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In recent years, edible insects have often been mentioned as new and innovative food items. Food identity, culture, and traditions are a strong justification and argument for food choices. In the present study, we collected, reviewed, and summarized the findings of published qualitative studies about the cultural aspects and the main barriers to the consumption of edible insects in different geographical regions of the world. While insects are extensively employed as a source of animal feed across numerous areas in Latin America, Asia, and Africa, there exists cultural reluctance in various regions, particularly in the Western world, hindering widespread acceptance. This cultural resistance plays a crucial role in shaping the acceptability and prioritization of utilizing insects as food. Cultural factors play an essential role in what? For example, the use of an insect species may be accepted by a region's population, but it is considered inedible in neighboring tribes. For example, In Iran, a type of cricket (mostly, Psalmocharias alhageos) is prevalent among local people in parts of Kerman Province and South Khorasan, while in other provinces, they do not consume it. The main obstacles to using insects for animal feed are customs and cultures, fear of consuming food, disgust, and disease risk factors. Therefore, there is a need for measures such as education, public policies, and cultural and marketing interventions that can lead to risk reduction, change of beliefs, cultural norms, and social acceptance. Despite persistent cultural barriers, there is a growing inclination towards altering cultural beliefs, resulting in increased acceptance and consumption of edible insects.

ABSTRACT Aim In previous studies, the researchers observed an increase in insulin secretion in STZ‐treated diabetic rats following treatment with the hydroalcoholic extract of Securigera securidaca (HESS) seeds. This study focuses on the relationship between the antioxidant properties of HESS with changes in diabetic pancreatic tissue and the gene expression of factors that impact insulin secretion. Methods In this controlled experimental study, three varying doses of HESS were administered to three groups of diabetic rats induced by STZ. Oxidative stress indicators like total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde were assessed in both pancreatic and liver tissues. Pancreatic histology was studied post‐haematoxylin staining. Insulin and FGF21 levels in the blood were measured using the ELISA method. The expression of Nrf2 and FGF21 genes in the pancreas and liver, along with MafA and PDX‐1 genes in the pancreas, was quantified using real‐time PCR. Results The administration of HESS in varying doses led to a dose‐dependent rise in blood insulin levels and a decrease in blood glucose levels and oxidative stress. By reducing oxidative stress, HESS treatment lowered the heightened levels of NRF2 and FGF21 in the liver and pancreas of diabetic rats, improving pancreatic tissue health. As oxidative stress decreased, the expression of MafA and PDX1 genes in the pancreas approached levels seen in healthy rats. Conclusion HESS elicits an increase in insulin secretion through the mitigation of oxidative stress and tissue damage, as well as the modulation of gene expression related to the insulin transcription factors PDX‐1 and MafA.

IntroductionCulex quinquefasciatus is one of the most important carriers of human pathogens. Using the insecticides is one of the most important methods of combating this vector. But the genetic resistance created in Culex quinquefasciatus led to disruption in the fight against this pest. Consequently, it is necessary to know the level of resistance to fight this vector. Based on this, the present study was conducted to investigate the prevalence of kdr resistance in Culex quinquefasciatus against organochlorine insecticides in the world.MethodsThis study was conducted by systematic review, and meta-analysis on the prevalence of kdr resistance and mortality rate in Culex quinquefasciatus against organochlorine insecticides in the world. All pertinent articles were extracted and analyzed in accordance with this information during an unrestricted search of the scientific databases Web of Science, PubMed, Scopus, biooan.org, Embase, ProQuest, and Google Scholar until the end of November 2023. Statistical analysis of data was done using fixed and random effects model in meta-analysis, I2 index, Cochran's test, and meta-regression by STATA version 17 software.ResultsSeventy articles were included in the meta-analysis process. Based on the findings, the prevalence of Kdr in Culex quinquefasciatus against organochlorine insecticide was estimated at 63.1%. Moreover, the mortality rate against the insecticide deltamethrin was 46%, DDT 18.5%, permethrin 42.6%, malathion 54.4% and lambdacyhalothrin 53%.ConclusionMore than half of Cx. quinquefasciatus had Kdr. This vector was relatively resistant to DDT and permethrin insecticides and sensitive to malathion, deltamethrin and lambdacyhalothrin. In order to prevent the development of resistance to alternative insecticides, it is consequently critical to combat this vector with efficacious insecticides.

The purpose of this research is to use the ensemble learning model to combine the predictions of random forest models, short-term long memory and recurrent neural network to provide an algorithmic trading system based on its. In this research, a prediction model based on ensemble machine learning model is presented and its performance is compared with each of the sub-algorithms and real data. In this research, in the first stage, using three machine learning models, the price top and bottom of Bitcoin have been predicted. In the second stage, the outputs of the models are presented as feature variables to the XGboost and LightGBM models to predict the roof and floors. Then, in the third stage, the outputs of the second stage are combined with the collective voting classification pattern to predict the next ceiling and floor. Bitcoin price top and bottom data in the 1-hour time frame from 1/1/2018 to the end of 6/30/2022 have been used as target variables and 31 technical analysis indicators as feature variables for three models in the first stage. Finally, forecast values and algorithmic trading systems were evaluated and compared with real data for 3 models and the introduced ensemble learning model. The obtained results show the improvement of the precision and accuracy of the proposed collective learning model in predicting the top and bottom of Bitcoin, as well as its better performance than the sub-algorithms.

The present study aims to investigate the effect of corporate irresponsibility on stock price crash risk by emphasizing the moderating role of financial expertise of the audit committee in companies listed on the Tehran Stock Exchange. To estimate the multiple regression model to test the hypothesis, the aforementioned model was used using panel data by the pooled data method in companies listed on the Tehran Stock Exchange and Eviews 9 statistical software was used for statistical analysis. In this research, 150 companies (1050 company-years) were selected to test the research hypothesis between 2014 and 2020. The Levin, Lien and Wu tests were used to test the reliability of research data, the Jarque-Bera test was used to determine the normality of the data, the regression method was used to express the relationship between variables, t-test statistics to test the significance of regression coefficients, and finally the F-test statistic was used to determine the significance of the equation. In general, the results of testing the research hypotheses indicate that corporate irresponsibility has a significant positive effect on stock price crash risk. The results also show that the financial expertise of the audit committee has a significant moderating effect on the relationship between corporate irresponsibility and stock price crash risk. In fact, the financial expertise of the audit committee reduces the positive relationship between corporate irresponsibility and stock price crash risk.

Market disorder and irrational behavior of investors escalate stock market volatility. This research has been conducted to identify drivers and consequences of behavioral bias and strategies for reducing the effects of bias behavioral in institutional investors by implementing the correlation research method. The evidence collected from a possible statistical sample of 607 legal investors has been analyzed using a questionnaire, confirmatory factor analysis, and structural equation modeling. The results have shown that increasing the causes and bases of bias (social and psychological factors, knowledge and experience, and market) leads to an increase in behavioral biases and the use of behavioral biases strategy in investors' decision-making. Also, the strategy to reduce behavioral biases is influenced by behavioral biases, background factors, and intervening factors. In the end, the success of investors is significantly influenced by behavioral bias reduction strategy, the causes of the behavior biases, and the behavioral biases. Evidence has shown that the investigated model has predictive validity for investment performance, and institutional investors can benefit from this study by understanding the influence of behavioral factors on investors' decisions.

Abstract Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) protein is one of the factors associated with oxidative stress and dyslipidemia disorders. Objective: This study aimed to evaluate the lipid profile, PCSK9 levels, and oxidative stress in preeclampsia. Materials and Methods: This case-control study was conducted at Sina hospital in Hamadan University of Medical Sciences, Hamadan, Iran from August 2020-May 2021. The average maternal age of included participants was 30 yr with 30 preeclampsia and 30 healthy pregnant women. After clinical examination, the fasting blood samples were collected, and the serum PCSK9 protein concentration, superoxide dismutase, glutathione peroxidase activities, and glutathione levels were determined by enzyme-linked immunosorbent assay. Total antioxidant capacity, total oxidant status, and malondialdehyde levels were determined manually. Results: The average maternal age of participants were 29.97 ± 4.75 and 31.23 ± 5.85 yr, respectively. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), PCSK9, total antioxidant capacity, and malondialdehyde levels were higher in the preeclampsia group compared with control (p < 0.02). Total oxidant status, glutathione levels, superoxide dismutase, glutathione peroxidase activities were lower in the cases group compared with the control group (p < 0.01). The PCSK9 variable had a significant negative association with antioxidant parameters; however, a significant positive association was observed between PCSK9 level and parameters of LDL-C. Conclusion: PCSK9 is associated with increased serum levels of LDL-C and oxidative factors in pregnant women that increase the risk of endothelial damage and hypertension in preeclampsia.

12 public and private banks are currently present in the stock exchange market in the “bank and credit institution” group. This study examines the behavioral bias of legal clients of stock exchange investors according to the literature on the behavioral finance. The grounded theory approach has been used to examine the patterns of behavioral bias of legal clients. The research data are the narratives of the participants (legal clients of stock market investors) for 2021. Nineteen people were selected using the purpose-based sampling method, and their narratives were collected through semi-structured interviews and coded by MaxQda software and analyzed in three stages. The findings of the study have shown that institutional investor behavioral bias is formed on social, emotional and psychological bias platforms, whose drivers are social factors, market, knowledge and experience, and psychological factors. To reduce the impact of behavioral bias, strategies for portfolio diversification strategies, investment strategies, investment analysis, and the use of information, are used which in turn result in improved capital market efficiency and investor success. Furthermore, the strategies are influenced, on the one hand, by cultural, political and economic factors, and on the other hand by the financial characteristics of the company, the policy of the company, and the institutional characteristics.

The purpose of this research was to identify the factors affecting financing of small and medium-sized enterprises in the Tehran Stock Exchange (TSE). The method of this study was to use the multiple regression model and panel data to test the hypotheses. The statistical population included 63 small and medium-sized companies admitted to the TSE, which were tested for the period of 2006 to 2021. The contribution was the use of market cap as a criterion for determining small and medium-sized companies. According to the findings, company size has a significant effect on internal financing. In addition, company size had a significant relationship with external financing through debt and share issuance. Also, there was a significant relationship between intangible assets and internal financing, while the ages of the small and medium sized enterprises did not have a significant relationship with external financing. It is suggested that small and medium-sized enterprises pay more attention to the significant variables for financing. Keywords: Financing, Debt, Equity, Intangible Assets, Small and Medium-Sized Enterprises. Introduction The primary focus of this study was to investigate the financing of the capital structure of Small and Medium-sized Enterprises (SMEs) in Iran. SMEs play a crucial role in the economies of both developed and developing countries. According to the theory posed by Schumacher, a renowned German economist, as presented in the book "Small is Beautiful", creating job opportunities in rural areas and small towns can be achieved by making modest investments to generate employment, utilizing relatively simple production methods and leveraging local resources to establish small industries. SMEs serve as the backbone of the developing world's economy (Memarnejad, 2019). In today's world, financing has become a significant concern for countries, whether they are developing or developed. A well-designed capital structure possesses the potential and capacity to adapt to changes in the surrounding environment and, in turn, influences its surroundings by generating appropriate returns. SMEs play a crucial role in poverty alleviation, wealth creation, and fostering greater participation of marginalized sections of society, such as youth and women, in the economic development of nations. The growth of these enterprises strengthens the democratic ethos and civil society, while also encouraging entrepreneurs to actively engage in the economic, political, and social fabric of their countries. In fact, in most nations, the majority of employment opportunities are generated by SMEs. For instance, in the 30 high-income countries belonging to the Organization for Economic Cooperation and Development, two-thirds of the total workforce can be attributed to SMEs (Memarnejad, 2019). This study aimed to highlight the significance and role of SMEs in Iran's economy. However, certain selection criteria were applied, such as: a) selecting companies with fiscal years ending in March and no changes in their fiscal year, b) encountering incomplete data for some companies, and c) excluding banks, financial institutions, and financial investment companies due to their distinct nature of operations. Consequently, the number of companies studied was reduced to 63. Therefore, caution should be exercised when generalizing the findings of this study to other entities within the industry under consideration. Moreover, it is important to note that financing is influenced by various macroeconomic factors, including the inflation rate, gross domestic product, interest rates on facilities, and exchange rates. However, these factors were not incorporated into this study, and consequently, might impact the results. Various factors, such as asset structure, age, profitability, growth, and industry, have been identified as key determinants that can significantly influence the capital structure (Hall, 2002). Indeed, a wide range of variables have been found to impact the choice of an appropriate capital structure (Chen, 2004; Çekrezi, 2013). Additionally, this study examined factors that could potentially affect both the capital structure and profitability of companies. Recognizing that the capital structure can impact the overall value of a company, it is crucial to investigate the factors that effectively and predictably influence it. Numerous authors have conducted studies in this area, leading to the development of theories, such as the static equilibrium theory, the pecking order theory, and the agency theory. The static equilibrium theory emphasizes the balance between the tax shield of interest rate and the costs associated with debt issuance. According to this theory, a company should strive to achieve an optimal level of debt that maximizes its profitability. When the value of the tax benefit exceeds the present value of the costs associated with debt issuance, the company is considered to be at an optimal equilibrium point. Therefore, a manager aiming to maximize shareholders' wealth should carefully select a level of debt for the company that ensures the resulting tax shield outweigh the current value of the costs associated with debt creation (Rasiah & Kim, 2011). Another prominent theory of capital structure is the pecking order theory, initially proposed by Myers and Majluf. This theory suggests a preference for financing investment projects using internal funds, such as retained earnings (internal financing), rather than relying on external resources obtained through equity issuance and debt issuance. According to this theory, managers prioritize utilizing retained earnings for funding their projects. Once the accumulated earnings are depleted, they turn to debt issuance as a source of financial resources. Finally, when it becomes impractical to take on additional debt, they resort to share issuance to meet their financial needs (Rasiah & Kim, 2011). On the other hand, the agency theory posits that the optimal capital structure is achieved by minimizing the costs arising from conflicts of interest between stakeholders (Jensen and William, 1976). In this context, agency costs play a significant role in funding decisions due to the potential conflicts that may arise between shareholders and debt holders. The size of an enterprise has a profound impact on its capital structure (Rajan & Zingales, 1995; Titman & Wessels, 1988). Small firms, in particular, face unique challenges compared to larger businesses as they have often limited access to external sources of capital, such as debt. Consequently, they are compelled to make alternative financing decisions (Ang, 1991). This supports the notion that SMEs are more susceptible to financial difficulties and confront higher levels of uncertainty and risk compared to newer, smaller firms (Engel & Stiebale, 2013; Rosenbusch Brinckmann & Müller, 2013). Based on the proposed conceptual framework, the following hypotheses were put forth: Hypothesis 1: The size of small and medium-sized enterprises exhibits a significant relationship with internal financing. Hypothesis 2: The size of small and medium-sized enterprises demonstrates a significant relationship with external financing in the form of debt. Hypothesis 3: The size of small and medium-sized enterprises displays a significant relationship with external financing through equity issuance. Intangible assets possess the potential to create valuable knowledge-based competitive advantages, thereby fostering future growth (Barney, 1991; Hitt et al., 2001). However, these assets are often challenging to transfer to other businesses, making it difficult to secure external funding sources (Brierley, 2001; Revest and Sapio, 2012). Firms with intangible assets face a greater problem of asymmetric information as these assets are difficult to value. This, in turn, reduces their opportunities to obtain external financing (Clarysse et al., 2003; Harris et al., 1991). Based on the above, the following hypothesis was proposed: Hypothesis 4: Intangible assets exhibit a significant relationship with internal financing in small and medium-sized enterprises. The age of a company also plays a crucial role in determining its capital structure. Faulkender (2005) highlights an interesting point, suggesting that younger firms have less established track records and may not be as recognized by their more experienced competitors. Consequently, small and medium-sized enterprises often struggle to secure sufficient financial resources (Demirel & Parris, 2015). The pecking order theory further supports the notion that internal financing should be prioritized followed by debt financing (Myers & Majluf, 1984). Based on the aforementioned cases, the following hypotheses were proposed: Hypothesis 5: The age of small and medium-sized enterprises exhibits a significant relationship with external financing through equity issuance. Hypothesis 6: The age of small and medium-sized enterprises demonstrates a significant relationship with external financing in the form of debt. Materials & Methods The aim of this study was to examine the impact of size, age, and intangible asset variables on the dependent funding variable. Additionally, control variables, such as the operating cash, operating income ratio, current account ratio, fixed asset ratio, and working capital, were included. This study was conducted through a literature review, analyzing relevant literature and employing descriptive and inferential analyses of the data. The statistical population for this study consisted of small and medium-sized collected listed in the Tehran Stock Exchange (TSE). A sample of 63 companies was selected for the period of 2006-2021. The hypotheses were based on the models proposed by Neville & Lucy (2022) and Aghaei (2015). Regression analysis was employed to test the effect of factors on the models of internal financing, external financing, and ownership ratio. Three regression models were utilized and their definitions and methods of obtaining the variables were explained as follows: INTRNLit=β0+β1INTANGPERCit+β2CURRENTRATIOit+β3FIXEDASSETit+β4SIZEit+β5OPERATINGCASHTOINCOMEit+β6WORKINGCAPITALit+eit Model (1) Model 2 was employed to test the hypotheses regarding the factors influencing external financing (debt). In this model, the following variables were considered: INTRNL is internal financing represented as a percentage of the total capital. It is calculated by dividing the capital increase from reserves, cash inflows, and current receivables by the total capital. INTANGPER is intangible asset ratio determined by dividing the value of intangible assets by the total assets listed on the balance sheet. CURRENTRATIO is current ratio calculated by dividing current assets by current liabilities. FIXEDASSETRATIO is fixed asset ratio obtained by dividing fixed assets by total assets. SIZE is size of the enterprises measured by using the logarithm of the book value of assets. OPERATINGCASHBYINCOME is the relationship between operating cash and operating profit calculated by dividing operating cash by operating profit. WORKINGCAPITAL is net working capital calculated as the difference between current assets and liabilities. These variables were analyzed in Model 2 to assess their impacts on external financing (debt) and test the hypotheses. DEBTit=β0+β1AGEit+β2CURRENTRATIOit+β3FIXEDASSETit+β4SIZEit+β5OPERATINGCASHTOINCOMEit+β6WORKINGCAPITALit+eit Model (2) In the above model, DEBT represents the proportion of total debt to total assets, indicating the extent to which the company is financed through debt. AGE refers to the age of the enterprises calculated based on the logarithm of the number of years of activity. In addition to these variables, other control variables, such as the capital ratio, current ratio, operating cash ratio, and working capital were included. Model 3 was developed to test and validate the assumptions regarding the factors influencing the ownership ratio. The aim of this model was to investigate the variables that contributed to determining the ownership structure of the sample enterprises. EQUITYit=β0+β1AGEit+β2WORKINGCAPITALit+β3CURRENTRATIOit+β4FIXEDASSETit+β5SIZEit+β6OPERATINGCASHTOINCOMEit +eit Model (3) EQUITY represents the shareholder ratio, which is calculated by dividing the total funding by the total capital. Selection of the dependent and independent variables was based on the study conducted by Neville and Lucy (2022). Findings The data used in this study were combined at the enterprise-year level and econometric diagnostic tests were conducted. Based on the evidence, Hypothesis 1, which posited a significant relationship between the size of SMEs and internal financing, was confirmed. Additionally, Hypothesis 4, which suggested a significant relationship between intangible assets and internal financing, was also supported. The results of Model 1 can be observed in Table 1. Table 1: The results of estimating model 1 Variable Coefficient t statistic Significance level OPERATINGCASHTOREVENUE -0.73 -2.00 0.04 SIZE 0.03 3.01 0.00 WORKINGCAPITAL -4.18 -1.39 0.16 CURRENTRATIO -0.04 -1.13 0.25 FIXEDASSETRATIO -0.14 -0.94 0.34 INIBLETANGIBLEASSETRATIO 7.46 2.19 0.03 C -0.76 -2.34 0.02 AR(1) 0.01 0.47 0.63 F statistic probability 0.00 4.27 Durbin Watson statistics 2.39 Coefficient of Determination 0.58 Adjusted coefficient of determination 0.44 According to the Table 1, the coefficient of the variable of working capital is found to be significant at the given significance level, indicating a direct relationship with external financing (debt). On the other hand, the variables, such as size, operating cash ratio, current ratio, and fixed asset ratio, exhibit a significant and inverse relationship with external financing. Based on the evidence, Hypothesis 2, which suggested a significant relationship between the size of small and medium-sized enterprises and external financing (debt), was confirmed. However, Hypothesis 6, which proposed a significant relationship between the age of small and medium-sized enterprises and external financing (debt), was not supported. The results of Model 2 are presented in Table 2. Table 2: The results of estimating Model 2 Variable Coefficient t statistic Significance level AGE 0.03 1.57 0.11 SIZE -0.24 -15.09 0.00 OPERATINGCASHTOINCOME -0.043 -2.40 0.01 CURRENTRATIO -0.07 -11.68 0.00 FIXED ASSETRATIO -0.14 -4.14 0.00 WORKINGCAPITAL 1.91 2.11 0.03 C -51.90 -1.53 0.12 AR(1) 0.74 21.90 0.00 F statistic probability 0.00 69.31 Durbin Watson statistics 2.11 Coefficient of Determination 0.89 Adjusted coefficient of determination 0.87 Based on the Table 2, the variables of size, fixed asset ratio, current ratio, and operating cash ratio are found to be significantly and positively associated with the ownership ratio, while the working capital ratio exhibits a significant and negative relationship. Based on the evidence, Hypothesis 3, which suggested a significant relationship between the size of small and medium-sized enterprises and external financing (proprietary rights), was confirmed. However, Hypothesis 5, which proposed a significant relationship between the age of SMEs and external financing (proprietary rights), was not supported. The results of Model 3 are presented in Table 3. Table 3: The results of Hypothesis Test Model 3 Variable Coefficient t statistic Significance level AGE -0.02 -0.24 0.80 SIZE 0.21 15.41 0.00 WORKING CAPITAL -2.00 -3.14 0.00 FIXED ASSET RATIO 0.15 4.45 0.00 CURRENT RATIO 0.07 12.42 0.00 OPERATING CASH TO INCOME 0.03 1.97 0.04 C 29.80 0.24 0.81 AR(1) 0.71 22.70 0.00 F statistic probability 0.00 0.01 Durbin Watson statistics 2.01 Coefficient of Determination 0.87 Adjusted coefficient of determination 0.85 Discussion & Conclusions The findings of this study supported the 1st and 3rd hypotheses, which suggested a positive and significant relationship between company size and the dependent variables of internal financing and ownership ratio, respectively. Conversely, company size exhibited a negative and significant relationship with debt, in line with the second hypothesis. Additionally, the results indicated a significant positive relationship between intangible assets and internal financing, aligning with the 4th hypothesis. These findings suggested that small and medium-sized companies relied more on internal financing and utilize less debt, which aligned with the pecking order theory. This is consistent with the study conducted by O'Brien (2003). Furthermore, the study did not find a significant relationship between the age of SMEs and internal and external financing (capital structure), contradicting the 5th hypothesis. In conclusion, the results of this study highlighted the importance of company size and intangible assets in determining the financing choices of SMEs. These findings contributed to our understanding of the capital structure decisions made by SMEs. Regarding the relationship between the size of small and medium-sized enterprises and their internal and external financing, the findings align with the studies conducted by Neville and Lucy (2022), Sunaina (2020), and Aghaei et al. (2014). However, the results differ from those of Ozkan (2001), which can be attributed to variations in the economic structure, such as inflation rate and exchange rate, of the countries. Furthermore, the results support the findings of Neville and Lucy (2022) and O'Brien (2003), regarding the relationship between intangible assets, such as ideas, intellectual property, brands, business methods, and internal financing. It was confirmed that companies with a higher proportion of intangible assets faced more challenges and barriers when seeking external financing, which is consistent with the hierarchical theory. Regarding the relationship between the age of small companies and external financing, specifically through debt and ownership rights, the findings of this study are consistent with the studies conducted by Gregory (2005), Neville and Lucy (2022), and Wasiuzzaman and Nurdin (2019). However, the results differ from the study conducted by Faulkner et al. (2006), which focused on credit limits and the distinction between the public debt market (bonds) and the private debt market (banks). In their study conducted in England, they found a negative relationship between debt and age of company. The disparity in findings could be attributed to the different economic structures of the countries. This variation highlighted the importance of considering the specific context and economic conditions when analyzing the relationship between company age and external financing.

In this work, we consider product-type operators $T^m_{u,v,\varphi}$ from minimal M\"{o}bius invariant spaces into Zygmund-type spaces. Firstly, some characterizations for the boundedness of these operators are given. Then some estimates of the essential norms of these operators are obtained. Therefore, some compactness conditions will be given.

Let $\mathbb{B}_n$ be the open unit ball in $\mathbb{C}^n$ and $\mathbb{B}_n^2 = \mathbb{B}_n \times \mathbb{B}_n$. The symmetric lifting operator which lifts analytic functions from $H(\mathbb{B}_n)$ to $H(\mathbb{B}_n^2)$ is defined as follow\[L(f)(z,w) = \frac{f(z) - f(w)}{z-w}.\]In this paper we investigate the action of symmetric lifting operator on the Bergman space in the unit ball. Also, we state a characterization for Dirichlet space and consider symmetric lifting operator on the Dirichlet space in the unit ball.

The purpose of the present research is to use machine learning models to predict the price of Bitcoin, representing the cryptocurrency market. The price prediction model can be considered as the most important component in algorithmic trading. The performance of machine learning and its models, due to the nature of price behavior in financial markets, have been reported to be well in studies. In this respect, measuring and comparing the accuracy and precision of random forest (RF), long-short-term memory (LSTM), and recurrent neural network (RNN) models in predicting the top and bottom of Bitcoin prices are the main objectives of the present study. The approach to predicting top and bottom prices using machine learning models can be considered as the innovative aspect of this research, while many studies seek to predict prices as time series, simple, or logarithmic price returns. Pricing top and bottom data as target variables and technical analysis indicators as feature variables in the 1-hour time frame from 1/1/2018 to 6/31/2022 served as input to the mentioned models for learning. Validation and testing are presented and used. 70% of the data are considered learning data, 20% as validation data, and the remaining 10% as test data. The result of this research shows over 80% accuracy in predicting the top and bottom Bitcoin price, and the random forest model’s prediction is more accurate than the LSTM and RNN models.

The behavioral characteristics of managers are among the most crucial factors in making decisions on financing and capital structure of the company. The most important characteristics of managers include optimism, overconfidence, and myopia. Thus, the study investigated the influence of the behavioral characteristics (optimism, overconfidence, and myopia) of managing directors on the financial flexibility of companies with the moderating role of managing directors efficiency and political connections. Accordingly, the data of 130 companies listed in the Tehran Stock Exchange from 2014 to 2018 were examined using multivariate regression. Hypothesis testing revealed that there was no significant relationship between managing directors optimism and the financial flexibility. However, the relationship of managing directors overconfidence and managing directors myopia with financial flexibility was significant and negative. managing directors efficiency moderated the relationship between managing directors overconfidence and financial flexibility, whereas the political connections moderated the relationship between managing directors myopia and financial flexibility.

Introduction: Although house flies (Musca domestica) do not directly cause disease in humans, they transmit pathogens to them, which provide the basis for many diseases. The main way to deal with this insect is to use insecticides. Due to the resistance from insecticides, the fight against house flies has been hampered. This study aimed to determine the prevalence of knockdown resistance against organochlorine insecticides in house flies worldwide. Methods: This study was conducted via a systematic review and meta-analysis to investigate the prevalence of knockdown resistance against organochlorine insecticides in house flies. Accordingly, by searching the databases of Web of Science, PubMed, Scopus, Proquest, Bioone, and Embase, all published articles were extracted, and reviewed until the end of May 2022. Statistical data analysis was performed using the random-effects model in the meta-analysis, meta-regression, and I2 index. Results: Nine studies entered the meta-analysis process. Based on this, the prevalence of knockdown resistance against organochlorine insecticide in house flies was estimated to be 49.1%. Meta-regression showed that the prevalence of knockdown resistance increased with increasing years of study but decreased with increasing sample size. Conclusion: According to the findings, about 50% of house flies have knockdown resistance against organochlorine insecticide. As a result, it is necessary to adopt effective and combined methods to combat this insect to control it and prevent the transmission of diseases caused by it.

Introduction: Pediculosis is one of the most common annoying infections caused by parasitic lice in humans. Pyrethroids are one of the main insecticides used to treat this infection. But recently, due to the Resistance of lice to this group of insecticides, its insecticidal effects have been affected. The present study was conducted through a meta-analysis to investigate the prevalence of pyrethroid resistance against these insecticides worldwide. Methods: This study was conducted as a meta-analysis of the prevalence of treatment resistance in human head lice against pyrethroid insecticides worldwide. Based on this, all articles published without a time limit until the end of June 2022 in PubMed/MEDLINE, Web of Science (ISI), Scopus, and Google Scholar databases were extracted and using random-effects meta-analysis model statistical methods in the meta-analysis, Cochrane, Index I2, and funnel plot were analyzed by STATA software. Results: Twenty studies were included in the meta-analysis process. According to this, the prevalence of pyrethroid resistance insecticides in human head lice was estimated at 59% (CI95%: 50%–68%). Among pyrethroid insecticides, the highest prevalence of pyrethroid resistance against permethrin insecticide was 65%. Regarding the prevalence of Resistance by year, the prevalence before 2004 was estimated at 33%, but after 2015, this rate reached 82%. Also, the majority of pyrethroid resistance was estimated at 68% using genetic diagnosis methods and 43% using clinical diagnosis methods. Conclusion: More than half of human head lice pyrethroid resistance insecticides. Based on this, it is recommended that before using this treatment method to treat human head lice Infestation, it should investigate the prevalence of pyrethroid resistance in that area, and if the majority of Resistance is high, alternative or combined treatment methods should be used.

Objective: The Audit Committee, as one of the corporate governance oversight committees in listed companies, has become a very important factor in the financial reporting process to increase the credibility of financial reports. Therefore, the audit committee needs to hold meetings to perform its duties, and so far Limited research has been done to examine the factors affecting the number of meetings of the audit committee. This study sought to investigate factors influencing the number of meetings of the audit committees held in companies enlisted in the Tehran Stock Exchange (TSE). This study specifically aims to examine whether the number of meetings of the audit committees is affected by factors such as ownership concentration, board size, board independence, audit committee size, audit committee independence, and audit committee financial experience. Methods: Accordingly, the financial statements of 150 companies enlisted in the TSE during the eight-year period from 2013 to 2020 were analyzed. To test the research hypotheses, Tobit regression model with combined data method and random effects method was used. Results: Testing the research hypotheses showed that the concentration of ownership, size of the board, independence of the board, size of the audit committee, and independence of the audit committee have a significant positive effect on the number of meetings of the audit committees. The results also showed that the financial expertise of the audit committees has a significant negative effect on the number of their meetings. Conclusion: The results indicated with increasing ownership concentration want more supervision over managers' performance and the number of audit committee meetings increases. In addition, any increase in the size of the board, the independence of the board, the size of the audit committee, and the independence of the audit committee as criteria for corporate governance increases the number of meetings of the audit committee. This is while any increase in financial expertise of the members of the audit committee, ends in a decrease in the need to convene the number of meetings of the audit committee.

Rising inflation in recent years has caused financial distress and many problems for companies. Most of these problems are affected by life cycle stages. One way out of these problems is to increase corporate social responsibility (CSR) performance. Therefore, our aim in this study is to investigate the effect of CSR performance on financial distress over the life cycle of the company for a period of 10 years. Data collection was done through the website of the Tehran Stock Exchange and related software for a sample of 112 companies during the period 2009 to 2019. The mathematical method (directional distance function) is used to evaluate the CSR performance, and the models of Berger et al., Almida, Campello, and Altman are used to measure financial distress. The research hypotheses are tested using panel data and fixed effects by multivariate regression statistical method. The results show that CSR performance alone does not affect financial distress. The combination of CSR and life cycle in the growth and maturity phases has a significant and negative effect on financial distress. The CSR performance and life cycle together reduce financial distress. The combination of CSR performance and life cycle in the recession phase has a positive and significant effect on financial distress and in the fall phase, does not affect it. Given that companies compete more in the phase of growth and maturity than other phases of the life cycle, they also pay more attention to CSR. Therefore, according to these results, it can be concluded that the life cycle of the company and the CSR performance together, reduce financial distress.

Background and Aim: Premature birth is one of the most important causes of mortality in the world and is regarded one of the major health problems. In this study, we investigated the relationship of the serum levels of omentin-1with insulin resistance and inflammatory markers in preterm infants. Material and Methods: This study included 32 preterm and 21 full-term newborns. Serum levels of insulin and omentin-1 were measured by ELISA. Fasting blood glucose and C-reactive protein (CRP) were measured with an autoanalyzer. Hematological parameters were measured by Sysmex XS800i analyser. Results: We found lower levels of serum omentin-1(p

Background and purpose: The harmful effects of morphine on the liver after withdrawal syndrome are unclear. In this experiment, we investigated the effects of exercise on oxidative stress, liver inflammation, liver enzymes, and liver histology after morphine withdrawal in rats. Materials and methods: In this experimental study, male Wistar rats (n=30) were randomly divided into five groups: ‎‎control, withdrawal syndrome (addicted), withdrawal syndrome+‎endurance training, withdrawal syndrome+‎resistance training, withdrawal syndrome+concurrent training. The experimental groups received morphine for 28 days, and after withdrawal, training interventions were done for 10 weeks. At the end of the study, the rats were sacrificed and liver was removed. Antioxidant activity ‎was measured and histopathological evaluation of ‎liver was done. Also, the TNF-α levels were determined.‎ Results: Compared with control rats, the levels of total antioxidant capacity (TAC), and the activities of glutathione and superoxide dismutase (SOD) significantly decreased in morphine withdrawal group (P

The present study investigated the role of strategic cost management as a moderating variable on the relationship between supply chain practices, Top Management Support (TMS), and financial performance improvement. Financial performance improvement was considered as a dependent variable, while supply chain practices, strategic cost management, and TMS were taken as the main independent variables. Besides, the financial structure and the firm size were considered as control variables. The research sample included 165 companies that were selected using random sampling from among companies listed on the Tehran Stock Exchange. The data were collected using the Senior Management Survey (SMS) to measure supply chain practices, TMS, and strategic cost management. The results of the structural equation modeling after discriminant tests showed that strategic cost management had a positive and significant effect on the relationship between different subscales of supply chain practices and different measures of financial performance improvement. The results also showed that the relationship between strategic cost management, senior management support, supply chain activities and improving financial performance is non-linear and so that Supply Chain Integration (SCI) is more effective at low and medium levels and at higher levels. The above has a lesser or even negative effect.

Environmental Impact Assessment (EIA) has been recognized as an analysis of the impacts that a project can impose on the environment, with the purpose of balancing the positive and negative impacts of the project. Forest road construction is one of the costliest and most important projects that its outcomes need to be evaluated because of being involved in the development of different forestry operations. The purpose of the current study was to assess the environmental impacts of a road network in the Kheyrud forest (Hyrcanian forest), in northern Iran, at three stages including before, during, and after the road construction phase. We used Geocybernetic Assessment Matrix (GAM) criteria listed scores by using the views of experts who have observed the problems associated with road construction in three stages. By applying this method, a suitable tool is obtained to ensure that the project is properly implemented or should be stopped. It can be a method of determining, predicting and interpreting the environmental, social and economic impacts of road construction on the whole environment and the health of the ecosystems on which human life and sustainability depend. The results indicated that the total geocybernetic score was in the range of 0 to -121 (very weak unsustainability) for before, during and after road construction, indicating that although road construction in the Kheyrud forest had negative impacts on the environment especially during the construction phase, social and economic services, especially after road construction, have left the total geocybernetic score in that range.

Power, as one of the characteristics of CEO, can play a significant role in corporate decisions about financial reporting. If CEO use power in line with their interests, their power will be problematic and affect the audit time of the company. Thus, the present study aimed to investigate the effect of CEO power on audit report lag using Hansen's threshold regression approach. The research sample included 150 companies listed on the Tehran Stock Exchange during 2011-2018. This study was applied and the research hypothesis was tested using the threshold regression analysis. The results of testing the research hypothesis indicated that the CEO power has a negative effect on audit report lag in the companies where the CEO power is lower than the threshold limit while the power of CEO has a positive effect on audit report lag in the companies where the CEO power is higher than the threshold limit.

Introduction The COVID-19 pandemic has changed aspects of patient care in the many scheduled medical activities, restricted access to healthcare facilities, and affected the diagnosis and organisation of patients with other health problems, specifically skin cancer. Skin cancer, the uninhibited progress of atypical skin cells, happens with unrepaired DNA genetic faults that lead them to multiply and create malignant tumours. Currently, dermatologists perform skin cancer diagnosis based on their specialised experience using the results of pathological tests from the skin biopsy. Sometimes, some specialists advise sonography imaging to check the skin tissue as a non-invasive method. The outbreak has led to postponements in the treatment and diagnosis of patients with skin cancer, including diagnostic delays because of limitations of diagnostic capacities and delays in referring patients to the physician. The purpose of this review is to improve our understanding of the impact of the COVID-19 outbreak on the diagnosis of patients with skin cancer and conduct a scoping review to identify whether routine skin cancer diagnoses are affected by the persistent incidence of COVID-19.Methods and analysis The structure of research was compiled using Population/Intervention/Comparison/Outcomes/Study Design and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. First, we will find the main keywords to capture scientific studies related to the impact of the COVID-19 pandemic on the diagnosis of skin cancer: COVID-19 and skin neoplasms. To warrant sufficient coverage and identify potential articles, we will search the combination of four electronic databases PubMed/MEDLINE, Scopus, Web of Science and EMBASE, and ProQuest from 1 January 2019 until 30 September 2022. The screening, selection and data extraction of studies will be performed by two independent authors, who will then assessed the quality of the included studies according to Newcastle–Ottawa Scale.Ethics and dissemination As this study will be a systematic review without human participants’ involvement, no formal ethical assessment is required. Findings will be presented at conferences related to this field and will be disseminated in a peer-reviewed journal.PROSPERO registration number CRD42022361569.

Objective: The purpose of this study was to investigate that behavioural factors play an important role in decision-making and subsequently formation of markets phenomena. Methods: The population of this study consist of all companies listed in The Tehran Stock Exchange of various industries and groups and samples were collected between the years 2007 and 2017. Using regression analysis, we estimated the influence of institutional investors anchoring bias on the 52-week highest price by the cross-sectional regression model, as well as measuring the effect of increasing proximity of price to the 52-week highest price next abnormal returns in parallel with controlling of the other factors over PEAD. Results: Given the statistically significant anchorage coefficient, it can be stated that there is a significant relationship at a 95% confidence level between the anchorage bias and the abnormal returns resulting from the profit declaration. Also, the level of institutional ownership has a significant relationship with the abnormal returns of profit declarations. In institutionally-owned companies, the role of the anchor variable is not even significant. However, in companies with low institutional ownership, this role is positively significant with a 0.13 coefficient. Conclusion: Anchoring bias plays a minor role in explaining the additional returns resulting from the profit declaration in companies that are institutionally owned. Therefore it can be said that the first hypothesis of this research on the minor effect of anchorage variable in case of low institutional ownership is confirmed.

Abstract Background Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria. Antibiotic therapy and the use of diphtheria antitoxin is a recommended strategy to control diphtheria. Although mammalian antibodies are used to treat patients, IgY antibody has advantages over mammalian ones, including cost-effectiveness and production through non-invasive means. Moreover, in contrast to mammalian antibodies, IgY does not bind to the rheumatoid factor and does not activate the complement system. The objective of this study was to evaluate the in vitro neutralizing effect of IgY against diphtheria toxin. Results Anti-DT IgY was produced by immunization of the laying white leghorn chickens. Indirect enzyme-linked immunosorbent assay revealed successful immunization of the animals, and the IgY was purified with a purity of 93% via polyethylene glycol precipitation method. The neutralizing activity of the purified IgY was evaluated by Vero cell viability assay. This assay confirmed that 1.95 μg (8.6 μg/ml of culture medium) of anti-DT IgY would neutralize 10 fold of cytotoxic dose 99% of DT, which was 0.3 ng (1.33 ng/ml of culture medium). Conclusion This anti-DT IgY may be applicable for diphtheria treatment and quality controls in vaccine production.

Objective(s): Hypercholesterolemia is correlated with brain amyloid-β (Aβ) deposition and impaired cognitive functions and contributes to Alzheimer’s disease. Effects of cholesterol-lowering dill tablets and aqueous extract of Ocimum basilicum L. (basil) on learning and memory and hippocampus fatty acid composition were examined. mRNA levels of the genes involved in cholesterol homeostasis were also determined in high-cholesterol diet (HCD) fed rats. Materials and Methods: Forty male Wistar rats were allocated to 4 groups: rats fed chow diet (C); rats fed high-cholesterol (2%) diet (HCD); rats treated with HCD+300 mg/kg dill tablets (HCD+Dill); and finally, rats fed HCD and treated with 400 mg/kg basil aqueous extract (HCD+basil). Treatment was carried out for 16 weeks. Hippocampus Aβ(1-42) level was determined. Spatial and passive avoidance tests were used to examine cognitive functions. Hippocampal FA composition was assessed by gas chromatography. Basil aqueous extract was analyzed by GC-double mass spectroscopy (GC-MS/MS) and expression of LXR-α, LXR-β, and ABCA1 genes was assessed by qRT-PCR. Results: Dill tablets and basil extract remarkably ameliorated serum cholesterol (p

Let $\mathbb {D}$ be the open unit disk in the complex plane $\mathbb{C}$ and $H(\mathbb{D})$ be the set of all analytic functions on $\mathbb{D}$. Let $u, v\in H(\mathbb{D})$ and $\varphi$ be an analytic self-map of $\mathbb{D}$. A class of operator related weighted composition operators is defined as follow \begin{align*} T_{u, v, \varphi}f(z) = u(z) f{(\varphi(z))}+ v(z) f'(\varphi(z)) ,\quad f\in H(\mathbb{D} ), \quad z\in \mathbb{D}. \end{align*} In this work, we obtain some new characterizations for boundedness and essential norm of operator $T_{u, v, \varphi}$ between Zygmund space.

Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD). Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with kiwifruit at two concentrations (i.e., 1.86 g/kg and 3.73 g/kg), a HFD comprised of 15% butterfat + 0.05% cholesterol (the control high-fat group), and a HFD supplemented with kiwifruit at two concentrations (i.e., 1.86 and 3.73 g/kg) for 8 weeks. Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwifruit (1.86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups. Conclusion: Our findings suggested that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1.

Objective: Investors myopic means to overstate the short-term earnings and understate the long-term earnings by active investors in the capital market. As myopic investors have a short-term horizon of vision in the capital market, they focus on the short-term performance of the company and this behavior of investors may motivate managers to better report than reality the company's short-term performance through profit management and investment reduction. Therefore, the purpose of the present research is to investigate the effect of investors' myopia on the profit and investment management of the listed companies in the Tehran Stock Exchange. Methods: The data required to test the research hypotheses were gathered from financial statements of 150 companies during the six-year period from 2011 to 2017. In order to test research hypotheses, fixed effects multivariate regression model for panel data was used. In this research, Del Rio and Santa Maria model (2016) was used to measure the investors' myopia. Additionally, the modified Jones model (1991) and the expenses paid for investment were used to measure the profit management and company's investment, respectively. Results: Findings from testing the research hypotheses revealed that the investors' myopia has a significant positive effect on the profit management in companies listed in the Tehran Stock Exchange. Moreover, the investors' myopia has a significant negative effect on the companies' investment. Conclusion: The results of this research show that by increasing the investors' myopia in Tehran Stock Exchange, the companies' managers focus on short-term performance in meeting the myopic investors' expectations to improve profitability and the current stock price for companies. Instead of focusing on the long-term objectives and planning, the managers thus focus on the short-term objectives. Therefore, by profit manipulation through discretionary accruals and future investment reduction, they make attempts to meet the myopic investors' expectations.

Subject and Purpose of the Article: The Social Security Organization, like any other for-profit and non-profit organization, is always faced with the issue of budget allocation. This article aims to design a performance-based budgeting model with an emphasis on the model used in performance based budgeting (input, process, output and outcome continuum) in the Social Security Organization. Research Method: The elements of this model are identified using cognitive mapping technique, organizational experts' opinions and semi-structured interviews, identification, based on hierarchical analytical technique of leveling, using pairwise comparisons to determine the coefficient of importance and using TOPSIS technique at each priority level. Were classified. Research Findings: The research findings show that the organization for its survival should pay special attention to the sustainability of economic activities in the country and on the other hand to perform optimal organizational affairs, reduce unnecessary traffic… Virtual social security should be expanded and developed. Conclusion, Originality and its Contribution to the Knowledge: In order to get rid of the current recession, the organization should refrain from relying solely on receiving premiums as the main source and spend most of its funds on major matters such as developing national organizational, operational and evaluation plans.

The companies with major customers can supply a considerable source of cash flows by selling a large portion of their products to them. Since the lack of purchase, loss, or bankruptcy of major customers can result in a significant reduction in cash flows in the company, thus the risk is the companies with major customers is higher than other companies. Thus, the present study aimed to investigate the effect of customer concentration on company risks. For this purpose, the effect of customer concentration on three criteria of stock price crash risk, bankruptcy risk, and employment risk was studied. The research sample included 127 companies listed in the Tehran Stock Exchange during 2011-2018. Multivariate regression models with panel data were used by the random-effects method to test the research hypotheses. The research findings indicated that customer concentration has a significant positive effect on stock price crash risk, bankruptcy risk, and employment risk. In other words, stock price crash risk, bankruptcy risk, and employment risk are higher in the companies where the concentration of major customers is higher.

Objective: The aim of this study was to provide a model for tax risk measurment in the first step, and to examine the impact of tax risk and social responsibility as well as their interactive effect on the value of companies accepted in the Iranian capital market in single-, three-, four- and five-factor pricing models, in the next step. Another aim was to compare the explanatory power of the models of capital asset pricing. Methods: In this study, the data of 103 companies listed in the Tehran Stock Exchange, TSE, during the years 2011-2017 were collected, and then, analyzed using panel data estimation model. This research is an applied and analytical-explanatory one. Results: The research findings showed that tax risk and social responsibility have significant effects on the value of the company in all four capital asset pricing models in the companies in the TSE. Conclusion: The effect of tax risk on company value is an opposite effect, the impact of social responsibility on company value is a direct effect, but the interactive effect of tax risk and social responsibility on company value is not significant. Comparing the models, it is shown that the five-factor model explains the relationship between these variables in the Iranian capital market better than other models.

This research intends to examine the role of the auditor's ethical decision making on disclosing financial and non-financial secrets and to present a model of auditor's decision making, with emphasis on the moderating role of perceived ethical severity. The tool used in the present research is a questionnaire and the statistical population of the study includes all persons of the member of the official accountants community of Iran in 2019. To analyze the data, descriptive statistics and structural equation modeling were used in this research. All calculations and statistical analyzes were performed by PLS software. The results of the research indicate that there is a positive relationship between ethical awareness and professional judgment and emotions. There is a positive relationship between feelings and professional judgment. Also, there is a positive relationship between professional judgments and disclosure of secrets, and the model of ethical decision making affecting disclosure of secrets, with an emphasis on analyzing the role of moderating the perceived ethical intensity of auditors was presented.

In recent financial scandals, related parties transactions (RPTs) have been as one of the major concerns, so that the targeted use of these transactions and lack of their disclosure or insufficient disclosure are some of the factors in the failure of the corporates. In RPTs, there is a risk that the related party may be favoured with terms that could harm the interests of the company’s shareholders. The purpose of this study was to investigate the effects of different types of related parties transactions on the firm value with the moderating role of the audit committee incorporates listed in Tehran Stock Exchange. The research statistical sample consists of 100 listed firms in the Tehran Stock Exchange in 6 years of 2013-2018. This research, based on the nature and content, is a descriptive/ correlational research. Using Panel data and multiple regression, the results of the research show that there is a negative relationship between RPTs and the firm value. The findings also show that there is a positive relationship between the audit committee and the firm value. Also, the findings show that different types of RPTs have a different effect on the firm value. The results also show that the audit committee does not affect the relationship between RPTs and the firm value.

Stock return predictability has been extensively considered as a stylized reality. Theories indicate that returns should change along the time, and various studies have presented evidence on this point. On the other hand, there is an optimal portfolio in each regime, and one cannot claim that a specific portfolio can minimize risk and returns in each regime. On the other hand, the financial conditions index (FCI) is an important index to specify monetary policy conditions. Regarding the importance of the issue, this research aims to present a comprehensive index, including all monetary transmission mechanisms. In this regard, it is attempted to improve the efficiency of stock return predictability in Iran's economy by incorporating an FCI and identifying relationships between FCI and stock returns using the TVP-DMA model, which can resolve shortcomings of traditional models. The study is applied research in terms of purpose. Seasonal data over the period of April 1991 to July 2019 is used. The results based on TPV, DMS, and DMA models indicate that liquidity growth rate, economic growth rate, unemployment rate, exchange rate, financial condition index, oil revenues, misery index, and budget deficit, has significantly affected factors of stock returns in 30, 50, 11, 49, 66, 54, 7, and 84 periods of 104 periods, respectively. Accordingly, budget deficit, financial condition index, oil revenues, and economic growth are the most effective factors of stock returns predictability in Iran. Further, the incorporation of flexibility in coefficients of the financial development index leads to higher forecast accuracy.

Background: In Iran, the prospect of malaria control relies mainly on insecticides used against the genus Anopheles (Diptera: Culicidae) as important vectors of malaria, arboviruses, and so on. Only eight out of 30 malaria mosquito vectors (Anopheles species) have been examined for insecticide resistance in Iran. This study aimed to review articles related to the incremental trend in insecticide resistance and their mechanisms among anopheline malaria vectors in Iran. Methods: A literature review was conducted based on such search engines as Iran doc, Web of Science, SID, PubMed, Scopus, and Google Scholar websites using the following keywords: “Anopheles,” “Malaria,” “Resistance,” “Vectors,” “Insecticide Resistance,” and “Iran” for data collection. Published papers in English or Persian covering 1980 to 2020 were reviewed. Results: A total of 1125 articles were screened, only 16 of which were filtered to be pertinent in this review. While most of the mosquito vectors of malaria, such as Anopheles stephensi, were resistant to DDT, dieldrin, malathion, and becoming less susceptible to deltamethrin and other synthetic pyrethroid insecticides, few like Anopheles fluviatilis s. l. were susceptible to all insecticides. A disseminating trend in insecticide resistance among different anopheline mosquito vector species was evident. Metabolic and insecticide target-site resistance mechanisms were involved with organochlorines and pyrethroids, respectively. Conclusions: Insecticide resistance is becoming a severe scourge to the effectiveness of vector-borne disease management measures. This event is especially critical in developing and marginalized communities that applied chemical-based vector elimination programs for malaria; therefore, it is crucial to monitor insecticide resistance in malaria vectors in Iran using biochemical and molecular tools.

In this research, novel CuO-ZnO/ZiF-8 metal–organic frameworks (MOFs) photocatalyst with different mass percentages of ZiF-8 were prepared for water purification applications under visible light. The precipitation method was used to synthesize CuO-ZnO/ZiF-8 photocatalysts. Some techniques, including XRD, FESEM, EDX, BET-BJH, FTIR, DRS, and pHpzc, were performed to determine the structural, chemical, and optical properties of the prepared samples. DRS analysis represented that CuO-ZnO/ZiF-8(20) had narrower band gap energy compared to CuO-ZnO and ZiF-8. Also, BET-BJH analysis results showed that CuO-ZnO had a low surface area that impeded the absorption of pollutant molecules. In contrast, the CuO-ZnO/ZiF-8(20) sample, due to the presence of ZiF-8, had a high specific surface area which enabled higher pollutant adsorption on the photocatalyst surface.Moreover, the synthesized samples were evaluated for the solar-light-driven removal of different organic dyes, such as Acid Orange 7, Methylene blue, and Malachite green. The tremendously enhanced photocatalytic activity under the simulated solar light with 98.1% removal of AO7 was observed over CuO-ZnO/ZiF-8(20) sample. Then, the effect of initial solution pH as an essential factor on photocatalytic activity was investigated. Finally, the reaction mechanism of AO7 degradation over CuO-ZnO/ZiF-8(20) was proposed.

The coronavirus disease 2019 (COVID-19) pandemic is a global crisis, with devastating health, business and social impacts. Vaccination is a safe, simple, and effective way of protecting a person against COVID-19. By the end of August 2021, only 24.6% of the world population has received two doses of a COVID-19 vaccine. Since the emergence of COVID-19, several COVID-19 vaccines have been developed and approved for emergency use. Current vaccines have shown efficacy with low risk of adverse effects. However, COVID-19 vaccines have been related to a relatively small number of cases of heart inflammation, anaphylaxis (allergic reactions), and blood clots formation. On the other hand, COVID-19 vaccination is not recommended for children less than 12 years of age. Furthermore, It has been proposed that some new variants (e.g., Lambda and Delta) are proficient in escaping from the antiviral immunity elicited by vaccination. Herein we present current considerations regarding the COVID-19 vaccines including: efficacy against new variants, challenges in distribution, disparities in availability, dosage gender and race difference, COVID-19 vaccine transport and storage, limitations in children and pregnant women. Long-time monitoring is essential in order to find vaccine efficacy and to rule out related side effects.

Background: High-fat high-cholesterol diet induces a phenotype similar to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in humans. In NAFLD and NASH, cholesterol and bile acid metabolisms are impaired to accumulate lipids and toxic bile acids along with cholestatic hepatic damage. Recently, the use of herbal-derived cholesterol lowering products has attracted much attention as possible therapeutic strategies for NAFLD. Hence, the aim of this study was to determine the effects of an Anethum graveolens (dill) on liver cholesterol 7 alpha-hydroxylase and liver fat accumulation in rats. Method: Thirty-six rats were randomly divided into 6 groups (n = 6) and received normal diet (ND) or a mixture of chow diet+2% cholesterol+0.5% cholic acid + 20% corn oil as high cholesterol/fat (HC–HF) diet (NAFLD model). Animals were also treated daily with dill tablet or dill extract (300 mg/kg). At the end of the 30 days experiments, serum and liver lipid profile and liver total antioxidant capacity were determined. Cholesterol 7 alpha-hydroxylase mRNA and protein expression levels were determined in the liver and histopathological changes in liver tissues were analyzed by microscope. Results: Lipid profiles significantly decreased in dill treated groups (p

Background and aims: Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO2 NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO2 NPs in two models of liver injury, non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride (CCl4)-induced liver fibrosis, in rats. Methods: In this experimental study, male rats were randomly divided into different experimental groups including: Experiment 1; group1: healthy rats received normal saline, 2: CCl4 group, 3: CCl4 + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore. Results: Total antioxidant capacity (TAC) and glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and total oxidant status (TOS) were significantly increased in the liver, and intestine of the NAFLD and CCl4 group compared with control rats. However, the use of nanoparticles significantly normalized these markers. The levels of the TNF-α were significantly reduced in the nanoparticle group as compared with NAFLD model and CCl4-treated rats. CeO2 NPs also normalized the liver and intestinal histological changes. Conclusions: Our finding revealed that CeO2 NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation.

As of August 5, 2021, there were about 200,000,000 global confirmed patients of COVID-19, with more than 4,250,000 deaths. The COVID-19 disease which is a tremendous public health threat, jumps unpredictably and outbreaks very quickly. The overall mortality rate of COVID-19 infection is 1%–15% but reaches up to 17–38% in older cases with chronic disorders and in intensive care unit (ICU) subjects. Diabetic patients, particularly those whose disease is not well controlled can be more susceptible to COVID-19. Although diabetes was present in 5.3%–42.3% of fatalities from COVID-19, the underlying pathophysiological mechanisms of action of novel coronavirus in diabetic patients are unknown. Based on the elevating of global prevalence, diabetes is the main medical problem associated with COVID-19. It is plausible that diabetes can forecast elevated severity of pneumonia. The mortality of lung infection among diabetes is remarkably higher compared with non-diabetic patients. Mechanisms responsible for severe pneumonia in the diabetic patients as well as treatment of diabetic patients infected with COVID-19 are largely speculative. Hence, this paper will summarize the recent findings related to the mechanisms of pneumonia and treatment strategies in diabetic patients.

When an athlete takes maximum advantage of his released degrees of freedom, he is called a motor elite. The aim of this study was to investigate the eliteness by combining speed constraint and explicit, errorless and analogical inference constraints. 21 physical education students (three of them were excluded from this study: 21-3=18) from Kharazmi University voluntarily participated in this study. The participants in three distinct groups (explicit, errorless and analogical inference) participated in four sessions; each season consisted of 20 blocks and each block 6 attempts so eventually they had 480 repetitions in dart throe skill. One-way ANOVA, Kruskal-Wallis, paired t test and Wilcoxon test were used to investigate the significance of the hypotheses. The results showed that implicit learning emerged as a result of the combination of the speed constraint and the constraints of all three methods (P≤0.05). Adding speed constraint to other training methods (explicit, errorless and analogical inference) makes them implicit and changes the order of the system in errorless method and increases errors. However, for a certain conclusion, subsequent studies are better using muscle activity registration to consider degrees of freedom as a criterion of eliteness. These results can help skill learners, instructors and especially physical education teachers to adopt efficient teaching methods given their time limits.

Objective: The effects of kiwifruit on the histology and cell size of adipose tissue in hyperlipidemic models have not yet been reported. Therefore, this study aimed to investigate the effect of kiwifruit on the adipose tissue cell size and activity as well as the gene expression of cholesteryl ester transfer protein (CETP) in high-fat diet (HFD) fed hamsters. Materials and Methods: Forty-two male Syrian hamsters were divided into six groups. Control normal (CN) hamsters received normal diet, control HFD (CHF) were fed with a HFD plus a normal diet (15% butter fat + 0.05% cholesterol + a normal diet). Two groups were fed with normal diet including kiwifruit (1.86; Nd.1 or 3.73 g/kg; Nd.2) and two groups were fed with HFD including kiwifruit (1.86;HFd.1or 3.73 g/kg; HFd.2), for 8 weeks. Results: Histological examination of adipose tissue showed that the cell size was significantly reduced in the kiwifruit-treated groups (low and high dose) in comparison to their control groups (p Conclusion: Kiwifruit consumption reduces the size of adipocytes and increases the expression of CETPgene in adipose tissue cells. Despite the increases in CETP expression in adipose tissue, its activity in serum was not changed following kiwifruit supplementation.

Background: Recently, the use of incretins has been considered as a therapeutic target for diabetes. One of the important incretins in the improvement of diabetes is glucagon-like peptide (GLP-1), which is secreted by the gut and reduces the apoptosis of pancreatic β-cells and improves insulin sensitivity. In this experiment we determined the effects of resveratrol and probiotics on insulin resistance, oxidative stress, and GLP-1 in type 2 diabetes (T2D) rats. Methods: In this study, 40 male Wistar male rats were divided into 5 groups: 1. Control group, 2. T2D, 3. T2D treated with probiotics, 4. T2D treated with resveratrol, 5. T2D group treated with probiotics and resveratrol. After four weeks, the intestine were removed for histopathological analysis, biochemical tests, and oxidative stress markers. Results: Probiotics and resveratrol significantly decreased (p

The main goal of this paper is to investigate the boundedness and essential norm of a class of product-type operators Tu,v,φm,m∈ℕ from Hardy spaces into nth weighted-type spaces. As a corollary, we obtain some equivalent conditions for compactness of such operators.

Objectives: The aim of this study was to evaluate the effects of resistance, endurance, and concurrent exercise on oxidative stress markers and histological changes of the intestine after morphine withdrawal in rats. Methods: A total of 30 male Wistar rats were randomly divided into 5 groups (n=6) including healthy control, withdrawal (rat received morphine for 21 days and 8 weeks of withdrawal period), withdrawal + endurance exercises, withdrawal + resistance exercises, and withdrawal + concurrent exercises. The rats practiced endurance, resistance, and concurrent exercises for 10 weeks. Then, their intestines were removed and used for biochemical and histological analysis. Next, several factors were measured such as total protein levels, malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC), and total oxidant status (TOS). Finally, the morphological alteration of intestine was examined under the light microscope. Results: Morphine withdrawal significantly increased the levels of MDA in the intestine of withdrawal rats compared to those of the control group while endurance, resistance, and concurrent exercise reduced the MDA levels in the intestine. In addition, morphine withdrawal led to a decrease in TAC and GSH levels in the intestine compared to control rats whereas endurance, resistance, and concurrent exercise noticeably increased TAC and GSH levels. Interestingly, the change in the concurrent group was more significant. Moreover, the levels of TOS demonstrated a significant increase in the addicted rat as compared to the control group. Conversely, endurance, resistance, and concurrent exercise significantly decreased TOS levels and the reduction was more significant in the concurrent group. Finally, the intestine of withdrawal rat was morphologically abnormal while it restored by the exercise. Conclusion: Overall, endurance, resistance, and concurrent exercise significantly normalized oxidative stress and the morphological changes of the intestine in withdrawal rats.

BACKGROUND: High lipid accumulation in hepatocyte and blood vessels can lead to non-alcoholic fatty liver disease (NAFLD) and heart diseases, respectively. These disorders are the main reasons of mortality in various countries. In this experiment, we evaluated the effect of leaf extracts of Anethum graveolens (AG), also known as Dill, and AG tablet on expression of low-density lipoprotein receptor (LDLR) and liver lipid in hypercholesterolemic hamsters.METHODS: In this experimental study, 36 male golden hamsters were divided into 6 groups: 1) standard diet + 0.5% cholic acid + 2% cholesterol [high cholesterol diet (HCD)], 2) HCD + 100 mg/kg hydroalcoholic extract of Dill, 3) HCD + 200 mg/kg hydroalcoholic extract of Dill, 4) HCD + 100 mg/kg Dill tablet, 5) HCD + 200 mg/kg Dill tablet, 6) chow. At the end of study (30th day), hamsters were anesthetized and blood sample and liver tissue were collected. Biochemical factors and antioxidant parameters were determined. LDLR messenger ribonucleic acid (mRNA) level was measured using real time polymerase chain reaction (RT-PCR). Histopathological change of liver was determined using light microscope.RESULTS: Compared to HCD group, blood lipids (P < 0.0010) and liver enzymes (P < 0.0010) markedly reduced in AG-treated groups. The expression of LDLR did not change significantly in animals which received low dose of hydroalcoholic extract or AG tablet, but it increased in animals receiving high dose of extract or tablet (P < 0.0100). Liver antioxidant significantly increased by AG (P < 0.0010). Liver histopathological changes were normalized by AG.CONCLUSION: AG can significantly increase LDLR gene expression in HCD animals. This study showed that both AG extract and AG tablet had potential antioxidant and hypolipidemic effects in hamsters.

Background: Although acetaminophen (APAP) is considered safe at therapeutic doses, intake of high amounts of this drug can cause liver failure. In the present experiment, we examined the hepatoprotective effects of resveratrol (RES) in HepG2 cells and rat liver. Objectives: This study aimed to evaluate the influence of RES on liver function in rat model of necrosis and HepG2 cells. Materials and Methods: In this study, rats were randomly assigned into 4 groups (7 rats in each group) as follows; group 1: control rats (received normal saline), group 2: hepatotoxic control (control rats that received 640 mg/kg/d APAP), group 3: positive control (received 150 mg/kg N-acetylcysteine), group 4: RES (received 30 mg/kg RES). The animals were treated for 7 days. Afterwards, the levels of liver enzymes, protein carbonyl content, glutathione (GSH) level, and Tumor necrosis factor (TNF-α) level were determined. Results: In the in vitro experiment, APAP-induced HepG2 cells were treated with RES at different concentrations and various factors such as cell viability, liver enzymes, GSH and TNF-α levels were measured. Conclusions: Our results indicated that RES could normalize all these factors in vitro and in vivo (P

Non-alcoholic fatty liver disease (NAFLD) is a main cause of liver disease and its global prevalence is estimated to be 24%. At present no approved medicines are available for NAFLD treatment. Glucagon-like peptide-1 (GLP-1) is a significant regulator of energy balance, show potential efficacy in the management of NAFLD. GLP-1 and GLP-1 receptor agonist (GLP-1RAs) are attractive options for the treatment of type 2 diabetes (T2D) since they efficiently reduce weight, HbA1C and blood glucose without having a risk of hypoglycaemia. This incretin hormone by normalizing of insulin resistance (IR), oxidative stress, lipid accumulation, lipotoxicity, and liver cell apoptosis is proposed for the management of NAFLD and nonalcoholic steatohepatitis (NASH) patient. Hence, the aim of this review was to discuss the useful effects of GLP-1, GLP-1 receptor agonist (GLP-1RAs) and dipeptidyl peptidase-4 (DPP-4) on NAFLD. In this paper we provided a new finding which highlighted the role of GLP-1 and GLP-1RAs in the treatment of NAFLD.

Background: Platelet indices (PIs), including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) are used to predict clinical outcomes in patients with various medical conditions. The current study aimed at evaluating the correlation between serum iron saturation (IS) and PIs among the female students living in the Northwest of Iran. Methods: The current cross sectional study included 254 high school female (HSF) students aged 15 to 18 years in Hamadan, Iran, from September to January 2016. After completion of a questionnaire, the hematological parameters were determined using standard methods. HSF afflicted with infections and acute hemorrhage, and the ones with malignancies and inflammatory diseases were excluded. The correlation between the serum levels of IS and PIs in the female residents of Northwest of Iran was evaluated using the Pearson correlation test. Results: The reference range of PIs in healthy HSF in the Northwest of Iran was as follows: PC 241 ± 53 109/L, MPV 9.67 ± 0.88 fL, PDW 11.904% ± 1.68%, and P-LCR 22.908 ± 6.69 fL. Decreased IS and MPV resulted in increased PC in the current study population. An inverse correlation was observed between PC and IS (P < 0.05). There was no correlation between MPV, PDW, P-LCR, and IS (P > 0.05), but a linear correlation was observed between PDW and MPV (P < 0.001) as well as PDW and P-LCR (P < 0.001). Conclusions: The current study data indicated IS as one of the most important factors affecting PC. PIs can serve as a clue to the severity of iron deficiency in HSF. It is recommended to conduct complementary studies to identify prognostic and diagnostic utilities of PIs in clinical practices.