin, Ecay, Mirian, Escher, Claus, Estanga, Ainara, Esteban, Ester, Fanjaud, Guy, Fauria, Karine, Felez Sanchez, Marta, Feukam Talla, Patrick, Ford, Lisa, Frisoni, Giovanni B, Fuster, David, Gabelle, Audrey, Gaubert, Sinead, Gauci, Cédric, Geldhof, Christine, Georges, Jean, Ghika, Joseph, González, Elena, Goovaerts, Valerie, Goulart, Denis Mariano, Grasselli, Caroline, Gray, Katherine, Greensmith, Martin, Grozn, Laure, Guillemaud, Céline, Gunn, Fiona, Guntur Ramkumar, Prasad, Hagman, Göran, Hansseuw, Bernard, Heeman, Fiona, Hendriks, Janine, Himmelmann, Jakob, Hitzel, Anne, Hives, Florent, Hoenig, Merle, Hourrègue, Claire, Hudson, Justine, Huguet, Jordi, Ibarria, Marta, Iidow, Ifrah, Indart, Sandrine, Ingala, Silvia, Ivanoiu, Adrian, Jacquemont, Charlotte, Jelic, Vesna, Jiao, Jieqing, Jofresa, Sara, Jonsson, Cathrine, Kaliukhovich, Dzmitry, Kern, Silke, Kivipelto, Miia, Knezevic, Iva, Kuchcinski, Grégory, Laforce, Manon, Lafuente, Asunción, Lala, Françoise, Lammertsma, Adriaan, Lax, Michelle, Lebouvier, Thibaud, Lee, Ho-Yun, Lee, Lean, Leeuwis, Annebet, Lefort, Amandine, Legrand, Jean-François, Leroy, Mélanie, Lesoil Markowski, Constance, Levy, Marcel, Lhommel , Renaud, Lopes, Renaud, Lopes Alves, Isadora, Lorenzini, Luigi, Lorette, Adrien, Luckett, Emma, Lundin, Marie, Mackowiak, Marie-Anne, Malotaux, Vincent, Manber, Richard, Manyakov, Nikolay, Markiewicz, Pawel, Marne, Paula, Marquié, Marta, Martín, Elvira, Martínez, Joan, Martinez Lage, Pablo, Mastenbroek, Sophie E, Maureille, Aurélien, Meersmans, Karen, Mett, Anja, Milne, Joseph, Minguillón, Carolina, Modat, Marc, Montrreal, Laura, Müller, Theresa, Muniz, Graciela, Mutsarts, Henk Jan, Nilsson, Ted, Ninerola, Aida, Nordberg, Agneta, Novaes, Wilse, Nuno Carmelo Pires Silva, Joao, Operto, Greg, Orellana, Adela, Ousset, Pierre-Jean, Outteryck, Olivier, Pallardy, Amandine, Palombit, Alessandro, Pancho, Ana, Pappon, Martin, Paquet, Claire, Pariente, Jérémie, Pasquier, Florence, Payoux, Pierre, Peaker, Harry, Pelejà, Esther, Pennetier, Delphine, Pérez-Cordón, Alba, Perissinotti, Andrés, Perrenoud, Matthieu Paul, Petit, Sandrine, Petyt, Grégory, Pfeil, Julia, Pirotte, Blanche, Pla, Sandra, Plaza Wuthrich, Sonia, Poitrine, Lea, Pollet, Marianne, Poncelet, Jean-Benoit, Prior, John, Pruvo, Jean-Pierre, Putallaz, Pauline, Queneau, Mathieu, Quenon , Lisa, Rădoi, Andreea, Rafiq, Marie, Ramage, Fiona, Ramis, Maribel, Reinwald, Michael, Rios, Gonzalo, Ritchie, Craig, Rodriguez, Elena, Rollin, Adeline, Rouaud, Olivier, Sacuiu, Simona, Saint-Aubert, Laure, Sala, Arianna, Salabert, Anne-Sophie, Saldias, Jon, Salvadó, Gemma, Sanabria, Angela, Sannemann, Lena, Sastre, Nathalie, Savina, Daniela, Savitcheva, Irina, Schaeverbeke, Jolien, Schildermans, Carine, Schmidt, Mark, Schöll, Michael, Schuermans, Jeroen, Semah, Franck, Shekari, Mahnaz, Skoog, Ingmar, Sotolongo-Grau, Oscar, Stephens, Andrew, Stewart, Tiffany, Stutzmann, Jennyfer, Tait, Murray, Tárraga, Lluis, Tartari, Juan Pablo, Tysen-backstrom, Ann-christine, Valero, Sergi, Vallez Garcia, David, van Berckel, Bart N M, van Essen, Martijn, Van Laere, Koen, van Leur, Jeroen, van Maurik, Ingrid S, Vandenberghe, Rik, Vellas, Bruno, Virolinen, Jukka, Visser, Pieter Jelle, Walles, Håkan, Wallin, Emilia, Whitelaw, Grant, Wimberley, Catriona, Win , Zarni, Wink, Alle Meije, Wolz, Robin, Woodside, John, Yaqub, Maqsood, Zettergren, Anna, Medical Psychology, APH - Personalized Medicine, APH - Quality of Care, Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, CCA - Cancer Treatment and quality of life, CCA - Imaging and biomarkers, Neurology, Dekyndt, Bérengère, Delbeuck, Xavier, Delrieu, Julien, Demonet, Jean-François, Deramecourt, Vincent, Desclaux, Françoise, Diaz, Carlos, Diego, Susana, Djafar, Mehdi, Dölle, Britta, Doull, Laura, Dricot, Laurence, Drzezga, Alexander, Dubois, Bruno, Dumont, Julien, Dumur, Jean, Dumurgier, Julien, Dvorak, Martin, Ecay, Mirian, Edison, Paul, Escher, Claus, Estanga, Ainara, Esteban, Ester, Fanjaud, Guy, Farrar, Gill, Fauria, Karine, Felez Sanchez, Marta, Feukam Talla, Patrick, Ford, Lisa, Frisoni, Giovanni B, Fuster, David, Gabelle, Audrey, Garibotto, Valentina, Gaubert, Sinead, Gauci, Cédric, Geldhof, Christine, Georges, Jean, Ghika, Joseph, Gismondi, Rossella, Gispert, Juan Domingo, González, Elena, Goovaerts, Valerie, Goulart, Denis Mariano, Grasselli, Caroline, Grau-Rivera, Oriol, Gray, Katherine, Greensmith, Martin, Grozn, Laure, Guillemaud, Céline, Gunn, Fiona, Guntur Ramkumar, Prasad, Hagman, Göran, Hansseuw, Bernard, Heeman, Fiona, Hendriks, Janine, Himmelmann, Jakob, Hitzel, Anne, Hives, Florent, Hoenig, Merle, Hourrègue, Claire, Hudson, Justine, Huguet, Jordi, Ibarria, Marta, Iidow, Ifrah, Indart, Sandrine, Ingala, Silvia, Ivanoiu, Adrian, Jacquemont, Charlotte, Jelic, Vesna, Jessen, Frank, Jiao, Jieqing, Jofresa, Sara, Jonsson, Cathrine, Kaliukhovich, Dzmitry, Kern, Silke, Kivipelto, Miia, Knezevic, Iva, Kuchcinski, Grégory, Laforce, Manon, Lafuente, Asunción, Lala, Françoise, Lammertsma, Adriaan, Lax, Michelle, Lebouvier, Thibaud, Lee, Ho-Yun, Lee, Lean, Leeuwis, Annebet, Lefort, Amandine, Legrand, Jean-François, Leroy, Mélanie, Lesoil Markowski, Constance, Levy, Marcel, Lhommel, Renaud, Lopes, Renaud, Lopes Alves, Isadora, Lorenzini, Luigi, Lorette, Adrien, Luckett, Emma, Lundin, Marie, Mackowiak, Marie-Anne, Malotaux, Vincent, Manber, Richard, Manyakov, Nikolay, Markiewicz, Pawel, Marne, Paula, Marquié, Marta, Martín, Elvira, Martínez, Joan, Martinez Lage, Pablo, Mastenbroek, Sophie E, Maureille, Aurélien, Meersmans, Karen, Mett, Anja, Milne, Joseph, Minguillón, Carolina, Modat, Marc, Molinuevo, José Luis, Montrreal, Laura, Moro, Christian, Müller, Theresa, Muniz, Graciela, Mutsarts, Henk Jan, Nilsson, Ted, Ninerola, Aida, Nordberg, Agneta, Novaes, Wilse, Nuno Carmelo Pires Silva, Joao, Operto, Greg, Orellana, Adela, Ousset, Pierre-Jean, Outteryck, Olivier, Pallardy, Amandine, Palombit, Alessandro, Pancho, Ana, Pappon, Martin, Paquet, Claire, Pariente, Jérémie, Pasquier, Florence, Payoux, Pierre, Peaker, Harry, Abdelnour, Carla, Pelejà, Esther, Pennetier, Delphine, Pérez-Cordón, Alba, Perissinotti, Andrés, Perrenoud, Matthieu Paul, Petit, Sandrine, Petyt, Grégory, Pfeil, Julia, Pirotte, Blanche, Pla, Sandra, Aguilera, Nuria, Plaza Wuthrich, Sonia, Poitrine, Lea, Pollet, Marianne, Poncelet, Jean-Benoit, Prior, John, Pruvo, Jean-Pierre, Putallaz, Pauline, Queneau, Mathieu, Quenon, Lisa, Rădoi, Andreea, Aksman, Leon, Rafiq, Marie, Ramage, Fiona, Ramis, Maribel, Reinwald, Michael, Rios, Gonzalo, Ritchie, Craig, Rodriguez, Elena, Rollin, Adeline, Rouaud, Olivier, Sacuiu, Simona, Alarcón-Martín, Emilio, Saint-Aubert, Laure, Sala, Arianna, Salabert, Anne-Sophie, Saldias, Jon, Salvadó, Gemma, Sanabria, Angela, Sannemann, Lena, Sastre, Nathalie, Savina, Daniela, Savitcheva, Irina, Alegret, Montse, Schaeverbeke, Jolien, Scheltens, Philip, Schildermans, Carine, Schmidt, Mark, Schöll, Michael, Schuermans, Jeroen, Semah, Franck, Shekari, Mahnaz, Skoog, Ingmar, Sotolongo-Grau, Oscar, Alonso-Lana, Silvia, Stephens, Andrew, Stewart, Tiffany, Stutzmann, Jennyfer, Tait, Murray, Tárraga, Lluis, Tartari, Juan Pablo, Tysen-Backstrom, Ann-Christine, Valero, Sergi, Vallez Garcia, David, van Berckel, Bart N M, Altomare, Daniele, van Essen, Martijn, Van Laere, Koen, van Leur, Jeroen, van Maurik, Ingrid S, Vandenberghe, Rik, Vellas, Bruno, Virolinen, Jukka, Visser, Pieter Jelle, Walker, Zuzana, Walles, Håkan, Andersen, Pia, Wallin, Emilia, Whitelaw, Grant, Wimberley, Catriona, Win, Zarni, Wink, Alle Meije, Wolz, Robin, Woodside, John, Yaqub, Maqsood, Zettergren, Anna, Zeyen, Philip, Arab, Majd, Aspö, Malin, Bader, Ilona, Bader, Ilse, Banton, Nigel, Barkhof, Frederik, Barnes, Rodrigo, Barrie, Dawn, Battle, Mark, Belén Collado, Ana, Bellet, Julie, Berkhof, Johannes, Biger, Marine, Birck, Cindy, Bischof, Gerard, Boada, Mercè, Boellaard, Ronald, Bogdanovic, Nenad, Bollack, Ariane, Bombois, Stéphanie, Borg, Stefan, Borjesson-Hanson, Anne, Boskov, Vladimir, Boutantin, Justine, Boutoleau-Bretonniere, Claire, Bouwman, Femke, Breuilh, Laetitia, Bringman, Eva, Brunel, Baptiste, Bucci, Marco, Buckley, Chris, Buendía, Mar, Bullich, Santi, Calvet, Anna, Cañada, Laia, Cañada, Marta, Caprioglio, Camilla, Cardoso, Jorge, Carlier, Jasmine, Carre, Elise, Carrie, Isabelle, Cassagnaud, Pascaline, Cassol, Emmanuelle, Castilla-Martí, Miguel, Cazalon, Elodie, Chaarriau, Tiphaine, Chaigeau, Rachel, Chalmers, Taylor, Clerc, Marie-Thérèse, Clerigue, Montserrat, Cognat, Emmanuel, Coll, Nina, Collij, Lyduine E, Connely, Peter, Cordier, Elodie, Costes, Corine, Coulange, Camille, Courtemanche, Hélène, Creisson, Eric, Crinquette, Charlotte, Cuevas, Rosario, Cufi, Marie-Noëlle, Dardenne, Sophie, de Arriba, Maria, de Costa Luis, Casper, de Gier, Yvonne, de Verbizier Lonjon, Delphine, and Dekker, Veronique

Subjects
Male, Adult, metabolism [Brain], Positron-Emission Tomography, diagnosis [Alzheimer Disease], diagnostic imaging [Cognitive Dysfunction], Humans, metabolism [Amyloid beta-Peptides], ddc:610, Prospective Studies, Disclosure, General Medicine, Aged
Abstract

ImportanceIndividuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+ undergo amyloid-positron emission tomography (PET) as part of research studies and frequently wish to know their amyloid status; however, the disclosure of a positive amyloid-PET result might have psychological risks.ObjectiveTo assess the psychological outcomes of the amyloid-PET result disclosure in individuals with SCD+ and explore which variables are associated with a safer disclosure in individuals who are amyloid positive.Design, Setting, and ParticipantsThis prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). The setting was 5 European memory clinics, and participants included patients with SCD+ who underwent amyloid-PET. Statistical analysis was performed from July to October 2022.ExposuresDisclosure of amyloid-PET result.Main Outcomes and MeasuresPsychological outcomes were defined as (1) disclosure related distress, assessed using the Impact of Event Scale–Revised (IES-R; scores of at least 33 indicate probable presence of posttraumatic stress disorder [PTSD]); and (2) anxiety and depression, assessed using the Hospital Anxiety and Depression scale (HADS; scores of at least 15 indicate probable presence of severe mood disorder symptoms).ResultsAfter disclosure, 27 patients with amyloid-positive SCD+ (median [IQR] age, 70 [66-74] years; gender: 14 men [52%]; median [IQR] education: 15 [13 to 17] years, median [IQR] Mini-Mental State Examination [MMSE] score, 29 [28 to 30]) had higher median (IQR) IES-R total score (10 [2 to 14] vs 0 [0 to 2]; P P P P P = .06) and Depression (–1.0 [–2.0 to 0.0] vs –1.0 [–3.0 to 0.0]; P = .46) deltas (score after disclosure – scores at baseline). In patients with amyloid-positive SCD+, despite the small sample size, higher education was associated with lower disclosure-related distress (ρ = –0.43; P = .02) whereas the presence of study partner was associated with higher disclosure-related distress (W = 7.5; P = .03). No participants with amyloid-positive SCD+ showed probable presence of PTSD or severe anxiety or depression symptoms at follow-up.Conclusions and RelevanceThe disclosure of a positive amyloid-PET result to patients with SCD+ was associated with a bigger psychological change, yet such change did not reach the threshold for clinical concern.

Published
2023
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42. Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial

Author

Altomare, Daniele, Barkhof, Frederik, Moro, Christian, Delrieu, Julien, Payoux, Pierre, Saint-Aubert, Laure, Hitzel, Anne, Molinuevo, José Luis, Grau-Rivera, Oriol, Gispert, Juan Domingo, Drzezga, Alexander, Jessen, Frank, Caprioglio, Camilla, Zeyen, Philip, Nordberg, Agneta, Savitcheva, Irina, Jelic, Vesna, Walker, Zuzana, Edison, Paul, Demonet, Jean-François, Gismondi, Rossella, Farrar, Gill, Stephens, Andrew W, Collij, Lyduine E, Frisoni, Giovanni B, Disease, Amyloid Imaging to Prevent Alzheimer’s, Scheltens, Philip, Lopes Alves, Isadora, Bouwman, Femke, Berkhof, Johannes, van Maurik, Ingrid S, Garibotto, Valentina, Cuevas, Rosario, Cufi, Marie-Noëlle, Dardenne, Sophie, de Arriba, Maria, de Costa Luis, Casper, de Gier, Yvonne, de Verbizier Lonjon, Delphine, Dekker, Veronique, Dekyndt, Bérengère, Delbeuck, Xavier, Delrieu, Julien, Demonet, Jean-François, Deramecourt, Vincent, Desclaux, Françoise, Diaz, Carlos, Diego, Susana, Djafar, Mehdi, Dölle, Britta, Doull, Laura, Dricot, Laurence, Drzezga, Alexander, Dubois, Bruno, Dumont, Julien, Dumur, Jean, Dumurgier, Julien, Dvorak, Martin, Ecay, Mirian, Edison, Paul, Escher, Claus, Estanga, Ainara, Esteban, Ester, Fanjaud, Guy, Farrar, Gill, Fauria, Karine, Felez Sanchez, Marta, Feukam Talla, Patrick, Ford, Lisa, Frisoni, Giovanni B, Fuster, David, Gabelle, Audrey, Garibotto, Valentina, Gaubert, Sinead, Gauci, Cédric, Geldhof, Christine, Georges, Jean, Ghika, Joseph, Gismondi, Rossella, Gispert, Juan Domingo, González, Elena, Goovaerts, Valerie, Goulart, Denis Mariano, Grasselli, Caroline, Grau-Rivera, Oriol, Gray, Katherine, Greensmith, Martin, Grozn, Laure, Guillemaud, Céline, Gunn, Fiona, Guntur Ramkumar, Prasad, Hagman, Göran, Hansseuw, Bernard, Heeman, Fiona, Hendriks, Janine, Himmelmann, Jakob, Hitzel, Anne, Hives, Florent, Hoenig, Merle, Hourrègue, Claire, Hudson, Justine, Huguet, Jordi, Ibarria, Marta, Iidow, Ifrah, Indart, Sandrine, Ingala, Silvia, Ivanoiu, Adrian, Jacquemont, Charlotte, Jelic, Vesna, Jessen, Frank, Jiao, Jieqing, Jofresa, Sara, Jonsson, Cathrine, Kaliukhovich, Dzmitry, Kern, Silke, Kivipelto, Miia, Knezevic, Iva, Kuchcinski, Grégory, Laforce, Manon, Lafuente, Asunción, Lala, Françoise, Lammertsma, Adriaan, Lax, Michelle, Lebouvier, Thibaud, Lee, Ho-Yun, Lee, Lean, Leeuwis, Annebet, Lefort, Amandine, Legrand, Jean-François, Leroy, Mélanie, Lesoil Markowski, Constance, Levy, Marcel, Lhommel, Renaud, Lopes, Renaud, Lopes Alves, Isadora, Lorenzini, Luigi, Lorette, Adrien, Luckett, Emma, Lundin, Marie, Mackowiak, Marie-Anne, Malotaux, Vincent, Manber, Richard, Manyakov, Nikolay, Markiewicz, Pawel, Marne, Paula, Marquié, Marta, Martín, Elvira, Martínez, Joan, Martinez Lage, Pablo, Mastenbroek, Sophie E, Maureille, Aurélien, Meersmans, Karen, Mett, Anja, Milne, Joseph, Minguillón, Carolina, Modat, Marc, Molinuevo, José Luis, Montrreal, Laura, Moro, Christian, Müller, Theresa, Muniz, Graciela, Mutsarts, Henk Jan, Nilsson, Ted, Ninerola, Aida, Nordberg, Agneta, Novaes, Wilse, Nuno Carmelo Pires Silva, Joao, Operto, Greg, Orellana, Adela, Ousset, Pierre-Jean, Outteryck, Olivier, Pallardy, Amandine, Palombit, Alessandro, Pancho, Ana, Pappon, Martin, Paquet, Claire, Pariente, Jérémie, Pasquier, Florence, Payoux, Pierre, Peaker, Harry, Pelejà, Esther, Pennetier, Delphine, Pérez-Cordón, Alba, Perissinotti, Andrés, Perrenoud, Matthieu Paul, Petit, Sandrine, Petyt, Grégory, Pfeil, Julia, Pirotte, Blanche, Pla, Sandra, Plaza Wuthrich, Sonia, Poitrine, Lea, Pollet, Marianne, Poncelet, Jean-Benoit, Prior, John, Pruvo, Jean-Pierre, Putallaz, Pauline, Queneau, Mathieu, Quenon, Lisa, Rădoi, Andreea, Rafiq, Marie, Ramage, Fiona, Ramis, Maribel, Reinwald, Michael, Rios, Gonzalo, Ritchie, Craig, Rodriguez, Elena, Rollin, Adeline, Rouaud, Olivier, Sacuiu, Simona, Saint-Aubert, Laure, Sala, Arianna, Salabert, Anne-Sophie, Saldias, Jon, Salvadó, Gemma, Sanabria, Angela, Sannemann, Lena, Sastre, Nathalie, Savina, Daniela, Savitcheva, Irina, Schaeverbeke, Jolien, Scheltens, Philip, Schildermans, Carine, Schmidt, Mark, Schöll, Michael, Schuermans, Jeroen, Semah, Franck, Shekari, Mahnaz, Skoog, Ingmar, Sotolongo-Grau, Oscar, Stephens, Andrew, Stewart, Tiffany, Stutzmann, Jennyfer, Tait, Murray, Tárraga, Lluis, Tartari, Juan Pablo, Tysen-Backstrom, Ann-Christine, Valero, Sergi, Vallez Garcia, David, van Berckel, Bart N M, van Essen, Martijn, Van Laere, Koen, van Leur, Jeroen, van Maurik, Ingrid S, Vandenberghe, Rik, Vellas, Bruno, Virolinen, Jukka, Visser, Pieter Jelle, Walker, Zuzana, Walles, Håkan, Wallin, Emilia, Whitelaw, Grant, Abdelnour, Carla, Wimberley, Catriona, Win, Zarni, Wink, Alle Meije, Wolz, Robin, Woodside, John, Yaqub, Maqsood, Zettergren, Anna, Zeyen, Philip, Aguilera, Nuria, Aksman, Leon, Alarcón-Martín, Emilio, Alegret, Montse, Alonso-Lana, Silvia, Altomare, Daniele, Andersen, Pia, Arab, Majd, Aspö, Malin, Bader, Ilona, Bader, Ilse, Banton, Nigel, Barkhof, Frederik, Barnes, Rodrigo, Barrie, Dawn, Battle, Mark, Belén Collado, Ana, Bellet, Julie, Berkhof, Johannes, Biger, Marine, Birck, Cindy, Bischof, Gerard, Boada, Mercè, Boellaard, Ronald, Bogdanovic, Nenad, Bollack, Ariane, Bombois, Stéphanie, Borg, Stefan, Borjesson-Hanson, Anne, Boskov, Vladimir, Boutantin, Justine, Boutoleau-Bretonniere, Claire, Bouwman, Femke, Breuilh, Laetitia, Bringman, Eva, Brunel, Baptiste, Bucci, Marco, Buckley, Chris, Buendía, Mar, Bullich, Santi, Calvet, Anna, Cañada, Laia, Cañada, Marta, Caprioglio, Camilla, Cardoso, Jorge, Carlier, Jasmine, Carre, Elise, Carrie, Isabelle, Cassagnaud, Pascaline, Cassol, Emmanuelle, Castilla-Martí, Miguel, Cazalon, Elodie, Chaarriau, Tiphaine, Chaigeau, Rachel, Chalmers, Taylor, Clerc, Marie-Thérèse, Clerigue, Montserrat, Cognat, Emmanuel, Coll, Nina, Collij, Lyduine E, Connely, Peter, Cordier, Elodie, Costes, Corine, Coulange, Camille, Courtemanche, Hélène, Creisson, Eric, and Crinquette, Charlotte

Subjects
Male, Amyloid, psychology [Alzheimer Disease], Amyloid beta-Peptides, metabolism [Amyloid beta-Peptides], Amyloidogenic Proteins, metabolism [Brain], Positron-Emission Tomography, Humans, Female, Cognitive Dysfunction, ddc:610, Prospective Studies, 3-(3,5-dichlorophenyl)-1-methyl-2,5-pyrrolidinedione, Aged, metabolism [Amyloid]
Abstract

Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed studies demonstrating its clinical effect.To assess the clinical effect of amyloid PET in memory clinic patients.The AMYPAD-DPMS is a prospective randomized clinical trial in 8 European memory clinics. Participants were allocated (using a minimization method) to 3 study groups based on the performance of amyloid PET: arm 1, early in the diagnostic workup (within 1 month); arm 2, late in the diagnostic workup (after a mean [SD] 8 [2] months); or arm 3, if and when the managing physician chose. Participants were patients with subjective cognitive decline plus (SCD+; SCD plus clinical features increasing the likelihood of preclinical Alzheimer disease), mild cognitive impairment (MCI), or dementia; they were assessed at baseline and after 3 months. Recruitment took place between April 16, 2018, and October 30, 2020. Data analysis was performed from July 2022 to January 2023.Amyloid PET.The main outcome was the difference between arm 1 and arm 2 in the proportion of participants receiving an etiological diagnosis with a very high confidence (ie, ≥90% on a 50%-100% visual numeric scale) after 3 months.A total of 844 participants were screened, and 840 were enrolled (291 in arm 1, 271 in arm 2, 278 in arm 3). Baseline and 3-month visit data were available for 272 participants in arm 1 and 260 in arm 2 (median [IQR] age: 71 [65-77] and 71 [65-77] years; 150/272 male [55%] and 135/260 male [52%]; 122/272 female [45%] and 125/260 female [48%]; median [IQR] education: 12 [10-15] and 13 [10-16] years, respectively). After 3 months, 109 of 272 participants (40%) in arm 1 had a diagnosis with very high confidence vs 30 of 260 (11%) in arm 2 (P < .001). This was consistent across cognitive stages (SCD+: 25/84 [30%] vs 5/78 [6%]; P < .001; MCI: 45/108 [42%] vs 9/102 [9%]; P < .001; dementia: 39/80 [49%] vs 16/80 [20%]; P < .001).In this study, early amyloid PET allowed memory clinic patients to receive an etiological diagnosis with very high confidence after only 3 months compared with patients who had not undergone amyloid PET. These findings support the implementation of amyloid PET early in the diagnostic workup of memory clinic patients.EudraCT Number: 2017-002527-21.

Published
2023
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44. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Crook, Harry, primary, Ramirez, Alfredo, additional, Hosseini, Akram, additional, Vavougyios, Georgios, additional, Lehmann, Clara, additional, Bruchfeld, Judith, additional, Schneider, Anja, additional, D'Avossa, Giovanni, additional, Lo Re, Vincenzina, additional, Salmoiraghi, Alberto, additional, Mukaetova-Ladinska, Elizabeta, additional, Katshu, Mohammad, additional, Boneschi, Filippo M., additional, Håkansson, Krister, additional, Geerlings, Mirjam, additional, Pracht, Elisabeth, additional, Ruiz, Agustín, additional, Jansen, Jacobus F.A., additional, Snyder, Heather, additional, Kivipelto, Miia, additional, and Edison, Paul, additional

Published
2023
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46. Incidencia de la covid-19 en las dimensiones de impacto pedagógico educativas - organizacionales y tecnológicas. Una mirada en América Latina

Author

Santillán Lima, Juan Carlos; Universidad Nacional de La Plata. Facultad de Ciencias Informáticas. La Plata, Argentina, Villagómez Cabezas, Alexandra Valeria; Universidad Nacional de Chimborazo. Facultad de Ciencias de la Educación, Humanas y Tecnologías, Carrera de pedagogía de la Historia y las Ciencias Sociales. Riobamba, Ecuador, Bonifaz Aranda, Edison Fernando; Universidad Nacional de Chimborazo, Facultad de Ciencias Políticas y Administrativas, Riobamba, Ecuador, Barba Tamayo, Edison Paul; Universidad Nacional de Chimborazo. Facultad de Ciencias Políticas y Administrativas, Carrera de Derecho. Riobamba. Ecuador, Monge Patiño, Sintia Elizabeth; Dirección distrital Cumandá – Pallatanga. Unidad Educativa Carlos María la Condamine. Pallatanga., Cadena Oleas, Byron Napoleón; Escuela Superior Politécnica de Chimborazo Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría y carrera de y Administración de Empresas. Riobamba. Ecuador, Vallejo-Chávez, Luz-Maribel; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera de Mercadotecnia. Riobamba. Ecuador., Benítez-Santillán, Lourdes del Rocío; Escuela Superior Politécnica de Chimborazo. Facultad Salud Pública. Carrera Nutrición y Dietética. Riobamba., Colcha Ortiz, Alfredo Rodrigo; Universidad Nacional de Chimborazo. Riobamba. Ecuador, Samaniego Erazo, Florípes del Rocío; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría. Riobamba. Ecuador., Samaniego Erazo, Carmen Amelia; Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador, Parra Álvarez, Paulina Fernanda; Universidad Nacional de Chimborazo, Riobamba, Ecuador, Garrido Bayas, Irma Yolanda; Escuela Superior Politécnica de Chimborazo Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría. Riobamba. Ecuador, Colcha Ortiz, Raquel Virginia; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera Administración de Empresas. Panamericana sur KM 1 ½ Ec060155, Riobamba. Ecuador, Mera Herrera, Viviana del Roció; Universidad Nacional de Chimborazo. Facultad de Ciencias de la Salud – Carrera de Enfermería. Riobamba. Ecuador, Santillán Lima, Juan Carlos; Universidad Nacional de La Plata. Facultad de Ciencias Informáticas. La Plata, Argentina, Villagómez Cabezas, Alexandra Valeria; Universidad Nacional de Chimborazo. Facultad de Ciencias de la Educación, Humanas y Tecnologías, Carrera de pedagogía de la Historia y las Ciencias Sociales. Riobamba, Ecuador, Bonifaz Aranda, Edison Fernando; Universidad Nacional de Chimborazo, Facultad de Ciencias Políticas y Administrativas, Riobamba, Ecuador, Barba Tamayo, Edison Paul; Universidad Nacional de Chimborazo. Facultad de Ciencias Políticas y Administrativas, Carrera de Derecho. Riobamba. Ecuador, Monge Patiño, Sintia Elizabeth; Dirección distrital Cumandá – Pallatanga. Unidad Educativa Carlos María la Condamine. Pallatanga., Cadena Oleas, Byron Napoleón; Escuela Superior Politécnica de Chimborazo Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría y carrera de y Administración de Empresas. Riobamba. Ecuador, Vallejo-Chávez, Luz-Maribel; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera de Mercadotecnia. Riobamba. Ecuador., Benítez-Santillán, Lourdes del Rocío; Escuela Superior Politécnica de Chimborazo. Facultad Salud Pública. Carrera Nutrición y Dietética. Riobamba., Colcha Ortiz, Alfredo Rodrigo; Universidad Nacional de Chimborazo. Riobamba. Ecuador, Samaniego Erazo, Florípes del Rocío; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría. Riobamba. Ecuador., Samaniego Erazo, Carmen Amelia; Escuela Superior Politécnica de Chimborazo, Riobamba, Ecuador, Parra Álvarez, Paulina Fernanda; Universidad Nacional de Chimborazo, Riobamba, Ecuador, Garrido Bayas, Irma Yolanda; Escuela Superior Politécnica de Chimborazo Facultad de Administración de Empresas, Carrera de Contabilidad y Auditoría. Riobamba. Ecuador, Colcha Ortiz, Raquel Virginia; Escuela Superior Politécnica de Chimborazo, Facultad de Administración de Empresas, Carrera Administración de Empresas. Panamericana sur KM 1 ½ Ec060155, Riobamba. Ecuador, and Mera Herrera, Viviana del Roció; Universidad Nacional de Chimborazo. Facultad de Ciencias de la Salud – Carrera de Enfermería. Riobamba. Ecuador

Abstract

, El objetivo de la presente obra fue medir la incidencia causada por la pandemia por la presencia de la COVID-19 en las dimensiones pedagógico educativo, organizacional, tecnológico, financiero, entre otras, en las universidades de América Latina. Desde el punto de vista metodológico la construcción de los capítulos fue realizado desde el enfoque tanto cualitativo como cuantitativo, en las líneas de investigación descriptiva, relacional y explicativa, son de tipo retrospectivos y se utilizaron métodos tanto teóricos como empíricos. Los siete capítulos del libro fueron desarrollados bajo una revisión exhaustiva de la base científica como evidencia de estudios previos al impacto que causó la Covid – 19 en las dimensiones anteriormente indicadas. De los resultados encontrados, se puede dejar indicado que, la Pandemia tuvo una incidencia significativa en las instituciones universitarias de América Latina, éstas fueron una preocupación en el ámbito mundial, se ha pasado de un modelo de aprendizaje presencial a uno en línea, lo que ha llevado a una mayor implementación de herramientas y recursos digitales. Las organizaciones han tenido que adaptar sus estructuras organizacionales y estrategias de comunicación para adaptarse a los acuerdos de trabajo remoto. Tecnológicamente, hubo un aumento en la adopción y el desarrollo de herramientas y plataformas digitales para la enseñanza, el aprendizaje y la colaboración. La adopción del modelo online, obligo a los estudiantes a adquirir en un 56,66 % computadoras portátiles, el 21,67 % celulares inteligentes, el 20,42 % computadoras de escritorio, el 1,25% tablets; el 83,33% lo hizo en efectivo, el 15% solicitaron prestadas y el 1,67% alquilaron; el precio promedio fue de 500 dólares, de ahí que las finanzas personales tomaron nuevas prioridades frente al nuevo modelo educativo impuesto. La pandemia ha acelerado el cambio hacia el aprendizaje en línea y mixto, destacando la importancia de dotar a educadores y estudiantes de las ha

Published
2023

47. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Cardiovasculaire Epi Team 5, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Håkansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustín, Jansen, Jacobus F.A., Snyder, Heather, Kivipelto, Miia, Edison, Paul, Cardiovasculaire Epi Team 5, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Håkansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustín, Jansen, Jacobus F.A., Snyder, Heather, Kivipelto, Miia, and Edison, Paul

Published
2023

48. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'Avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Hakansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustin, Jansen, Jacobus F. A., Snyder, Heather, Kivipelto, Miia, Edison, Paul, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'Avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Hakansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustin, Jansen, Jacobus F. A., Snyder, Heather, Kivipelto, Miia, and Edison, Paul

Abstract

Background: The emergence of COVID-19 was rapidly followed by infection and the deaths of millions of people across the globe. With much of the research and scientific advancement rightly focused on reducing the burden of severe and critical acute COVID-19 infection, the long-term effects endured by those who survived the acute infection has been previously overlooked. Now, an appreciation for the post-COVID-19 condition, including its neurological manifestations, is growing, although there remain many unknowns regarding the etiology and risk factors of the condition, as well as how to effectively diagnose and treat it.Methods: Here, drawing upon the experiences and expertise of the clinicians and academics of the European working group on COVID-19, we have reviewed the current literature to provide a comprehensive overview of the neurological sequalae of the post-COVID-19 condition.Results: In this review, we provide a summary of the neurological symptoms associated with the post-COVID-19 condition, before discussing the possible mechanisms which may underly and manifest these symptoms. Following this, we explore the risk factors for developing neurological symptoms as a result of COVID-19 and the post-COVID-19 condition, as well as how COVID-19 infection may itself be a risk factor for the development of neurological disease in the future. Lastly, we evaluate how the post-COVID condition could be accurately diagnosed and effectively treated, including examples of the current guidelines, clinical outcomes, and tools that have been developed to aid in this process, as well as addressing the protection provided by COVID-19 vaccines against the post-COVID-19 condition.Conclusions: Overall, this review provides a comprehensive overview of the neurological sequalae of the post-COVID-19 condition. Impact statementWith our understanding of the neurological complications of the post-COVID-19 condition currently lacking sufficient depth, this review aimed at highlighting th

Published
2023

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