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194 results on '"Easley, Jeremiah T."'

10. Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model.

Author

Luan, Tammy, Liu, Xuhui, Easley, Jeremiah T, Ravishankar, Bharat, Puttlitz, Christian, and Feeley, Brian T

Subjects
Physical Injury - Accidents and Adverse Effects, 6.7 Physical, Evaluation of treatments and therapeutic interventions, Musculoskeletal, acute rotator cuff repair, fatty infiltration, fibrosis, SREBP-1, PPAR gamma, PPARγ, Physiology, Human Movement and Sports Sciences, Medical Physiology
Abstract

Introductionrotator cuff tears (RCTs) are the most common tendon injury seen in orthopedic patients. Muscle atrophy and fatty infiltration of the muscle are crucial factors that dictate the outcome following rotator cuff surgery. Though less studied in humans, rotator cuff muscle fibrosis has been seen in animal models as well and may influence outcomes as well. The purpose of this study was to determine if the rotator cuff would develop muscle changes even in the setting of an acute repair in a sheep model. We hypothesized that fatty infiltration and fibrosis would be present even after an acute repair six months after initial surgery.Methodstwelve female adult sheep underwent an acute rotator cuff tear and immediate repair on the right shoulder. The left shoulder served as a control and did not undergo a tear or a repair. Six months following acute rotator cuff repairs, sheep muscles were harvested to study atrophy, fatty infiltration, and fibrosis by histological analysis, western blotting, and reverse transcription polymerase chain reaction (RT-PCR).Resultsthe repair group demonstrated an increase expression of muscle atrophy, fatty infiltration, and fibrosis related genes. Significantly increased adipocytes, muscle fatty infiltration, and collagen deposition was observed in rotator cuff muscles in the tendon repair group compared to the control group.Conclusionsrotator cuff muscle undergoes degradation changes including fatty infiltration and fibrosis even after the tendons are repair immediately after rupture.Level of evidenceBasic Science Study.

Published
2015

15. Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc

Author

Tang, Shirley N., primary, Bonilla, Andres F., additional, Chahine, Nadeen O., additional, Colbath, Aimee C., additional, Easley, Jeremiah T., additional, Grad, Sibylle, additional, Haglund, Lisbet, additional, Le Maitre, Christine L., additional, Leung, Victor, additional, McCoy, Annette M., additional, Purmessur, Devina, additional, Tang, Simon Y., additional, Zeiter, Stephan, additional, and Smith, Lachlan J., additional

Published
2022
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20. A Large Animal Model for Orthopedic Foot and Ankle Research

Author

Gadomski, Benjamin C., primary, Labus, Kevin M., additional, Stewart, Holly L., additional, Bisazza, Katie T., additional, Nelson, Brad B., additional, Puttlitz, Christian M., additional, McGilvray, Kirk C., additional, Regan, Daniel P., additional, and Easley, Jeremiah T., additional

Published
2022
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28. Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer ( rhPDGF‐BB ) combined with a bovine collagen/β‐tricalcium phosphate ( β‐TCP ) matrix in an ovine model

Author

Gadomski, Benjamin C., primary, Labus, Kevin M., additional, Puttlitz, Christian M., additional, McGilvray, Kirk C., additional, Regan, Daniel P., additional, Nelson, Brad, additional, Seim, Howard B., additional, and Easley, Jeremiah T., additional

Published
2021
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30. Laparoscopic Ovariectomy in a Domestic Yak

Author

Koch, Drew W., Simpson, Katharine M., Easley, Jeremiah T., and Hackett, Eileen S.

Subjects
Article Subject
Abstract

Owners of a juvenile domestic yak elected bilateral ovariectomy to prevent future reproduction. The yak was noted to be healthy at presentation. Both ovaries were removed using a laparoscopic approach as follows: after induction and maintenance of general inhalant anesthesia, 15 degrees Trendelenburg positioning was required to view the ovaries. Ovariectomy was conducted within a surgical time of 50 minutes. Due to the small ovarian size, portal enlargement was not necessary for removal. Mild hemorrhage from the left ovarian pedicle was controlled with application of a vessel-sealing device. Postoperative complications were not encountered during hospitalization. At 12 months following surgery, the yak was healthy, and the owner was highly satisfied with the procedure. The described approach was successful for performing laparoscopic ovariectomy in a juvenile yak. Positioning for surgery was similar to other small ruminant species. Further case enrollment is needed to optimize the surgical approach and better describe clinical outcomes.

Published
2020
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34. Outcomes after cervical vertebral interbody fusion using an interbody fusion device and polyaxial pedicle screw and rod construct in 10 horses (2015‐2019).

Author

Pezzanite, Lynn M., Easley, Jeremiah T., Bayless, Rosemary, Aldrich, Ellison, Nelson, Brad B., Seim, Howard B., and Nout‐Lomas, Yvette S.

Abstract

Background: Further development of surgical techniques for equine cervical stabilisation is necessary to make the procedure less technically demanding, reduce complications and improve outcomes. Objective: To describe clinical outcomes and owner reports in horses undergoing placement of an interbody fusion device and polyaxial pedicle screw and rod construct for cervical vertebral fusion in horses with cervical vertebral compressive myelopathy. Study design: Retrospective case series. Methods: Data were retrieved from medical records of 10 horses undergoing cervical vertebral fusion (2015‐2019). Records were evaluated for signalment, duration of clinical signs, number and location of compression sites, grade of ataxia, duration of hospitalisation and complications. Long‐term follow‐up was obtained through clinical re‐evaluation, postoperative radiographs and owner contact. Results: Breeds were mixed. Median age was 24 (range 12‐168) months. There were 2/10 mares, 4/10 geldings and 4/10 stallions. Preoperative grade of ataxia ranged from 1‐3/5. Fusion was performed at one (n = 3) or two (n = 7) sites. Two horses were euthanised within the first year. In 6 of 8 horses with ≥1‐year follow‐up, ataxia improved by 1‐3 grades, with an average improvement of 1.25 grades. In four horses, ataxia improved to grade 0‐1. In two horses the gait was unaffected, but neck comfort improved. Complications included seroma formation (n = 9), pain (n = 5), fever (n = 4), upper respiratory tract obstruction (n = 2), azotemia (n = 2), screw breakage (n = 2), progression of neurological signs (n = 1), Horner's Syndrome (n = 1), dysphagia (n = 1), hives (n = 1), implant infection (n = 1) and nondisplaced fracture (n = 1). Main limitations: Small case series, heterogeneous patient population. Conclusions: This technique resulted in ≥1 grade gait improvement in 6/10 cases operated and 6/8 cases for which ≥1‐year follow‐up was available, similar to other methods. Fatal complications related to implant placement did not occur. This technique may represent a safer alternative to current techniques of ventral interbody fusion with similar outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Mechanical, biochemical, and morphological topography of ovine knee cartilage.

Author

Risch, Makayla, Easley, Jeremiah T., McCready, Erin G., Troyer, Kevin L., Johnson, James W., Gadomski, Benjamin C., McGilvray, Kirk C., Kisiday, John D., and Nelson, Brad B.

Subjects
*ARTICULAR cartilage, *CARTILAGE, *KNEE, *COLLAGEN, *TOPOGRAPHY
Abstract

The knee is the most common site for translational cartilage research in sheep, though topographic features of articular cartilage across surfaces are unspecified. We aimed to characterize the mechanical, morphological, and biochemical properties of articular cartilage across ovine knee surfaces and document variations between and within surface locations. Regions of interest (ROIs) were delineated across surfaces of 10 healthy ovine knees. Articular cartilage at each ROI was measured for creep indentation, thickness, and glycosaminoglycan (GAG) and collagen content. Variables were compared between surface locations (trochlea, and lateral [LFC] and medial [MFC] femoral condyles) and between ROIs within each surface location. Correlations between variables were also assessed. Articular surface location had a significant effect on creep (P <.0001), thickness (P <.0001), and collagen (P =.0007), but not GAG (P =.28). Significant differences in percent creep between ROIs were found within the LFC (P <.0001), MFC (P <.0001), and trochlea (P =.0002). Cartilage thickness was different between ROIs within the LFC, MFC, and trochlea (all P <.0001). The LFC (P =.002) and trochlea (P =.01) each had significant differences in GAG between ROIs. Collagen content between ROIs was different within the LFC (P =.0003), MFC (P =.0005), and trochlea (P <.0001). Collagen content was correlated with thickness (r = −.55), percent creep (r =.47), and GAG (r = −.21). Percent creep was correlated with thickness (r = −.64) and GAG (r = −.19). Topographic variations in mechanical, morphological, and biochemical properties exist across knee cartilage surfaces in sheep. Recognition of this variability is important to optimize study protocols and improve accuracy of results. [ABSTRACT FROM AUTHOR]

Published
2021
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