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9 results on '"Eddy, Jared J"'

1. Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease

Author

Strnad, Luke, Varley, Cara, Lapidus, Jodi, Philley, Julie, McShane, Pamela, Devine, Megan, Griffith, David E., Kasperbauer, Shannon H., Huitt, Gwen, Eddy, Jared J., Marras, Theodore K., Brode, Sarah K., Addrizzo-Harris, Dorreen, Springer, Amy, Flume, Patrick, Mingora, Christina, Alkabab, Yursa, Dorman, Susan, Naureckas, Ted, Aksamit, Timothy R., Ruoss, Stephen, Hornick, Douglas B., Mirsaeidi, Mehdi, Salathe, Matthias, Waller, Stephen, Schmid, Andreas, ElMaraachli, Wael, Cowell, Anne, Thakur, Neeta, Nahid, Payam, Zha, Shoshana, Ignatius, Elisa H., Zenilman, Jonathan, Cohen, Keira, Belz, Daniel C., Ali, Juzar, Lapinel, Nicole, Swenson, Colin, Kapolka, Rebecca, Horne, David, Salerno, Daniel, DiMango, Angela, Moretta, Dafne, Tan, Laren, Furukawa, Brian, Wysham, Nicholas, Noone, Peader, Daniels, Leigh Anne, Chris Saddler, Misch, Elizabeth Ann, Hayes, Lisa, Epstein, Marcia, Kim, Angela, Myers, Janet N., Henkle, Emily, Quittner, Alexandra L., Dieckmann, Nathan F., Franklin, Heather, Brunton, Amanda E., Daley, Charles L., and Winthrop, Kevin L.

Published
2023
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5. Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium aviumComplex Pulmonary Disease

Author

Henkle, Emily, Quittner, Alexandra L., Dieckmann, Nathan F., Franklin, Heather, Brunton, Amanda E., Daley, Charles L., Winthrop, Kevin L., Strnad, Luke, Varley, Cara, Lapidus, Jodi, Philley, Julie, McShane, Pamela, Devine, Megan, Griffith, David E., Kasperbauer, Shannon H., Huitt, Gwen, Eddy, Jared J., Marras, Theodore K., Brode, Sarah K., Addrizzo-Harris, Dorreen, Springer, Amy, Flume, Patrick, Mingora, Christina, Alkabab, Yursa, Dorman, Susan, Naureckas, Ted, Aksamit, Timothy R., Ruoss, Stephen, Hornick, Douglas B., Mirsaeidi, Mehdi, Salathe, Matthias, Waller, Stephen, Schmid, Andreas, ElMaraachli, Wael, Cowell, Anne, Thakur, Neeta, Nahid, Payam, Zha, Shoshana, Ignatius, Elisa H., Zenilman, Jonathan, Cohen, Keira, Belz, Daniel C., Ali, Juzar, Lapinel, Nicole, Swenson, Colin, Kapolka, Rebecca, Horne, David, Salerno, Daniel, DiMango, Angela, Moretta, Dafne, Tan, Laren, Furukawa, Brian, Wysham, Nicholas, Noone, Peader, Daniels, Leigh Anne, Saddler, Chris, Misch, Elizabeth Ann, Hayes, Lisa, Epstein, Marcia, Kim, Angela, and Myers, Janet N.

Abstract

Nontuberculous mycobacteria (NTM), predominately Mycobacterium aviumcomplex (MAC), cause chronic pulmonary disease. Improvements in symptoms and health-related quality of life (HRQoL) are important treatment outcomes, but no validated patient-reported outcome (PRO) measure exists.

Published
2023
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6. Characteristics and Outcomes of Ambulatory Patients with Suspected COVID-19 at a Respiratory Referral Center

Author

Guntur, Vamsi P., primary, Modena, Brian D., additional, Manka, Laurie A., additional, Eddy, Jared J., additional, Liao, Shu-Yi, additional, Goldstein, Nir M., additional, Zelarney, Pearlanne, additional, Horn, Carrie A., additional, Keith, Rebecca C., additional, Make, Barry J., additional, Petrache, Irina, additional, and Wechsler, Michael E., additional

Published
2021
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9. Enhanced Human Immunodeficiency Virus-1 Replication in CD4+ T Cells Derived From Individuals With Latent Mycobacterium tuberculosis Infection.

Author

He, Xianbao, Eddy, Jared J, Jacobson, Karen R, Henderson, Andrew J, and Agosto, Luis M

Subjects
*AIDS, *T cells, *MYCOBACTERIUM tuberculosis, *MYCOBACTERIAL diseases, *BLOOD plasma, *TUBERCULOUS meningitis
Abstract

Background Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) coinfection increases mortality, accelerates progression to acquired immune deficiency syndrome, and exacerbates tuberculosis disease. However, the impact of pre-existing Mtb infection on subsequent HIV infection has not been fully explored. We hypothesized that Mtb infection creates an immunological environment that influences the course of HIV infection, and we investigated whether pre-existing Mtb infection impacts the susceptibility of CD4+ T cells to HIV-1 infection. Methods Plasma and blood CD4+ T cells isolated from HIV-negative individuals across the Mtb infection spectrum and non-Mtb-infected control individuals were analyzed for inflammation markers and T-cell phenotypes. CD4+ T cells were infected with HIV-1 in vitro and were monitored for viral replication. Results We observed differences in proinflammatory cytokines and the relative proportion of memory T-cell subsets depending on Mtb infection status. CD4+ T cells derived from individuals with latent Mtb infection supported more efficient HIV-1 transcription, release, and replication. Enhanced HIV-1 replication correlated with higher percentages of CD4+ TEM and TTD cells. Conclusions Pre-existing Mtb infection creates an immunological environment that reflects Mtb infection status and influences the susceptibility of CD4+ T cells to HIV-1 replication. These findings provide cellular and molecular insights into how pre-existing Mtb infection influences HIV-1 pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2020
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