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14 results on '"Eckert, Andrew W."'

1. Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn’s Disease

Author

Baldassano, Robert N., Bradfield, Jonathan P., Monos, Dimitri S., Kim, Cecilia E., Glessner, Joseph T., Casalunovo, Tracy, Frackelton, Edward C., Otieno, F. George, Kanterakis, Stathis, Shaner, Julie L., Smith, Ryan M., Eckert, Andrew W., Robinson, Luke J., Onyiah, Chioma C., Abrams, Debra J., Chiavacci, Rosetta M., Skraban, Robert, Devoto, Marcella, Grant, Struan F.A., and Hakonarson, Hakon

Published
2007
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2. Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

Author

Grant, Struan F.A., Qu, Hui-Qi, Bradfield, Jonathan P., Marchand, Luc, Kim, Cecilia E., Glessner, Joseph T., Grabs, Rosemarie, Taback, Shayne P., Frackelton, Edward C., Eckert, Andrew W., Annaiah, Kiran, Lawson, Margaret L., Otieno, F. George, Santa, Erin, Shaner, Julie L., Smith, Ryan M., Skraban, Robert, Imielinski, Marcin, Chiavacci, Rosetta M., Grundmeier, Robert W., Stanley, Charles A., Kirsch, Susan E., Waggott, Daryl, Paterson, Andrew D., Monos, Dimitri S., Polychronakos, Constantin, and Hakonarson, Hakon

Published
2009

3. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry

Author

Sleiman, Patrick M.A., Annaiah, Kiran, Imielinski, Marcin, Bradfield, Jonathan P., Kim, Cecilia E., Frackelton, Edward C., Glessner, Joseph T., Eckert, Andrew W., Otieno, George F., Santa, Erin, Thomas, Kelly, Smith, Ryan M., Glaberson, Wendy, Garris, Maria, Gunnlaugsson, Sigfus, Chiavacci, Rosetta M., Allen, Julian, Spergel, Jonathan, Grundmeier, Robert, Grunstein, Michael M., Magnusson, Mark, Bisgaard, Hans, Grant, Struan F.A., and Hakonarson, Hakon

Published
2008

4. Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma

Author

Maris, John M., Mosse, Yael P., Bradfield, Jonathan P., Hou, Cuiping, Monni, Stefano, Scott, Richard H., Asgharzadeh, Shahab, Attiyeh, Edward F., Diskin, Sharon J., Laudenslager, Marci, Winter, Cynthia, Cole, Kristina A., Glessner, Joseph T., Kim, Cecilia, Frackelton, Edward C., Casalunovo, Tracy, Eckert, Andrew W., Capasso, Mario, Rappaport, Eric F., McConville, Carmel, London, Wendy B., Seeger, Robert C., Rahman, Nazneen, Devoto, Marcella, Grant, Struan F.A., Li, Hongzhe, and Hakonarson, Hakon

Published
2008
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5. A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

Author

Hakonarson, Hakon, Qu, Hui-Qi, Bradfield, Jonathan P., Marchand, Luc, Kim, Cecilia E., Glessner, Joseph T., Grabs, Rosemarie, Casalunovo, Tracy, Taback, Shayne P., Frackelton, Edward C., Eckert, Andrew W., Annaiah, Kiran, Lawson, Margaret L., Otieno, F. George, Santa, Erin, Shaner, Julie L., Smith, Ryan M., Onyiah, Chioma C., Skraban, Robert, Chiavacci, Rosetta M., Robinson, Luke J., Stanley, Charles A., Kirsch, Susan E., Devoto, Marcella, Monos, Dimitri S., Grant, Struan F.A., and Polychronakos, Constantin

Published
2008

6. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn’s disease

Author

Baldassano, Robert N, Bradfield, Jonathan P, Monos, Dimitri S, Kim, Cecilia E, Glessner, Joseph T, Casalunovo, Tracy, Frackelton, Edward C, Otieno, F George, Kanterakis, Stathis, Shaner, Julie L, Smith, Ryan M, Eckert, Andrew W, Robinson, Luke J, Onyiah, Chioma C, Abrams, Debra J, Chiavacci, Rosetta M, Skraban, Robert, Devoto, Marcella, Grant, Struan F A, and Hakonarson, Hakon

Published
2007

7. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

Author

Kugathasan, Subra, primary, Baldassano, Robert N, additional, Bradfield, Jonathan P, additional, Sleiman, Patrick M A, additional, Imielinski, Marcin, additional, Guthery, Stephen L, additional, Cucchiara, Salvatore, additional, Kim, Cecilia E, additional, Frackelton, Edward C, additional, Annaiah, Kiran, additional, Glessner, Joseph T, additional, Santa, Erin, additional, Willson, Tara, additional, Eckert, Andrew W, additional, Bonkowski, Erin, additional, Shaner, Julie L, additional, Smith, Ryan M, additional, Otieno, F George, additional, Peterson, Nicholas, additional, Abrams, Debra J, additional, Chiavacci, Rosetta M, additional, Grundmeier, Robert, additional, Mamula, Petar, additional, Tomer, Gitit, additional, Piccoli, David A, additional, Monos, Dimitri S, additional, Annese, Vito, additional, Denson, Lee A, additional, Grant, Struan F A, additional, and Hakonarson, Hakon, additional

Published
2008
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8. Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

Author

Grant, Struan F. A., primary, Li, Mingyao, additional, Bradfield, Jonathan P., additional, Kim, Cecilia E., additional, Annaiah, Kiran, additional, Santa, Erin, additional, Glessner, Joseph T., additional, Casalunovo, Tracy, additional, Frackelton, Edward C., additional, Otieno, F. George, additional, Shaner, Julie L., additional, Smith, Ryan M., additional, Imielinski, Marcin, additional, Eckert, Andrew W., additional, Chiavacci, Rosetta M., additional, Berkowitz, Robert I., additional, and Hakonarson, Hakon, additional

Published
2008
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9. Association of HMGA2 Gene Variation with Height in Specific Pediatric Age Categories

Author

Grant, Struan F.A., primary, Li, Mingyao, additional, Bradfield, Jonathan P., additional, Kim, Cecilia E., additional, Annaiah, Kiran, additional, Santa, Erin, additional, Glessner, Joseph T., additional, Casalunovo, Tracy, additional, Frackelton, Edward C, additional, Otieno, F. George, additional, Shaner, Julie L., additional, Smith, Ryan M., additional, Eckert, Andrew W., additional, Imielinski, Marcin, additional, Chiavacci, Rosetta M., additional, Berkowitz, Robert I., additional, and Hakonarson, Hakon, additional

Published
2008
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11. ▪Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn’s Disease.

Author

Baldassano, Robert N., Bradfield, Jonathan P., Monos, Dimitri S., Kim, Cecilia E., Glessner, Joseph T., Casalunovo, Tracy, Frackelton, Edward C., Otieno, F. George, Kanterakis, Stathis, Shaner, Julie L., Smith, Ryan M., Eckert, Andrew W., Robinson, Luke J., Onyiah, Chioma C., Abrams, Debra J., Chiavacci, Rosetta M., Skraban, Robert, Devoto, Marcella, Grant, Struan F.A., and Hakonarson, Hakon

Subjects
INTERLEUKINS, CROHN'S disease, JUVENILE diseases, STATISTICAL hypothesis testing
Abstract

Background & Aims: Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn’s disease (CD) as a consequence of a genome-wide association study of this disease in adults. We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children. Methods: By using data from our ongoing genome-wide association study in our cohort of 142 pediatric CD patients and 281 matched controls, we investigated the association of the previously reported SNPs at the IL23R locus with the childhood form of this disease. Results: By using the Fisher exact test, the minor allele frequency of rs11209026 in the patients was 1.75%, whereas it was 6.61% in the controls, yielding a protective odds ratio (OR) of 0.25 (95% confidence interval, 0.10–0.65; 1-sided P = 9.2 × 10−4). Furthermore, of all the SNPs previously reported, rs11209026 was associated the most strongly. A subsequent family based association test (which is more resistant to population stratification) with 65 sets of trios derived from our initial patient cohort yielded significant association with rs11209026 in a transmission disequilibrium test (1-sided P = .0017). In contrast, no association was detected to the caspase-recruitment domain 15 gene for the inflammatory bowel disease phenotype. Conclusions: The OR of the IL23R variant in our pediatric study is highly comparable with that reported previously in a non-Jewish adult inflammatory bowel disease case-control cohort (OR, 0.26). As such, variants in the IL23R gene confer a similar magnitude of risk of CD to children as for their adult counterparts. [Copyright &y& Elsevier]

Published
2007
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12. Association of the T300A non- synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.

Author

Boldassano, Robert N., Bradfield, Jonathan P., Manos, Dimitri S., Kim, Cecilia E., Glessner, Joseph T., Casalunovo, Tracy, Frackelton, Edward C., Otieno, F. George, Kanterakis, Stathis, Shaner, Julie L., Smith, Ryan M., Eckert, Andrew W., Robinson, Luke J., Onyiah, Chioma C., Abrams, Debra J., Chiavacci, Rosetta M., Skraban, Robert, Devoto, Marcella, Grant, Struaan F. A., and Hakonarson, Hakon

Subjects
LETTERS to the editor, CROHN'S disease
Abstract

A letter to the editor which offers information about the association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to pediatric Crohn's disease is presented.

Published
2007
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14. Association of the BANK 1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry.

Author

Grant SF, Petri M, Bradfield JP, Kim CE, Santa E, Annaiah K, Frackelton EC, Glessner JT, Otieno FG, Shaner JL, Smith RM, Eckert AW, Chiavacci RM, Imielinski M, Sullivan KE, and Hakonarson H

Abstract

Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs10516487, within the B-cell gene BANK1 and systemic lupus erythematosus (SLE) as a consequence of a genome wide association study of this disease in European and Argentinean populations. In a bid for replication, we examined the effects of the R61H non-synonymous variant with respect to SLE in our genotyped American cohorts of European and African ancestry. Utilizing data from our ongoing genome-wide association study in our cohort of 178 Caucasian SLE cases and 1808 Caucasian population-based controls plus 148 African American (AA) SLE cases and 1894 AA population-based controls we investigated the association of the previously described non-synonymous SNP at the BANK1 locus with the disease in the two ethnicities separately. Using a Fisher's exact test, the minor allele frequency (MAF) of rs10516487 in the Caucasian cases was 22.6% while it was 31.2% in Caucasian controls, yielding a protective odds ratio (OR) of 0.64 (95% CI 0.49-0.85; one-sided p = 7.07 × 10(-4)). Furthermore, the MAF of rs10516487 in the AA cases was 18.7% while it was 23.3% in AA controls, yielding a protective OR of 0.75 (95% CI 0.55-1.034; one-sided p = 0.039). The OR of the BANK1 variant in our study cohorts is highly comparable with that reported previously in a South American/European SLE case-control cohort (OR = 0.72). As such, R61H in the BANK1 gene confers a similar magnitude of SLE protection, not only in European Americans, but also in African Americans.

Published
2009
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