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18. EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer. Part II—2024 Update: Treatment of Relapsing and Metastatic Prostate Cancer

Author

Tilki, Derya, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, J.L.H. van Leenders, Geert, Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter-Paul M., and Cornford, Philip

Published
2024
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19. EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer—2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent

Author

Cornford, Philip, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, van Leenders, Geert J.L.H., Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter-Paul M., and Tilki, Derya

Published
2024
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20. A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer

Author

Slevin, Finbar, Zattoni, Fabio, Checcucci, Enrico, Cumberbatch, Marcus G.K., Nacchia, Antonio, Cornford, Philip, Briers, Erik, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Liew, Matthew, Linares Espinós, Estefania E., Oldenburg, Jan, Oprea-Lager, Daniela E., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo G., Smith, Emma Jane, Stranne, Johan, Tilki, Derya, Smith, Catrin Tudur, Van Den Bergh, Roderick C.N., Van Oort, Inge M., Wiegel, Thomas, Yuan, Cathy Y., Van den Broeck, Thomas, and Henry, Ann M.

Published
2024
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25. Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international Delphi consensus

Author

Tan, Wei Phin, Rastinehad, Ardeshir R, Klotz, Laurence, Carroll, Peter R, Emberton, Mark, Feller, John F, George, Arvin K, Gill, Inderbir S, Gupta, Rajan T, Katz, Aaron E, Lebastchi, Amir H, Marks, Leonard S, Marra, Giancarlo, Pinto, Peter A, Song, Daniel Y, Sidana, Abhinav, Ward, John F, Sanchez-Salas, Rafael, de la Rosette, Jean, Polascik, Thomas J, Authors, Focal Therapy Group, Katz, Aaron, Aminsharifi, Alireza, Lebastchi, Amir, Abreu, Andre, Villers, Arnauld, Schulman, Ariel, Rastinehad, Ardeshir, George, Arvin, Oto, Aytekin, Turkbey, Baris, Malavaud, Bernard, Muller, Berrend, Moore, Caroline, Eberli, Daniel, Margolis, Daniel, Song, Daniel, Lomas, Derek, Orabi, Hazem, Lepor, Herbert, Tan, Hui Meng, Jambor, Ivan, Grummet, Jeremy, Feller, John, Ward, John, Colemen, Jonathan, Gregg, Justin, Tay, Kae Jack, Marks, Leonard, Deane, Leslie, Laguna, M Pilar, Kimura, Masaki, Tsivian, Matvey, Gorin, Michael, Siddiqui, Minhaj, Ukimura, Osamu, Gontero, Paolo, Carroll, Peter, Pinto, Peter, Mozer, Pierre, Arcot, Ro, Taneja, Samir, Ghai, Sangeet, Crouzet, Sebastian, Mehralivand, Sherif, Joniau, Steven, Shoji, Sunao, Shiraishi, Takumi, Polascik, Thomas, Shin, Toshitaka, Lindnet, Uri, Tammisetti, Varaha, van den Bos, Willemien, and Matsuoka, Yoh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Urologic Diseases, Prostate Cancer, Clinical Research, Ablation Techniques, Aged, Aged, 80 and over, Consensus, Delphi Technique, Humans, Male, Middle Aged, Prostatic Neoplasms, Watchful Waiting, Localized prostate cancer, Focal therapy, Partial gland ablation, Active surveillance, Focal Therapy Group Authors, Urology & Nephrology, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundWith the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS).MethodsA 3-stage Delphi consensus on CaP and FT was conducted. Consensus was defined as agreement by ≥80% of physicians. An in-person meeting was attended by 17 panelists to formulate the consensus statement.ResultsFifty-six respondents participated in this interdisciplinary consensus study (82% urologist, 16% radiologist, 2% radiation oncology). The participants confirmed that there is a role for FT in men discontinuing AS (48% strongly agree, 39% agree). The benefit of FT over radical therapy for men coming off AS is: less invasive (91%), has a greater likelihood to preserve erectile function (91%), has a greater likelihood to preserve urinary continence (91%), has fewer side effects (86%), and has early recovery post-treatment (80%). Patients will need to undergo mpMRI of the prostate and/or a saturation biopsy to determine if they are potential candidates for FT. Our limitations include respondent's biases and that the participants of this consensus may not represent the larger medical community.ConclusionsFT can be offered to men coming off AS between the age of 60 to 80 with grade group 2 localized cancer. This consensus from a multidisciplinary, multi-institutional, international expert panel provides a contemporary insight utilizing FT for CaP in select patients who are discontinuing AS.

Published
2021

29. Impact of Epithelial Histological Types, Subtypes, and Growth Patterns on Oncological Outcomes for Patients with Nonmetastatic Prostate Cancer Treated with Curative Intent: A Systematic Review

Author

Marra, Giancarlo, van Leenders, Geert J.L.H., Zattoni, Fabio, Kesch, Claudia, Rajwa, Pawel, Cornford, Philip, van der Kwast, Theodorus, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, De Meerleer, Gert, De Santis, Maria, Eberli, Daniel, Farolfi, Andrea, Gillessen, Silke, Grivas, Nikolaos, Grummet, Jeremy P., Henry, Ann M., Lardas, Michael, Lieuw, Matt, Linares Espinós, Estefania, Mason, Malcolm D., O'Hanlon, Shane, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Rouvière, Olivier, Schoots, Ivo.G., Stranne, Johan, Tilki, Derya, Wiegel, Thomas, Willemse, Peter-Paul M., Mottet, Nicolas, and Gandaglia, Giorgio

Published
2023
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34. Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries

Author

Heidegger, Isabel, Resch, Johannes Mischinger Irene, Turba, Simon, Zeder, Robin, Lodeta, Braninimir, Van Praet, Charles, Ghysel, Christophe, Arentsen, Harm C., Beysens, Matthias, Vinckier, Marie-Hélène, Mottrie, Alexandre, de Groote, Ruben, Timev, Aleksandar Ivanov, Georgiev, Marincho Ivanov, Yanev, Krassimir Prodanov, Mladenov, Boris, Ivanov, Atanas Slavchev, Antonov, Petar, Valkanov, Stanislav, Tomašković, Igor, Kulis, Tomislav, Bokarica, Pero, Pavlović, Oliver, Krajina, Vinko, Situm, Marijan, Boban, Toni, Soric, Tomislav, Vidic, Ivan, Benko, Goran, Peršec, Zoran, Sović, Tomislav, Zachoval, Roman, Stejskal, Jiri, Capoun, Otakar, Pitra, Tomáš, Gojdič, Marek, Babjuk, Marek, Novák, Vojtěch, Grepl, Michal, Broul, Marek, Novák, Jan, Lund, Lars, Nordström Joensen, Ulla, Borre, Michael, Veskimäe, Priit, Baum, Peep, Tamm, Toomas, Okas, Rauno, Jämsä, Pyry, Lahdensuo, Kanerva, Siltari, Sirkku, Seikkula, Heikki, Palmberg, Christian, Isotalo, Taina, Fiard, Gaelle, Verrier, Cecile, Wiedemann, Laura, Lecornet, Emilie, Leon, Priscilla, Millet, Clementine, Ponzio, Charles, Ploussard, Guillaume, Xylinas, Evanguelos, Ingels, Alexandre, Bigot, Pierre, Le Corre, Vincent, Audenet, François, Berg, Sebastian, Palisaar, Rein-Jueri, Heidenreich, Axel, Seelemeyer, Felix, Krege, Susanne, Leyh-Bannurah, Sami-Ramzi, Witt, Jörn H., Abdirahman, Ayanle, Truß, Michael C., Kranz, Jennifer, Andreas, Karagiannis, Vassileios, Tzortzis, Andreas, Andreou, Paparidis, Spyridon, Davis, Nikolaos Ferakis Niall F., Keane, Kevin G., Fuentes, Adrian, Scuderi, Simone, Barletta, Francesco, Manfredi, Matteo, Porpiglia, Francesco, Cerruto, Maria Angela, Antonelli, Alessandro, Esperto, Francesco, Rossanese, Marta, Veneziano, Domenico, Castelli, Tommaso, Mantica, Roberto La Rocca Marcello Scarcia Guglielmo, Rebuffo, Silvia, Pomara, Giorgio, Pavan, Nicola, Silvestri, Tommaso, Reale, Giulio Francesco, Polara, Andrea, Falagario, Ugo Giovanni, Carrieri, Giuseppe, Ferrari, Giovanni, Brausi, Maurizio, Orecchia, Luca, Annino, Filippo, Kazlauskas, Gražvydas, Stavridis, Sotir, Radovic, Nenad, Vukovic, Marko, van der Slot, Margaretha Adriana, Bruins, Harman Maxim, van Oort, Inge, Witjes, Fred, van der Poel, Henk, Beisland, Christian, Lilleåsenm, Gunder, Müller, Stig, Haug, Erik S., Dimmen, Magne, Czech, Anna K., Nyk, Lukasz, Jaskulski, Jaroslaw, Ratajczyk, Krzysztof, Azevedo, Nuno, Braga, Isaac, Pereira, João, Lúcio, Rui, Pina, João, da Silva, Edgar Miguel Calvo Loureiro Tavares, Furriel, Frederico, Mota, Paulo, Rodrigues, Miguel, Radavoi, George Daniel, Crisan, Nicolae, Andras, Iulia, Robert, Stoica, Bratu, Ovidiu, Surcel, Cristian, Kotov, Sergei, Malkhasyan, Vigen, Petrov, Sergei, Reva, Sergei, Bumbasirevic, Uros, Kováčik, Viktor, Perečinský, Ivan, Rybár, Ľuboš, Šulgan, Ján, Briš, Lukáš, Jursová, Katarína, Chovan, Miroslav, Kička, Tomáš, Taskovska, Milena, Kovačič, Rok, Miklavžina, Andraž, Alvarez-Maestro, Mario, De Castro, Javier Mayor, Aragón-Chamizo, Juan, Sutil, Raquel Sopeña, Perrello, Carmen Garau, Vilaseca, Antoni, Perez, Jorge Huguet, Ovide, Julia Aumatell, Planas, Jacques, Borque-Fernando, Angel, Sánchez-Izquierdo, Elena, Jimenez, Jose Luis Marenco, Lendínez-Cano, Guillermo, Puche-Sanz, Ignacio, Garcia-Baquero, Rodrigo, Esteban, Mario Domínguez, Pérez-Fentes, Daniel, Serván, Patricia Parra, Koskela, Lotta Renström, Stranne, Johan, Scholtz, Bianca, Torbrand, Christian, Wagenius, Magnus, Ugge, Henrik, Örtegren, Joakim, Langenauer, Janine, Zumstein, Valentin, Schmid, Hans Peter, Rieken, Malte, Saba, Karim, Strebel, Raeto T., Mortezavi, Ashkan, Rentsch, Cyrill, Roth, Beat, Eberli, Daniel, Pascal, Oechslin, Auer, Rebecca, John, Hubert, Thalmann, George N., Baltacı, Sümer, Mungan, Aydın, Sözen, Sinan, Cetin, Serhat, Aslan, Guven, Türkeri, Levent, İzol, Volkan, Demirdağ, Çetin, Ozden, Sami Berk, Toktaş, Gökhan, Sarikaya, Şaban, Tinay, İlker, Müezzinoğlu, Talha, Erbatu, Oguzcan, Sagnak, Levent, Akdoğan, Bülent, Can, Cavit, Şahin, Hayrettin, Yazıcı, Cenk Murat, Volkov, Serhii, Shulyak, Olexandr, Douglas, David, Hemmant, Joshua, El-Taji, Omar, Ahmad, Imran, Nalagatla, Sarika, Janebdar, Husay, Veeratterapillay, Rajan, Rai, Bhavan, Conroy, Samantha, Cumberbatch, Marcus, Malde, Sachin, MacLennan, Steven, Duncan, Eilidh, Dunsmore, Jennifer, Fullwood, Louise, Lumen, Nicolaas, Plass, Karin, Ribal, Maria J., Roobol, Monique J., Nieboer, Daan, Schouten, Natasha, Skolarus, Ted A., Smith, Emma Jane, N'Dow, James, Mottet, Nicolas, and Briganti, Alberto

Published
2023
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40. Simultaneous Autophagy and Androgen Receptor Inhibition in a Prostate Cancer Xenograft Model.

Author

Salemi, Souzan, Kranzbühler, Benedikt, Baumgartner, Valentin, Breitenmoser, Lara, Kuzmanov, Aleksandar, Lehner, Fabienne, and Eberli, Daniel

Subjects
ABIRATERONE acetate, BIOLOGICAL models, COMBINATION drug therapy, AUTOPHAGY, DATA analysis, RESEARCH funding, PROSTATE tumors, CHLOROQUINE, XENOGRAFTS, DESCRIPTIVE statistics, MICE, GENE expression, PROSTATE-specific membrane antigen, ANIMAL experimentation, ANALYSIS of variance, STATISTICS, DATA analysis software, ANDROGEN receptors, PHARMACODYNAMICS, CHEMICAL inhibitors
Abstract

Simple Summary: Recent advancements in anticancer drug treatments face significant challenges due to drug resistance, often leading to only partial or short-term responses in patients. Our previous in vitro studies indicated that autophagy is linked to drug resistance in prostate cancer (PCa). Consequently, combination therapies targeting multiple pathways could help overcome resistance and extend treatment efficacy. To validate our earlier findings, we conducted in vivo experiments. Our data demonstrated that combining Abiraterone (Abi) with an autophagy inhibitor such as Chloroquine (Chl) not only reduces autophagy but also suppresses tumors more effectively than Abi alone. Thus, the combination of Abi with autophagy inhibitors represents a promising therapeutic strategy that could potentially offer a novel approach for patients. Objective: Abi, when used in conjunction with prednisone, is an established treatment for advanced PCa. Our goal was to explore the level of autophagy induced by Abi treatment, both alone and in combination with the autophagy inhibitor Chl, in a castrated mouse xenograft model. Methods: LNCaP cells were injected into the left and right sides of the back of nude mice that had been previously castrated. Mice were divided into four groups and treated daily with intraperitoneal injections of vehicle (control), Abi (10 mg/kg), Abi (10 mg/kg) combined with Chl (10 mg/kg), or Chl (10 mg/kg), and were monitored for periods of 2 and 3 weeks. Results: A significant reduction in tumor weight was observed in mice treated with the combination therapy, as opposed to those receiving vehicle control, Abi, or Chl alone. Mice receiving Abi + Chl exhibited reduced expression of ATG5, Beclin 1, and LC3 punctuations, along with an increase in P62, as determined by immunofluorescence and WES analysis. AR expression decreased significantly in all treatment groups compared to the control. PSMA expression was highest in the vehicle and combined treatment groups after 3 weeks, with a significant reduction observed with Chl treatment. Conclusions: These findings demonstrate that Abi + Chl treatment lowers autophagy levels and suppresses tumors more effectively than Abi alone. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Illumination matters part I: comparative analysis of light sources and illumination in flexible ureteroscopy-fundamental findings from a PEARLS analysis

Author

Kwok, Jia-Lun, primary, De Coninck, Vincent, additional, Corrales, Mariela, additional, Sierra, Alba, additional, Panthier, Frédéric, additional, Ventimiglia, Eugenio, additional, Gauhar, Vineet, additional, Schmid, Florian Alexander, additional, Hunziker, Manuela, additional, Poyet, Cédric, additional, Eberli, Daniel, additional, Traxer, Olivier, additional, and Keller, Etienne Xavier, additional

Published
2024
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43. MP43-13 PULSED THULIUM:YAG LASER: READY TO DUST ALL URINARY STONE COMPOSITION TYPES? RESULTS FROM a PEARLS ANALYSIS

Author

Kwok, Jia-Lun, primary, Ventimiglia, Eugenio, additional, De Coninck, Vincent, additional, Corrales, Mariela, additional, Sierra, Alba, additional, Panthier, Frédéric, additional, Pauchard, Felipe, additional, Schmid, Florian Alexander, additional, Hunziker, Manuela, additional, Poyet, Cédric, additional, Daudon, Michel, additional, Traxer, Olivier, additional, Eberli, Daniel, additional, and Keller, Etienne Xavier, additional

Published
2024
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49. EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer. Part II—2024 Update: Treatment of Relapsing and Metastatic Prostate Cancer

Author

Zorgeenheid Urologie Medisch, MS Urologische Oncologie, Cancer, Tilki, Derya, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, J.L.H. van Leenders, Geert, Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter Paul M., Cornford, Philip, Zorgeenheid Urologie Medisch, MS Urologische Oncologie, Cancer, Tilki, Derya, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, J.L.H. van Leenders, Geert, Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter Paul M., and Cornford, Philip

Published
2024

50. EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer—2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent

Author

Zorgeenheid Urologie Medisch, MS Urologische Oncologie, Cancer, Cornford, Philip, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, van Leenders, Geert J.L.H., Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter Paul M., Tilki, Derya, Zorgeenheid Urologie Medisch, MS Urologische Oncologie, Cancer, Cornford, Philip, van den Bergh, Roderick C.N., Briers, Erik, Van den Broeck, Thomas, Brunckhorst, Oliver, Darraugh, Julie, Eberli, Daniel, De Meerleer, Gert, De Santis, Maria, Farolfi, Andrea, Gandaglia, Giorgio, Gillessen, Silke, Grivas, Nikolaos, Henry, Ann M., Lardas, Michael, van Leenders, Geert J.L.H., Liew, Matthew, Linares Espinos, Estefania, Oldenburg, Jan, van Oort, Inge M., Oprea-Lager, Daniela E., Ploussard, Guillaume, Roberts, Matthew J., Rouvière, Olivier, Schoots, Ivo G., Schouten, Natasha, Smith, Emma J., Stranne, Johan, Wiegel, Thomas, Willemse, Peter Paul M., and Tilki, Derya

Published
2024

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