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1. Imaging of single barium atoms in a second matrix site in solid xenon for barium tagging in a $^{136}$Xe double beta decay experiment

Author

Yvaine, M., Fairbank, D., Soderstrom, J., Taylor, C., Stanley, J., Walton, T., Chambers, C., Iverson, A., Fairbank, W., Kharusi, S. Al, Amy, A., Angelico, E., Anker, A., Arnquist, I. J., Atencio, A., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cesmecioglu, D., Chambers, E., Chana, B., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Hein, E., Holt, J. D., Hoppe, E. W., Karelin, A., Keblbeck, D., Kotov, I., Kuchenkov, A., Kumar, K. S., Kwiatkowski, A. A., Larson, A., Latif, M. B., Leach, K. G., Lennarz, A., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Masbou, J., McMichael, K., Peregrina, M. Medina, Moe, M., Mong, B., Moore, D. C., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Pocar, A., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rescia, S., Richardson, G., Ross, R., Rowson, P. C., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Si, L., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., van Bruggen, E., Vidal, M., Walent, M., Wamba, K., Wang, H. W., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Xu, H., Yang, L., Yu, M., and Zeldovich, O.

Subjects
Physics - Atomic Physics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Neutrinoless double beta decay is one of the most sensitive probes for new physics beyond the Standard Model of particle physics. One of the isotopes under investigation is $^{136}$Xe, which would double beta decay into $^{136}$Ba. Detecting the single $^{136}$Ba daughter provides a sort of ultimate tool in the discrimination against backgrounds. Previous work demonstrated the ability to perform single atom imaging of Ba atoms in a single-vacancy site of a solid xenon matrix. In this paper, the effort to identify signal from individual barium atoms is extended to Ba atoms in a hexa-vacancy site in the matrix and is achieved despite increased photobleaching in this site. Abrupt fluorescence turn-off of a single Ba atom is also observed. Significant recovery of fluorescence signal lost through photobleaching is demonstrated upon annealing of Ba deposits in the Xe ice. Following annealing, it is observed that Ba atoms in the hexa-vacancy site exhibit antibleaching while Ba atoms in the tetra-vacancy site exhibit bleaching. This may be evidence for a matrix site transfer upon laser excitation. Our findings offer a path of continued research toward tagging of Ba daughters in all significant sites in solid xenon., Comment: 9 pages, 8 figures

Published
2024

2. Supernova Electron-Neutrino Interactions with Xenon in the nEXO Detector

Author

nEXO Collaboration, Hedges, S., Kharusi, S. Al, Angelico, E., Brodsky, J. P., Richardson, G., Wilde, S., Amy, A., Anker, A., Arnquist, I. J., Arsenault, P., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Gillis, W., Goeldi, D., Gorham, A., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Heffner, M., Hein, E., Holt, J. D., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Kachru, P., Karelin, A., Keblbeck, D., Kuchenkov, A., Kumar, K. S., Larson, A., Latif, M. B., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., McMichael, K., Medina-Peregrina, M., Mong, B., Moore, D. C., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Piepke, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Rasiwala, H., Ray, D., Raymond, K., Rescia, S., Riot, V., Ross, R., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Soderstrom, J., Soma, A. K., Spadoni, F., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., van Bruggen, E., Vidal, M., Viel, S., Walent, M., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wei, W., Wen, L. J., Wichoski, U., Wu, X. M., Xu, H., Yang, H. B., Yang, L., Yu, M., Yvaine, M., Zeldovich, O., and Zhao, J.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Theory
Abstract

Electron-neutrino charged-current interactions with xenon nuclei were modeled in the nEXO neutrinoless double-beta decay detector (~5-tonne, 90% ${}^{136}$Xe, 10% ${}^{134}$Xe) to evaluate its sensitivity to supernova neutrinos. Predictions for event rates and detectable signatures were modeled using the MARLEY event generator. We find good agreement between MARLEY's predictions and existing theoretical calculations of the inclusive cross sections at supernova neutrino energies. The interactions modeled by MARLEY were simulated within the nEXO simulation framework and were run through an example reconstruction algorithm to determine the detector's efficiency for reconstructing these events. The simulated data, incorporating the detector response, were used to study the ability of nEXO to reconstruct the incident electron-neutrino spectrum and these results were extended to a larger xenon detector of the same isotope enrichment. We estimate that nEXO will be able to observe electron-neutrino interactions with xenon from supernovae as far as 5 to 8 kpc from earth, while the ability to reconstruct incident electron-neutrino spectrum parameters from observed interactions in nEXO is limited to closer supernovae., Comment: 17 pages, 16 figures

Published
2024

3. An integrated online radioassay data storage and analytics tool for nEXO

Author

Tsang, R. H. M., Piepke, A., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, C., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Cohen, J. R., Collister, R., Cvitan, M., Dalmasson, J., Darroch, L., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Echevers, J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Jamil, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., Massacret, N., McMichael, K., Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Peltz-Smalley, H., Perna, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rebeiro, B., Rescia, S., Retière, F., Richardson, G., Ringuette, J., Riot, V., Rowson, P. C., Roy, N., Rudolph, L., Saldanha, R., Sangiorgio, S., Schwartz, S., Soderstrom, J., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Barakoohi, E. Teimoori, Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., Underwood, R., van Bruggen, E., Veeraraghavan, V., Vidal, M., Viel, S., Walent, M., Wamba, K., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, S., Wu, X. M., Yang, H., Yang, L., Yvaine, M., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

Large-scale low-background detectors are increasingly used in rare-event searches as experimental collaborations push for enhanced sensitivity. However, building such detectors, in practice, creates an abundance of radioassay data especially during the conceptual phase of an experiment when hundreds of materials are screened for radiopurity. A tool is needed to manage and make use of the radioassay screening data to quantitatively assess detector design options. We have developed a Materials Database Application for the nEXO experiment to serve this purpose. This paper describes this database, explains how it functions, and discusses how it streamlines the design of the experiment.

Published
2023

4. Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO

Author

Gallina, G., Guan, Y., Retiere, F., Cao, G., Bolotnikov, A., Kotov, I., Rescia, S., Soma, A. K., Tsang, T., Darroch, L., Brunner, T., Bolster, J., Cohen, J. R., Franco, T. Pinto, Gillis, W. C., Smalley, H. Peltz, Thibado, S., Pocar, A., Bhat, A., Jamil, A., Moore, D. C., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Arsenault, P., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Brodsky, J. P., Brown, E., Caden, E., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y., Dolinski, M. J., Dragone, A., Echevers, J., Eckert, B., Elbeltagi, M., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gautam, P., Giacomini, G., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., Hößl, J., House, A., Hunt, W., Iverson, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lessard, G., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Margetak, P., Martel-Dion, P., Martin, L., Masbou, J., Massacret, N., McMichael, K., Mong, B., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Parent, S., Perna, A., Piepke, A., Pletskova, N., Pratte, J. F., Radeka, V., Raguzin, E., Ramonnye, G. J., Rao, T., Rasiwala, H., Raymond, K., Rebeiro, B. M., Richardson, G., Ringuette, J., Riot, V., Rossignol, T., Rowson, P. C., Rudolph, L., Saldanha, R., Sangiorgio, S., Shang, X., Spadoni, F., Stekhanov, V., Sun, X. L., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., Vachon, F., Vidal, M., Viel, S., Visser, G., Wagenpfeil, M., Walent, M., Wamba, K., Wang, Q., Wang, W., Wang, Y., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, W. H., Wu, X., Xie, L., Yan, W., Yang, H., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors
Abstract

Liquid xenon time projection chambers are promising detectors to search for neutrinoless double beta decay (0$\nu \beta \beta$), due to their response uniformity, monolithic sensitive volume, scalability to large target masses, and suitability for extremely low background operations. The nEXO collaboration has designed a tonne-scale time projection chamber that aims to search for 0$\nu \beta \beta$ of \ce{^{136}Xe} with projected half-life sensitivity of $1.35\times 10^{28}$~yr. To reach this sensitivity, the design goal for nEXO is $\leq$1\% energy resolution at the decay $Q$-value ($2458.07\pm 0.31$~keV). Reaching this resolution requires the efficient collection of both the ionization and scintillation produced in the detector. The nEXO design employs Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm scintillation light of liquid xenon. This paper reports on the characterization of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3 SiPMs specifically designed for nEXO, as well as new measurements on new test samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters (MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct crosstalk, correlated avalanches and photon detection efficiency were measured as a function of the applied over voltage and wavelength at liquid xenon temperature (163~K). The results from this study are used to provide updated estimates of the achievable energy resolution at the decay $Q$-value for the nEXO design.

Published
2022
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5. Development of a $^{127}$Xe calibration source for nEXO

Author

Lenardo, B. G., Hardy, C. A., Tsang, R. H. M., Ondze, J. C. Nzobadila, Piepke, A., Triambak, S., Jamil, A., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Belov, V., Bernard, E. P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cohen, J. R., Collister, R., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Echevers, J., Eckert, B., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Fu, Y. S., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Harouaka, K., Heffner, M., Hein, E., Hößl, J., House, A., Iverson, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Masbou, J., McMichael, K., Peregrina, M. Medina, Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Ning, Z., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Perna, A., Franco, T. Pinto, Pocar, A., Pratte, J. F., Priel, N., Raguzin, E., Ramonnye, G. J., Rasiwala, H., Raymond, K., Richardson, G., Richman, M., Ringuette, J., Rowson, P. C., Saldanha, R., Sangiorgio, S., Shang, X., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Todd, J., Totev, T., Tyuka, O. A., Vachon, F., Veeraraghavan, V., Viel, S., Wamba, K., Wang, Y., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Wu, W. H., Yan, W., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

We study a possible calibration technique for the nEXO experiment using a $^{127}$Xe electron capture source. nEXO is a next-generation search for neutrinoless double beta decay ($0\nu\beta\beta$) that will use a 5-tonne, monolithic liquid xenon time projection chamber (TPC). The xenon, used both as source and detection medium, will be enriched to 90% in $^{136}$Xe. To optimize the event reconstruction and energy resolution, calibrations are needed to map the position- and time-dependent detector response. The 36.3 day half-life of $^{127}$Xe and its small $Q$-value compared to that of $^{136}$Xe $0\nu\beta\beta$ would allow a small activity to be maintained continuously in the detector during normal operations without introducing additional backgrounds, thereby enabling in-situ calibration and monitoring of the detector response. In this work we describe a process for producing the source and preliminary experimental tests. We then use simulations to project the precision with which such a source could calibrate spatial corrections to the light and charge response of the nEXO TPC., Comment: 24 pages, 16 figures

Published
2022
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6. Fatigue crack initiation in nickel-based superalloys studied by microstructure-based FE modeling and scanning electron microscopy

Author

Fried M., Krechel C., Affeldt E.E., Eckert B., Kimmig S., Retze U., Höppel H.W., and Göken M.

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

In this work stage I crack initiation in polycrystalline nickel-based superalloys is investigated by analyzing anisotropic mechanical properties, local stress concentrations and plastic deformation on the microstructural length scale. The grain structure in the gauge section of fatigue specimens was characterized by EBSD. Based on the measured data, a microstructure-based FE model could be established to simulate the strain and stress distribution in the specimens during the first loading cycle of a fatigue test. The results were in fairly good agreement with experimentally measured local strains. Furthermore, the onset of plastic deformation was predicted by identifying shear stress maxima in the microstructure, presumably leading to activation of slip systems. Measurement of plastic deformation and observation of slip traces in the respective regions of the microstructure confirmed the predicted slip activity. The close relation between micro-plasticity, formation of slip traces and stage I crack initiation was demonstrated by SEM surface analyses of fatigued specimens and an in-situ fatigue test in a large chamber SEM.

Published
2014
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7. An integrated online radioassay data storage and analytics tool for nEXO

Author

Tsang, R.H.M., Piepke, A., Al Kharusi, S., Angelico, E., Arnquist, I.J., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E.P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P.A., Brodsky, J.P., Brown, E., Brunner, T., Caden, E., Cao, G.F., Cao, L.Q., Cesmecioglu, D., Chambers, C., Chambers, E., Chana, B., Charlebois, S.A., Chernyak, D., Chiu, M., Cleveland, B., Cohen, J.R., Collister, R., Cvitan, M., Dalmasson, J., Darroch, L., Deslandes, K., DeVoe, R., di Vacri, M.L., Ding, Y.Y., Dolinski, M.J., Echevers, J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fu, Y.S., Gallacher, D., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Guan, Y.D., Hardy, C.A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E.W., House, A., Hunt, W., Iverson, A., Jamil, A., Jiang, X.S., Karelin, A., Kaufman, L.J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K.S., Larson, A., Leach, K.G., Lenardo, B.G., Leonard, D.S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., Massacret, N., McMichael, K., Mong, B., Moore, D.C., Murray, K., Nattress, J., Natzke, C.R., Ngwadla, X.E., Ni, K., Nolan, A., Nowicki, S.C., Nzobadila Ondze, J.C., Orrell, J.L., Ortega, G.S., Overman, C.T., Peltz-Smalley, H., Perna, A., Pinto Franco, T., Pocar, A., Pratte, J.-F., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rebeiro, B.M., Rescia, S., Retière, F., Richardson, G., Ringuette, J., Riot, V., Rowson, P.C., Roy, N., Rudolph, L., Saldanha, R., Sangiorgio, S., Schwartz, S., Soderstrom, J., Soma, A.K., Spadoni, F., Stekhanov, V., Sun, X.L., Teimoori Barakoohi, E., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O.A., Underwood, R., van Bruggen, E., Veeraraghavan, V., Vidal, M., Viel, S., Walent, M., Wamba, K., Wang, Q.D., Wang, W., Wang, Y.G., Watts, M., Wei, W., Wen, L.J., Wichoski, U., Wilde, S., Worcester, M., Wu, S., Wu, X.M., Yang, H., Yang, L., Yvaine, M., Zeldovich, O., Zhao, J., and Ziegler, T.

Published
2023
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13. Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke

Author

Tiedt, Steffen, Herzberg, Moriz, Küpper, Clemens, Feil, Katharina, Kellert, Lars, Dorn, Franziska, Liebig, Thomas, Alegiani, Anna, Dichgans, Martin, Wollenweber, Frank A., Alber, B., Bangard, C., Berrouschot, J., Bode, F.J., Boeckh-Behrens, T., Bohner, G., Bormann, A., Braun, M., Eckert, B., Fiehler, J., Flottmann, F., Gerloff, C., Hamann, G.F., Henn, K.H., Kastrup, A., Kraemer, C., Krause, L., Lehm, M., Liman, J., Lowens, S., Mpotsaris, A., Nolte, C.H., Papanagiotou, P., Petersen, M., Petzold, G.C., Pfeilschifter, W., Psychogios, M.N., Reich, A., von Rennenberg, R., Röther, J., Schäfer, J.H., Siebert, E., Siedow, A., Solymosi, L., Thomalla, G., Thonke, S., Wagner, M., Wunderlich, S., and Zweynert, S.

Published
2020
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17. Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO

Author

Gallina, G., primary, Guan, Y., additional, Retiere, F., additional, Cao, G., additional, Bolotnikov, A., additional, Kotov, I., additional, Rescia, S., additional, Soma, A. K., additional, Tsang, T., additional, Darroch, L., additional, Brunner, T., additional, Bolster, J., additional, Cohen, J. R., additional, Franco, T. Pinto, additional, Gillis, W. C., additional, Smalley, H. Peltz, additional, Thibado, S., additional, Pocar, A., additional, Bhat, A., additional, Jamil, A., additional, Moore, D. C., additional, Adhikari, G., additional, Kharusi, S. Al, additional, Angelico, E., additional, Arnquist, I. J., additional, Arsenault, P., additional, Badhrees, I., additional, Bane, J., additional, Belov, V., additional, Bernard, E. P., additional, Bhatta, T., additional, Breur, P. A., additional, Brodsky, J. P., additional, Brown, E., additional, Caden, E., additional, Cao, L., additional, Chambers, C., additional, Chana, B., additional, Charlebois, S. A., additional, Chernyak, D., additional, Chiu, M., additional, Cleveland, B., additional, Collister, R., additional, Cvitan, M., additional, Dalmasson, J., additional, Daniels, T., additional, Deslandes, K., additional, DeVoe, R., additional, di Vacri, M. L., additional, Ding, Y., additional, Dolinski, M. J., additional, Dragone, A., additional, Echevers, J., additional, Eckert, B., additional, Elbeltagi, M., additional, Fabris, L., additional, Fairbank, W., additional, Farine, J., additional, Fu, Y. S., additional, Gallacher, D., additional, Gautam, P., additional, Giacomini, G., additional, Gingras, C., additional, Goeldi, D., additional, Gornea, R., additional, Gratta, G., additional, Hardy, C. A., additional, Hedges, S., additional, Heffner, M., additional, Hein, E., additional, Holt, J., additional, Hoppe, E. W., additional, Hößl, J., additional, House, A., additional, Hunt, W., additional, Iverson, A., additional, Jiang, X. S., additional, Karelin, A., additional, Kaufman, L. J., additional, Krücken, R., additional, Kuchenkov, A., additional, Kumar, K. S., additional, Larson, A., additional, Leach, K. G., additional, Lenardo, B. G., additional, Leonard, D. S., additional, Lessard, G., additional, Li, G., additional, Li, S., additional, Li, Z., additional, Licciardi, C., additional, Lindsay, R., additional, MacLellan, R., additional, Mahtab, M., additional, Majidi, S., additional, Malbrunot, C., additional, Margetak, P., additional, Martel-Dion, P., additional, Martin, L., additional, Masbou, J., additional, Massacret, N., additional, McMichael, K., additional, Mong, B., additional, Murray, K., additional, Nattress, J., additional, Natzke, C. R., additional, Ngwadla, X. E., additional, Ondze, J. C. Nzobadila, additional, Odian, A., additional, Orrell, J. L., additional, Ortega, G. S., additional, Overman, C. T., additional, Parent, S., additional, Perna, A., additional, Piepke, A., additional, Pletskova, N., additional, Pratte, J. F., additional, Radeka, V., additional, Raguzin, E., additional, Ramonnye, G. J., additional, Rao, T., additional, Rasiwala, H., additional, Raymond, K., additional, Rebeiro, B. M., additional, Richardson, G., additional, Ringuette, J., additional, Riot, V., additional, Rossignol, T., additional, Rowson, P. C., additional, Rudolph, L., additional, Saldanha, R., additional, Sangiorgio, S., additional, Shang, X., additional, Spadoni, F., additional, Stekhanov, V., additional, Sun, X. L., additional, Tidball, A., additional, Totev, T., additional, Triambak, S., additional, Tsang, R. H. M., additional, Tyuka, O. A., additional, Vachon, F., additional, Vidal, M., additional, Viel, S., additional, Visser, G., additional, Wagenpfeil, M., additional, Walent, M., additional, Wamba, K., additional, Wang, Q., additional, Wang, W., additional, Wang, Y., additional, Watts, M., additional, Wei, W., additional, Wen, L. J., additional, Wichoski, U., additional, Wilde, S., additional, Worcester, M., additional, Wu, W. H., additional, Wu, X., additional, Xie, L., additional, Yan, W., additional, Yang, H., additional, Yang, L., additional, Zeldovich, O., additional, Zhao, J., additional, and Ziegler, T., additional

Published
2022
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19. Endovascular thrombectomy in young patients with stroke

Author

Weller, Johannes M, primary, Dorn, Franziska, additional, Meissner, Julius N, additional, Stösser, Sebastian, additional, Beckonert, Niklas M, additional, Nordsiek, Julia, additional, Kindler, Christine, additional, Deb-Chatterji, Milani, additional, Petzold, Gabor C, additional, Bode, Felix J, additional, Reich, A., additional, Nikoubashman, O., additional, Röther, J., additional, Eckert, B., additional, Braun, M., additional, Hamann, G.F., additional, Siebert, E., additional, Nolte, C.H., additional, Bohner, G., additional, Eckert, R.M., additional, Borggrefe, J., additional, Schellinger, P., additional, Berrouschot, J., additional, Bormann, A., additional, Kraemer, C., additional, Leischner, H., additional, Petersen, M., additional, Stögbauer, F., additional, Boeck-Behrens, T., additional, Wunderlich, S., additional, Ludolph, A., additional, Henn, K.H., additional, Gerloff, C., additional, Fiehler, J., additional, Thomalla, G., additional, Alegiani, A., additional, Schäfer, J.H., additional, Keil, F., additional, Tiedt, S., additional, Kellert, L., additional, Trumm, C., additional, Ernemann, U., additional, Poli, S., additional, Liman, J., additional, Ernst, M., additional, Gröschel, K., additional, and Uphaus, T., additional

Published
2022
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21. IQWiG Arbeitspapier GA15-02: „Stents zur Behandlung intrakranieller Stenosen: VISSIT Studie und Akutbehandlung in Deutschland“: Kommentar des Berufsverbandes der Neuroradiologen (BDNR), der Deutschen Gesellschaft für Neuroradiologie (DGNR), der Deutschen Gesellschaft für Neurologie (DGN) und der Deutschen Schlaganfall-Gesellschaft (DSG)

Author

Kurre, W., Berlis, A., Diener, H.-C., Fiehler, J., Gold, R., Groden, C., Hamann, G. F., Röther, J., and Eckert, B.

Published
2015
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24. Development of a 127Xe calibration source for nEXO

Author

Lenardo, B.G., primary, Hardy, C.A., additional, Tsang, R.H.M., additional, Nzobadila Ondze, J.C., additional, Piepke, A., additional, Triambak, S., additional, Jamil, A., additional, Adhikari, G., additional, Al Kharusi, S., additional, Angelico, E., additional, Arnquist, I.J., additional, Belov, V., additional, Bernard, E.P., additional, Bhat, A., additional, Bhatta, T., additional, Bolotnikov, A., additional, Breur, P.A., additional, Brodsky, J.P., additional, Brown, E., additional, Brunner, T., additional, Caden, E., additional, Cao, G.F., additional, Cao, L., additional, Chana, B., additional, Charlebois, S.A., additional, Chernyak, D., additional, Chiu, M., additional, Cohen, J.R., additional, Collister, R., additional, Dalmasson, J., additional, Daniels, T., additional, Darroch, L., additional, DeVoe, R., additional, di Vacri, M.L., additional, Ding, Y.Y., additional, Dolinski, M.J., additional, Echevers, J., additional, Eckert, B., additional, Elbeltagi, M., additional, Fabris, L., additional, Fairbank, D., additional, Fairbank, W., additional, Farine, J., additional, Fu, Y.S., additional, Gallina, G., additional, Gautam, P., additional, Giacomini, G., additional, Gillis, W., additional, Gingras, C., additional, Gornea, R., additional, Gratta, G., additional, Harouaka, K., additional, Heffner, M., additional, Hein, E., additional, Hößl, J., additional, House, A., additional, Iverson, A., additional, Jiang, X.S., additional, Karelin, A., additional, Kaufman, L.J., additional, Krücken, R., additional, Kuchenkov, A., additional, Kumar, K.S., additional, Larson, A., additional, Leach, K.G., additional, Leonard, D.S., additional, Li, G., additional, Li, S., additional, Li, Z., additional, Licciardi, C., additional, Lindsay, R., additional, MacLellan, R., additional, Masbou, J., additional, McMichael, K., additional, Medina Peregrina, M., additional, Mong, B., additional, Moore, D.C., additional, Murray, K., additional, Nattress, J., additional, Natzke, C.R., additional, Ngwadla, X.E., additional, Ni, K., additional, Ning, Z., additional, Orrell, J.L., additional, Ortega, G.S., additional, Ostrovskiy, I., additional, Overman, C.T., additional, Perna, A., additional, Pinto Franco, T., additional, Pocar, A., additional, Pratte, J.F., additional, Priel, N., additional, Raguzin, E., additional, Ramonnye, G.J., additional, Rasiwala, H., additional, Raymond, K., additional, Richardson, G., additional, Richman, M., additional, Ringuette, J., additional, Rowson, P.C., additional, Saldanha, R., additional, Sangiorgio, S., additional, Shang, X., additional, Soma, A.K., additional, Spadoni, F., additional, Stekhanov, V., additional, Sun, X.L., additional, Thibado, S., additional, Tidball, A., additional, Todd, J., additional, Totev, T., additional, Tyuka, O.A., additional, Vachon, F., additional, Veeraraghavan, V., additional, Viel, S., additional, Wamba, K., additional, Wang, Y., additional, Wang, Q., additional, Wei, W., additional, Wen, L.J., additional, Wichoski, U., additional, Wilde, S., additional, Wu, W.H., additional, Yan, W., additional, Yang, L., additional, Zeldovich, O., additional, Zhao, J., additional, and Ziegler, T., additional

Published
2022
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25. Experimenting from a Distance in the Case of Rutherford Scattering

Author

Grober, S., Vetter, M., and Eckert, B.

Abstract

The Rutherford scattering experiment plays a central role in working out atomic models in physics and chemistry. Nevertheless, the experiment is rarely performed at school or in introductory physics courses at university. Therefore, we realized this experiment as a remotely controlled laboratory (RCL), i.e. the experiment is set up in reality and can be operated by a computer via the Internet. We present results of measurements and supplementary didactical material. In addition, we make suggestions on how to use the RCL in class and we describe the added value of performing this experiment as an RCL. (Contains 5 footnotes and 4 figures.)

Published
2010
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26. Experimenting from a Distance--Determination of Speed of Light by a Remotely Controlled Laboratory (RCL)

Author

Grober, S., Vetter, M., and Eckert, B.

Abstract

The speed of light is an essential topic in the teaching of physics at school and at university, either with respect to the type of experiment or of course with respect to its genuine inherent importance. In reality, the various available experiments are hardly ever performed in class for many reasons. Therefore, we offer this experiment as a remotely controlled laboratory (RCL). An RCL is a real experiment setup at location A which can be controlled via the Internet by a user at a distant location B. It allows several actions like in the hands-on experiment and delivers convincing results. Finally, we present experiences of the use of the RCL, describe the added value of this experiment as an RCL and give hints for implementing the RCL in teaching. (Contains 1 table, 7 figures and 2 footnotes.)

Published
2010
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28. World Pendulum--A Distributed Remotely Controlled Laboratory (RCL) to Measure the Earth's Gravitational Acceleration Depending on Geographical Latitude

Author

Grober, S., Vetter, M., and Eckert, B.

Abstract

We suggest that different string pendulums are positioned at different locations on Earth and measure at each place the gravitational acceleration (accuracy [delta]g is approximately equal to 0.01 m s[superscript -2]). Each pendulum can be remotely controlled via the internet by a computer located somewhere on Earth. The theoretical part describes the physical origin of this phenomenon g([psi]), that the Earth's effective gravitational acceleration g depends on the angle of latitude [psi]. Then, we present all necessary formula to deduce g([psi]) from oscillations of a string pendulum. The technical part explains tips and tricks to realize such an apparatus to measure all necessary values with sufficient accuracy. In addition, we justify the precise dimensions of a physical pendulum such that the formula for a mathematical pendulum is applicable to determine g([psi]) without introducing errors. To conclude, we describe the internet version--the string pendulum as a remotely controlled laboratory. The teaching relevance and educational value will be discussed in detail at the end of this paper including global experimenting, using the internet and communication techniques in teaching and new ways of teaching and learning methods. (Contains 2 footnotes, 2 tables, and 6 figures.)

Published
2007
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29. Endovascular thrombectomy in young patients with stroke.

Author

Weller, Johannes M, Dorn, Franziska, Meissner, Julius N, Stösser, Sebastian, Beckonert, Niklas M, Nordsiek, Julia, Kindler, Christine, Deb-Chatterji, Milani, Petzold, Gabor C, Bode, Felix J, Reich, A., Nikoubashman, O., Röther, J., Eckert, B., Braun, M., Hamann, G.F., Siebert, E., Nolte, C.H., Bohner, G., and Eckert, R.M.

Subjects
ENDOVASCULAR surgery, STROKE patients, ISCHEMIC stroke, OLDER patients, INTRACRANIAL hemorrhage
Abstract

Background: Endovascular treatment (ET) is standard of care in patients with acute ischemic stroke due to large vessel occlusion, but data on ET in young patients remain limited. Aim: We aim to compare outcomes for young stroke patients undergoing ET in a matched cohort. Methods: We analyzed patients from an observational multicenter cohort with acute ischemic stroke and ET, the German Stroke Registry—Endovascular Treatment trial. Baseline characteristics, procedural parameters, and functional outcome at 90 days were compared between young (<50 years) and older (⩾50 years) patients with and without nearest-neighbor 1:1 propensity score matching. Results: Out of 6628 acute ischemic stroke patients treated with ET, 363 (5.5%) were young. Young patients differed with regard to prognostic outcome characteristics. Specifically, National Institutes of Health Stroke Scale (NIHSS) at admission was lower (median 13, interquartile range (IQR) 8–17 vs. 15, IQR 9–19, p < 0.001), and prestroke dependence was less frequent (2.9% vs. 12.2%, p < 0.001) than in older patients. Compared to a matched cohort of older patients, ET was faster (time from groin puncture to flow restoration, 35 vs. 45 min, p < 0.001) and intracranial hemorrhage was less frequent in young patients (10.0% vs. 25.9%, p < 0.001). Good functional outcome (modified Rankin Scale (mRS) 0–2) at 3 months was achieved more frequently in young patients (71.6% vs. 44.1%, p < 0.001), and overall mortality was lower (6.7% vs. 25.4%, p < 0.001). Among previously employed young patients (n = 177), 37.9% returned to work at 3-month follow-up, while 74.1% of the remaining patients were still undergoing rehabilitation. Conclusion: Young stroke patients undergoing ET have better outcomes compared to older patients, even when matched for prestroke condition, comorbidities, and stroke severity. Hence, more liberal guidelines to perform ET for younger patients may have to be established by future studies. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Intravenous thrombolysis upon flow restoration improves outcome in endovascular thrombectomy

Author

Weller, Johannes M, Dorn, Franziska, Bormann, A., Braun, M., Eckert, B., Eckert, R. M., Ernemann, U., Ernst, M., Fiehler, J., Gerloff, C., Gröschel, K., Hamann, G. F., Petzold, Gabor C, Henn, K. H., Kellert, L., Kraemer, C., Leischner, H., Liman, J., Ludolph, A., Nikoubashman, O., Nolte, C. H., Petersen, M., Poli, S., Bode, Felix, Reich, A., Röther, J., Schäfer, J. H., Schellinger, P., Siebert, E., Stögbauer, F., Thomalla, G., Tiedt, S., Trumm, C., Uphaus, T., investigators, GSR-ET, Wunderlich, S., Alegiani, A., Berrouschot, J., Boeck-Behrens, T., Bohner, G., and Borggrefe, J.

Subjects
Stroke, Surgery, Neurology (clinical), General Medicine, ddc:610, Thrombolysis, Thrombectomy
Abstract

BackgroundWe hypothesized that ongoing IV thrombolysis (IVT) at flow restoration in patients with acute ischemic stroke (AIS) treated with IVT and endovascular thrombectomy (ET) is associated with improved outcome.MethodsWe included patients with IVT and successful recanalization (modified Thrombolysis in Cerebral Infarction score ≥2b) after ET from an observational multicenter cohort, the German Stroke Registry – Endovascular Treatment trial. Procedural characteristics and functional outcome at discharge and 90 days were compared between patients with and without ongoing IVT at flow restoration. To determine associations with functional outcome, adjusted ORs were calculated using ordinal multivariable logistic regression models adjusted for potential baseline confounder variables.ResultsAmong 1303 patients treated with IVT and ET who achieved successful recanalization, IVT was ongoing in 13.8% (n=180) at flow restoration. Ongoing IVT was associated with better functional outcome at discharge (adjusted OR 1.61; 95% CI 1.13 to 2.30) and at 90 days (adjusted OR 1.52; 95% CI 1.06 to 2.18).ConclusionThese results provide preliminary evidence for a benefit of ongoing IVT at flow restoration in patients with AIS treated with ET.

Published
2022

37. Antithrombotic treatment and outcome after endovascular treatment and acute carotid artery stenting in stroke patients with atrial fibrillation.

Author

Weller, Johannes M., Dorn, Franziska, Meissner, Julius N., Stösser, Sebastian, Beckonert, Niklas M., Nordsiek, Julia, Kindler, Christine, Riegler, Christoph, Keil, Fee, Petzold, Gabor C., Bode, Felix J., the GSR-ET investigators, Reich, A., Nikoubashman, O., Röther, J., Eckert, B., Braun, M., Hamann, G. F., Siebert, E., and Nolte, C. H.

Subjects
ENDOVASCULAR surgery, CAROTID artery, ATRIAL fibrillation, STROKE patients, TREATMENT effectiveness, PLATELET aggregation inhibitors
Abstract

Background: Oral anticoagulation (OAC) is the mainstay of secondary prevention in ischemic stroke patients with atrial fibrillation (AF). However, in AF patients with large vessel occlusion stroke treated by endovascular therapy (ET) and acute carotid artery stenting (CAS), the optimal antithrombotic medication remains unclear. Methods: This is a subgroup analysis of the German Stroke Registry—Endovascular Treatment (GSR-ET), a prospective multicenter cohort of patients with large vessel occlusion stroke undergoing ET. Patients with AF and CAS during ET were included. We analyzed baseline and periprocedural characteristics, antithrombotic strategies and functional outcome at 90 days. Results: Among 6635 patients in the registry, a total of 82 patients (1.2%, age 77.9 ± 8.0 years, 39% female) with AF and extracranial CAS during ET were included. Antithrombotic medication at admission, during ET, postprocedural and at discharge was highly variable and overall mortality in hospital (21%) and at 90 days (39%) was high. Among discharged patients (n = 65), most frequent antithrombotic regimes were dual antiplatelet therapy (DAPT, 37%), single APT + OAC (25%) and DAPT + OAC (20%). Comparing DAPT to single or dual APT + OAC, clinical characteristics at discharge were similar (median NIHSS 7.5 [interquartile range, 3–10.5] vs 7 [4–11], p = 0.73, mRS 4 [IQR 3–4] vs. 4 [IQR 3–5], p = 0.79), but 90-day mortality was higher without OAC (32 vs 4%, p = 0.02). Conclusions: In AF patients who underwent ET and CAS, 90-day mortality was higher in patients not receiving OAC. Registration: https://www.clinicaltrials.gov; Unique identifier: NCT03356392. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Mechanical Thrombectomy in Patients with Acute Ischemic Stroke and Concomitant Intracranial Hemorrhage.

Author

Weller, Johannes M., Meissner, Julius N., Stösser, Sebastian, Dorn, Franziska, Petzold, Gabor C., Bode, Felix J., GSR-ET investigators, Reich, A., Nikoubashman, O., Röther, J., Eckert, B., Braun, M., Hamann, G. F., Siebert, E., Nolte, C. H., Bohner, G., Eckert, R. M., Borggrefe, J., Schellinger, P., and Berrouschot, J.

Abstract

Purpose: Intravenous thrombolysis and mechanical thrombectomy (MT) are standard of care in patients with acute ischemic stroke due to large vessel occlusion. Data on MT in patients with intracranial hemorrhage prior to intervention is limited to anecdotal reports, as these patients were excluded from thrombectomy trials. Methods: We analyzed patients from an observational multicenter cohort with acute ischemic stroke and endovascular treatment, the German Stroke Registry—Endovascular Treatment trial, with intracranial hemorrhage before MT. Baseline characteristics, procedural parameters and functional outcome at 90 days were analyzed and compared to a propensity score matched cohort. Results: Out of 6635 patients, we identified 32 patients (0.5%) with acute ischemic stroke due to large vessel occlusion and preinterventional intracranial hemorrhage who underwent MT. Risk factors of intracranial hemorrhage were head trauma, oral anticoagulation and intravenous thrombolysis. Overall mortality was high (50%) but among patients with a premorbid modified Rankin scale (mRS) of 0–2 (n = 15), good clinical outcome (mRS 0–2) at 90 days was achieved in 40% of patients. Periprocedural and outcome results did not differ between patients with and without preinterventional intracranial hemorrhage. Conclusion: Preinterventional intracranial hemorrhage in acute ischemic stroke patients with large vessel occlusion is rare. The use of MT is technically feasible and a substantial number of patients achieve good clinical outcome, indicating that MT should not be withheld in patients with preinterventional intracranial hemorrhage. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Poster abstracts

Author

Marshall, N. S., Almqvist, C., Grunstein, R. R., Marks, G. B., Nixon, G. M., Wawruszak, M., Verginis, N., Horne, R. S. C., Davey, M. J., Blunden, S. L., Chervin, R. D., Ng, M. L., O’Driscoll, D. M., Yang, J. S. C., Noa, A. M., Lushington, K., Camfferman, D., Gold, M., Kennedy, D., Galland, B. C., Taylor, B. J., Tripp, E. G., Phillips, A. M., Lrichardson, H., Verbeek, M., Parslow, P., Scott, S., Walker, A. M., Harding, R., Richards, H., Lack, L., Gradisar, M., Harris, J., Vu, T., Mitchell, P. I., Toth, K. A., Mcculloch, B. J., Campbell, A., Signal, T. L., O’Keeffe, K., Kanbayashi, T., Kondo, H., Satoh, S., Takemura, T., Kaneko, Y., Kanayama, H., Abe, M., Nishino, S., Ishikawa, H., Shimizu, T., Stadler, D., Catcheside, P., George, K., Thompson, C., Ryan, M., Mcevoy, R. D., Wilkinson, V., Nicholas, C., Worsnop, C., Jordan, A., Malhotra, A., Steiner, K., White, D., Trinder, J., Hellgren, J., Lee, Y., O’Brien, D., Yee, B., Rimmer, J., Grunstein, R., Hilditch, C. J., Catcheside, P. G., Rischmueller, M., Kirkness, J. P., Schneider, H., Patil, S. P., Mcginley, B. M., Smith, P. L., Schwartz, A. R., Maddison, K. J., Walsh, J. H., Philippe, D. L., Platt, P. R., Hillman, D. R., Eastwood, P. R., Yeo, A., Thomson, K., Melehan, K. L., Bartlett, D. J., Wong, K. K., Car, G., Feenstra, J. F. E., Eckert, B., Rixon, K., Hukins, C., Crummy, F., Kossmann, T., Cameron, P., Naughton, M. T., Larby, J. R., Curtin, D., Semple, K., Douglas, J., Lee, Y. H., Edwards, N., Sullivan, C. E., Lehman, S., Antic, N. A., Mcevoy, D., Mukherjee, S., Fedson, A., Palmer, L. J., Love, G., Singh, B., James, A., Cullen, S. C., Mcardle, N., Hillman, D., Clarke, P. F., Van Eps, C., Hawley, C., Lee, R. W., Chan, A. S., Cistulli, P. A., Abdul Latif, H., Stick, S., Maul, J., Wilson, A., Suresh, S., James, J., Byrne, S., Doull, I., Evans, H., Parsley, C. L., Williams, G., Dakin, C., Harris, M., Cooper, D. M., Heussler, H., Chan, E. Y.-T., Hyde, M. L., Yuill, M., Harris, M. A., Schibler, A., Wilson, S., Cooper, D., Maclean, J. E., Fitzsimons, D., Waters, K., Fitzgerald, D., Coussens, S., Berryman, M., Parsons, D., Saint, D., Pamula, Y., Martin, A. J., Abbot, D., Piper, A. J., Wang, D., Yee, B. J., Willson, G. N., Flunt, D., Bassin, D., Bateman, P., Ratnavadivel, R., Lester, S., Huang, Q. R., He, H. X., Chow, C. M., Jones, A. C., Visvalingam, V. V., Lui, P., Buchanan, P., Duce, B. L., Bliss, R. A., Bruck, D., Afaghi, A., O’Connor, H., Smith, S. S., Kilby, S., Jorgensen, G., Douglas, J. A., Johns, M. W., Tucker, A. J., Chapman, R. J., Michael, N. J., Beale, C. A., Stephens, M. N., Ferguson, S. A., Lamond, N., Jay, S. M., Dorrian, J., Jones, C. B., Roach, G. D., Dawson, D., Jackson, M. L., Howard, M. E., Kennedy, G., Swann, P., Pierce, R. J., Loughran, S. P., Wood, A. W., Croft, R. J., Barton, J. M., Thompson, B., Stough, C., Kandelaars, K., Warman, G. R., Bolton, C. A., Fernando, III, A. T., Cheeseman, J. F., Inglis, C., Huang, H.-C. C., Wlee, R., Richards, D., Turton, A., Copland, J., Ho, M., Rochford, P. D., Brazzale, D. J., Zubrinich, C., Roebuck, T. J., Toman, P., Ho, S., Szollosi, I., Naughton, M., Ruehland, W., Churchward, T., Ruehland, W. R., Churchward, T. J., Barnes, M., Lakey, T., Denotti, A. L., Dungan, G. C., Wong, K. K. H., Gilholme, J. W., Cunnington, D., Cherry, G., Teichtahl, H., Mietus, J. E., Goldberger, A. L., Thomas, R. J., Linklater, S., Martin, J., Galilogadr, S., Mihai, R., Gulliver, T., Wales, P., Salvini, A., Whitehead, B., Laybutt, N., Latham-Smith, F., Shine, N. P., Coates, H. L., Lannigan, F. J., Ng, A. T., Darendeliler, M. A., Zeng, B., Ng, A., Darendeliler, A., Cistulli, P., Qian, J., Hanssen, K., Schnider, H., Lewis, R. H., De Fazio, D., Pierce, R., Pretto, J., Mcdonald, C., Howard, M., Baulk, S. D., Biggs, S. N., Van Den Heuvel, C. J., Reid, K., Vakulin, A., Anderson, R., Banks, S., Davies, A. N., Williams, A. D., Almond, J., Beard, D., Peisker, C., Ball, M., Taylor, A., Wright, H., Clark, R., Hensley, M., Rowland, S., Windler, S., Kennedy, G. A., Gullo, M., Clarke, C., Gain, K., Murphy, M., Rebus, C., Saunders, K., Imazu, M., Morgan, H., Kwan, M., Nicholls, G., Tolson, J., Worsnop, C. J., Navin, C., Baker, G., and Van Der Touw, T.

Published
2006
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48. The Bigger the Better? Center Volume Dependent Effects on Procedural and Functional Outcome in Established Endovascular Stroke Centers.

Author

Hahn, Marianne, Gröschel, Sonja, Tanyildizi, Yasemin, Brockmann, Marc A., Gröschel, Klaus, Uphaus, Timo, Reich, A, Nikoubashman, O, Röther, J, Eckert, B, Braun, M, Hamann, G F, Siebert, E, Nolte, C H, Bohner, G, Eckert, R M, Borggrefe, J, Schellinger, P, Berrouschot, J, and Bormann, A

Subjects
FUNCTIONAL status, LOGISTIC regression analysis, ENDOVASCULAR surgery, ISCHEMIC stroke, HEALTH facilities
Abstract

Background: Mechanical thrombectomy (MT) rates for the treatment of acute ischaemic stroke due to large vessel occlusion are steadily increasing, but are delivered in heterogenic settings. We aim to investigate effects of procedural load in centers with established MT-structures by comparing high- vs. low-volume centers with regard to procedural characteristics and functional outcomes. Methods: Data from 5,379 patients enrolled in the German Stroke Registry Endovascular Treatment (GSR-ET) between June 2015 and December 2019 were compared between three groups: high volume: ≥180 MTs/year, 2,342 patients; medium volume: 135–179 MTs/year, 2,202 patients; low volume: <135 MTs/year, 835 patients. Univariate analysis and multiple linear and logistic regression analyses were performed to identify differences between high- and low-volume centers. Results: We identified high- vs. low-volume centers to be an independent predictor of shorter intra-hospital (admission to groin puncture: 60 vs. 82 min, β = −26.458; p < 0.001) and procedural times (groin puncture to flow restoration: 36 vs. 46.5 min; β = −12.452; p < 0.001) after adjusting for clinically relevant factors. Moreover, high-volume centers predicted a shorter duration of hospital stay (8 vs. 9 days; β = −2.901; p < 0.001) and favorable medical facility at discharge [transfer to neurorehabilitation facility/home vs. hospital/nursing home/in-house fatality, odds ratio (OR) 1.340, p = 0.002]. Differences for functional outcome at 90-day follow-up were observed only on univariate level in the subgroup of primarily to MT center admitted patients (mRS 0–2 38.5 vs. 32.8%, p = 0.028), but did not persist in multivariate analyses. Conclusion: Differences in efficiency measured by procedural times call for analysis and optimization of in-house procedural workflows at regularly used but comparatively low procedural volume MT centers. [ABSTRACT FROM AUTHOR]

Published
2022
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