1. Ebola Virus Disease, Democratic Republic of the Congo, 2014
- Author
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Gary P. Kobinger, Miriam Alia, Carolina Nanclares, Andrea Bernasconi, Jimmy Kapetshi, Olimpia de la Rosa, Fanshen Lionetto, and Jean-Jacques Muyembe Tamfun
- Subjects
0301 basic medicine ,Zaire ebolavirus ,Male ,Epidemiology ,polymerase chain reaction ,lcsh:Medicine ,Filoviridae ,Kaplan-Meier Estimate ,medicine.disease_cause ,Disease Outbreaks ,0302 clinical medicine ,030212 general & internal medicine ,Child ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,Middle Aged ,Ebolavirus ,Infectious Diseases ,Geography ,PCR ,Child, Preschool ,Democratic Republic of the Congo ,RNA, Viral ,Female ,Microbiology (medical) ,Adult ,medicine.medical_specialty ,Adolescent ,Sudan ebolavirus ,Ebola virus disease ,History, 21st Century ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Young Adult ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,viruses ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Ebola virus ,Public health ,Research ,lcsh:R ,Outbreak ,Infant ,Hemorrhagic Fever, Ebola ,biology.organism_classification ,Virology ,Bundibugyo ebolavirus ,030104 developmental biology ,Ebola Virus Disease, Democratic Republic of the Congo, 2014 ,Basic reproduction number ,Demography - Abstract
Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control., During July–November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
- Published
- 2016