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1,669 results on '"Edelman, Elazer R"'

1. A Diffusion Model for Simulation Ready Coronary Anatomy with Morpho-skeletal Control

Author

Kadry, Karim, Gupta, Shreya, Sogbadji, Jonas, Schaap, Michiel, Petersen, Kersten, Mizukami, Takuya, Collet, Carlos, Nezami, Farhad R., and Edelman, Elazer R.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Virtual interventions enable the physics-based simulation of device deployment within coronary arteries. This framework allows for counterfactual reasoning by deploying the same device in different arterial anatomies. However, current methods to create such counterfactual arteries face a trade-off between controllability and realism. In this study, we investigate how Latent Diffusion Models (LDMs) can custom synthesize coronary anatomy for virtual intervention studies based on mid-level anatomic constraints such as topological validity, local morphological shape, and global skeletal structure. We also extend diffusion model guidance strategies to the context of morpho-skeletal conditioning and propose a novel guidance method for continuous attributes that adaptively updates the negative guiding condition throughout sampling. Our framework enables the generation and editing of coronary anatomy in a controllable manner, allowing device designers to derive mechanistic insights regarding anatomic variation and simulated device deployment., Comment: Accepted to ECCV 2024

Published
2024

2. Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

Author

Straughan, Ross, Kadry, Karim, Parikh, Sahil A., Edelman, Elazer R., and Nezami, Farhad R.

Subjects
Computer Science - Computational Engineering, Finance, and Science, Quantitative Biology - Tissues and Organs
Abstract

Despite recent advances in diagnosis and treatment, atherosclerotic coronary artery diseases remain a leading cause of death worldwide. Various imaging modalities and metrics can detect lesions and predict patients at risk; however, identifying unstable lesions is still difficult. Current techniques cannot fully capture the complex morphology-modulated mechanical responses that affect plaque stability, leading to catastrophic failure and mute the benefit of device and drug interventions. Finite Element (FE) simulations utilizing intravascular imaging OCT (Optical Coherence Tomography) are effective in defining physiological stress distributions. However, creating 3D FE simulations of coronary arteries from OCT images is challenging to fully automate given OCT frame sparsity, limited material contrast, and restricted penetration depth. To address such limitations, we developed an algorithmic approach to automatically produce 3D FE-ready digital twins from labeled OCT images. The 3D models are anatomically faithful and recapitulate mechanically relevant tissue lesion components, automatically producing morphologies structurally similar to manually constructed models whilst including more minute details. A mesh convergence study highlighted the ability to reach stress and strain convergence with average errors of just 5.9% and 1.6% respectively in comparison to FE models with approximately twice the number of elements in areas of refinement. Such an automated procedure will enable analysis of large clinical cohorts at a previously unattainable scale and opens the possibility for in-silico methods for patient specific diagnoses and treatment planning for coronary artery disease.

Published
2024
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5. Probing the Limits and Capabilities of Diffusion Models for the Anatomic Editing of Digital Twins

Author

Kadry, Karim, Gupta, Shreya, Nezami, Farhad R., and Edelman, Elazer R.

Subjects
Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Numerical simulations can model the physical processes that govern cardiovascular device deployment. When such simulations incorporate digital twins; computational models of patient-specific anatomy, they can expedite and de-risk the device design process. Nonetheless, the exclusive use of patient-specific data constrains the anatomic variability which can be precisely or fully explored. In this study, we investigate the capacity of Latent Diffusion Models (LDMs) to edit digital twins to create anatomic variants, which we term digital siblings. Digital twins and their corresponding siblings can serve as the basis for comparative simulations, enabling the study of how subtle anatomic variations impact the simulated deployment of cardiovascular devices, as well as the augmentation of virtual cohorts for device assessment. However, while diffusion models have been characterized in their ability to edit natural images, their capacity to anatomically edit digital twins has yet to be studied. Using a case example centered on 3D digital twins of cardiac anatomy, we implement various methods for generating digital siblings and characterize them through morphological and topological analyses. We specifically edit digital twins to introduce anatomic variation at different spatial scales and within localized regions, demonstrating the existence of bias towards common anatomic features. We further show that such anatomic bias can be leveraged for virtual cohort augmentation through selective editing, partially alleviating issues related to dataset imbalance and lack of diversity. Our experimental framework thus delineates the limits and capabilities of using latent diffusion models in synthesizing anatomic variation for in silico trials., Comment: 11 pages

Published
2023

6. A Diffusion Model for Simulation Ready Coronary Anatomy with Morpho-Skeletal Control

Author

Kadry, Karim, Gupta, Shreya, Sogbadji, Jonas, Schaap, Michiel, Petersen, Kersten, Mizukami, Takuya, Collet, Carlos, Nezami, Farhad R., Edelman, Elazer R., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Leonardis, Aleš, editor, Ricci, Elisa, editor, Roth, Stefan, editor, Russakovsky, Olga, editor, Sattler, Torsten, editor, and Varol, Gül, editor

Published
2025
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14. Validation study to determine the accuracy of central blood pressure measurement using the SphygmoCor XCEL cuff device in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Author

De la Torre Hernández, Jose M, Fernandez, Gabriela Veiga, Brown, Jonathan, Laso, Fermin Sainz, Lee, Dae‐Hyun, Fradejas, Victor, Camarero, Tamara Garcia, Elmariah, Sammy, Inglessis, Ignacio, Zueco, Javier, de Prada, Jose A Vazquez, Ben‐Assa, Eyal, and Edelman, Elazer R

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Transplantation, Cardiovascular, Clinical Research, Bioengineering, Aortic Valve Stenosis, Blood Pressure, Blood Pressure Determination, Humans, Hypertension, Transcatheter Aortic Valve Replacement, aortic stenosis, central aortic blood pressure, hypertension, transcatheter aortic valve replacement, Medical Biochemistry and Metabolomics, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Medical biochemistry and metabolomics
Abstract

Central aortic blood pressure could be helpful in the evaluation of patients with aortic stenosis (AS). The SphygmoCor XCEL device estimates central blood pressure (BP) measurement with its easy-to-use, operator-independent procedure. However, this device has not been properly validated against invasive measurement in patients with severe AS. We evaluated the relationship between cuff-brachial BP, transfer function-estimated and invasively measured central aortic pressure in patients with severe AS before and after transcatheter aortic valve replacement (TAVR). Agreement between techniques was analyzed and, according to the ARTERY Society recommendations, the minimum acceptable error was a mean difference ± SD ≤5 ± ≤8 mm Hg. A total of 94 patients with AS undergoing TAVR had simultaneous non-invasive and invasive measurements of central BP before and after the procedure. Before TAVR central systolic BP was in average slightly underestimated, though with wide variability, when using the default calibration of brachial-cuff SBP (mean difference ± SD, -3 ± 15 mm Hg), and after TAVR the degree of underestimation increased (mean difference ± SD, -9 ± 13 mm Hg). The agreement tended to improve for those patients with low aortic gradient stenosis compared to those with high gradient at baseline (mean difference ± SD, -2 ± 11 mm Hg vs. -4 ± 17, respectively, p = .3). The cuff-brachial systolic BP yielded numerically lower degree of agreement and weaker correlation with invasive measurements than SphygmoCor XCEL. In patients with severe AS the SphygmoCor XCEL cuff device, despite showing strong correlation, does not meet the ARTERY Society accuracy criteria for non-invasive measurement of central SBP.

Published
2021

22. A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis

Author

Rosalia, Luca, Ozturk, Caglar, Coll-Font, Jaume, Fan, Yiling, Nagata, Yasufumi, Singh, Manisha, Goswami, Debkalpa, Mauskapf, Adam, Chen, Shi, Eder, Robert A., Goffer, Efrat M., Kim, Jo H., Yurista, Salva, Bonner, Benjamin P., Foster, Anna N., Levine, Robert A., Edelman, Elazer R., Panagia, Marcello, Guerrero, Jose L., Roche, Ellen T., and Nguyen, Christopher T.

Published
2022
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24. Ventricular stroke work and vascular impedance refine the characterization of patients with aortic stenosis

Author

Ben-Assa, Eyal, Brown, Jonathan, Keshavarz-Motamed, Zahra, de la Torre Hernandez, Jose M, Leiden, Benjamin, Olender, Max, Kallel, Faouzi, Palacios, Igor F, Inglessis, Ignacio, Passeri, Jonathan J, Shah, Pinak B, Elmariah, Sammy, Leon, Martin B, and Edelman, Elazer R

Subjects
Clinical Research, Heart Disease, Cardiovascular, Aged, 80 and over, Aortic Valve Stenosis, Electric Impedance, Female, Heart Ventricles, Hemodynamics, Humans, Hypertension, Male, Pressure, Quality of Life, Biological Sciences, Medical and Health Sciences
Abstract

Aortic stenosis (AS) management is classically guided by symptoms and valvular metrics. However, the natural history of AS is dictated by coupling of the left ventricle, aortic valve, and vascular system. We investigated whether metrics of ventricular and vascular state add to the appreciation of AS state above valve gradient alone. Seventy patients with severe symptomatic AS were prospectively followed from baseline to 30 days after transcatheter aortic valve replacement (TAVR). Quality of life (QOL) was assessed using the Kansas City Cardiomyopathy Questionnaire. Left ventricular stroke work (SWLV) and vascular impedance spectrums were calculated noninvasively using in-house models based on central blood pressure waveforms, along with hemodynamic parameters from echocardiograms. Patients with higher preprocedural SWLV and lower vascular impedance were more likely to experience improved QOL after TAVR. Patients fell into two categories: those who did and those who did not exhibit increase in blood pressure after TAVR. In patients who developed hypertension (19%), vascular impedance increased and SWLV remained unchanged (impedance at zeroth harmonic: Z0, from 3964.4 to 4851.8 dyne·s/cm3, P = 0.039; characteristic impedance: Zc, from 376.2 to 603.2 dyne·s/cm3, P = 0.033). SWLV dropped only in patients who did not develop new hypertension after TAVR (from 1.58 to 1.26 J; P < 0.001). Reduction in valvular pressure gradient after TAVR did not predict change in SWLV (r = 0.213; P = 0.129). Reduction of SWLV after TAVR may be an important metric in management of AS, rather than relying solely on the elimination of transvalvular pressure gradients.

Published
2019

36. Optimization of 3D autologous chondrocyte-seeded polyglycolic acid scaffolds to mimic human ear cartilage

Author

Melgar-Lesmes, Pedro, Bosch, Oriol, Zubajlo, Rebecca, Molins, Gemma, Comfort, Sofia, Luque-Saavedra, Ainara, López-Moya, Mario, García-Polite, Fernando, Parri Ferrandis, Francisco José, Rogers, Carolyn, Gelabertó, Agata, Martorell, Jordi, Edelman, Elazer R., Balcells, Mercedes, Melgar-Lesmes, Pedro, Bosch, Oriol, Zubajlo, Rebecca, Molins, Gemma, Comfort, Sofia, Luque-Saavedra, Ainara, López-Moya, Mario, García-Polite, Fernando, Parri Ferrandis, Francisco José, Rogers, Carolyn, Gelabertó, Agata, Martorell, Jordi, Edelman, Elazer R., and Balcells, Mercedes

Abstract

Auricular reconstruction in children with microtia is one of the more complex procedures in plastic surgery. Obtaining sufficient native material to build an ear requires harvesting large fragments of rib cartilage in children. Herein, we investigated how to optimize autologous chondrocyte isolation, expansion and re-implantation using polyglycolic acid (PGA) scaffolds for generating enough cartilage to recapitulate a whole ear starting from a small ear biopsy. Ear chondrocytes isolated from human microtia subjects grew slower than microtia rib or healthy ear chondrocytes and displayed a phenotypic shift due to the passage number. Rabbit ear chondrocytes co-cultured with mesenchymal stem cells (MSC) at a 50 : 50 ratio recapitulated the cartilage biological properties in vitro. However, PGA scaffolds with different proportions of rabbit chondrocytes and MSC did not grow substantially in two months when subcutaneously implanted in immunosuppressed mice. In contrast, rabbit chondrocyte-seeded PGA scaffolds implanted in immunocompetent rabbits formed a cartilage 10 times larger than the original PGA scaffold. This cartilage mimicked the biofunctional and mechanical properties of an ear cartilage. These results indicate that autologous chondrocyte-seeded PGA scaffolds fabricated following our optimized procedure have immense potential as a solution for obtaining enough cartilage for auricular reconstruction and opens new avenues to redefine autologous cartilage replacement., European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación; National Institutes of Health

Published
2024

39. Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits

Author

Chowdhury, Mohammed M., Singh, Kanwarpal, Albaghdadi, Mazen S., Khraishah, Haitham, Mauskapf, Adam, Kessinger, Chase W., Osborn, Eric A., Kellnberger, Stephan, Piao, Zhonglie, Lino Cardenas, Christian L., Grau, Madeleine S., Jaff, Michael R., Rosenfield, Kenneth, Libby, Peter, Edelman, Elazer R., Lindsay, Mark E., Tearney, Guillermo J., and Jaffer, Farouc A.

Published
2020
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41. Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility

Author

Wu, Wei, Khan, Behram, Sharzehee, Mohammadali, Zhao, Shijia, Samant, Saurabhi, Watanabe, Yusuke, Murasato, Yoshinobu, Mickley, Timothy, Bicek, Andrew, Bliss, Richard, Valenzuela, Thomas, Iaizzo, Paul A., Makadia, Janaki, Panagopoulos, Anastasios, Burzotta, Francesco, Samady, Habib, Brilakis, Emmanouil S., Dangas, George D., Louvard, Yves, Stankovic, Goran, Dubini, Gabriele, Migliavacca, Francesco, Kassab, Ghassan S., Edelman, Elazer R., Chiastra, Claudio, and Chatzizisis, Yiannis S.

Published
2021
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47. Contributors

Author

Akyildiz, Ali C., primary, Antoniadis, Antonios P., additional, Athanasiou, Lambros S., additional, Barrett, Hilary E., additional, Billiar, Kristen, additional, Canet Soulas, Emmanuelle, additional, Cardoso, Luis, additional, Cawthon, Claire, additional, Chatzizisis, Yiannis S., additional, Chiastra, Claudio, additional, Cilla, Myriam, additional, Cloutier, Guy, additional, Coppel, Ricardo, additional, Demos, Catherine, additional, Dérimay, François, additional, Dubini, Gabriele, additional, Edelman, Elazer R., additional, Ehman, Richard L., additional, Finet, Gérard, additional, Fok, Pak-Wing, additional, Gasser, T. Christian, additional, Giddens, Don P., additional, Gijsen, Frank J.H., additional, Goerlich, Erin, additional, Gómez, Armida, additional, Goudot, Guillaume, additional, Guo, Xiaoya, additional, Hays, Allison G., additional, Hedin, Ulf, additional, Holzapfel, Gerhard A., additional, Jia, Haibo, additional, Jo, Hanjoong, additional, Kamm, Roger D., additional, Kassab, Ghassan S., additional, Kolipaka, Arunark, additional, Konofagou, Elisa E., additional, Lagache, Manuel, additional, Latorre, Álvaro T., additional, Le Floc'h, Simon, additional, Lehoux, Stephanie, additional, Ma, Genshan, additional, Maehara, Akiko, additional, Malvè, Mauro, additional, Martiel, Jean-Louis, additional, Martínez, Miguel A., additional, Matsumoto, Takeo, additional, Matsumura, Mitsuaki, additional, Migliavacca, Francesco, additional, Mintz, Gary S., additional, Mohammad Mirzaei, Navid, additional, Molony, David, additional, Nezami, Farhad Rikhtegar, additional, Ohayon, Jacques, additional, Oshinski, John N., additional, Peña, Estefanía, additional, Pernot, Mathieu, additional, Pettigrew, Roderic I., additional, Pomeroy, William L., additional, Rioufol, Gilles, additional, Roy, Joy, additional, Samady, Habib, additional, Shelton, Sarah E., additional, Stuber, Matthias, additional, Tacheau, Antoine, additional, Tamargo, Ian, additional, Tang, Dalin, additional, Timmins, Lucas H., additional, Turner, Emily A., additional, Wang, Liang, additional, Weinbaum, Sheldon, additional, Weiss, Robert G., additional, White, Richard D., additional, Yang, Chun, additional, Yazdani, Saami K., additional, Zheng, Jie, additional, and Zhu, Jian, additional

Published
2021
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50. Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome.

Author

Gordon, Leslie B., Basso, Sammy, Maestranzi, Justine, Aikawa, Elena, Clift, Cassandra L., Cammardella, Antonio Giovanni, Danesi, Tommaso Hinna, del Nido, Pedro J., Edelman, Elazer R., Hamdy, Abeer, Hegde, Sheila M., Kleinman, Monica E., Maschietto, Nicola, Mehra, Mandeep R., Mukundan, Srinivasan, Musumeci, Francesco, Russo, Marco, Rybicki, Frank J., Shah, Pinak Bipin, and Suarez, William A.

Published
2024
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