349 results on '"Eddy, Allison"'
Search Results
2. Lessons learned from regional training of paediatric nephrology fellows in Africa
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McCulloch, Mignon I., Argent, Andrew C., Morrow, Brenda, Nourse, Peter, Coetzee, Ashton, Du Buisson, Christel, Reddy, Deveshni, Buckley, Jonathan, Sinclair, Paul J., Gajjar, Priya, Semanska, Lucie, Eddy, Allison, Feehally, John, Cano, Francisco, and Warady, Bradley A.
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- 2023
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3. Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study
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Zhang, Yifan, Gutman, Talia, Tong, Allison, Craig, Jonathan C., Sinha, Aditi, Dart, Allison, and Eddy, Allison A.
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Psychiatric counseling -- Surveys -- Usage ,Chronic kidney failure -- Surveys -- Care and treatment ,Health education -- Surveys -- Usage ,Chronically ill children -- Surveys -- Care and treatment -- Psychological aspects ,Pediatric research ,Caregivers -- Surveys ,Health - Abstract
Background Children with chronic kidney disease (CKD) generally have worse educational and psychosocial outcomes compared with their healthy peers. This can impair their ability to manage their treatment, which in turn can have long-term health consequences through to adulthood. We attempted to capture the experiences of children with CKD and to describe the perspectives of their parents and caregivers on access to educational and psychosocial support. Methods Children with CKD (n = 34) and their caregivers (n = 62) were sampled via focus groups from pediatric hospitals in Australia, Canada, and the USA. Sixteen focus groups were convened and the transcripts were analyzed thematically. Results We identified four themes: disruption to self-esteem and identity (emotional turmoil of adolescence, wrestling with the sick self, powerlessness to alleviate child's suffering, balancing normality and protection); disadvantaged by lack of empathy and acceptance (alienated by ignorance, bearing the burden alone); a hidden and inaccessible support system (excluded from formal psychological support, falling behind due to being denied special considerations); and building resilience (finding partners in the journey, moving towards acceptance of the illness, re-establishing childhood). Conclusions Children with CKD and their caregivers encountered many barriers in accessing psychosocial and educational support and felt extremely disempowered and isolated as a consequence. Improved availability and access to psychosocial and educational interventions are needed to improve the wellbeing and educational advancement of children with CKD. Graphical Abstract A higher resolution version of the Graphical abstract is available as Supplementary information., Author(s): Yifan Zhang [sup.1] , Talia Gutman [sup.1] [sup.2] , Allison Tong [sup.1] [sup.2] , Jonathan C. Craig [sup.3] , Aditi Sinha [sup.4] , Allison Dart [sup.5] , Allison A. [...]
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- 2023
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4. Global Health Training Opportunities in North American Nephrology Fellowships
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Rope, Robert, Perl, Jeffrey, Anand, Shuchi, Board, International Society of Nephrology North American and Caribbean Regional, Kalantar-Zadeh, Kamyar, Levin, Adeera, Fogo, Agnes, Cheung, Alfred, Eddy, Allison, Garg, Amit, Kasiske, Bertram, Barton, Everard, Finkelstein, Fredric, Bargman, Joanne, Gill, John, Cerda, Jorge, Bonventre, Joseph, Ingelfinger, Julie, Yeates, Karen, Sotomayor, Karina, Berend, Kenrick, Sharma, Kumar, Dworkin, Lance, Tonelli, Marcello, Weir, Matthew, Rocco, Michael, Trask, Michele, Wolf, Myles, Mehta, Ravindra, Harris, Raymond, Andreoli, Sharon, Shankland, Stuart, Quaggin, Susan, and Vachharajani, Tushar
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Biomedical and Clinical Sciences ,Health Sciences ,International Society of Nephrology North American and Caribbean Regional Board ,Biomedical and clinical sciences ,Health sciences - Published
- 2019
5. Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop
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Tong, Allison, Manns, Braden, Wang, Angela Yee Moon, Hemmelgarn, Brenda, Wheeler, David C, Gill, John, Tugwell, Peter, Pecoits-Filho, Robert, Crowe, Sally, Harris, Tess, Van Biesen, Wim, Winkelmayer, Wolfgang C, Levin, Adeera, Thompson, Aliza, Perkovic, Vlado, Ju, Angela, Gutman, Talia, Bernier-Jean, Amelie, Viecelli, Andrea K, O’Lone, Emma, Shen, Jenny, Josephson, Michelle A, Cho, Yeoungjee, Johnson, David W, Sautenet, Bénédicte, Tonelli, Marcello, Craig, Jonathan C, Investigators, SONG Implementation Workshop, Craig, Jonathan, Wang, Angela, Wheeler, David, Pecoits-Filho, Roberto, van Biesen, Wim, Winkelmayer, Wolfgang, Sinha, Aditi, Ong, Albert, Denny, Alexis, Dart, Allison, Eddy, Allison, Kelly, Amy, Viecelli, Andrea, Davenport, Andrew, Narva, Andrew, Sharma, Ankit, Warrens, Anthony, Chapman, Arlene, Teixeira-Pinto, Armando, Kelly, Ayano, Murphy, Barbara, Sautenet, Benedicte, Padilla, Benita, Canaud, Bernard, Pullin, Brian, Schiller, Brigitte, Robinson, Bruce, Hanson, Camilla, Hawley, Carmel, Logeman, Charlotte, Lok, Charmaine, Wanner, Christoph, Herzog, Chuck, Rutherford, Claudia, Ahn, Curie, Sumpton, Daniel, Rosenbloom, David, Harris, David, Baron, David, Johnson, David, White, David, Gipson, Debbie, Fouque, Denis, Eilers, Denise, Bockenhauer, Detlef, O'Donoghue, Donal, Chen, Dongping, Dunning, Dyke, Brown, Edwina, Bavlovlenkov, Elena, Mannon, Elinor, Poggio, Emilo, O'Lone, Emma, Chemla, Eric, Dobbels, Fabienne, Zannad, Faiez, Caskey, Fergus, Tentori, Francesca, Hurst, Frank, Schaefer, Franz, and Wong, Germaine
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Clinical Trials and Supportive Activities ,Kidney Disease ,Clinical Research ,Comparative Effectiveness Research ,Renal and urogenital ,Generic health relevance ,Good Health and Well Being ,Consensus ,Endpoint Determination ,Humans ,Randomized Controlled Trials as Topic ,Renal Insufficiency ,Chronic ,Research Design ,Stakeholder Participation ,Treatment Outcome ,core outcome sets ,implementation ,kidney disease ,outcomes ,patient-centered care ,trials ,SONG Implementation Workshop Investigators ,Clinical Sciences ,Urology & Nephrology - Abstract
There are an estimated 14,000 randomized trials published in chronic kidney disease. The most frequently reported outcomes are biochemical endpoints, rather than clinical and patient-reported outcomes including cardiovascular disease, mortality, and quality of life. While many trials have focused on optimizing kidney health, the heterogeneity and uncertain relevance of outcomes reported across trials may limit their policy and practice impact. The international Standardized Outcomes in Nephrology (SONG) Initiative was formed to identify core outcomes that are critically important to patients and health professionals, to be reported consistently across trials. We convened a SONG Implementation Workshop to discuss the implementation of core outcomes. Eighty-two patients/caregivers and health professionals participated in plenary and breakout discussions. In this report, we summarize the findings of the workshop in two main themes: socializing the concept of core outcomes, and demonstrating feasibility and usability. We outline implementation strategies and pathways to be established through partnership with stakeholders, which may bolster acceptance and reporting of core outcomes in trials, and encourage their use by end-users such as guideline producers and policymakers to help improve patient-important outcomes.
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- 2018
6. Impact of training nephrologists from developing nations and strategies for sustaining a training program in its fourth decade
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Okpechi, Ikechi G., Eddy, Allison A., Jha, Vivekanand, Jacob, Thomas, Dupuis, Sophie, and Harris, David C.
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- 2021
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7. Drug-induced tubulointerstitial nephritis: hypersensitivity and necroinflammatory pathways
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Eddy, Allison A.
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Nephritis -- Causes of -- Complications and side effects ,Chronic kidney failure -- Risk factors ,Drugs -- Adverse and side effects ,Pediatric research ,Health - Abstract
More than 250 drugs carry a small but important dose-independent risk of initiating a delayed-type hypersensitivity reaction that leads to acute tubulointerstitial nephritis (TIN). Clinical manifestations are often non-specific, making epidemiological studies challenging. In severe cases, if cessation of the offending drug is not followed by a prompt improvement in renal function, corticosteroid therapy appears to enhance renal recovery rates. Other drugs, classified as potential nephrotoxins, may induce dose-dependent acute tubular necrosis. Studies over the past decade have identified a unique form of tubular cell death called 'necroptosis' that is accompanied by a specific and significant interstitial inflammatory response to certain insults, including some nephrotoxins. Insights into the molecular basis of this necroinflammatory pathway have emerged. There is still a paucity of pediatric data on these two distinct types of drug-induced TIN. Early recognition is essential to minimize the risk of chronic kidney damage., Author(s): Allison A. Eddy [sup.1] [sup.2] Author Affiliations: (1) grid.414137.4, 0000 0001 0684 7788, Department of Pediatrics, University of British Columbia and BC Children's Hospital Research Institute, , Vancouver, Canada [...]
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- 2020
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8. Interstitial Nephritis in Children
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Verghese, Priya S., Luckritz, Kera E., Eddy, Allison A., Geary, Denis F., editor, and Schaefer, Franz, editor
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- 2016
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9. Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease
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Chong, Lauren S.H., Sautenet, Benedicte, Tong, Allison, Hanson, Camilla S., Samuel, Susan, Zappitelli, Michael, Dart, Allison, Furth, Susan, Eddy, Allison A., Groothoff, Jaap, Webb, Nicholas J.A., Yap, Hui-Kim, Bockenhauer, Detlef, Sinha, Aditi, Alexander, Stephen I., Goldstein, Stuart L., Gipson, Debbie S., Raman, Gayathri, and Craig, Jonathan C.
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- 2017
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10. Perspectives of Clinicians on Shared Decision Making in Pediatric CKD: A Qualitative Study
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Kerklaan, Jasmijn, primary, Hanson, Camilla S., additional, Carter, Simon, additional, Tong, Allison, additional, Sinha, Aditi, additional, Dart, Allison, additional, Eddy, Allison A., additional, Guha, Chandana, additional, Gipson, Debbie S., additional, Bockenhauer, Detlef, additional, Hannan, Elyssa, additional, Yap, Hui-Kim, additional, Groothoff, Jaap, additional, Zappitelli, Michael, additional, Amir, Noa, additional, Alexander, Stephen I., additional, Furth, Susan L., additional, Samuel, Susan, additional, Gutman, Talia, additional, and Craig, Jonathan C., additional
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- 2022
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11. Pathophysiology of Progressive Renal Disease
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Eddy, Allison, Avner, Ellis, editor, Harmon, William, editor, Niaudet, Patrick, editor, and Yoshikawa, Norishige, editor
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- 2009
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12. Child and caregiver perspectives on access to psychosocial and educational support in pediatric chronic kidney disease: a focus group study
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Zhang, Yifan, primary, Gutman, Talia, additional, Tong, Allison, additional, Craig, Jonathan C., additional, Sinha, Aditi, additional, Dart, Allison, additional, Eddy, Allison A., additional, Gipson, Debbie S., additional, Bockenhauer, Detlef, additional, Yap, Hui-Kim, additional, Groothoff, Jaap, additional, Zappitelli, Michael, additional, J.A.Webb, Nicholas, additional, Alexander, Stephen I., additional, Furth, Susan, additional, Samuel, Susan, additional, Blydt-Hansen, Tom D., additional, Dionne, Janis, additional, Michael, Mini, additional, Wenderfer, Scott E., additional, Winkelmayer, Wolfgang C., additional, McTaggart, Steven, additional, Walker, Amanda, additional, Zimmerman, Cortney T., additional, Ralph, Angelique F., additional, Ju, Angela, additional, James, Laura J., additional, and Hanson, Camilla S., additional
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- 2022
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13. Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology—Children and Adolescents (SONG-KIDS) consensus workshops
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Guha, Abhjit, Solarin, Adaobi, Sinha, Aditi, Platona, Adriana, Hamilton, Alexander, Woods-Barnard, Alice, Neu, Alicia, Tong, Allison, Dart, Allison, Eddy, Allison, Karathanas, Alyssa, Baumgart, Amanda, Fielding, Amelia, LePage, Amelia, Bernier-Jean, Amelie, Kelly, Amy, Teixeira, Ana, Viecelli, Andrea, Matus, Andrea, Narva, Andrew, Ju, Angela, Wang, Angela Yee-Moon, Sharma, Ankit, Fielding, Anna, Francis, Anna, Meza, Anthony, Fielding, Aria, Teixeira-Pinto, Armando, Bagga, Arvind, Jankauskienė, Augustina, Kelly, Ayano, Gillespie, Barbara, Sautenet, Benedicte, Vogt, Beth, Foster, Bethany, Warady, Bradley, Dixon, Bradley, Manns, Braden, Hemmelgarn, Brenda, Bscardark, Brittney, Romeo, Brooklyn, Hanson, Camilla, Meza, Carlos, Brockett, Carter, Guha, Chandana, Prestidge, Chanel, Logeman, Charlotte, Green, Charmaine, Sanchez-Kazi, Cheryl, Perkins, Christy, Schmitt, Claus Peter, Fielding, Craig, Settee, Craig, Sumpton, Daniel, Meza, Daniel, Karathanas, Darien, Harris, David, Wheeler, David, Hooper, David, Gipson, Debbie, Geary, Denis, Bockenhauer, Detlef, Haffner, Dieter, Mekahli, Djalila, Drozdz, Dorota, Romeo, Ed, Ku, Elaine, Urbina, Elaine, Levtchenko, Elena, Balovlenkov, Elena, Hodson, Elisabeth, Morales, Emily, O'Lone, Emma, Machuca, Emma, Carlton, Emmah, Au, Eric, Olver, Erin, Morales, Estefania, Mirza, Fatima, Mackie, Fiona, Tentori, Francesca, Schaefer, Franz, Higgins, Gail, Deschenes, Georges, Plunkett, Georgia, Yoder, Gerilyn, Wong, Germaine, Morales, Giselle, Germino, Greg, Desmond, Hailey, Perkins, Hayley, Mitchell-Smith, Harrison, Coolican, Helen, Xu, Hong, Yap, Hui-Kim, Anochie, Ifeoma, Ha, Il-Soo, Davis, Ira, Liu, Isaac, Samaniego, Israel, Groothoff, Jaap, Machuca, Jaime, Machuca, James, Kerklaan, Jasmijn, Brockett, Jeff, Norton, Jenna, Shen, Jenny, Goebel, Jens, Rao, Jia, Machuca, Jimmy, Mitchell-Smith, Jo, Watson, Jo, Gill, John, Craig, Jonathan, Flynn, Joseph T., Kausman, Joshua, Samuels, Joshua, Bacchetta, Justine, Yoder, Kaleb, Manera, Karine, Azukaitis, Karolis, Twombley, Katherine, McMichael, Kelly-Ann, Ishikura, Kenji, Romeo, Kennedy, Settee, Kevin, Van, Kim Linh, McMichael, Lachlan, Trinh, Lany, Greenbaum, Larry, Sanchez, Laura, Fielding, Leo, Rees, Lesley, Lippincott, Leslie, Mejia-Saldivar, Levi, Saldivar, Lidia, Guay-Woodford, Lisa, Samaniego, Lizett, Hamiwka, Lorraine, Bell, Lorraine, Dunn, Louese, Barry, Lucinda, Macauley, Luke, Holmes, Luke, Karathanas, Madelynn, Mitchell-Smith, Madison, Walker, Mandy, Benavides, Manuel, Tonelli, Marcello, Ferris, Maria, Vivarelli, Marina, Wolfenden, Mark, Howell, Martin, Christian, Martin, Schreiber, Martin, Moxey-Mims, Marva, Leonard, Mary, Karathanas, Matthew, Pearl, Meghan, Natatmadja, Melissa, Brockett, Melissa, Bonilla-Felix, Melvin, Atkinson, Meredith, Zappitelli, Michael, Baum, Michel, Rheault, Michelle, McCulloch, Mignon, Matsuda-Abedini, Mina, Michael, Mini, Khan, Mohammad, Salih, Mohammad, Carlton, Mycah Ann, Benador, Nadine, Plunkett, Ngairre, Webb, Nick, Scholes-Robertson, Nicki, Larkins, Nicolas, Evangelidis, Nicole, Yoder, Nigel, Meza, Norma, Olver, Paige, Carlton, Paiyton, Brophy, Patrick, Tugwell, Peter, Cochat, Pierre, Mehrotra, Rajnish, Wolfenden, Raphael, Gbadegesin, Rasheed, Benavides, Raymond, Johnson, Rebecca, Morales, Ricardo, Jr., McGee, Richard, Fish, Richard, Gardos, Robert, Pecoits-Filho, Roberto, Vargas, Rocio, Saldivar, Rodolfo, Coppo, Rosanna, Shroff, Rukshana, Raina, Rupesh, Youssouf, Sajeda, Crowe, Sally, Anumudu, Samaya, Chan, Samuel, Baldacchino, Sarah, Wenderfer, Scott, Wolfenden, Sebastian, Carlton, Selah, Sutton, Shanna, Murphy, Shannon, Teo, Sharon, Salih, Sheyma, Sahney, Shobha, Carlton, Silas, Carter, Simon, Pearson, Simone, Khan, Simra, Wilson, Skyla, Sharma, Sonia, Alexander, Stephen, Marks, Stephen, Cornish, Stephen, Goldstein, Stuart, Samuel, Susan, Furth, Susan, Mendley, Susan, Lippincott, Susan, Charles, Symone, Gutman, Talia, Mitchell-Smith, Terri, Harris, Tess, Vetter, Thorsten, Carlton, Tiffany, Carlton, Timothy, Querfeld, Uwe, Saglimbene, Valeria, Charles, Virginia, van Biesen, Wim, Winkelmayer, Wolfgang, Machuca, Yenissey, Cho, Yeoungjee, Salih, Yusuf, Anh, Yo Han, Perkins, Zachary, Salih, Zeynab, Hanson, Camilla S., Craig, Jonathan C., Eddy, Allison A., Gipson, Debbie S., Webb, Nicholas J.A., Alexander, Stephen I., Furth, Susan L., Viecelli, Andrea K., Au, Eric H., Shen, Jenny I., Manera, Karine E., Carter, Simon A., and Walker, Amanda
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- 2020
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14. The impact of small kidneys
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Matsell, Douglas G., Cojocaru, Dan, Matsell, Eli W., and Eddy, Allison A.
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Dysplasia -- Research -- Risk factors ,Chronic kidney failure -- Research -- Risk factors -- Development and progression -- Care and treatment ,Health - Abstract
Background Small kidneys due to renal hypodysplasia (RHD) result from a decrease in nephron number. The objectives of this study were to identify clinical variables that determine long-term renal outcome in children with RHD and to define the role of kidney size as a predictor of developing end-stage renal disease (ESRD). Methods This was a single-center retrospective cohort analysis. The primary outcome was development of ESRD. We identified 202 RHD cases, with 25 (12 %) reaching ESRD at mean age of 8.9 (±6.6) years. Results Children with RHD with a known genetic syndrome had the smallest kidneys while those with posterior urethral valves (PUV) had the largest kidneys at diagnosis. Cases with bilateral RHD were most likely to develop ESRD. Younger gestational age (OR 0.8, CI 0.69-0.99, p = 0.05), smaller kidney size at diagnosis (OR 0.13, CI 0.03-0.47, p = 0.002), lower best-estimated glomerular filtration rate (eGFR) (OR 0.74, CI 0.58-0.93, p = 0.01), proteinuria (OR 1.03, CI 1.01-1.05, p < 0.001) and high blood pressure (OR 1.02, CI 1.01-1.04, p = 0.01) were associated with development of ESRD, while kidney size at diagnosis was independently associated with ESRD (HR 0.03, CI 0.01-0.72, p = 0.043). Conclusions In children with RHD, kidney size at diagnosis predicts the likelihood of developing ESRD. Electronic supplementary material The online version of this article (doi:10.1007/s00467-015-3079-5) contains supplementary material, which is available to authorized users., Author(s): Douglas G. Matsell[sup.1] [sup.2] [sup.3] [sup.4] , Dan Cojocaru[sup.1] , Eli W. Matsell[sup.1] , Allison A. Eddy[sup.1] [sup.2] [sup.3] [sup.4] Author Affiliations: (1) Department of Pediatrics, British Columbia Children's [...]
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- 2015
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15. Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy
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Zhang, Guoqiang, Thomas, Alison L, Marshall, Amanda L, Kernan, Kelly A, Su, Yanyuan, Zheng, Yi, Takano, Jiro, Saido, Takaomi C, and Eddy, Allison A
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- 2011
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16. Acute kidney injury and its association with in-hospital mortality among children with acute infections
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Imani, Peace D., Odiit, Amos, Hingorani, Sangeeta R., Weiss, Noel S., and Eddy, Allison A.
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Children -- Diseases ,Mortality -- Statistics -- Risk factors -- United States -- Canada ,Acute renal failure -- Distribution -- Diagnosis ,Hospital patients -- Demographic aspects -- Care and treatment ,Acute renal failure in children -- Distribution -- Diagnosis ,Company distribution practices ,Health - Abstract
Background We investigated prevalence of acute kidney injury (AKI) at hospitalization and its association with in-hospital mortality among Ugandan children hospitalized with common acute infections, and predictors of mortality among AKI children. Methods We enrolled 2,055 children hospitalized with primary diagnoses of acute gastroenteritis, malaria, or pneumonia. Serum creatinine, albumin, electrolytes, hemoglobin, and urine protein were obtained on admission. Participants were assessed for AKI based on serum creatinine levels. Demographic and clinical data were obtained using a primary care provider survey and medical chart review. Logistic regression was used to determine predictors of in-hospital mortality. Results A total of 278 (13.5%) of children had AKI on admission; for 76.2%, AKI was stage 2 (98/278) or stage 3 (114/278) defined as serum creatinine > 2- or 3-fold above normal upper limit for age, respectively. AKI prevalence was particularly high in gastroenteritis (28.6%) and underweight children (20.7%). Twenty-five percent of children with AKI died during hospitalization, compared to 9.9% with no AKI (adjusted odds ratio (aOR) 3.5 (95% CI, 2.2-5.5)). In-hospital mortality risk did not differ by AKI stage. Predictors of in-hospital mortality among AKI children included primary diagnosis of pneumonia, aOR 4.5 (95% CI, 1.8-11.2); proteinuria, aOR = 2.1 (95% CI, 1.0-4.9) and positive human immunodeficiency virus (HIV) status, aOR 5.0 (95% CI, 2.0-12.9). Conclusions Among children hospitalized with gastroenteritis, malaria, or pneumonia, AKI at admission was common and associated with high in-hospital mortality. Keywords Acute kidney injury * Acute infections * Children * Mortality * Uganda, Introduction Acute kidney injury (AKI) can develop as a complication of serious acute illnesses. While it is known to be associated with increased mortality, most published pediatric data are based [...]
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- 2013
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17. Phase 1 Trial of Adalimumab in Focal Segmental Glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) Study Group
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Joy, Melanie S., Gipson, Debbie S., Powell, Leslie, MacHardy, Jacqueline, Jennette, J. Charles, Vento, Suzanne, Pan, Cynthia, Savin, Virginia, Eddy, Allison, Fogo, Agnes B., Kopp, Jeffrey B., Cattran, Daniel, and Trachtman, Howard
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- 2010
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18. Patient and caregiver perspectives on blood pressure in children with chronic kidney disease.
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Wu, Justin Guang-Ao, Tong, Allison, Evangelidis, Nicole, Manera, Karine E, Hanson, Camilla S, Baumgart, Amanda, Amir, Noa, Sinha, Aditi, Dart, Allison, Eddy, Allison A, Guha, Chandana, Gipson, Debbie S, Bockenhauer, Detlef, Yap, Hui-Kim, Groothoff, Jaap, Zappitelli, Michael, Alexander, Stephen I, Furth, Susan L, Samuel, Susan, and Carter, Simon A
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BLOOD pressure ,PEDIATRIC nephrology ,CHRONIC kidney failure ,PATIENTS' attitudes ,PATIENT-centered care ,CARDIOVASCULAR diseases ,KIDNEY failure - Abstract
Background More than 50% of children with chronic kidney disease (CKD) have uncontrolled hypertension, increasing their long-term risk of cardiovascular disease and progression to kidney failure. Children receiving medications or dialysis may also experience acute blood pressure fluctuations accompanied by debilitating symptoms. We aimed to describe the perspectives of children with CKD and their parental caregivers on blood pressure to inform patient-centered care. Methods Secondary thematic analysis was conducted on qualitative data from the Standardized Outcomes in Nephrology—Children and Adolescents initiative, encompassing 16 focus groups, an international Delphi survey and two consensus workshops. We analyzed responses from children with CKD (ages 8–21 years) and caregivers (of children ages 0–21 years) pertaining to blood pressure. Results Overall, 120 patients and 250 caregivers from 22 countries participated. We identified five themes: invisibility and normalization (reassured by apparent normotension, absence of symptoms and expected links with CKD), confused by ambiguity (hypertension indistinguishable from cardiovascular disease, questioning the need for prophylactic intervention, frustrated by inconsistent messages and struggling with technical skills in measurement), enabling monitoring and maintaining health (gaging well-being and preventing vascular complications), debilitating and constraining daily living (provoking anxiety and agitation, helpless and powerless and limiting life activities) and burden of medications (overwhelmed by the quantity of tablets and distress from unexpected side effects). Conclusions For children with CKD and their caregivers, blood pressure was an important heath indicator, but uncertainty around its implications and treatment hampered management. Providing educational resources to track blood pressure and minimizing symptoms and treatment burden may improve outcomes in children with CKD. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Patient and caregiver perspectives on blood pressure in children with chronic kidney disease
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Wu, Justin Guang-Ao, primary, Tong, Allison, additional, Evangelidis, Nicole, additional, Manera, Karine E, additional, Hanson, Camilla S, additional, Baumgart, Amanda, additional, Amir, Noa, additional, Sinha, Aditi, additional, Dart, Allison, additional, Eddy, Allison A, additional, Guha, Chandana, additional, Gipson, Debbie S, additional, Bockenhauer, Detlef, additional, Yap, Hui-Kim, additional, Groothoff, Jaap, additional, Zappitelli, Michael, additional, Alexander, Stephen I, additional, Furth, Susan L, additional, Samuel, Susan, additional, Carter, Simon A, additional, Walker, Amanda, additional, Kausman, Joshua, additional, Martinez-Martin, David, additional, Gutman, Talia, additional, and Craig, Jonathan C, additional
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- 2021
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20. Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology—Children and Adolescents (SONG-KIDS) consensus workshops
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Hanson, Camilla S., primary, Craig, Jonathan C., additional, Logeman, Charlotte, additional, Sinha, Aditi, additional, Dart, Allison, additional, Eddy, Allison A., additional, Guha, Chandana, additional, Gipson, Debbie S., additional, Bockenhauer, Detlef, additional, Yap, Hui-Kim, additional, Groothoff, Jaap, additional, Zappitelli, Michael, additional, Webb, Nicholas J.A., additional, Alexander, Stephen I., additional, Furth, Susan L., additional, Samuel, Susan, additional, Neu, Alicia, additional, Viecelli, Andrea K., additional, Ju, Angela, additional, Sharma, Ankit, additional, Au, Eric H., additional, Desmond, Hailey, additional, Shen, Jenny I., additional, Manera, Karine E., additional, Azukaitis, Karolis, additional, Dunn, Louese, additional, Carter, Simon A., additional, Gutman, Talia, additional, Cho, Yeoungjee, additional, Walker, Amanda, additional, Francis, Anna, additional, Sanchez-Kazi, Cheryl, additional, Kausman, Joshua, additional, Pearl, Meghan, additional, Benador, Nadine, additional, Sahney, Shobha, additional, Tong, Allison, additional, Guha, Abhjit, additional, Solarin, Adaobi, additional, Platona, Adriana, additional, Hamilton, Alexander, additional, Woods-Barnard, Alice, additional, Eddy, Allison, additional, Karathanas, Alyssa, additional, Baumgart, Amanda, additional, Fielding, Amelia, additional, LePage, Amelia, additional, Bernier-Jean, Amelie, additional, Kelly, Amy, additional, Teixeira, Ana, additional, Viecelli, Andrea, additional, Matus, Andrea, additional, Narva, Andrew, additional, Wang, Angela Yee-Moon, additional, Fielding, Anna, additional, Meza, Anthony, additional, Fielding, Aria, additional, Teixeira-Pinto, Armando, additional, Bagga, Arvind, additional, Jankauskienė, Augustina, additional, Kelly, Ayano, additional, Gillespie, Barbara, additional, Sautenet, Benedicte, additional, Vogt, Beth, additional, Foster, Bethany, additional, Warady, Bradley, additional, Dixon, Bradley, additional, Manns, Braden, additional, Hemmelgarn, Brenda, additional, Bscardark, Brittney, additional, Romeo, Brooklyn, additional, Hanson, Camilla, additional, Meza, Carlos, additional, Brockett, Carter, additional, Prestidge, Chanel, additional, Green, Charmaine, additional, Perkins, Christy, additional, Schmitt, Claus Peter, additional, Fielding, Craig, additional, Settee, Craig, additional, Sumpton, Daniel, additional, Meza, Daniel, additional, Karathanas, Darien, additional, Harris, David, additional, Wheeler, David, additional, Hooper, David, additional, Gipson, Debbie, additional, Geary, Denis, additional, Haffner, Dieter, additional, Mekahli, Djalila, additional, Drozdz, Dorota, additional, Romeo, Ed, additional, Ku, Elaine, additional, Urbina, Elaine, additional, Levtchenko, Elena, additional, Balovlenkov, Elena, additional, Hodson, Elisabeth, additional, Morales, Emily, additional, O'Lone, Emma, additional, Machuca, Emma, additional, Carlton, Emmah, additional, Au, Eric, additional, Olver, Erin, additional, Morales, Estefania, additional, Mirza, Fatima, additional, Mackie, Fiona, additional, Tentori, Francesca, additional, Schaefer, Franz, additional, Higgins, Gail, additional, Deschenes, Georges, additional, Plunkett, Georgia, additional, Yoder, Gerilyn, additional, Wong, Germaine, additional, Morales, Giselle, additional, Germino, Greg, additional, Perkins, Hayley, additional, Mitchell-Smith, Harrison, additional, Coolican, Helen, additional, Xu, Hong, additional, Anochie, Ifeoma, additional, Ha, Il-Soo, additional, Davis, Ira, additional, Liu, Isaac, additional, Samaniego, Israel, additional, Machuca, Jaime, additional, Machuca, James, additional, Kerklaan, Jasmijn, additional, Brockett, Jeff, additional, Norton, Jenna, additional, Shen, Jenny, additional, Goebel, Jens, additional, Rao, Jia, additional, Machuca, Jimmy, additional, Mitchell-Smith, Jo, additional, Watson, Jo, additional, Gill, John, additional, Craig, Jonathan, additional, Flynn, Joseph T., additional, Samuels, Joshua, additional, Bacchetta, Justine, additional, Yoder, Kaleb, additional, Manera, Karine, additional, Twombley, Katherine, additional, McMichael, Kelly-Ann, additional, Ishikura, Kenji, additional, Romeo, Kennedy, additional, Settee, Kevin, additional, Van, Kim Linh, additional, McMichael, Lachlan, additional, Trinh, Lany, additional, Greenbaum, Larry, additional, Sanchez, Laura, additional, Fielding, Leo, additional, Rees, Lesley, additional, Lippincott, Leslie, additional, Mejia-Saldivar, Levi, additional, Saldivar, Lidia, additional, Guay-Woodford, Lisa, additional, Samaniego, Lizett, additional, Hamiwka, Lorraine, additional, Bell, Lorraine, additional, Barry, Lucinda, additional, Macauley, Luke, additional, Holmes, Luke, additional, Karathanas, Madelynn, additional, Mitchell-Smith, Madison, additional, Walker, Mandy, additional, Benavides, Manuel, additional, Tonelli, Marcello, additional, Ferris, Maria, additional, Vivarelli, Marina, additional, Wolfenden, Mark, additional, Howell, Martin, additional, Christian, Martin, additional, Schreiber, Martin, additional, Moxey-Mims, Marva, additional, Leonard, Mary, additional, Karathanas, Matthew, additional, Natatmadja, Melissa, additional, Brockett, Melissa, additional, Bonilla-Felix, Melvin, additional, Atkinson, Meredith, additional, Baum, Michel, additional, Rheault, Michelle, additional, McCulloch, Mignon, additional, Matsuda-Abedini, Mina, additional, Michael, Mini, additional, Khan, Mohammad, additional, Salih, Mohammad, additional, Carlton, Mycah Ann, additional, Plunkett, Ngairre, additional, Webb, Nick, additional, Scholes-Robertson, Nicki, additional, Larkins, Nicolas, additional, Evangelidis, Nicole, additional, Yoder, Nigel, additional, Meza, Norma, additional, Olver, Paige, additional, Carlton, Paiyton, additional, Brophy, Patrick, additional, Tugwell, Peter, additional, Cochat, Pierre, additional, Mehrotra, Rajnish, additional, Wolfenden, Raphael, additional, Gbadegesin, Rasheed, additional, Benavides, Raymond, additional, Johnson, Rebecca, additional, Morales, Ricardo, additional, McGee, Richard, additional, Fish, Richard, additional, Gardos, Robert, additional, Pecoits-Filho, Roberto, additional, Vargas, Rocio, additional, Saldivar, Rodolfo, additional, Coppo, Rosanna, additional, Shroff, Rukshana, additional, Raina, Rupesh, additional, Youssouf, Sajeda, additional, Crowe, Sally, additional, Anumudu, Samaya, additional, Chan, Samuel, additional, Baldacchino, Sarah, additional, Wenderfer, Scott, additional, Wolfenden, Sebastian, additional, Carlton, Selah, additional, Sutton, Shanna, additional, Murphy, Shannon, additional, Teo, Sharon, additional, Salih, Sheyma, additional, Carlton, Silas, additional, Carter, Simon, additional, Pearson, Simone, additional, Khan, Simra, additional, Wilson, Skyla, additional, Sharma, Sonia, additional, Alexander, Stephen, additional, Marks, Stephen, additional, Cornish, Stephen, additional, Goldstein, Stuart, additional, Furth, Susan, additional, Mendley, Susan, additional, Lippincott, Susan, additional, Charles, Symone, additional, Mitchell-Smith, Terri, additional, Harris, Tess, additional, Vetter, Thorsten, additional, Carlton, Tiffany, additional, Carlton, Timothy, additional, Querfeld, Uwe, additional, Saglimbene, Valeria, additional, Charles, Virginia, additional, van Biesen, Wim, additional, Winkelmayer, Wolfgang, additional, Machuca, Yenissey, additional, Salih, Yusuf, additional, Anh, Yo Han, additional, Perkins, Zachary, additional, and Salih, Zeynab, additional
- Published
- 2020
- Full Text
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21. Investigating mechanisms of chronic kidney disease in mouse models
- Author
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Eddy, Allison A., López-Guisa, Jesús M., Okamura, Daryl M., and Yamaguchi, Ikuyo
- Published
- 2012
- Full Text
- View/download PDF
22. Macrophage diversity in renal injury and repair
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Ricardo, Sharon D., van Goor, Harry, and Eddy, Allison A.
- Subjects
Kidney diseases -- Care and treatment ,Kidney diseases -- Prevention ,Kidney diseases -- Research ,Macrophages -- Health aspects ,Immune response -- Health aspects - Abstract
Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease in the context of fibrosis. Furthermore, parallels with pathological processes in many other organs also exist., Macrophages comprise a heterogeneous population of cells that belong to the mononuclear phagocyte system. They play an important role in tissue homeostasis and remodeling and are also potent immune regulators. [...]
- Published
- 2008
23. Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
- Author
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Okamura, Daryl M., Lopez-Guisa, Jesus M., Koelsch, Katie, Collins, Sarah, and Eddy, Allison A.
- Subjects
Fibrosis -- Observations ,Hypercholesterolemia -- Physiological aspects ,Blood lipoproteins -- Properties ,Lipoproteins -- Properties ,Proteolipids -- Properties ,Kidneys -- Injuries ,Kidneys -- Physiological aspects ,Biological sciences - Abstract
Okamura DM, L6pez-Guisa JM, Koelsch K, Collins S, Eddy AA. Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury. Am J Physiol Renal Physiol 293: F575-F585, 2007. First published May 30, 2007; doi: 10.1152/ajprenal.00063.2007.--Oxidized low-density lipoproteins (oxLDL) and their scavenger receptor (SR) binding partners play a central role in atherosclerosis and by analogy may play a role in chronic kidney disease pathogenesis. The present study was designed to investigate in C57BL/6 mice the effects of hypercholesterolemia on renal injury severity and oxLDL generation after unilateral ureteral obstruction (UUO). The expression profiles of CD36, SR class AI/II (SR-A), lectin-like receptor for oxidized low-density lipoprotein-1 (Lox-1), and SR that binds phosphatidylserine and oxLDL (SR-PSOX/CXCL16) were examined. Four experimental groups were studied: sham and UUO male mice on either a high-fat Western diet or a control diet. Significantly more oxLDL accumulated in the tubulointerstitium of hypercholesterolemic mice compared with normocholesterolemic mice after 14 days of UUO (P < 0.01). Total kidney collagen was significantly higher in the obstructed kidneys of hypercholesterolemic mice compared with normocholesterolemic mice on day 14 (P < 0.01). After 14 days of obstruction, the number of interstitial F4/80+ macrophages and NF-KB activation increased in hypercholesterolemic mice compared with normocholesterolemic mice (P < 0.01). In normal kidneys, CD36, SR-A, Lox-1, and CXCL16 were primarily localized to renal tubular epithelia. After ureteral obstruction, CD36 increased at day 7; SR-A and Lox-1 progressively decreased in a time-dependent manner; and CXCLI6 increased significantly with the onset of obstruction (P < 0.01). Strong tubular expression suggests that in addition to inflammatory interstitial cells, renal tubular scavenger receptors may help to orchestrate the inflammatory and fibrogenic pathways that are activated by oxLDL. interstitial fibrosis; CD36; SR-A; Lox-1; CXCL16; SR-PSOX; hypercholesterolemia; oxidized lipoprotein
- Published
- 2007
24. Endogenous urokinase lacks antifibrotic activity during progressive renal injury
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Yamaguchi, Ikuyo, Lopez-Guisa, Jesus, Cai, Xiaohe, Collins, Sarah J., Okamura, Daryl M., and Eddy, Allison A.
- Subjects
Kidney tubules -- Research ,Fibrosis -- Research ,Urokinase -- Research ,Ureters -- Obstructions ,Ureters -- Research ,Biological sciences - Abstract
Interstitial fibrosis is a universal feature of progressive kidney disease. Urokinase-type plasminogen activator (uPA) is thought to participate for several reasons: 1) uPA is produced predominantly in kidney, 2) its inhibitor plasminogen activator inhibitor-1 (PAI-1) is a strong promoter of interstitial fibrosis, whereas its receptor (uPAR) attenuates renal fibrosis, 3) uPA reduces fibrosis in liver and lung, and 4) uPA can activate hepatocyte growth factor (HGF), a potent antifibrotic growth factor. The present study tested the hypothesis that endogenous uPA reduces fibrosis severity by investigating the unilateral ureteral obstruction (UUO) model in wild-type (WT) and uPA-/-mice. Several outcomes were measured: renal collagen 3-21 days after UUO, macrophage accumulation (F4/80 Western blotting), interstitial myofibroblast density ([alpha]-smooth muscle actin immunostaining), and tubular injury (E-cadherin and Ksp-cadherin Western blotting). None of these measures differed significantly between WT and uPA-/- mice. uPA genetic deficiency was not associated with compensatory changes in renal uPAR mRNA levels, PAI-1 protein levels, or tissue plasminogen activator activity levels after UUO. Despite the known ability of uPA to activate latent HGF, immunoblotting failed to detect significant differences in levels of the active HGF [alpha]-chain and phosphorylated cMET (the activated HGF receptor) between the WT and uPA-/- groups. These findings suggest that the profibrotic actions of PAI-I are uPA independent and that an alternative pathway must activate HGF in kidney. Finally, these results highlight a significant organ-specific difference in basic fibrogenic pathways, as enhanced uPA activity has been reported to attenuate pulmonary and hepatic fibrosis. renal interstitial fibrosis: unilateral ureteral obstruction; serine protease doi: 10.1152/ajpregu.00380.2006
- Published
- 2007
25. Can renal fibrosis be reversed?
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Eddy, Allison A.
- Published
- 2005
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26. Expression of nephrin in acquired forms of nephrotic syndrome in childhood
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Hingorani, Sangeeta R., Finn, Laura S., Kowalewska, Jolanta, McDonald, Ruth A., and Eddy, Allison A.
- Published
- 2004
- Full Text
- View/download PDF
27. Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey
- Author
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Logeman, Charlotte, primary, Guha, Chandana, additional, Howell, Martin, additional, Hanson, Camilla S., additional, Craig, Jonathan C., additional, Samuel, Susan, additional, Zappitelli, Michael, additional, Matsuda-Abedini, Mina, additional, Dart, Allison, additional, Furth, Susan, additional, Eddy, Allison, additional, Groothoff, Jaap, additional, Yap, Hui-Kim, additional, Bockenhauer, Detlef, additional, Sinha, Aditi, additional, Alexander, Stephen I., additional, Goldstein, Stuart L., additional, Gipson, Debbie S., additional, Michael, Mini, additional, Walker, Amanda, additional, Kausman, Joshua, additional, Gaillard, Segolene, additional, Bacchetta, Justine, additional, Rheault, Michelle N., additional, Warady, Bradley A., additional, Neu, Alicia, additional, Christian, Martin, additional, McTaggart, Steven, additional, Liu, Isaac, additional, Teo, Sharon, additional, Sautenet, Benedicte, additional, Gutman, Talia, additional, Carter, Simon, additional, Teixeira-Pinto, Armando, additional, and Tong, Allison, additional
- Published
- 2020
- Full Text
- View/download PDF
28. The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with joubert syndrome
- Author
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Parisi, Melissa A., Bennett, Craig L., Eckert, Melissa L., Dobyns, William B., Gleeson, Joseph G., Shaw, Dennis W.W., McDonald, Ruth, Eddy, Allison, Chance, Phillip F., and Glass, Ian A.
- Subjects
Joubert syndrome -- Research ,Biological sciences - Published
- 2004
29. CONTRIBUTORS
- Author
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Albani, Salvatore, primary, Alsaeid, Khaled, additional, Athreya, Balu H., additional, Avčin, Tadej, additional, Babyn, Paul, additional, Bagga, Arvind, additional, Barron, Karyl S., additional, Benseler, Susanne, additional, Brogan, Paul, additional, Brunner, Hermine I., additional, Burgos-Vargas, Rubén, additional, Buyon, Jill P., additional, Cabral, David A., additional, Cassidy, James T., additional, Cimaz, Rolando, additional, Colbert, Robert A., additional, Davidson, Iris L., additional, De Benedetti, Fabrizio, additional, Dillon, Michael J., additional, Doria, Andrea Schwarz, additional, Dressler, Frank, additional, Duffy, Ciarán M., additional, Eddy, Allison A., additional, Falcini, Fernanda, additional, Feldman, Brian M., additional, Ferguson, Polly J., additional, Fuhlbrigge, Robert C., additional, Gattorno, Marco, additional, Giannini, Edward H., additional, Glass, David N., additional, Grom, Alexei A., additional, Houghton, Kristin, additional, Huppertz, Hans-Iko, additional, Ilowite, Norman T., additional, Kastner, Daniel L., additional, Kuchta, Gay, additional, Kuis, Wietse, additional, Laxer, Ronald M., additional, LeBlanc, Claire, additional, Lindsley, Carol B., additional, Martini, Alberto, additional, Nigrovic, Peter A., additional, O'Neil, Kathleen M., additional, Oen, Kiem G., additional, Özen, Seza, additional, Pepmueller, Peri Hickman, additional, Prakken, Berent J., additional, Rapoff, Michael A., additional, Rider, Lisa G., additional, Rosé, Carlos D., additional, Rosenbaum, James T., additional, Rosenberg, Alan M., additional, Schneider, Rayfel, additional, Sherry, David D., additional, Silverman, Earl D., additional, Sundel, Robert P., additional, Thompson, Susan D., additional, Tucker, Lori B., additional, van Montfrans, Joris, additional, Vázquez-Mellado, Janitzia, additional, Wenkert, Deborah, additional, Wouters, Carine H., additional, Wulffraat, Nico, additional, and Zulian, Francesco, additional
- Published
- 2011
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30. SYSTEMIC LUPUS ERYTHEMATOSUS
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Silverman, Earl, primary and Eddy, Allison, additional
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- 2011
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31. Nephrotic syndrome in childhood
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Eddy, Allison A. and Symons, Jordan M.
- Published
- 2003
32. Molecular basis of renal fibrosis
- Author
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Eddy, Allison A.
- Published
- 2000
- Full Text
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33. Plasminogen activator inhibitor-1 and the kidney
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Eddy, Allison A.
- Subjects
Kidneys -- Physiological aspects ,Plasminogen activators -- Physiological aspects ,Fibrinolysis -- Physiological aspects ,Cell adhesion -- Physiological aspects ,Fibrosis -- Physiological aspects ,Biological sciences - Abstract
Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that was isolated 20 years ago. First recognized as an inhibitor of intravascular fibrinolysis, it is now evident that PAI-1 is a multifunctional protein with actions that may be dependent on or independent of its protease inhibitory effects. The latter often involve interactions between PAI-1 and vitronectin or the urokinase receptor. The protease-inhibitory actions of PAI-1 extend beyond fibrinolysis and include extracellular matrix turnover and activation of several proenzymes and latent growth factors. PAI-1 has been implicated in several renal pathogenetic processes, including thrombotic microangiopathies and proliferative and/or crescentic glomerulopathies. Most recently, it has become clear that PAI-1 also plays a pivotal role in progressive renal disease, both glomerulosclerosis and tubulointerstitial fibrosis. An active area of present research interest, untold stories are likely to be uncovered soon. fibrinolysis; fibrosis; thrombotic microangiopathy; cellular adhesion; glomerulonephritis; renal fibrosis
- Published
- 2002
34. Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2
- Author
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Chang, Alice M., Ohse, Takamoto, Krofft, Ron D., Wu, Jimmy S., Eddy, Allison A., Pippin, Jeffrey W., and Shankland, Stuart J.
- Published
- 2012
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- View/download PDF
35. Renal remodelling in dietary protein modified rat polycystic kidney disease
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Bankovic-Calic, Neda, Eddy, Allison, Sareen, Sanjay, and Ogborn, M. R.
- Published
- 1999
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36. Interstitial Nephritis
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Verghese, Priya S., primary, Luckritz, Kera E., additional, and Eddy, Allison A., additional
- Published
- 2008
- Full Text
- View/download PDF
37. Contributors
- Author
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Alcon, Juan J., primary, Alexander, Stephen I., additional, Amaral, Joao Guilherme, additional, Amore, Alessandro, additional, Andreoli, Sharon Phillips, additional, Andrews, Walter S., additional, Aufricht, Christoph, additional, Avni, Fred E., additional, Bagga, Arvind, additional, Bakkaloglu, Aysin, additional, Batisky, Donald L., additional, Bauman, Mary, additional, Becker, Jan Ulrich, additional, Bergmann, Carsten, additional, Bettinelli, Alberto, additional, Bianchetti, Mario G., additional, Blowey, Douglas L., additional, Böckenhauer, Detlef, additional, Brophy, Patrick D., additional, Chand, Deepa H., additional, Cochat, Pierre, additional, Connolly, Bairbre, additional, Coppo, Rosanna, additional, Craig, Jonathan C., additional, Csaicsich, Dagmar, additional, Cuzzolin, Laura, additional, Dharnidharka, Vikas R., additional, Durkan, Anne M., additional, Eddy, Allison A., additional, Eggermann, Thomas, additional, Fanos, Vassilios, additional, Filler, Guido, additional, Fleming, Geoffrey M., additional, Furth, Susan L., additional, Gbadegesin, Rasheed, additional, Geary, Denis F., additional, Gerson, Arlene C., additional, Gipson, Debbie S., additional, Goldstein, Stuart L., additional, Gowrishankar, Manjula, additional, Graf, Nicole, additional, Greenbaum, Larry A., additional, Groothoff, Jaap W., additional, Gulati, Sanjeev, additional, Hadtstein, Charlotte, additional, Haffner, Dieter, additional, Hall, Michelle, additional, Harrison, Christine, additional, Hébert, Diane, additional, Hodson, Elisabeth M., additional, Hooper, Stephen, additional, Hoppe, Bernd, additional, Hothi, Daljit K., additional, Hoyer, Peter F., additional, Ingelfinger, Julie R., additional, Ismaili, Khalid, additional, Kashtan, Clifford E., additional, Kawasaki, Yukihiko, additional, Khoury, Antoine E., additional, Konrad, Martin, additional, Kumar, Alok, additional, Langlois, Valerie, additional, Lau, Perry Yew-Weng, additional, Leumann, Ernst, additional, Li, Xiaomei, additional, Licht, Christoph, additional, Lim, Ruth, additional, Lorenzo, Armando J., additional, Luckritz, Kera E., additional, Lurbe, Empar, additional, Mahan, John D., additional, Mak, Robert, additional, Marks, Stephen D., additional, Patricia Massicotte, M., additional, Mathews, Ranjiv, additional, Mattoo, Tej K., additional, Maxwell, Heather, additional, Mehls, Otto, additional, Melk, Anette, additional, Mengel, Michael, additional, Menon, Shina, additional, Milliner, Dawn S., additional, Mitsnefes, Mark, additional, Neu, Alicia M., additional, Niaudet, Patrick, additional, Nissel, Richard, additional, Ermisch-Omran, Beate, additional, Omran, Heymut, additional, Ozen, Seza, additional, Perfumo, Francesco, additional, Phan, Veronique, additional, Pinsk, Maury, additional, Piscione, Tino D., additional, Querfeld, Uwe, additional, Ramage, Ian John, additional, Redon, Josep, additional, Robinson, Lisa A., additional, Robinson, Renee F., additional, Rosenblum, Norman D., additional, Salomon, Remi, additional, Sandhu, Gagandeep K., additional, Schaefer, Franz, additional, Schmitt, Claus P., additional, Schröder, Cornelis H., additional, Secker, Donna, additional, Sherali, Afroze Ramzan, additional, Sihoe, Jennifer Dart Yin, additional, Smoyer, William E., additional, Suzuki, Hitoshi, additional, Tasic, Velibor, additional, Tönshoff, Burkhard, additional, Traubici, Jeffrey, additional, Tullus, Kjell, additional, van't Hoff, William G., additional, Verghese, Priya S., additional, Verrina, Enrico Eugenio, additional, Vester, Udo, additional, Vohra, Sunita, additional, Waldegger, Siegfried, additional, Warady, Bradley A., additional, Waters, Aoife, additional, Webb, Nicholas J.A., additional, Weber, Stefanie, additional, Williams, Gabrielle, additional, Wong, Sik-Nin, additional, Wühl, Elke, additional, Yang, Li, additional, Yap, Hui-Kim, additional, Yeung, Chung-Kwong, additional, Yiu, Verna, additional, Zerres, Klaus, additional, and Zimmerhackl, Lothar Bernd, additional
- Published
- 2008
- Full Text
- View/download PDF
38. The TGF-β Route to Renal Fibrosis Is Not Linear: The miR-21 Viaduct
- Author
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Eddy, Allison A.
- Published
- 2011
- Full Text
- View/download PDF
39. Round 3 at JASN (2001 to 2007): Recollections of the Third Editorial Team
- Author
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Couser, William, Eddy, Allison A., and Hill, Carol
- Published
- 2010
- Full Text
- View/download PDF
40. In Memoriam Norman J. Siegel, MD 1943–2006
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Couser, William G. and Eddy, Allison A.
- Published
- 2006
- Full Text
- View/download PDF
41. Ramping up endogenous defences against chronic kidney disease
- Author
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Eddy, Allison A.
- Published
- 2006
42. The origin of scar-forming kidney myofibroblasts: whereas diabetes and hypertension predominate as the etiology of chronic kidney disease (CKD), all primary causes share a common progression pathway due to scarring or fibrosis. Understanding what cells are the sources of scar-forming cells is of utmost importance (pages 1047-1053)
- Author
-
Eddy, Allison A.
- Subjects
Chronic kidney failure -- Development and progression -- Care and treatment -- Research ,Fibroblasts -- Physiological aspects -- Genetic aspects -- Research ,Biological sciences ,Health - Abstract
The destruction of normal parenchymal tissue within solid organs due to scar-generating extra-cellular matrix (ECM) deposits is a fundamental process for many chronic diseases. The human kidney is especially vulnerable, [...]
- Published
- 2013
43. Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1–overexpressing mice
- Author
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MATSUO, SHUNYA, LÓPEZ-GUISA, JESÚS M., CAI, XIAOHE, OKAMURA, DARYL M., ALPERS, CHARLES E., BUMGARNER, ROGER E., PETERS, METTE A., ZHANG, GUOQIANG, and EDDY, ALLISON A.
- Published
- 2005
44. Experimental insights into the mechanisms of tubulo-interstitial scarring
- Author
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Jernigan, Stephanie M, primary and Eddy, Allison A, additional
- Published
- 2000
- Full Text
- View/download PDF
45. Tubulointerstitial nephritis
- Author
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Jones, Colin L. and Eddy, Allison A.
- Published
- 1992
- Full Text
- View/download PDF
46. Why is proteinuria an ominous biomarker of progressive kidney disease?
- Author
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ZANDI-NEJAD, KAMBIZ, EDDY, ALLISON A., GLASSOCK, RICHARD J., and BRENNER, BARRY M.
- Published
- 2004
47. Mitogenic Signaling of Urokinase Receptor–Deficient Kidney Fibroblasts: Actions of an Alternative Urokinase Receptor and LDL Receptor–Related Protein
- Author
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ZHANG, GUOQIANG, CAI, XIAOHE, LÓPEZ-GUISA, JESÚS M., COLLINS, SARAH J., and EDDY, ALLISON A.
- Published
- 2004
- Full Text
- View/download PDF
48. Proteinuria and interstitial injury
- Author
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Eddy, Allison A.
- Published
- 2004
49. Urokinase Receptor Modulates Cellular and Angiogenic Responses in Obstructive Nephropathy
- Author
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Zhang, Guoqiang, Kim, Heungsoo, Cai, Xiaohe, Lopez-Guisa, Jesus M., Carmeliet, Peter, and Eddy, Allison A.
- Published
- 2003
- Full Text
- View/download PDF
50. Urokinase Receptor Deficiency Accelerates Renal Fibrosis in Obstructive Nephropathy
- Author
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Zhang, Guoqiang, Kim, Heungsoo, Cai, Xiaohe, López-Guisa, Jesús M., Alpers, Charles E., Liu, Youhua, Carmeliet, Peter, and Eddy, Allison A.
- Published
- 2003
- Full Text
- View/download PDF
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