45 results on '"Ederra, María"'
Search Results
2. Occupational exposures and mammographic density in Spanish women
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Lope, Virginia, García-Pérez, Javier, Pérez-Gómez, Beatriz, Pedraza-Flechas, Ana María, Alguacil, Juan, González-Galarzo, Mª Carmen, Alba, Miguel Angel, van der Haar, Rudolf, Cortés-Barragán, Rosa Ana, Pedraz-Pingarrón, Carmen, Moreo, Pilar, Santamariña, Carmen, Ederra, María, Vidal, Carmen, Salas-Trejo, Dolores, Sánchez-Contador, Carmen, Llobet, Rafael, and Pollán, Marina
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- 2018
3. Shift work and colorectal cancer risk in the MCC-Spain case–control study
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Papantoniou, Kyriaki, Castaño-Vinyals, Gemma, Espinosa, Ana, Turner, Michelle C, Alonso-Aguado, Maria Henar, Martin, Vicente, Aragonés, Nuria, Pérez-Gómez, Beatriz, Pozo, Benito Mirón, Gómez-Acebo, Inés, Ardanaz, Eva, Altzibar, Jone M, Peiro, Rosana, Tardon, Adonina, Lorca, José Andrés, Chirlaque, Maria Dolores, García-Palomo, Andrés, Jimenez-Moleon, Jose Juan, Dierssen, Trinidad, Ederra, Maria, Amiano, Pilar, Pollan, Marina, Moreno, Victor, and Kogevinas, Manolis
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- 2017
4. Author Correction: Validating a breast cancer score in Spanish women. The MCC-Spain study
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Dierssen-Sotos, Trinidad, Gómez-Acebo, Inés, Palazuelos, Camilo, Fernández-Navarro, Pablo, Altzibar, Jone M., González-Donquiles, Carmen, Ardanaz, Eva, Bustamante, Mariona, Alonso-Molero, Jessica, Vidal, Carmen, Bayo-Calero, Juan, Tardón, Adonina, Salas, Dolores, Marcos-Gragera, Rafael, Moreno, Víctor, Rodriguez-Cundin, Paz, Castaño-Vinyals, Gemma, Ederra, María, Vilorio-Marqués, Laura, Amiano, Pilar, Pérez-Gómez, Beatriz, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, and Llorca, Javier
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- 2020
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5. Perinatal and childhood factors and risk of breast cancer subtypes in adulthood
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Lope, Virginia, García-Esquinas, Esther, Pérez-Gómez, Beatriz, Altzibar, Jone M., Gracia-Lavedan, Esther, Ederra, María, Molina de la Torre, Antonio José, LLorca, Francisco Javier, Tardón, Adonina, Moreno, Víctor, Bayo, Juan, Salas-Trejo, Dolores, Marcos-Gragera, Rafael, Pumarega, José, Dierssen-Sotos, Trinidad, Lera, Juan Pablo Barrio, de Miguel Medina, M.A. Concepción, Tusquets, Ignasi, Amiano, Pilar, Boldo, Elena, Kogevinas, Manolis, Aragonés, Nuria, Castaño-Vinyals, Gemma, and Pollán, Marina
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- 2016
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6. Association of occupational heat exposure and colorectal cancer in the MCC-Spain study
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Hinchliffe, Alice, primary, Kogevinas, Manolis, additional, Molina, Antonio J, additional, Moreno, Victor, additional, Aragonés, Nuria, additional, Castaño-Vinyals, Gemma, additional, Jiménez Moleón, José Juan, additional, Gómez Acebo, Inés, additional, Ederra, María, additional, Amiano, Pilar, additional, Molina-Barceló, Ana, additional, Fernandez-Tardon, Guillermo, additional, Alguacil, Juan, additional, Chirlaque, María-Dolores, additional, Hernández-Segura, Natalia, additional, Pérez-Gómez, Beatriz, additional, Pollan, Marina, additional, and Turner, Michelle C, additional
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- 2023
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7. Validating a breast cancer score in Spanish women. The MCC-Spain study
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Dierssen-Sotos, Trinidad, Gómez-Acebo, Inés, Palazuelos, Camilo, Fernández-Navarro, Pablo, Altzibar, Jone M, González-Donquiles, Carmen, Ardanaz, Eva, Bustamante, Mariona, Alonso-Molero, Jessica, Vidal, Carmen, Bayo-Calero, Juan, Tardón, Adonina, Salas, Dolores, Marcos-Gragera, Rafael, Moreno, Víctor, Rodriguez-Cundin, Paz, Castaño-Vinyals, Gemma, Ederra, María, Vilorio-Marqués, Laura, Amiano, Pilar, Pérez-Gómez, Beatriz, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, and Llorca, Javier
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- 2018
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8. Occupation and mammographic density: A population-based study (DDM-Occup)
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García-Pérez, Javier, Pollán, Marina, Pérez-Gómez, Beatriz, González-Sánchez, Mario, Cortés Barragán, Rosa Ana, Blasco, Jerónimo Maqueda, González-Galarzo, María Carmen, Alba, Miguel Ángel, van der Haar, Rudolf, Casas, Silvia, Vicente, Cándida, Medina, Pilar, Ederra, María, Santamariña, Carmen, Moreno, María Pilar, Casanova, Francisco, Pedraz-Pingarrón, Carmen, Moreo, Pilar, Ascunce, Nieves, García, Montse, Salas-Trejo, Dolores, Sánchez-Contador, Carmen, Llobet, Rafael, and Lope, Virginia
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- 2017
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9. Independent Role of Severe Obesity as a Risk Factor for COVID‐19 Hospitalization: A Spanish Population‐Based Cohort Study
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Fresán, Ujué, Guevara, Marcela, Elía, Fernando, Albéniz, Esther, Burgui, Cristina, Castilla, Jesús, Martín, Carmen, Navascués, Ana, Portillo, María Eugenia, Polo, Isabel, Ezpeleta, Carmen, Gorricho, Javier, Ardanaz, Eva, Ascunce, Nieves, Arriazu, Maite, Barricarte, Aurelio, Barriuso, Laura, Casado, Itziar, Díaz, Jorge, Ederra, María, Egüés, Nerea, Garde, Carmen, Gómez‐Ibáñez, Carlos, García Cenoz, Manuel, García, Vega, Iriarte, Nerea, Martínez‐Baz, Iván, Moreno‐Iribas, Conchi, Sayón, Carmen, and Vidán, Juana
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Population ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Body Mass Index ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Poisson regression ,Risk factor ,Prospective cohort study ,education ,Pandemics ,Aged ,education.field_of_study ,Nutrition and Dietetics ,SARS-CoV-2 ,business.industry ,Incidence ,Incidence (epidemiology) ,COVID-19 ,Middle Aged ,Obesity, Morbid ,3. Good health ,Hospitalization ,Intensive Care Units ,Spain ,Relative risk ,Cohort ,symbols ,Female ,business ,Cohort study - Abstract
Objectives This study analyzed the association between severe obesity and coronavirus disease 2019 (COVID-19) hospitalization and severe disease. Methods The incidence of hospitalization for laboratory-confirmed COVID-19 was evaluated in a prospective population-based cohort of 433,995 persons aged 25 to 79 years in Spain during March and April of 2020. Persons with and without class 3 obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) from class 3 obesity of COVID-19 hospitalization and of severe disease (intensive care unit admission or death). Differences in the effect by age, sex, and chronic conditions were evaluated. Results Individuals with class 3 obesity had a higher risk of hospitalization (aRR = 2.20, 95% CI: 1.66-2.93) and developing severe COVID-19 (aRR = 2.30, 95% CI: 1.20-4.40). In people younger than 50 years, these effects were more pronounced (aRR = 5.02, 95% CI: 3.19-7.90 and aRR = 13.80, 95% CI: 3.11-61.17, respectively), whereas no significant effects were observed in those aged 65 to 79 years (aRR = 1.22, 95% CI: 0.70-2.12 and aRR = 1.42, 95% CI: 0.52-3.88, respectively). Sex and chronic conditions did not modify the effect of class 3 obesity in any of the outcomes. Conclusions Severe obesity is a relevant risk factor for COVID-19 hospitalization and severity in young adults, having a magnitude similar to that of aging. Tackling the current obesity pandemic could alleviate the impact of chronic and infectious diseases.
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- 2020
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10. Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study)
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Hernández-García, Marta, primary, Molina-Barceló, Ana, additional, Vanaclocha-Espi, Mercedes, additional, Zurriaga, Óscar, additional, Pérez-Gómez, Beatriz, additional, Aragonés, Nuria, additional, Amiano, Pilar, additional, Altzibar, Jone M., additional, Castaño-Vinyals, Gemma, additional, Sala, María, additional, Ederra, María, additional, Martín, Vicente, additional, Gómez-Acebo, Inés, additional, Vidal, Carmen, additional, Tardón, Adonina, additional, Marcos-Gragera, Rafael, additional, Pollán, Marina, additional, Kogevinas, Manolis, additional, and Salas, Dolores, additional
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- 2021
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11. Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21
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Fernandez-Navarro, Pablo, González-Neira, Anna, Pita, Guillermo, Díaz-Uriarte, Ramón, Moreno, Leticia Tais, Ederra, María, Pedraz-Pingarrón, Carmen, Sánchez-Contador, Carmen, Vázquez-Carrete, Jose Antonio, Moreo, Pilar, Vidal, Carmen, Salas-Trejo, Dolores, Stone, Jennifer, Southey, Melissa C., Hopper, John L., Pérez-Gómez, Beatriz, Benitez, Javier, and Pollan, Marina
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- 2015
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12. Recalibration of the Gail model for predicting invasive breast cancer risk in Spanish women: a population-based cohort study
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Pastor-Barriuso, Roberto, Ascunce, Nieves, Ederra, María, Erdozáin, Nieves, Murillo, Alberto, Alés-Martínez, José E., and Pollán, Marina
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- 2013
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13. Impact of intermediate mammography assessment on the likelihood of false-positive results in breast cancer screening programmes
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Ascunce, Nieves, Ederra, María, Delfrade, Josu, Baroja, Araceli, Erdozain, Nieves, Zubizarreta, Raquel, Salas, Dolores, Castells, Xavier, and the Cumulative False Positive Risk (CFPR) Group
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- 2012
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14. Childhood factors associated with mammographic density in adult women
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Lope, Virginia, Pérez-Gómez, Beatriz, Moreno, María Pilar, Vidal, Carmen, Salas-Trejo, Dolores, Ascunce, Nieves, Román, Isabel González, Sánchez-Contador, Carmen, Santamariña, María Carmen, Carrete, Jose Antonio Vázquez, Collado-García, Francisca, Pedraz-Pingarrón, Carmen, Ederra, María, Ruiz-Perales, Francisco, Peris, Mercé, Abad, Soledad, Cabanes, Anna, Pollán, Marina, and DDM Spain
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- 2011
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15. Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design = Estudio multicaso-control de base poblacional de tumores comunes en España (MCC-Spain): razón y diseño del estudio
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Castaño-Vinyals, Gemma, Aragonés, Nuria, Pérez-Gómez, Beatriz, Martín, Vicente, Llorca, Javier, Moreno, Victor, Altzibar, Jone-Miren, Ardanaz, Eva, Sanjosé Llongueras, Silvia de, Jiménez Moleón, José Juan, García Tardón, Adonina, Alguacil, Juan, Peiró Pérez, Rosana, Marcos-Gragera, Rafael, Navarro, Carmen, Pollán, Marina, Kogevinas, Manolis, Alonso, Maria Teresa, Amiano, Pilar, Arias, Cristina, Azpiri, Mikel, Benavente, Yolanda, Boldo, Elena, Bueno, Aurora, Bustamante, Mariona, Caballero, Francisco Javier, Campo Güerri, Elias, Cantón, Rafael, Capelo, Rocío, Carmona García, Maria Carme, Casabonne, Delphine, Chirlaque, María Dolores, Cirac, Judith, Clofent, Juan, Colado, Enrique, Costas, Laura, Crous, Marta, Campo, Rosa del, Díaz Santos, Marian, Dierssen Sotos, Trinidad, Ederra, María, Espinosa, Ana, Fernández Cabrera, Marieta, Fernández Somoano, Ana, Fernández-Villa, Tania, García García-Esquinas, Esther, García Martín, Paloma, Gómez Acebo, Inés, González Puga, Cristina, Gracia Lavedan, Esther, Guevara, Marcela, Guinó, Elisabet, Huerta, José María, Lope, Virginia, López-Abente Ortega, Gonzalo, López-Otín, Carlos, Martínez Argüelles, Begoña, Merino Salas, Sergio, Mirón Pozo, Benito, Molina de la Torre, Antonio José, Moreno, Eduardo, Moreno Iribas, Conchi, Olea, Nicolás, Osca-Gelis, Gemma, Paré, Laia, Porta, Miquel, Puig, Montse, Rivas del Fresno, Manuel, Robles, Claudia, Rodríguez Suarez, Marta María, Romero, Beatriz, Sáez Castillo, Ana Isabel, Sala i Serra, Maria, Salas Trejo, Dolores, Santaballa, Ana, Santibáñez, Miguel, Sierra, Ángeles, Souto, Ana, Villanueva, Cristina M., Carrasco, Estela, Sabaté, Yasmin, Persavento, Cecília, García, Mireia, Carrasco, Glòria, Expósito, Ainara, Andreu, Montse, Bessa, Xavier, Piracés, Mercè, Lorente, José Antonio, Tusquets, Ignasi, Collet, Inma, Bory, Felip, Pera, Manuel, Abella, Eugènia, Garcia, Francesc, Salar, Antonio, Piñol, Marta, Fernández-Llamazares Rodríguez, Jaume, Viciano Martín, Marta, and Garsot, Elisenda
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Epidemiology ,Epidemiologia ,Càncer ,Cancer - Abstract
MCC-Spain study group: Maria Teresa Alonso, Pilar Amiano, Cristina Arias, Mikel Azpiri, Yolanda Benavente, Elena Boldo, Aurora Bueno, Mariona Bustamante, Francisco Javier Caballero, Elías Campo, Rafael Cantón, Rocío Capelo, Carme Carmona, Delphine Casabonne, María Dolores Chirlaque, Judith Cirac, Juan Clofent, Enrique Colado, Laura Costas, Marta Crous, Rosa del Campo, Marian Díaz Santos, Trinidad Dierssen-Sotos, María Ederra, Ana Espinosa, Marieta Fernández Cabrera, Ana Fernández Somoano, Fernández-Villa, Tania, Esther García García-Esquinas, Paloma García Martín, Inés Gómez-Acebo, Cristina González Puga, Esther Gràcia, Marcela Guevara Eslava, Elisabet Guinó, José María Huerta, Virginia Lope, Gonzalo López-Abente, Carlos Lopez-Otín, Begona˜ Martinez Argüelles, Sergio Merino Salas, Benito Mirón Pozo, Antonio José Molina de la Torre, Eduardo Moreno, Concepción Moreno Iribas, Nicolás Olea, Gemma Osca Gelis, Laia Paré, Miquel Porta, Montse Puig, Manuel Rivas del Fresno, Claudia Robles, Marta María Rodríguez Suarez, Beatriz Romero, Ana Isabel Sáez Castillo, Maria Sala Serra, Dolores Salas Trejo, Ana Santaballa, Miguel Santibánez, ˜ Ángeles Sierra, Ana Souto, Cristina M Villanueva We present the protocol of a large population-based case-control study of 5 common tumorsin Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and pri-mary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer,1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chroniclymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age,sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) andfrom 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociode-mographic factors, environmental exposures, occupation, medication, lifestyle, and personal and familymedical history. In addition, participants completed a self-administered food-frequency questionnaireand telephone interviews. Blood samples were collected from 76% of participants while saliva sampleswere collected in CLL cases and participants refusing blood extractions. Clinical information was recordedfor cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals.Genotyping was done through an exome array enriched with genetic markers in specific pathways. Mul-tiple analyses are planned to assess the association of environmental, personal and genetic risk factorsfor each tumor and to identify pleiotropic effects.Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiol-ogy & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancersand will promote cancer research and prevention in Spain
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- 2020
16. Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer
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Suárez, Javier, primary, Mata, Elena, additional, Guerra, Ana, additional, Jiménez, Gloria, additional, Montes, Marta, additional, Arias, Fernando, additional, Ciga, Miguel A., additional, Ursúa, Eugenia, additional, Ederra, María, additional, Arín, Beñat, additional, Laiglesia, Matilde, additional, Sanz, Asunción, additional, and Vera, Ruth, additional
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- 2020
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17. Evaluation of mammographic density patterns: reproducibility and concordance among scales
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Garrido-Estepa Macarena, Ruiz-Perales Francisco, Miranda Josefa, Ascunce Nieves, González-Román Isabel, Sánchez-Contador Carmen, Santamariña Carmen, Moreo Pilar, Vidal Carmen, Peris Mercé, Moreno María P, Váquez-Carrete Jose A, Collado-García Francisca, Casanova Francisco, Ederra María, Salas Dolores, and Pollán Marina
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classifying mammograms as high- or low-density. Methods The study covered 3572 mammograms drawn from women included in the DDM-Spain study, carried-out in seven Spanish Autonomous Regions. Each mammogram was read by an expert radiologist and classified using the Wolfe, Tabár, BI-RADS and Boyd scales. In addition, 375 mammograms randomly selected were read a second time to estimate intra-rater agreement for each scale using the kappa statistic. Owing to the ordinal nature of the scales, weighted kappa was computed. The entire set of mammograms (3572) was used to calculate agreement among the different scales in classifying high/low-density patterns, with the kappa statistic being computed on a pair-wise basis. High density was defined as follows: percentage of dense tissue greater than 50% for the Boyd, "heterogeneously dense and extremely dense" categories for the BI-RADS, categories P2 and DY for the Wolfe, and categories IV and V for the Tabár scales. Results There was good agreement between the first and second reading, with weighted kappa values of 0.84 for Wolfe, 0.71 for Tabár, 0.90 for BI-RADS, and 0.92 for Boyd scale. Furthermore, there was substantial agreement among the different scales in classifying high- versus low-density patterns. Agreement was almost perfect between the quantitative scales, Boyd and BI-RADS, and good for those based on the observed pattern, i.e., Tabár and Wolfe (kappa 0.81). Agreement was lower when comparing a pattern-based (Wolfe or Tabár) versus a quantitative-based (BI-RADS or Boyd) scale. Moreover, the Wolfe and Tabár scales classified more mammograms in the high-risk group, 46.61 and 37.32% respectively, while this percentage was lower for the quantitative scales (21.89% for BI-RADS and 21.86% for Boyd). Conclusions Visual scales of mammographic density show a high reproducibility when appropriate training is provided. Their ability to distinguish between high and low risk render them useful for routine use by breast cancer screening programs. Quantitative-based scales are more specific than pattern-based scales in classifying populations in the high-risk group.
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- 2010
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18. Decline in age at menarche among Spanish women born from 1925 to 1962
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Barcos Ana, Ederra María, Vidal Enrique, Ascunce Nieves, Cabanes Anna, Erdozain Nieves, Lope Virginia, and Pollán Marina
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background While the timing of reproductive events varies across populations, a downward trend in age at menarche has nevertheless been reported in most of the developed world over the past century. Given the impact of change in age at menarche on health conditions, this study sought to examine secular trends in age at menarche among women living in Navarre (Northern Spain) who participated in a population-based breast cancer screening programme. Methods The study was based on 110545 women born from 1925 to 1962. Trends were tested using a linear regression model, in which year of birth was entered continuously as the predictor and age at menarche (years) as the response variable, using size of town and region of birth as covariates. Results Among women born in Navarre between 1925 and 1962, age at menarche declined steadily from an average of 13.72 years in the 1925-1929 birth-cohorts to 12.83 years in the 1958-1962 birth-cohorts. Controlling for size of town or city of birth, age at menarche declined by an average of 0.132 years every 5 years over the period 1925-1962. This decline was greater in women born in rural versus urban settings. Trends were also different among regions of birth. Conclusion We report a population-based study showing a downward trend in age of onset of menarche among Spanish women born in the period 1925-1962, something that is more pronounced among women born in rural settings and varies geographically.
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- 2009
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19. Occupational exposures and mammographic density in Spanish women
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Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Ministerio de Economía y Competitividad, Federación Española de Cáncer de Mama, Lope, Virginia, García-Pérez, Javier, Pérez-Gómez, Beatriz, Pedraza-Flechas, Ana María, Alguacil, Juan, González-Galarzo, María Carmen, Alba, Miguel Angel, van der Haar, Rudolf, Cortés Barragán, Rosa Ana, Pedraz-Pingarrón, Carmen, Moreo, María Pilar, Santamariña, Carmen, Ederra, María, Vidal, Carmen, Salas-Trejo, Dolores, Llobet Azpitarte, Rafael, Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Ministerio de Economía y Competitividad, Federación Española de Cáncer de Mama, Lope, Virginia, García-Pérez, Javier, Pérez-Gómez, Beatriz, Pedraza-Flechas, Ana María, Alguacil, Juan, González-Galarzo, María Carmen, Alba, Miguel Angel, van der Haar, Rudolf, Cortés Barragán, Rosa Ana, Pedraz-Pingarrón, Carmen, Moreo, María Pilar, Santamariña, Carmen, Ederra, María, Vidal, Carmen, Salas-Trejo, Dolores, and Llobet Azpitarte, Rafael
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[EN] Objectives The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women. Methods This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms. Results Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (e(beta)=1.51; 95% CI 1.04 to 2.19), ionising radiation (e(beta)=1.23; 95% CI 0.99 to 1.52) and mould spores (e(beta)=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation. Conclusions Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings.
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- 2018
20. Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
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Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, Ministerio de Economía y Competitividad, del Pozo, Maria del Pilar, Castelló, Adela, Vidal, Carmen, Salas -Trejo, Dolores, Sanchez Contador, Carmen, Pedraz-Pingarrón, Carmen, Moreno, María Pilar, Santamariña, Carmen, Ederra, María, Llobet Azpitarte, Rafael, Vioque, Jesús, Perez Gómez, Beatriz, Pollán, Marina, Lope, Virginia, Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, Ministerio de Economía y Competitividad, del Pozo, Maria del Pilar, Castelló, Adela, Vidal, Carmen, Salas -Trejo, Dolores, Sanchez Contador, Carmen, Pedraz-Pingarrón, Carmen, Moreno, María Pilar, Santamariña, Carmen, Ederra, María, Llobet Azpitarte, Rafael, Vioque, Jesús, Perez Gómez, Beatriz, Pollán, Marina, and Lope, Virginia
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[EN] Objectives: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women. Study design: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet. Main outcome measure: Mammographic density. Results: Those women with an excessive caloric intake ( > 40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study. Conclusions: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype
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- 2018
21. Impact of the COVID‐19 pandemic during Spain's state of emergency on the diagnosis of colorectal cancer.
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Suárez, Javier, Mata, Elena, Guerra, Ana, Jiménez, Gloria, Montes, Marta, Arias, Fernando, Ciga, Miguel A., Ursúa, Eugenia, Ederra, María, Arín, Beñat, Laiglesia, Matilde, Sanz, Asunción, and Vera, Ruth
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- 2021
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22. Independent Role of Severe Obesity as a Risk Factor for COVID‐19 Hospitalization: A Spanish Population‐Based Cohort Study.
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Fresán, Ujué, Guevara, Marcela, Elía, Fernando, Albéniz, Esther, Burgui, Cristina, Castilla, Jesús, Martín, Carmen, Navascués, Ana, Portillo, María Eugenia, Polo, Isabel, Ezpeleta, Carmen, Gorricho, Javier, Ardanaz, Eva, Ascunce, Nieves, Arriazu, Maite, Barricarte, Aurelio, Barriuso, Laura, Casado, Itziar, Díaz, Jorge, and Ederra, María
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COVID-19 ,COHORT analysis ,HOSPITAL care ,INTENSIVE care units ,POISSON regression - Abstract
Objectives: This study analyzed the association between severe obesity and coronavirus disease 2019 (COVID‐19) hospitalization and severe disease. Methods: The incidence of hospitalization for laboratory‐confirmed COVID‐19 was evaluated in a prospective population‐based cohort of 433,995 persons aged 25 to 79 years in Spain during March and April of 2020. Persons with and without class 3 obesity were compared using Poisson regression to estimate the adjusted relative risk (aRR) from class 3 obesity of COVID‐19 hospitalization and of severe disease (intensive care unit admission or death). Differences in the effect by age, sex, and chronic conditions were evaluated. Results: Individuals with class 3 obesity had a higher risk of hospitalization (aRR = 2.20, 95% CI: 1.66‐2.93) and developing severe COVID‐19 (aRR = 2.30, 95% CI: 1.20‐4.40). In people younger than 50 years, these effects were more pronounced (aRR = 5.02, 95% CI: 3.19‐7.90 and aRR = 13.80, 95% CI: 3.11‐61.17, respectively), whereas no significant effects were observed in those aged 65 to 79 years (aRR = 1.22, 95% CI: 0.70‐2.12 and aRR = 1.42, 95% CI: 0.52‐3.88, respectively). Sex and chronic conditions did not modify the effect of class 3 obesity in any of the outcomes. Conclusions: Severe obesity is a relevant risk factor for COVID‐19 hospitalization and severity in young adults, having a magnitude similar to that of aging. Tackling the current obesity pandemic could alleviate the impact of chronic and infectious diseases. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
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del Pozo, María del Pilar, primary, Castelló, Adela, additional, Vidal, Carmen, additional, Salas-Trejo, Dolores, additional, Sánchez-Contador, Carmen, additional, Pedraz-Pingarrón, Carmen, additional, Moreo, Pilar, additional, Santamariña, Carmen, additional, Ederra, María, additional, Llobet, Rafael, additional, Vioque, Jesús, additional, Pérez-Gómez, Beatriz, additional, Pollán, Marina, additional, and Lope, Virginia, additional
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- 2018
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24. High mammographic density in long-term night shift workers: DDM-Spain /Var-DDM
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Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Fundación Gent per Gent, Instituto de Salud Carlos III, European Regional Development Fund, Federación Española de Cáncer de Mama, Pedraza-Flechas, Ana María, Lope, Virginia, Sanchez-Contador, Carmen, Santamarina, Carmen, Pedraz-Pingarron, Carmen, Moreo, Pilar, Ederra, María, Miranda-Garcia, Josefa, Vidal, Carmen, Llobet Azpitarte, Rafael, Aragonés, Nuria, Salas-Trejo, Dolores, Pollán, Marina, Pérez-Gómez, Beatriz, Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Fundación Gent per Gent, Instituto de Salud Carlos III, European Regional Development Fund, Federación Española de Cáncer de Mama, Pedraza-Flechas, Ana María, Lope, Virginia, Sanchez-Contador, Carmen, Santamarina, Carmen, Pedraz-Pingarron, Carmen, Moreo, Pilar, Ederra, María, Miranda-Garcia, Josefa, Vidal, Carmen, Llobet Azpitarte, Rafael, Aragonés, Nuria, Salas-Trejo, Dolores, Pollán, Marina, and Pérez-Gómez, Beatriz
- Abstract
[EN] Background: Night-shift work (NSW) has been suggested as a possible cause of breast cancer, and its association with mammographic density (MD), one of the strongest risk factors for breast cancer, has been scarcely addressed. This study examined NSW and MD in Spanish women. Methods: The study covered 2,752 women aged 45-68 years recruited in 2007-2008 in 7 population-based public breast cancer screening centers, which included 243 women who had performed NSW for at least one year. Occupational data and information on potential confounders were collected by personal interview. Two trained radiologist estimated the percentage of MD assisted by a validated semiautomatic computer tool (DM-scan). Multivariable mixed linear regression models with random screening center-specific intercepts were fitted using log-transformed percentage of MD as the dependent variable and adjusting by known confounding variables. Results: Having ever worked in NSW was not associated with MD [e(beta):0.96; 95% confidence interval (CI), 0.86-1.06]. However, the adjusted geometric mean of the percentage of MD in women with NSW for more than 15 years was 25% higher than that of those without NSW history (MD>15 (years):20.7% vs. MDnever:16.5%; e(beta):1.25; 95% CI, 1.01-1.54). This association was mainly observed in postmenopausal participants (e(beta):1.28; 95% CI, 1.00-1.64). Among NSW-exposed women, those with <= 2 night-shifts per week had higher MD than those with 5 to 7 nightshifts per week (e(beta):1.42; 95% CI, 1.10-1.84). Conclusions: Performing NSW was associated with higherMD only in women with more than 15 years of cumulated exposure. These findings warrant replication in futures studies. (C)2017 AACR.
- Published
- 2017
25. Occupation and mammographic density: A population-based study (DDM-Occup)
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Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Federación Española de Cáncer de Mama, García-Pérez, Javier, Pollán, Marina, Pérez-Gómez, Beatriz, González-Sánchez, Mario, Cortés Barragán, Rosa Ana, Maqueda Blasco, Jerónimo, González-Galarzo, María Carmen, Alba, Miguel Ángel, van der Haar, Rudolf, Casas, Silvia, Vicente, Cándida, Medina, Pilar, Ederra, María, Santamariña, Carmen, Moreno, María Pilar, Llobet Azpitarte, Rafael, Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, AstraZeneca, Instituto de Salud Carlos III, Asociación Española Contra el Cáncer, Federación Española de Cáncer de Mama, García-Pérez, Javier, Pollán, Marina, Pérez-Gómez, Beatriz, González-Sánchez, Mario, Cortés Barragán, Rosa Ana, Maqueda Blasco, Jerónimo, González-Galarzo, María Carmen, Alba, Miguel Ángel, van der Haar, Rudolf, Casas, Silvia, Vicente, Cándida, Medina, Pilar, Ederra, María, Santamariña, Carmen, Moreno, María Pilar, and Llobet Azpitarte, Rafael
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[EN] Introduction: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. Methods: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index,menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms. Results: Mammographic density was higher, although non-statistically significant, among secondary school teachers (e(beta) = 1.41; 95%CI = 0.98-2.03) and nurses (e(beta) = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (e(beta) = 0.81; 95%CI = 0.66-1.00) and housewives (e(beta) = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035). Conclusions: Nurses and secondary schoo
- Published
- 2017
26. Occupational exposures and mammographic density in Spanish women
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Lope, Virginia, primary, García-Pérez, Javier, additional, Pérez-Gómez, Beatriz, additional, Pedraza-Flechas, Ana María, additional, Alguacil, Juan, additional, González-Galarzo, Mª Carmen, additional, Alba, Miguel Angel, additional, van der Haar, Rudolf, additional, Cortés-Barragán, Rosa Ana, additional, Pedraz-Pingarrón, Carmen, additional, Moreo, Pilar, additional, Santamariña, Carmen, additional, Ederra, María, additional, Vidal, Carmen, additional, Salas-Trejo, Dolores, additional, Sánchez-Contador, Carmen, additional, Llobet, Rafael, additional, and Pollán, Marina, additional
- Published
- 2017
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27. High Mammographic Density in Long-Term Night-Shift Workers: DDM-Spain/Var-DDM
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Pedraza-Flechas, Ana María, primary, Lope, Virginia, additional, Sánchez-Contador, Carmen, additional, Santamariña, Carmen, additional, Pedraz-Pingarrón, Carmen, additional, Moreo, Pilar, additional, Ederra, María, additional, Miranda-García, Josefa, additional, Vidal, Carmen, additional, Llobet, Rafael, additional, Aragonés, Nuria, additional, Salas-Trejo, Dolores, additional, Pollán, Marina, additional, and Pérez-Gómez, Beatriz, additional
- Published
- 2017
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28. Use of hormone therapy and isoflavones and mammographic density in Spain
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Isidoro, Beatriz, primary, Lope, Virginia, additional, Whelan, Denis, additional, Pedraz, Carmen, additional, Sánchez-Contador, Carmen, additional, Santamariña, Carmen, additional, Moreo, Pilar, additional, Vidal, Carmen, additional, Salas-Trejo, Dolores, additional, Ederra, María, additional, Aragonés, Nuria, additional, Pérez-Gómez, Beatriz, additional, and Pollán, Marina, additional
- Published
- 2016
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29. Vasoconstricción adrenérgica en arterias cerebrales aisladas de cabra
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Lluch López, Salvador, Conde Ederra, María Victoria, Lluch López, Salvador, and Conde Ederra, María Victoria
- Published
- 2015
30. Cumplimiento de las recomendaciones dietéticas vigentes y variabilidadgeográfica de la dieta en mujeres participantes en 7 programas de cribadode cáncer de mama en España
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García-Arenzana, N, Navarrete-Muñoz, E M, Vázquez-Carrete, J A, Moreno, M P, Vidal, C, Salas, D, Ederra, María, Pedraz, C, Collado-García, F, Sánchez-Contador, Carmen, González-Román, I, García-López, M, Miranda, J, Peris, M, Moreo, P, Santamariña, C, Pérez-Gómez, B, Vioque, J, Pollan-Santamaria, Marina, Instituto de Salud Carlos III, AstraZeneca, and Astra-Zéneca
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España ,Breast Neoplasms ,Diet, Mediterranean ,Vitaminas ,Nutrition Policy ,Humans ,Mass Screening ,Obesity ,Aged ,Geography ,Dietary habits ,Avitaminosis ,Vitamins ,Feeding Behavior ,Middle Aged ,Overweight ,Diet ,Hábitos die-téticos ,Postmenopause ,Spain ,Vita-mins ,Patient Compliance ,Dieta ,Female ,Menopausia ,Menopause - Abstract
[ES] Introducción:Una dieta saludable es especialmenteimportante durante la menopausia, periodo en el queaumenta el riesgo de varios problemas de salud. Analiza-mos la dieta de mujeres peri y postmenopáusicas españo-las y el grado de cumplimiento de las recomendacionesactuales. Material y métodos:Estudio transversal en 3.574 muje-res de 45-68 años que acuden al cribado de cáncer demama en 7 centros (A Coruña, Barcelona, Burgos, Palmade Mallorca, Pamplona, Valencia y Zaragoza). Se recogióla dieta mediante un cuestionario de frecuencia de ali-mentos validado para población española. Para la valora-ción del cumplimiento de las recomendaciones actuales seutilizaron los rangos recomendados por la SociedadEspañola de Nutrición Comunitaria para ingesta de gru-pos de alimentos y las Ingestas Diarias Recomendadas(IDR) para energía, vitaminas y minerales de la Federa-ción Española de Nutrición, Alimentación y Dietética. Resultados:El 29% de las mujeres eran obesas y un42% tenía sobrepeso. El aporte calórico medio fue de2.053 kcal (DE: 480). El perfil calórico general fue de: 43% de la energía aportada por lo carbohidratos, 36%por las grasas, 20% por las proteínas. Se evidenció unaingesta deficiente de vitamina D en todos los nodos delestudio, con una ingesta media general de 2,14 μg/día. Sedetectó a su vez una ingesta deficitaria de vitamina E en ACoruña y Burgos. Todos los centros presentaron unaingesta elevada de productos lácteos y de legumbres. Elconsumo de frutas y verduras fue muy heterogéneosiendo especialmente elevada su ingesta en Mallorca yValencia mientras que fue baja para ambos grupos de ali-mentos en A Coruña. La ingesta de aceite de oliva fue ele-vada en todos los centros exceptuando Burgos con un74,3% de las mujeres estudiadas por debajo de las 3raciones al día recomendadas. Conclusiones:Una dieta con menos grasas y proteínasy más rica en vegetales, frutos secos y alimentos ricos enhidratos de carbono equilibraría el balance energético ymejoraría la calidad de la dieta corrigiendo las bajasingestas de vitaminas D y E. Estas recomendaciones sonespecialmente importantes en las ciudades más alejadasde la costa mediterránea donde se han detectado mayoresincumplimientos de las recomendaciones vigentes y unadieta más alejada de la dieta mediterránea. [EN] A healthy diet is especially important during menopause, a period which increases the risk of various health problems. We analyzed the diet of periand postmenopausal Spanish women and the degree of compliance with current recommendations. We studied 3574 women 45-68 years old who attended breast cancer screening programmes in 7 centres (A Coruña, Barcelona, Burgos, Palma de Mallorca, Pamplona, Valencia and Zaragoza). Diet information was collected using a food frequency questionnaire validated for the Spanish population. For the assessment of compliance with current guidelines we used the recommendations by the Spanish Society of Community Nutrition for food groups intake and by the Spanish Federation of Nutrition, Food and Dietetics for energy, vitamins and minerals intake. The 29% of women were obese and 42% overweight. The average caloric intake was 2.053 kcal (SD 480). The general energy profile was: 43% of the energy from the carbohydrates, 36% from fats, and 20% from proteins. There was a low vitamin D intake in all centres of the study, with an overall mean intake of 2.14 mg/day. A deficit of vitamin E intake in A Coruña and Burgos was also detected. Intake of dairy products and vegetables was high in all the study centers. The consumption of fruits and vegetables was very heterogeneous, with high intakes observed in Mallorca and Valencia and low for both food groups in A Coruña. The olive oil intake was high in all centers except Burgos with 74.3% of the women studied below the recommended 3 servings per day. A diet with less fat and protein and a higher consumption of vegetables, nuts and foods rich in carbohydrate might balance the energy intake and improve the quality of the diet correcting the low intakes of vitamins D and E. These recommendations are especially important in cities far from the Mediterranean coast where more breaches have been detected over the current recommendations with a lower adherence to the Mediterranean diet. Este estudio ha recibido financiación del Fondo deInvestigación Ssanitaria (proyecto PI060386) y de Astra-Zéneca (convenio de colaboración entre Astra-Zeneca y el Instituto de salud Carlos III 1306-1306EPY). Sí
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- 2011
31. Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21
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Fernandez-Navarro, Pablo, primary, González-Neira, Anna, additional, Pita, Guillermo, additional, Díaz-Uriarte, Ramón, additional, Tais Moreno, Leticia, additional, Ederra, María, additional, Pedraz-Pingarrón, Carmen, additional, Sánchez-Contador, Carmen, additional, Vázquez-Carrete, Jose Antonio, additional, Moreo, Pilar, additional, Vidal, Carmen, additional, Salas-Trejo, Dolores, additional, Stone, Jennifer, additional, Southey, Melissa C., additional, Hopper, John L., additional, Pérez-Gómez, Beatriz, additional, Benitez, Javier, additional, and Pollan, Marina, additional
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- 2014
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32. Programas de detección precoz de cáncer de mama en España: características y principales resultados
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Ascunce, Nieves, primary, Delfrade, Josu, additional, Salas, Dolores, additional, Zubizarreta, Raquel, additional, and Ederra, María, additional
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- 2013
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33. Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study
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Pollán, Marina, primary, Ascunce, Nieves, additional, Ederra, María, additional, Murillo, Alberto, additional, Erdozáin, Nieves, additional, Alés-Martínez, Jose Enrique, additional, and Pastor-Barriuso, Roberto, additional
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- 2013
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34. Diet quality and related factors among Spanish female participants in breast cancer screening programs
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García-Arenzana, Nicolás, primary, Navarrete-Muñoz, Eva María, additional, Peris, Mercé, additional, Salas, Dolores, additional, Ascunce, Nieves, additional, Gonzalez, Isabel, additional, Sánchez-Contador, Carmen, additional, Santamariña, Carmen, additional, Moreo, Pilar, additional, Moreno, María Pilar, additional, Carrete, Jose Antonio Vazquez, additional, Collado-García, Francisca, additional, Pedraz-Pingarrón, Carmen, additional, Ederra, María, additional, Miranda-García, Josefa, additional, Vidal, Carmen, additional, Aragonés, Nuria, additional, Pérez-Gómez, Beatriz, additional, Vioque, Jesús, additional, and Pollán, Marina, additional
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- 2012
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35. Decline in age at menarche among Spanish women born from 1925 to 1962
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Cabanes, Anna, primary, Ascunce, Nieves, additional, Vidal, Enrique, additional, Ederra, María, additional, Barcos, Ana, additional, Erdozain, Nieves, additional, Lope, Virginia, additional, and Pollán, Marina, additional
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- 2009
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36. Association between the Adherence to the International Guidelines for Cancer Prevention and Mammographic Density.
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Castelló, Adela, Prieto, Leandro, Ederra, María, Salas-Trejo, Dolores, Vidal, Carmen, Sánchez-Contador, Carmen, Santamariña, Carmen, Pedraz, Carmen, Moreo, Pilar, Aragonés, Nuria, Pérez-Gómez, Beatriz, Lope, Virginia, Vioque, Jesús, Pollán, Marina, and null, null
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CANCER prevention ,BREAST cancer ,MAMMOGRAMS ,PATIENT compliance ,EARLY detection of cancer ,POSTMENOPAUSE ,ALCOHOLIC beverages - Abstract
Introduction: Mammographic density (MD) is considered a strong predictor of Breast Cancer (BC). The objective of the present study is to explore the association between MD and the compliance with the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention. Methods: Data of 3584 women attending screening from a population-based multicenter cross-sectional study (DDM-Spain) collected from October 7, 2007 through July 14, 2008, was used to calculate a score that measures the level of compliance with the WCRF/AICR recommendations: R1)Maintain adequate body weight; R2)Be physically active; 3R)Limit the intake of high density foods; R4)Eat mostly plant foods; R5)Limit the intake of animal foods; R6)Limit alcohol intake; R7)Limit salt and salt preserved food intake; R8)Meet nutritional needs through diet. The association between the score and MD (assessed by a single radiologist using a semi-quantitative scale) was evaluated using ordinal logistic models with random center-specific intercepts adjusted for the main determinants of MD. Stratified analyses by menopausal status and smoking status were also carried out. Results: A higher compliance with the WCRF/AICR recommendations was associated with lower MD (OR
1-unit increase = 0.93 95%CI:0.86;0.99). The association was stronger in postmenopausal women (OR = 0.91 95%CI:0.84;0.99) and nonsmokers (OR = 0.87;95%CI:0.80;0.96 for nonsmokers, OR = 1.01 95%CI:0.91;1.12 for smokers, P-interaction = 0.042). Among nonsmokers, maintaining adequate body weight (OR = 0.81 95%CI:0.65;1.01), practicing physical activity (OR = 0.68 95%CI:0.48;0.96) and moderating the intake of high-density foods (OR = 0.58 95%CI:0.40;0.86) and alcoholic beverages (OR = 0.76 95%CI:0.55;1.05) were the recommendations showing the strongest associations with MD. Conclusions: postmenopausal women and non-smokers with greater compliance with the WCRF/AICR guidelines have lower MD. These results may provide guidance to design specific recommendations for screening attendants with high MD and therefore at higher risk of developing BC. [ABSTRACT FROM AUTHOR]- Published
- 2015
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37. Evaluation of mammographic density patterns:reproducibility and concordance among scales.
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Garrido-Estepa, Macarena, Ruiz-Perales, Francisco, Miranda, Josefa, Ascunce, Nieves, González-Román, Isabel, Sánchez-Contador, Carmen, Santamariña, Carmen, Moreo, Pilar, Vidal, Carmen, Peris, Mercé, Moreno, María P., Váquez-Carrete, Jose A., Collado-García, Francisca, Casanova, Francisco, Ederra, María, Salas, Dolores, and Pollán, Marina
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BREAST cancer ,MAMMOGRAMS ,MEDICAL screening ,CANCER risk factors ,DIAGNOSTIC imaging centers ,BIOTECHNOLOGY - Abstract
Background: Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classifying mammograms as high- or low-density. Methods: The study covered 3572 mammograms drawn from women included in the DDM-Spain study, carriedout in seven Spanish Autonomous Regions. Each mammogram was read by an expert radiologist and classified using the Wolfe, Tabár, BI-RADS and Boyd scales. In addition, 375 mammograms randomly selected were read a second time to estimate intra-rater agreement for each scale using the kappa statistic. Owing to the ordinal nature of the scales, weighted kappa was computed. The entire set of mammograms (3572) was used to calculate agreement among the different scales in classifying high/low-density patterns, with the kappa statistic being computed on a pair-wise basis. High density was defined as follows: percentage of dense tissue greater than 50% for the Boyd, "heterogeneously dense and extremely dense" categories for the BI-RADS, categories P2 and DY for the Wolfe, and categories IV and V for the Tabár scales. Results: There was good agreement between the first and second reading, with weighted kappa values of 0.84 for Wolfe, 0.71 for Tabár, 0.90 for BI-RADS, and 0.92 for Boyd scale. Furthermore, there was substantial agreement among the different scales in classifying high- versus low-density patterns. Agreement was almost perfect between the quantitative scales, Boyd and BI-RADS, and good for those based on the observed pattern, i.e., Tabár and Wolfe (kappa 0.81). Agreement was lower when comparing a pattern-based (Wolfe or Tabár) versus a quantitative-based (BI-RADS or Boyd) scale. Moreover, the Wolfe and Tabár scales classified more mammograms in the high-risk group, 46.61 and 37.32% respectively, while this percentage was lower for the quantitative scales (21.89% for BI-RADS and 21.86% for Boyd). Conclusions: Visual scales of mammographic density show a high reproducibility when appropriate training is provided. Their ability to distinguish between high and low risk render them useful for routine use by breast cancer screening programs. Quantitative-based scales are more specific than pattern-based scales in classifying populations in the high-risk group. [ABSTRACT FROM AUTHOR]
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- 2010
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38. Vasoconstricción adrenérgica en arterias cerebrales aisladas de cabra
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Conde Ederra, María Victoria and Lluch López, Salvador
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Neurociencias ,Farmacia - Published
- 1979
39. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
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Medicina Preventiva, Obón Santacana, Mireia, Romaguera, Dora, Gracia Lavedan, Esther, Molinuevo, Amaia, Molina Montes, Esther, Shivappa, Nitin, Hebert, James R., Tardón, Adonina, Castaño Vinyals, Gemma, Moratalla, Ferran, Guinó, Elisabet, Marcos Gragera, Rafael, Azpiri, Mikel, Gil, Leire, Olmedo Requena, Rocío, Lozano Lorca, Macarena, Alguacil, Juan, Fernández Villa, Tania, Martín Sánchez, Vicente, Molina de la Torre, Antonio José, Ederra, María, Moreno Iribas, Conchi, Pérez, Beatriz, Aragonés, Nuria, Castelló, Adela, Huerta, José, Dierssen Sotos, Trinidad, Gómez Acebo, Inés, Molina Barceló, Ana, Pollán, Marina, Kogevinas, Manolis, Moreno González, Víctor, Amiano, Pilar, Medicina Preventiva, Obón Santacana, Mireia, Romaguera, Dora, Gracia Lavedan, Esther, Molinuevo, Amaia, Molina Montes, Esther, Shivappa, Nitin, Hebert, James R., Tardón, Adonina, Castaño Vinyals, Gemma, Moratalla, Ferran, Guinó, Elisabet, Marcos Gragera, Rafael, Azpiri, Mikel, Gil, Leire, Olmedo Requena, Rocío, Lozano Lorca, Macarena, Alguacil, Juan, Fernández Villa, Tania, Martín Sánchez, Vicente, Molina de la Torre, Antonio José, Ederra, María, Moreno Iribas, Conchi, Pérez, Beatriz, Aragonés, Nuria, Castelló, Adela, Huerta, José, Dierssen Sotos, Trinidad, Gómez Acebo, Inés, Molina Barceló, Ana, Pollán, Marina, Kogevinas, Manolis, Moreno González, Víctor, and Amiano, Pilar
- Abstract
[EN] Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
40. Association of occupational heat exposure and colorectal cancer in the MCC-Spain study
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Medicina Preventiva, Hinchliffe, Alice, Kogevinas, Manolis, Molina de la Torre, Antonio José, Moreno González, Víctor, Aragonés, Nuria, Castaño Vinyals, Gemma, Jiménez Moleon, José Juan, Gómez Acebo, Inés, Ederra, María, Amiano, Pilar, Molina Barceló, Ana, Fernández Tardón, Guillermo, Alguacil, Juan, Chirlaque, María Dolores, Hernández Segura, Natalia, Perez Gomez, Beatriz, Pollán, Marina, Turner, Michelle C., Medicina Preventiva, Hinchliffe, Alice, Kogevinas, Manolis, Molina de la Torre, Antonio José, Moreno González, Víctor, Aragonés, Nuria, Castaño Vinyals, Gemma, Jiménez Moleon, José Juan, Gómez Acebo, Inés, Ederra, María, Amiano, Pilar, Molina Barceló, Ana, Fernández Tardón, Guillermo, Alguacil, Juan, Chirlaque, María Dolores, Hernández Segura, Natalia, Perez Gomez, Beatriz, Pollán, Marina, and Turner, Michelle C.
- Abstract
[EN] Objective Heat exposure and heat stress/strain is a concern for many workers. There is increasing interest in potential chronic health effects of occupational heat exposure, including cancer risk. We examined potential associations of occupational heat exposure and colorectal cancer (CRC) risk in a large Spanish multi-case–control study. Methods We analyzed data on 1198 histologically confirmed CRC cases and 2690 frequency-matched controls. The Spanish job-exposure matrix, MatEmEsp, was used to assign heat exposure estimates to the lifetime occupations of participants. Three exposure indices were assessed: ever versus never exposed, cumulative exposure and duration (years). We estimated odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression adjusting for potential confounders. Results Overall, there was no association of ever, compared with never, occupational heat exposure and CRC (OR 1.09, 95% CI 0.92–1.29). There were also no associations observed according to categories of cumulative exposure or duration, and there was no evidence for a trend. There was no clear association of ever occupational heat exposure and CRC in analysis conducted among either men or women when analyzed separately. Positive associations were observed among women in the highest categories of cumulative exposure (OR 1.81, 95% CI 1.09–3.03) and duration (OR 2.89, 95% CI 1.50–5.59) as well as some evidence for a trend (P<0.05). Conclusion Overall, this study provides no clear evidence for an association between occupational heat exposure and CRC.
41. Síndrome de apnea-hipoapnea del sueño y riesgo cardiovascular
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Téllez Moreno, Sergio, Conde Ederra, María Victoria, and UAM. Departamento de Cirugía
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Hypopnea sleep apnea syndrome ,Riesgo cardiovascular ,Síndrome de apnea hipopnea del sueño ,Continuous positive airway pressure ,Presión positiva continua de aire ,Enfermería ,Cardiovascular risk - Abstract
Trabajo fin de grado en Enfermería, Objetivos: El Síndrome de Apneas Hipopneas (SAHS) es una enfermedad que afecta a un gran número de personas en sus esferas biológicas, psicológicas y sociales. El objetivo de este trabajo es el de clarificar si existe una relación entre el SAHS y los factores de riesgo cardiovascular. Además se muestra el papel que juega el profesional de enfermería en su detección, seguimiento y prevención. Metodología: Se realizó una búsqueda bibliográfica en las bases de datos de PubMed, Cochrane, CINAHL, Cuiden asi como una búsqueda libre de diversos artículos y monografías en internet. Resultados: El SAHS, a través de diferentes rutas fisiopatológicas, aumenta la probabilidad de desarrollar un evento cardiovascular. Esto, sumado a los factores de riesgo del propio paciente, repercute de manera negativa sobre su calidad de vida. Discusión/Conclusiones: Se encuentra una relación entre el SAHS y el riesgo cardiovascular, aunque aún no se sabe cuál es la ruta fisiopatológica exacta que provoca esta asociación. Dado que se trata de un problema multidisciplinar, la enfermera tiene un importante papel en la detección, seguimiento y educación del paciente en aras de reducir la sintomatología y mejorar la calidad de vida de la persona., Objectives: Hypopnea apnea syndrome (OSAS) is a disease that affects a large number of people in their biological, psychological and social spheres. The objective of this work is to clarify whether or not there is a relationship between osas and cardiovascular risk factors. It also shows the role that the nursing professional plays in its detection, monitoring and prevention. Methodology: A bibliographical search was carried out in the databases of PubMed, Cochrane, CINAHL, as well as a free search of various articles and monographs on the Internet.Results: The Osas, through different physiopathological routes, increases the probability of developing a cardiovascular event. This, in addition to the patient's own risk factors, has a negative impact on their quality of life. Discussion/Conclusions: there is a relationship between osas and cardiovascular risk, although it is not yet known which is the exact pathophysiological route that causes this association. Since it is a multidisciplinary problem, the nurse has an important role in the detection, monitoring and education of the patient in order to reduce the symptoms and improve the quality of life of the person.
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- 2018
42. Síndrome de apnea-hipoapnea del sueño y riesgo cardiovascular
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Albarrán Fernández, Almudena, Conde Ederra, María Victoria, and UAM. Departamento de Cirugía
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Quality of life ,Sleep Apnea Hypoapnea Syndrome ,Riesgo cardiovascular ,Calidad de vida ,Somnolencia ,Continuous positive airway pressure ,Dispositivo de presión positiva continua ,Enfermería ,Síndrome apnea hipoapnea del sueño ,Drowsiness ,Cardiovascular risk - Abstract
Trabajo fin de grado en Enfermería, Objetivos: El Síndrome de Apnea e Hipoapnea del Sueño (SAHS) es una enfermedad que afecta a todas las esferas del individuo, por ello el objetivo de este trabajo es el de conocer la existencia de riesgo cardiovascular asociado al SAHS. Además, se darán a conocer diferentes actuaciones del personal de enfermería para su abordaje y prevención. Metodología: Se realizó una revisión narrativa a través de las diferentes bases de datos de Ciencias de la Salud como PubMed, Cuiden, Cochrane, búsqueda libre y monografías. Se utilizaron criterios de inclusión y exclusión para concretar la búsqueda. Resultados: Diversos mecanismos fisiopatológicos desencadenados por el SAHS tienen repercusiones cardiovasculares que, junto con los factores de riesgo suponen un cambio en la calidad de vida de estos pacientes. Discusión/ Conclusiones: Existe relación entre SAHS y el riesgo cardiovascular por lo que es importante el abordaje multidisciplinar. La actuación de enfermería es importante en la detección de posibles casos, la educación y el acuerdo con el paciente de medidas para reducir los factores de riesgo y paliar los síntomas. Es necesaria la concienciación del problema en los profesionales sanitarios., Objectives: Sleep Apnea Hypoapnea Syndrome (SAHS) is a desease that affects all areas of the person, therefore the objective of this review is to know the relation between SAHS and cardiovascular risk. In addition, it will be announced differents nursing activities for its approach and prevention. Methodology: a narrative review was performed through a research on differents Health Science databases as PubMed, Cuiden, Cochrane, free search and monographys. Inclusion and exclusión criterios were used to shrink the search. Results: many different physiopathological mechanisms triggered by the SAHS have cardiovascular implications which represent a change in the quality of life of the patients. Moreover, the risk factors represent that change too. Discussion/ Conclusions: there is a relation between SAHS and cardiovascular risk and it is important a multidisciplinary approach. The nursing action is imspotant at case detection, education and the agreement with the patient about measures to reduce risk factors and relieve symptoms. It is required the awareness of the problem in the health care professionals.
- Published
- 2017
43. Impacto psicológico y social de una colostomía en el paciente desde el enfoque de enfermería
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Andrés Martín, Laura, Conde Ederra, María Victoria, and UAM. Departamento de Cirugía
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Patient experiences ,Estoma ,Adaptación ,Patient education ,Experiencias del paciente ,Colostomía ,Stoma ,Educación del paciente ,Impacto ,Impact ,Colostomy ,Enfermería ,Adaptation ,Psicosocial ,Psychosocial - Abstract
Trabajo fin de grado en Enfermería, INTRODUCCION. La palabra “estoma” es de origen griego y significa boca o abertura. De acuerdo a esto, se puede decir que una colostomía es una intervención quirúrgica llevada a cabo con el objetivo de establecer una abertura artificial entre el colon y la pared abdominal proporcionando así una ruta alternativa para la eliminación fecal. Esta nueva situación del paciente afecta directamente a todos sus ámbitos y la adaptación del paciente conlleva asumir cambios y en función de ellos reorganizar la vida. Se han producido notables avances en los dispositivos para los pacientes con colostomías que hacen que la eliminación del contenido fecal sea más fácil e higiénica, sin embargo, se muestra que los problemas psicosociales son comunes y no disminuyen en la misma línea en la que aumentan las mejoras en la gestión del estoma. Es necesario que los profesionales de la salud puedan comprender como es vivir con una colostomía en la dimensión psicológica y social, de manera que puedan ofertar un cuidado que dé respuesta a sus necesidades. Esta revisión bibliográfica de la literatura tiene como propósito explorar el impacto psicológico y social de la colostomía en el paciente con un enfoque sobre el papel de las enfermeras durante el proceso. MATERIAL Y METODOS. Para la realización de esta revisión bibliográfica, se han utilizado fuentes electrónicas como las bases de datos de Pubmed, Medline, Cuiden y Scielo. Para la estrategia de búsqueda en las bases de datos se utilizaron los términos de tesauros Medical Subject Headings [MeSH] y Descriptores en Ciencias de la Salud [DeCS]: “Colostomy”,”Colostomía”, “Stoma”, “Estoma”, “Impact”, “Impacto”, “Adaptation”, “Adaptación”, “Psychosocial”, “Psicosocial” “Patient experiences”, “Experiencias del paciente” “Patient education”, “Educación del paciente, “Nursing”, “Enfermería”. RESULTADOS Para elaborar la revisión bibliográfica se han seleccionado 10 artículos. A partir de ellos, los resultados obtenidos se han organizado conforme a dos líneas temáticas: 1) el impacto psicosocial de la colostomía en el paciente y 2) las intervenciones profesiones que influyen en la adaptación psicosocial del paciente a vivir con una colostomía. Varios estudios afirmaron que la mayoría de los pacientes experimentan sentimientos negativos como consecuencia de la formación del estoma. Estas cuestiones les llevo a tener dificultades a la hora de participar en actividades de la vida social y de reanudar sus actividades normales. Sin embargo, se ha observado que 4 las personas que aceptaron su colostomía, fueron capaces de gestionarla de forma más eficaz y apenas experimentaron dificultades en las interacciones sociales. También se releva el impacto positivo de la educación sobre las necesidades psicosociales del paciente. Las técnicas de aprendizaje en grupo se han visto como un método eficaz en la adaptación social del paciente. CONCLUSIONES. Las contribuciones de esta revisión permiten visualizar aspectos relevantes a tener en cuenta en la atención de enfermería. Los cambios en la imagen corporal y la pérdida del control del cuerpo conducen a problemas a la hora de retomar las actividades de la vida diaria y a una reducción de la vida social. Debe fomentarse que los pacientes retomen en la medida de lo posible su vuelta a las actividades sociales y su inclusión en programas de interacción grupal guiado por especialistas en estomas y contar con aquellas personas que ya tienen ya un estoma para que puedan proporcionar sus experiencias reales. Además se propone incluir al paciente en todo el proceso de toma de decisiones desde antes de la cirugía ya que les permite sentir un mayor control sobre su proceso mostrando así mayores niveles de ajuste., INTRODUCTION. The word "stoma" is of greek origin and means mouth or opening. For that, can say that a colostomy is a surgical procedure carried out with the aim of establishing an artificial gap between the colon and abdominal wall thus providing an alternative route for faecal elimination. This new patient´s situation affects all his areas and patient´s adaptation means taking changes and reorganize. It feature life. have the advances in the devices for colostomy patients that make the removal of the content of fecal more easy and hygienic, however, it shows that they are common psychosocial problems and do not diminish in the same line that increase management stoma. It is necessary that health professionals can understand how it is to live with a colostomy in the psychological and social dimension so that they can offer care to their needs. This literature review of the literature aims explore the psychological and social impact, colostomy in patients with a focus on the role of nurses in the process. MATERIAL AND METHODS. For the realization of esta literature review, they are to be used as sources Electronic Databases of PubMed, Medline, Cuiden and Scielo. Strategy for exact search databases Terms of Tesauros Medical Subject Headings [MeSH] and Descriptores en Ciencias de la Salud [DeCS]: “Colostomy”,”Colostomía”, “Stoma”, “Estoma”, “Impact”, “Impacto”, “Adaptation”, “Adaptación”, “Psychosocial”, “Psicosocial” “Patient experiences”, “Experiencias del paciente” “Patient education”, “Educación del paciente, “Nursing”, “Enfermería”. RESULTS. To develop the literature review are selected 10 articles. From them, the results are organized under two themes: 1) The psychosocial impact of colostomy patient and 2) Interventions professions influencing patient´s psychosocial adaptation to living with a colostomy. Several studies said that the majority of patients experience negative feelings as result of the formation of the stoma. These issues led them having problems when participating in activities of social life, and resume normal activities. However, it has been observed that people who accepted his colostomy were able to manage in a more efficient and experienced less problems in social interactions. Also it relieves the positive impact of education on the psychosocial needs of the patient. Learning techniques group itself han seen as an effective method in social adaptation of the patient. CONCLUSIONS. Contributions of this review relevant aspects for the nursing care. Changes in body image and lose control of the body drive to have problems in the activities of daily living and to reduce the social life. Should be encouraged to patients resume the extent possible do return to social activities and inclusion in programs group interaction guided specialists of stoma and have those who have a stoma so they can provide their experiences. Proposed include the patient in the whole process of decision-making from the surgery before allowing them control of their process showing thus Higher levels of fit.
- Published
- 2016
44. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study).
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Obón-Santacana M, Romaguera D, Gracia-Lavedan E, Molinuevo A, Molina-Montes E, Shivappa N, Hebert JR, Tardón A, Castaño-Vinyals G, Moratalla F, Guinó E, Marcos-Gragera R, Azpiri M, Gil L, Olmedo-Requena R, Lozano-Lorca M, Alguacil J, Fernández-Villa T, Martín V, Molina AJ, Ederra M, Moreno-Iribas C, Perez B, Aragonés N, Castello A, Huerta JM, Dierssen-Sotos T, Gómez-Acebo I, Molina-Barceló A, Pollán M, Kogevinas M, Moreno V, and Amiano P
- Subjects
- Breast Neoplasms diagnosis, Breast Neoplasms prevention & control, Case-Control Studies, Colorectal Neoplasms diagnosis, Colorectal Neoplasms prevention & control, Female, Humans, Inflammation diagnosis, Inflammation prevention & control, Male, Oxidation-Reduction, Prognosis, Protective Factors, Risk Assessment, Risk Factors, Spain epidemiology, Antioxidants administration & dosage, Breast Neoplasms epidemiology, Colorectal Neoplasms epidemiology, Diet adverse effects, Inflammation epidemiology
- Abstract
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII
® ), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p -trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p -trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p -trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent., Competing Interests: Dr. James R. Hébert owns controlling interest in Connecting Health Innovations LLC (CHI), a company that has licensed the right to his invention of the dietary inflammatory index (DII®) from the University of South Carolina in order to develop computer and smartphone applications for patient counseling and dietary intervention in clinical settings. Dr. Nitin Shivappa is an employee of CHI. The subject matter of this paper will not have any direct bearing on that work, nor has that activity exerted any influence on this project. The authors have no other potential competing interest to disclose. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.- Published
- 2019
- Full Text
- View/download PDF
45. [Breast cancer screening: characteristics and results of the Spanish programs].
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Ascunce N, Delfrade J, Salas D, Zubizarreta R, and Ederra M
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- Age Factors, Aged, Breast Neoplasms diagnostic imaging, Breast Neoplasms pathology, Carcinoma, Ductal, Breast diagnostic imaging, Carcinoma, Ductal, Breast epidemiology, Carcinoma, Ductal, Breast pathology, Female, Humans, Lymphatic Metastasis, Middle Aged, Patient Acceptance of Health Care, Program Evaluation, Spain epidemiology, Breast Neoplasms epidemiology, Early Detection of Cancer statistics & numerical data, Government Programs statistics & numerical data, Mammography statistics & numerical data
- Abstract
Background and Objective: To describe national and regional indicators of process and outcome of breast cancer screening programs in Spain., Patients and Method: Overall results and broken down by regions are studied for the period 2007-2008. Outcome indicators (participation, cancer detection rate and characteristics of tumors detected) and process indicators (and intermediate mammograms), classified by types of women screened (initial and consequent regular and irregular) and age groups, are analyzed. Results are compared with reference values established in the European Guidelines., Results: Breast cancer screening coverage is 100% in the country. The overall participation was 69.68% with an adherence of 91.35%. Further assessments of any procedure were performed in 4.93% and invasive further assessments in 0.66%. Intermediate mammograms were indicated in 3.56%. The detection rate was 3.49‰ (5.35‰ age-adjusted); 14.29% of the tumors were intraductal. The 29.49% of the invasive tumors were≤1cm in diameter with 62.22% showing no axillary lymph node involvement., Conclusions: Despite the variability evident in the data provided by the different autonomous communities and the need to improve the homogeneity of information systems as a whole, the assessed indicators meet the standards specified in the European guidelines., (Copyright © 2011 Elsevier España, S.L. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
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