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4. The development of a core outcome set for studies of pregnant women with multimorbidity

Author

Lee, Siang Ing, Hanley, Stephanie, Vowles, Zoe, Plachcinski, Rachel, Moss, Ngawai, Singh, Megha, Gale, Chris, Fagbamigbe, Adeniyi Francis, Azcoaga-Lorenzo, Amaya, Subramanian, Anuradhaa, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Dolk, Helen, Hope, Holly, Phillips, Katherine, Abel, Kathryn M., Eastwood, Kelly-Ann, Kent, Lisa, Locock, Louise, Loane, Maria, Mhereeg, Mohamed, Brocklehurst, Peter, McCann, Sharon, Brophy, Sinead, Wambua, Steven, Hemali Sudasinghe, Sudasing Pathirannehelage Buddhika, Thangaratinam, Shakila, Nirantharakumar, Krishnarajah, and Black, Mairead

Published
2023
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6. Key outcomes for reporting in studies of pregnant women with multiple long-term conditions: a qualitative study

Author

Lee, Siang Ing, Hanley, Stephanie, Vowles, Zoe, Plachcinski, Rachel, Azcoaga-Lorenzo, Amaya, Taylor, Beck, Nelson-Piercy, Catherine, McCowan, Colin, O’Reilly, Dermot, Hope, Holly, Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Singh, Megha, Moss, Ngawai, Brophy, Sinead, Nirantharakumar, Krishnarajah, Thangaratinam, Shakila, and Black, Mairead

Published
2023
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7. Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Author

Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah

Published
2023
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8. Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O’Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Published
2022
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9. Clinical utility of 3D power Doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies

Author

Eastwood, Kelly-Ann and Young, Ian

Subjects
618.3
Abstract

Globally, pre-eclampsia is a leading cause of maternal and fetal morbidity and mortality. Approximately 2% of all pregnant women develop pre-eclampsia; women with high-risk co-morbidities are particularly at risk with reported incidences of up to 20%. Evolving evidence suggests that an integrated screening tool combining medical history, ultrasound parameters and serum biomarkers may be of use in defining the patient-specific risk for pre-eclampsia. Against this background, this thesis examines the ability of baseline maternal characteristics, placental vascularisation indices, uterine artery Doppler and maternal serum biomarkers (Pregnancy Associated Plasma Protein-A (PAPP-A), Placental like Growth Factor (PlGF), soluble Fms-like tyrosine kinase (sFLt-1) and soluble Endoglin (sEng)) measured in the first and second trimesters of pregnancy to predict pre-eclampsia in high-risk women. To determine the added clinical utility and predictive value of these biophysical and biochemical parameters, a prospective longitudinal observational study of high-risk women and low-risk control participants was carried out (PREDICT). Set within the context of a systematic review evaluating the ability of (first trimester) placental vascularisation indices to predict pre-eclampsia, findings from the PREDICT study demonstrate that placental vascularisation indices perform well for prediction of pre-eclampsia in the first trimester and that measurements are repeatable and reproducible within a high-risk cohort. The added clinical utility of uterine artery Doppler ultrasound for prediction of pre-eclampsia in high-risk women was not apparent, however the additional clinical utility of a number of first (sFlt-1, sFlt-1:PlGF) and second trimester biomarkers (PlGF:sEng) was demonstrated. Results from the PREDICT study indicate a potential role for a first trimester combined screening model in high-risk women incorporating information about baseline maternal characteristics, vascularisation flow index and sFlt-1. In addition, an integrated screening model combining baseline maternal characteristics and flow index is proposed for prediction of pre-eclampsia in the second trimester. Exploratory sub-group analysis demonstrated differences in performance of placental vascularisation indices, uterine artery Doppler and serum biomarkers in prediction of pre-eclampsia. In particular, this thesis highlights the increased prevalence of obesity in pregnancy and its subsequent impact on performance of placental vascularisation indices and maternal serum biomarkers. Future research should focus on better understanding the underlying mechanisms for pre-eclampsia in different sub-groups. Additional research is needed to extend current understanding of pre-eclampsia risk in relation to Body Mass Index trajectory and to explore suitable biomarker threshold ranges for prediction of pre-eclampsia in obese cohorts. Adoption of a combined screening model early in pregnancy to identify those women at highest risk of pre-eclampsia has the potential to significantly improve maternal and neonatal outcomes. It is evident that supplementary research to investigate the role of combined screening models for pre-eclampsia within high-risk sub-groups is required before introduction in a clinical setting. In challenging the existing pathways of antenatal care, clinicians have an opportunity to provide personalised medical care for women at greatest risk.

Published
2018

10. Added Value of Fetal Cardiac MRI in Rare Case of Suspected PAPVD with LPA Sling

Author

Forte, Mari Nieves Velasco, primary, Caldas, Patricia, additional, Vigneswaran, Trisha, additional, Konta, Laura, additional, Eastwood, Kelly-Ann, additional, Schot, Vico, additional, Biglino, Giovanni, additional, Caputo, Massimo, additional, Narayan, Srinivas, additional, Pouppel, Milou van, additional, Pushparajah, Kuberan, additional, and Lloyd, David, additional

Published
2024
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12. Autoimmune diseases and adverse pregnancy outcomes: an umbrella review

Author

Singh, Megha, primary, Wambua, Steven, additional, Lee, Siang Ing, additional, Okoth, Kelvin, additional, Wang, Zhaonan, additional, Fazla, Fathima, additional, Fayaz, Ahamed, additional, Eastwood, Kelly-Ann, additional, Nelson-Piercy, Catherine, additional, Nirantharakumar, Krishnarajah, additional, and Crowe, Francesca, additional

Published
2023
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13. Detection and evaluation of signals associated with exposure to individual and combination of medications in pregnancy: a signal detection study protocol

Author

Subramanian, Anuradhaa, primary, Lee, Siang Ing, additional, Hemali Sudasinghe, Sudasing Pathirannehelage Buddhika, additional, Wambua, Steven, additional, Phillips, Katherine, additional, Singh, Megha, additional, Azcoaga-Lorenzo, Amaya, additional, Cockburn, Neil, additional, Wang, Jingya, additional, Fagbamigbe, Adeniyi, additional, Usman, Muhammad, additional, Damase-Michel, Christine, additional, Yau, Christopher, additional, Kent, Lisa, additional, McCowan, Colin, additional, OReilly, Dermot, additional, Santorelli, Gillian, additional, Hope, Holly, additional, Kennedy, Jonathan, additional, Mhereeg, Mohamed, additional, Abel, Kathryn Mary, additional, Eastwood, Kelly-Ann, additional, Black, Mairead, additional, Loane, Maria, additional, Moss, Ngawai, additional, Brophy, Sinead, additional, Brocklehurst, Peter, additional, Dolk, Helen, additional, Nelson-Piercy, Catherine, additional, and Nirantharakumar, Krishnarajah, additional

Published
2023
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18. Maternal and child outcomes for pregnant women with pre-existing multiple long-term conditions: protocol for an observational study in the UK

Author

Lee, Siang Ing, primary, Hope, Holly, additional, O’Reilly, Dermot, additional, Kent, Lisa, additional, Santorelli, Gillian, additional, Subramanian, Anuradhaa, additional, Moss, Ngawai, additional, Azcoaga-Lorenzo, Amaya, additional, Fagbamigbe, Adeniyi Francis, additional, Nelson-Piercy, Catherine, additional, Yau, Christopher, additional, McCowan, Colin, additional, Kennedy, Jonathan Ian, additional, Phillips, Katherine, additional, Singh, Megha, additional, Mhereeg, Mohamed, additional, Cockburn, Neil, additional, Brocklehurst, Peter, additional, Plachcinski, Rachel, additional, Riley, Richard D, additional, Thangaratinam, Shakila, additional, Brophy, Sinead, additional, Hemali Sudasinghe, Sudasing Pathirannehelage Buddhika, additional, Agrawal, Utkarsh, additional, Vowles, Zoe, additional, Abel, Kathryn Mary, additional, Nirantharakumar, Krishnarajah, additional, Black, Mairead, additional, and Eastwood, Kelly-Ann, additional

Published
2023
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20. Association of pregnancy complications/risk factors with the development of future long-term health conditions in women: overarching protocol for umbrella reviews

Author

Singh, Megha, primary, Crowe, Francesca, additional, Thangaratinam, Shakila, additional, Abel, Kathryn Mary, additional, Black, Mairead, additional, Okoth, Kelvin, additional, Riley, Richard, additional, Eastwood, Kelly-Ann, additional, Hope, Holly, additional, Wambua, Steven, additional, Healey, Jemma, additional, Lee, Siang Ing, additional, Phillips, Katherine, additional, Vowles, Zoe, additional, Cockburn, Neil, additional, Moss, Ngawai, additional, and Nirantharakumar, Krishnarajah, additional

Published
2022
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21. Additional file 9 of Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Author

Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah

Abstract

Additional file 9: Figure S5. Risk factors associated with polypharmacy during the entire pregnancy period.

Published
2023
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22. Additional file 3 of Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Author

Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah

Abstract

Additional file 3: Figure S3. Polypharmacy (5 or more medications) prevalence trend from 2000 to 2019.

Published
2023
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23. Additional file 8 of Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Author

Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah

Abstract

Additional file 8: Figure S4. Risk factors associated with polypharmacy during the first trimester of pregnancy.

Published
2023
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24. Additional file 1 of Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019

Author

Subramanian, Anuradhaa, Azcoaga-Lorenzo, Amaya, Anand, Astha, Phillips, Katherine, Lee, Siang Ing, Cockburn, Neil, Fagbamigbe, Adeniyi Francis, Damase-Michel, Christine, Yau, Christopher, McCowan, Colin, O’Reilly, Dermot, Santorelli, Gillian, Hope, Holly, Kennedy, Jonathan I., Abel, Kathryn M., Eastwood, Kelly-Ann, Locock, Louise, Black, Mairead, Loane, Maria, Moss, Ngawai, Plachcinski, Rachel, Thangaratinam, Shakila, Brophy, Sinead, Agrawal, Utkarsh, Vowles, Zoe, Brocklehurst, Peter, Dolk, Helen, Nelson-Piercy, Catherine, and Nirantharakumar, Krishnarajah

Abstract

Additional file 1: Figure S1. Flow diagram showing the selection of eligible pregnancies from the CPRD pregnancy register.

Published
2023
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27. Maternal and children’s outcomes for pregnant women with pre-existing multiple long-term conditions: a study protocol of an observational study in the United Kingdom

Author

Lee, Siang Ing, primary, Hope, Holly, additional, O’Reilly, Dermot, additional, Kent, Lisa, additional, Santorelli, Gillian, additional, Subramanian, Anuradhaa, additional, Moss, Ngawai, additional, Azcoaga-Lorenzo, Amaya, additional, Fagbamigbe, Adeniyi Francis, additional, Nelson-Piercy, Catherine, additional, Yau, Christopher, additional, McCowan, Colin, additional, Kennedy, Jonathan I, additional, Phillips, Katherine, additional, Singh, Megha, additional, Mhereeg, Mohamed, additional, Cockburn, Neil, additional, Brocklehurst, Peter, additional, Plachcinski, Rachel, additional, Riley, Richard, additional, Thangaratinam, Shakila, additional, Brophy, Sinead, additional, Sudasinghe, Sudasing Pathirannehelage Buddhika, additional, Agrawal, Utkarsh, additional, Vowles, Zoe, additional, Abel, Kathryn M, additional, Nirantharakumar, Krishnarajah, additional, Black, Mairead, additional, and Eastwood, Kelly-Ann, additional

Published
2022
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31. Additional file 2 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 2. Read codes and International Classification of Disease-version 10 (ICD-10) codes for health conditions.

Published
2022
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32. Additional file 5 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 5. Limitations of CPRD, SAIL, SMR.

Published
2022
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33. Additional file 12 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 12: Table 6. Post hoc logistic regression removing conditions that were associated with less deprived IMD quintiles in CPRD England study cohort (n = 13,075).

Published
2022
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34. Additional file 8 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 8: Table 2. Percentage of pregnant women by the total morbidity count in CPRD, SAIL, SMR in 2018.

Published
2022
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35. Additional file 7 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 7: Table 1. Practice level index of multiple deprivation (IMD) quintile by nations in the CPRD 2018 pregnancy cohort.

Published
2022
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36. Additional file 9 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 9: Table 3. Prevalence of pre-existing multimorbidity in pregnant women in CPRD, SAIL, SMR in 2018 by women���s characteristics.

Published
2022
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37. Additional file 4 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 4. The RECORD statement.

Published
2022
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38. Additional file 3 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 3. Phenome definitions of health conditions.

Published
2022
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39. Additional file 6 of Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study

Author

Lee, Siang Ing, Azcoaga-Lorenzo, Amaya, Agrawal, Utkarsh, Kennedy, Jonathan I., Fagbamigbe, Adeniyi Francis, Hope, Holly, Subramanian, Anuradhaa, Anand, Astha, Taylor, Beck, Nelson-Piercy, Catherine, Damase-Michel, Christine, Yau, Christopher, Crowe, Francesca, Santorelli, Gillian, Eastwood, Kelly-Ann, Vowles, Zoe, Loane, Maria, Moss, Ngawai, Brocklehurst, Peter, Plachcinski, Rachel, Thangaratinam, Shakila, Black, Mairead, O���Reilly, Dermot, Abel, Kathryn M., Brophy, Sinead, Nirantharakumar, Krishnarajah, and McCowan, Colin

Abstract

Additional file 6: Figure 1. Flow chart for selection of study population.

Published
2022
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40. Trends in maternal body mass index in Northern Ireland: a cross-sectional and longitudinal study: A cross-sectional and longitudinal study

Author

Kent, Lisa, Cardwell, Christopher, Young, Ian, and Eastwood, Kelly-Ann

Subjects
obesity, SDG 3 - Good Health and Well-being, social determinants of health, Public Health, Environmental and Occupational Health, epidemiology, Family Practice, maternal health, maternal welfare
Abstract

Objectives: Explore (1) associations between maternal body mass index (BMI), demographic and clinical characteristics, (2) longitudinal trends in BMI, (3) geographical distributions in prevalence of maternal overweight and obesity.Design: Retrospective population-based study. Setting Linked, anonymised, routinely collected healthcare data and official statistics from Northern Ireland. Participants All pregnancies in Northern Ireland (2011-2017) with BMI measured at ≤16 weeks gestation. Methods: Analysis of variance and χ 2 tests were used to explore associations. Multiple linear regression was used to explore longitudinal trends and spatial visualisation illustrated geographical distribution. Main outcomes are prevalence of overweight (BMI ≥25 kg/m 2) and obesity (BMI ≥30 kg/m 2).Results: 152 961 singleton and 2362 multiple pregnancies were included. A high prevalence of maternal overweight and obesity in Northern Ireland is apparent (singleton: 52.4%; multiple: 48.3%) and is increasing. Obesity was positively associated with older age, larger numbers of previous pregnancies and unplanned pregnancy (pConclusions: The prevalence of maternal BMI >25 kg/m 2 is increasing over time in Northern Ireland. Women are entering pregnancy with additional comorbidities likely to impact their life course beyond pregnancy. This highlights the need for prioritisation of preconception and inter-pregnancy support for management of weight and chronic conditions.

Published
2021

42. Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a cross-sectional study

Author

Lee, Siang Ing, primary, Azcoaga-Lorenzo, Amaya, additional, Agrawal, Utkarsh, additional, Kennedy, Jonathan I, additional, Fagbamigbe, Adeniyi Francis, additional, Hope, Holly, additional, Subramanian, Anuradhaa, additional, Anand, Astha, additional, Taylor, Beck, additional, Nelson-Piercy, Catherine, additional, Damase-Michel, Christine, additional, Yau, Christopher, additional, Crowe, Francesca, additional, Santorelli, Gillian, additional, Eastwood, Kelly-Ann, additional, Vowles, Zoe, additional, Loane, Maria, additional, Moss, Ngawai, additional, Brocklehurst, Peter, additional, Plachcinski, Rachel, additional, Thangaratinam, Shakila, additional, Black, Mairead, additional, O'Reilly, Dermot, additional, Abel, Kathryn M, additional, Brophy, Sinead, additional, Nirantharakumar, Krishnarajah, additional, and McCowan, Colin, additional

Published
2021
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43. Protocol for the development of a core outcome set for studies of pregnant women with pre-existing multimorbidity

Author

Lee, Siang Ing, primary, Eastwood, Kelly-Ann, additional, Moss, Ngawai, additional, Azcoaga-Lorenzo, Amaya, additional, Subramanian, Anuradhaa, additional, Anand, Astha, additional, Taylor, Beck, additional, Nelson-Piercy, Catherine, additional, Yau, Christopher, additional, McCowan, Colin, additional, O'Reilly, Dermot, additional, Hope, Holly, additional, Kennedy, Jonathan Ian, additional, Abel, Kathryn Mary, additional, Locock, Louise, additional, Brocklehurst, Peter, additional, Plachcinski, Rachel, additional, Brophy, Sinead, additional, Agrawal, Utkarsh, additional, Thangaratinam, Shakila, additional, Nirantharakumar, Krishnarajah, additional, and Black, Mairead, additional

Published
2021
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44. FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function

Author

Alqudah, Abdelrahim, primary, Eastwood, Kelly-Ann, additional, Jerotic, Djurdja, additional, Todd, Naomi, additional, Hoch, Denise, additional, McNally, Ross, additional, Obradovic, Danilo, additional, Dugalic, Stefan, additional, Hunter, Alyson J., additional, Holmes, Valerie A., additional, McCance, David R., additional, Young, Ian S., additional, Watson, Chris J., additional, Robson, Tracy, additional, Desoye, Gernot, additional, Grieve, David J., additional, and McClements, Lana, additional

Published
2021
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45. NOVEL MIRNAS AS TARGETS OF MESENCHYMAL STEM CELLS-BASED THERAPY FOR TREATMENT OF PREECLAMPSIA

Author

Alqudah, Abdelrahim, primary, Suvakov, Sonja, additional, Richards, Claire, additional, Todd, Naomi, additional, Eastwood, Kelly-Ann, additional, Hunter, Alyson J., additional, Holmes, Valerie A., additional, Mccance, David R., additional, Young, Ian S., additional, Furlong, Fiona, additional, Ali, Ahlam, additional, Krasnodembskaya, Anna, additional, Lopez-Campos, Guillermo, additional, Garovic, Vesna D., additional, and Mcclements, Lana, additional

Published
2021
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46. FKBPL and SIRT-1, key angiogenesis proteins, are downregulated by diabetes in pregnancy

Author

Alqudah, Abdelrahim, primary, Eastwood, Kelly-Ann, additional, Jerotic, Djurdja, additional, Todd, Naomi, additional, Hoch, Denise, additional, McNally, Ross, additional, Obradovic, Danilo, additional, Dugalic, Stefan, additional, Hunter, Alyson J., additional, Holmes, Valerie A., additional, McCance, David R., additional, Young, Ian S., additional, Watson, Chris J, additional, Robson, Tracy, additional, Desoye, Gernot, additional, Grieve, David J, additional, and McClements, Lana, additional

Published
2020
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47. Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment

Author

Todd, Naomi, primary, McNally, Ross, additional, Alqudah, Abdelrahim, additional, Jerotic, Djurdja, additional, Suvakov, Sonja, additional, Obradovic, Danilo, additional, Hoch, Denise, additional, Hombrebueno, Jose R, additional, Campos, Guillermo Lopez, additional, Watson, Chris J, additional, Gojnic-Dugalic, Miroslava, additional, Simic, Tatjana P, additional, Krasnodembskaya, Anna, additional, Desoye, Gernot, additional, Eastwood, Kelly-Ann, additional, Hunter, Alyson J, additional, Holmes, Valerie A, additional, McCance, David R, additional, Young, Ian S, additional, Grieve, David J, additional, Kenny, Louise C, additional, Garovic, Vesna D, additional, Robson, Tracy, additional, and McClements, Lana, additional

Published
2020
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50. Role of A Novel Angiogenesis FKBPL-CD44 Pathway in Preeclampsia Risk Stratification and Mesenchymal Stem Cell Treatment.

Author

Todd, Naomi, McNally, Ross, Alqudah, Abdelrahim, Jerotic, Djurdja, Suvakov, Sonja, Obradovic, Danilo, Hoch, Denise, Hombrebueno, Jose R, Campos, Guillermo Lopez, Watson, Chris J, Gojnic-Dugalic, Miroslava, Simic, Tatjana P, Krasnodembskaya, Anna, Desoye, Gernot, Eastwood, Kelly-Ann, Hunter, Alyson J, Holmes, Valerie A, McCance, David R, Young, Ian S, and Grieve, David J

Subjects
MESENCHYMAL stem cells, STEM cell treatment, PREECLAMPSIA, NEOVASCULARIZATION, PREGNANCY complications, CELL physiology, STEM cell transplantation, PREECLAMPSIA diagnosis, RESEARCH, CELL culture, RESEARCH methodology, CELL receptors, CASE-control method, PROGNOSIS, MEDICAL cooperation, EVALUATION research, RISK assessment, CELLULAR signal transduction, COMPARATIVE studies, PATHOLOGIC neovascularization, DRUG therapy, RESEARCH funding, EPITHELIAL cells
Abstract

Context: Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.Objective: To investigate the diagnostic and therapeutic target potential of the angiogenesis proteins, FK506-binding protein like (FKBPL) and CD44.Design and Intervention: FKBPL and CD44 plasma concentration or placental expression were determined in women pre- or postdiagnosis of preeclampsia. Trophoblast and endothelial cell function was assessed following mesenchymal stem cell (MSC) treatment and in the context of FKBPL signaling.Settings and Participants: Human samples prediagnosis (15 and 20 weeks of gestation; n ≥ 57), or postdiagnosis (n = 18 for plasma; n = 4 for placenta) of preeclampsia were used to determine FKBPL and CD44 levels, compared to healthy controls. Trophoblast or endothelial cells were exposed to low/high oxygen, and treated with MSC-conditioned media (MSC-CM) or a FKBPL overexpression plasmid.Main Outcome Measures: Preeclampsia risk stratification and diagnostic potential of FKBPL and CD44 were investigated. MSC treatment effects and FKBPL-CD44 signaling in trophoblast and endothelial cells were assessed.Results: The CD44/FKBPL ratio was reduced in placenta and plasma following clinical diagnosis of preeclampsia. At 20 weeks of gestation, a high plasma CD44/FKBPL ratio was independently associated with the 2.3-fold increased risk of preeclampsia (odds ratio = 2.3, 95% confidence interval [CI] 1.03-5.23, P = 0.04). In combination with high mean arterial blood pressure (>82.5 mmHg), the risk further increased to 3.9-fold (95% CI 1.30-11.84, P = 0.016). Both hypoxia and MSC-based therapy inhibited FKBPL-CD44 signaling, enhancing cell angiogenesis.Conclusions: The FKBPL-CD44 pathway appears to have a central role in the pathogenesis of preeclampsia, showing promising utilities for early diagnostic and therapeutic purposes. [ABSTRACT FROM AUTHOR]

Published
2021
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