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8 results on '"Eaton, Kiefer"'

3. Cost Savings of Expedited Care with Upfront Next-Generation Sequencing Testing versus Single-Gene Testing among Patients with Metastatic Non-Small Cell Lung Cancer Based on Current Canadian Practices

Author

Sheffield, Brandon S., primary, Eaton, Kiefer, additional, Emond, Bruno, additional, Lafeuille, Marie-Hélène, additional, Hilts, Annalise, additional, Lefebvre, Patrick, additional, Morrison, Laura, additional, Stevens, Andrea L., additional, Ewara, Emmanuel M., additional, and Cheema, Parneet, additional

Published
2023
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4. Prevalence, Treatment Patterns, and Outcomes of Individuals with EGFR Positive Metastatic Non-Small Cell Lung Cancer in a Canadian Real-World Setting: A Comparison of Exon 19 Deletion, L858R, and Exon 20 Insertion EGFR Mutation Carriers

Author

O’Sullivan, Dylan E., primary, Jarada, Tamer N., additional, Yusuf, Amman, additional, Hu, Leo (Xun Yang), additional, Gogna, Priyanka, additional, Brenner, Darren R., additional, Abbie, Erica, additional, Rose, Jennifer B., additional, Eaton, Kiefer, additional, Elia-Pacitti, Julia, additional, Ewara, Emmanuel M., additional, Pabani, Aliyah, additional, Cheung, Winson Y., additional, and Boyne, Devon J., additional

Published
2022
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5. Prevalence, Treatment Patterns, and Outcomes of Individuals with EGFR Positive Metastatic Non-Small Cell Lung Cancer in a Canadian Real-World Setting: A Comparison of Exon 19 Deletion, L858R, and Exon 20 Insertion EGFR Mutation Carriers.

Author

O'Sullivan, Dylan E., Jarada, Tamer N., Yusuf, Amman, Hu, Leo, Gogna, Priyanka, Brenner, Darren R., Abbie, Erica, Rose, Jennifer B., Eaton, Kiefer, Elia-Pacitti, Julia, Ewara, Emmanuel M., Pabani, Aliyah, Cheung, Winson Y., and Boyne, Devon J.

Subjects
NON-small-cell lung carcinoma, EPIDERMAL growth factor, GENOMES, DIAGNOSIS, METASTASIS
Abstract

Real-world evidence surrounding EGFR positive NSCLC patients in Canada is limited. Administrative databases in Alberta, Canada were used to evaluate EGFR testing and mutation prevalence in de novo metastatic NSCLC, as well as the characteristics, treatment patterns, and outcomes of individuals with Exon 19, L858R and Exon20ins mutations. Between 2013–2019, 2974 individuals underwent EGFR testing, of which 451 (15.2%) were EGFR positive. Among EGFR positive individuals, 221 (49.0%) had an Exon 19 mutation, 159 (35.3%) had an L858R mutation, and 18 (4%) had an Exon20ins mutation. The proportion of individuals who initiated 1L systemic therapy was 89.1% for Exon19, 85.5% for L858R, and 72.2% for Exon20ins carriers. The primary front-line systemic therapy was gefitinib or afatinib monotherapy for individuals with Exon 19 (93.4%) and L858R (94.1%) mutations versus platinum combination therapy for individuals with Exon20ins mutations (61.5%). The Exon20ins cohort had worse median overall survival from initiation of 1L systemic therapy (10.5 months [95% CI: 8.0-not estimable]) than the Exon19 (20.6 months [95% CI: 18.4–24.9]), and L858R cohorts (19.1 months [95% CI: 14.5–23.1]). These findings highlight that Exon20ins mutations represent a rare subset of NSCLC in which treatment options are limited and survival outcomes are worse relative to individuals with more common types of EGFR mutations. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Comparative effectiveness of guselkumab in psoriatic arthritis: results from systematic literature review and network meta-analysis

Author

Mease, Philip J, primary, McInnes, Iain B, additional, Tam, Lai-Shan, additional, Eaton, Kiefer, additional, Peterson, Steve, additional, Schubert, Agata, additional, Chakravarty, Soumya D, additional, Parackal, Anna, additional, Karyekar, Chetan S, additional, Nair, Sandhya, additional, Boehncke, Wolf-Henning, additional, and Ritchlin, Christopher, additional

Published
2021
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8. Treatment of Atrial Fibrillation Using Ablation Index-Guided Contact Force Ablation: A Matching-Adjusted Indirect Comparison to Cryoballoon Ablation

Author

Hussein, Ahmed, primary, Gupta, Dhiraj, additional, De Potter, Tom, additional, Spin, Paul, additional, Eaton, Kiefer, additional, Goldstein, Laura, additional, Velleca, Maria, additional, Costa, Graça, additional, Grima, Daniel, additional, Patel, Leena, additional, and Stabile, Giuseppe, additional

Published
2019
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