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Introdução: O efeito da circuncisão sobre a função sexual masculina é controverso, podendo ter efeitos positivos ou negativos em vários domínios da sexualidade (função erétil, ejaculação, orgasmo, desejo). O objetivo foi avaliar o efeito da circuncisão na função sexual. Métodos: Amostra composta por todos os doentes circuncisados pelo mesmo cirurgião (investigador principal) nos últimos 26 meses, com idade inferior a 60 anos e com atividade sexual nos 30 dias prévios às entrevistas. Para avaliação da função sexual pré e pós-circuncisão foram usados os questionários International Index of Erectile Function-5 (IIEF-5) e o Brief Male Sexual Function Inventory (BMSFI), sendo que os dados pré-circuncisão foram obtidos de forma retrospetiva. Foram ainda questionados o motivo da circuncisão, o tempo de latência intravaginal e o grau de satisfação dos doentes com o procedimento. Resultados: Amostra composta por 25 doentes, idade média de 36,3±10,3 anos (lim: 22-55), sendo a avaliação realizada em média 11,4±5,4 meses após a cirurgia (lim: 5-26). Dos indivíduos avaliados, 52.0% referiram melhoria da vida sexual, 44,0% não notaram diferença e 4,0% referiram agravamento. Repetiriam a cirurgia 92,0% dos indivíduos.Não existiram diferenças estatisticamente significativas entre os resultados pré-circuncisão e pós-circuncisão em relação ao IELT (p=0,608), satisfação sexual “subjetiva” (p=0,130), score total do BMFSI (p=0.054) e score do IIEF-5 (p=0,351).Há uma correlação entre os scores BMFSI pré-circuncisão e pós-circuncisão e os scores IIEF-5 pré e pós-circuncisão, respetivamente (p

Background Rating of Perceived Exertion (RPE) is a subjective scale to monitor overload and fatigue during exercise. Hypoxia may worsen the perception of fatigue, compromising the self-reported perception of effort and increasing RPE. The objective was to evaluate the effects of carbohydrate (CHO) supplementation on RPE during exercise in hypoxia simulating 4200 m. Methods Eight male physically active volunteers performed two exercises at 50% VO2peak and 1% slope: exercise in hypoxia + placebo or exercise in hypoxia + CHO (6% maltodextrin) with supplementation at 20, 40, and 60 min during exercise. Oxygen Saturation (SaO2%) was assessed at baseline and after exercise, while RPE and HR were measured each 10 min during the trial. Results SaO2% decreased after exercise in both conditions of hypoxia compared to rest. The RPE did not differ between groups. However, the RPE increased in hypoxia after 20 min of exercise in relation to 10 min. The Area Under the Curve (AUC) of RPE was lower in hypoxia + CHO compared to hypoxia. The AUC of the HR/RPE ratio in the hypoxia + CHO group was higher in relation to hypoxia. Conclusions Our results indicate that CHO supplementation does not change RPE induced by 60 min of exercise at 50% VO2peak in hypoxia equivalent to 4200 m at the different times analyzed. However, in hypoxia + CHO the (AUC)-60 min of total RPE decreased during exercise, while the heart rate/RPE ratio improved, indicating lower RPE in the hypoxic environment.

(1) Purpose: Performing strenuous exercises negatively impacts the immune and gastrointestinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Therefore, the objective of the current study was to verify the effects of probiotic supplementation on cytokine production by monocytes and infections in the upper respiratory tract after an acute strenuous exercise. (2) Methods: Fourteen healthy male marathon runners received either 5 billion colony forming units (CFU) of a multi-strain probiotic, consisting of 1 billion CFU of each of Lactobacillus acidophilus LB-G80, Lactobacillus paracasei LPc-G110, Lactococcus subp. lactis LLL-G25, Bifidobacterium animalis subp. lactis BL-G101, and Bifidobacterium bifidum BB-G90, or a placebo for 30 days before a marathon. Plasma cytokines, salivary parameters, glucose, and glutamine were measured at baseline, 24 h before, immediately after, and 1 h after the race. Subjects self-reported upper respiratory tract infection (URTI) using the Wisconsin Upper Respiratory Symptom Survey (WURSS—21). The statistical analyses comprised the general linear model (GLM) test followed by the Tukey post hoc and Student’s t-test with p &lt, 0.05. (3) Results: URTI symptoms were significantly lower in the probiotic group compared to placebo. The IL-2 and IL-4 plasma cytokines were lower 24 h before exercise, while the other cytokines showed no significant differences. A lower level of IL-6 produced by monocytes was verified immediately after the race and higher IL-10 at 1 h post. No differences were observed in salivary parameters. Conclusion: Despite the low number of marathoners participating in the study, probiotic supplementation suggests its capability to preserve the functionality of monocytes and mitigate the incidence of URTI.

Made available in DSpace on 2021-06-25T11:02:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Probiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marathon race. Twenty-seven male marathonists were double-blinded randomly into probiotic (Bifidobacterium-animalis-subsp.-Lactis (10 × 109) and Lactobacillus-Acidophilus (10 × 109) + 5 g of maltodextrin) and placebo (5 g of maltodextrin) group. They received 30 sachets and supplemented 1 portion/day during 30 days before the race. Blood were collected 30 days before (rest), 1 day before (pre), 1 h after (post) and 5 days after the race (recovery). Both chronic and acute exercise modulated a different T lymphocyte population (CD3+CD4−CD8− T-cells), increasing pre-race, decreasing post and returning to rest values at the recovery. The total number of CD8 T cell and the memory subsets statistically decreased only in the placebo group post-race. Pro-inflammatory cytokine production by stimulated lymphocytes decreased in the probiotic group after the supplementation period. 30 days of probiotic supplementation maintained CD8 T cell and effector memory cell population and played an immunomodulatory role in stimulated lymphocytes. Both, training and marathon modulated a non-classical lymphocyte population regardless of probiotic supplementation. Immunometabolism Research Group Institute of Biomedical Sciences University of São Paulo (USP) Programa de pós-graduação em psicobiologia Universidade Federal de São Paulo Laboratory of Applied Nutrition and Metabolism School of Physical Education and Sports University of São Paulo Department of Immunology Institute of Biomedical Sciences University of São Paulo Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences University of São Paulo Exercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences Department of Exercise Physiology and Sports Therapy Justus-Liebig-University Giessen Department of Bioscience Universidade Federal de São Paulo Department of Cell and Developmental Biology University of São Paulo, 1524, Prof Lineu Prestes Av. Exercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences FAPESP: 2016/10561-8

The present study aimed to verify the effects of caffeine supplementation on psychobiological parameters and its relationship with inflammatory cytokines in non-athlete subjects. We hypothesized that IL-10 may be responsible for the reduction in fatigue perception in response to caffeine supplementation. It was a randomized, double-blinded, cross-over, placebo-controlled study. Ten non-athlete subjects (26.9 ± 4.01 years old; 73.44 ± 9.57 kg; 15.94 ± 4.32 body fat kg) were evaluated. Sixty-min after caffeine (6 mg−1.kg−1 body mass) or placebo supplementation, high-intensity interval exercise test (1 min at 90% of Wmax and 2 min at 50% of Wmax) was performed to maximum voluntary exhaustion. Cytokine concentrations and psychobiological parameters were evaluated before (BE), immediately after (post-PE) and 1 h after exercise (1 h post-PE). We verify that IL-6 (0.35; 95% CI: 0.13 to 0.56; z = 3.24; p = 0.001; d = 1.14) and IL-10 (9.06; 95% CI 0.41 to 17.70; z = 2.05; p = 0.04; d = 1.12) increases post-PE in CAF group versus PLA group. Still, IL-10 levels were higher in CAF group 1 h post-PE (25.04; 95% CI: 8.95 to 41.31; z = 3.05; p = 0.002; d = 1.9) than PLA group. Moreover, 1 h post-PE vigor level was higher in the CAF group versus PLA group (4.53; 95% CI: 1.27 to 7.80; z = 2.72; p = 0.006; d = 0.46), and fatigue was lower in CAF group than PLA group (-5.08; 95% CI: −9.93 to −0.227; z = -2.05; p = 0.040; d = 0.67). We conclude that 1 h post-PE caffeine was able to decrease fatigue and increase vigor perception. IL-10 levels were higher 1 h post-PE in CAF group, suggesting, according to our hypothesis, that IL-10 may be associated with decrease fatigue perceptions after exercise.

Objectives The aim of this study was to evaluate the combined effects of carbohydrate (CHO) and glutamine (Gln) supplementation on cytokine production by monocytes after exercise until exhaustion performed in hypoxia. Methods Fifteen physically active men underwent three exercises until exhaustion with an intensity of 70% maximal oxygen intake at a simulated height of 4500 m under the following supplementation: placebo, CHO (maltodextrin 8%/200 mL for 20 min), and CHO + Gln (Gln 20 g/d for 6 d and maltodextrin 8%/200 mL for 20 min) during exercise and for 2 h of recovery. Analysis of variance for repeated measures followed by the Tukey's post hoc test was realized and P Results Oxygen saturation of arterial blood (SaO2%) decreased in the three trials compared with baseline. Two hours post-exercise, the SaO2% was high in CHO + Gln condition compared with placebo. Two hours after exercise, interleukin (IL)-1β decreased compared with post-exercise in placebo and was lower compared with baseline in the CHO + Gln condition. Tumor necrosis factor-α decreased 2 h after exercise compared with baseline and pre-exercise in the CHO + Gln condition. No changes were observed in myeloperoxidase or IL-6 production. Two hours after exercise, Gln decreased compared with baseline and post-exercise in placebo and decreased 2 h after exercise in relation to post-exercise in the CHO condition. Gln increased post-exercise compared with pre-exercise in the CHO + Gln condition. Although erythropoietin did not change in this condition, it was high post-exercise and 2 h after exercise in the placebo condition compared with baseline and 2 h after exercise compared with baseline and pre-exercise in the CHO condition. Conclusions Gln supplementation for 6 d before exercise, associated with CHO supplementation during exercise, was able to revert Gln reduction after exercise and after 2 h of recovery and may have contributed to reducing tumor necrosis factor-α production, suggesting a possible anti-inflammatory effect of supplementation.

Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a rare renal cancer type, recently recognized by the World Health Organization (WHO) in 2004, with indolent behavior. We present a case of a 50-year-old female that revealed a renal mass on an abdominal echography, incidentally discovered during a hepatic hemangioma follow-up. The patient underwent partial nephrectomy, and after pathological evaluation the final diagnosis of MTSCC was made. MSTCC is a special renal cancer type, with low degree of malignancy and a favorable prognosis. Surgical resection is the treatment of choice. It’s important to be aware of this entity in order to differentiate MTSCC with renal cancers of less favorable prognosis and higher degree of malignancy like papillary renal cell carcinoma., Diagnostic Pathology, 2015