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3 results on '"Early and lifetime comorbidities"'

1. Investigation of early and lifetime clinical features and comorbidities for the risk of developing treatment-resistant depression in a 13-year nationwide cohort study

Author

Shiau-Shian Huang, Hsi-Han Chen, Jui Wang, Wei J. Chen, Hsi-Chung Chen, and Po-Hsiu Kuo

Subjects
Treatment-resistant depression, Antidepressants, Early and lifetime comorbidities, Prescription pattern, Health-seeking behavior, Psychiatry, RC435-571
Abstract

Abstract Background To investigate the risk of treatment-resistant depression (TRD) in patients with depression by examining their clinical features, early prescription patterns, and early and lifetime comorbidities. Methods In total, 31,422 depressive inpatients were followed-up from diagnostic onset for more than 10-years. Patients were diagnosed with TRD if their antidepressant treatment regimen was altered ≥two times or if they were admitted after at least two different antidepressant treatments. Multiple Cox regression model were used to determine whether physical and psychiatric comorbidities, psychosis, and prescription patterns increased the risk of TRD by controlling for relevant demographic covariates. Survival analyses were performed for important TRD-associated clinical variables. Results Females with depression (21.24%) were more likely to suffer from TRD than males (14.02%). Early anxiety disorders were more commonly observed in the TRD group than in the non-TRD group (81.48 vs. 58.96%, p

Published
2020
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3. Investigation of early and lifetime clinical features and comorbidities for the risk of developing treatment-resistant depression in a 13-year nationwide cohort study

Author

Hsi-Han Chen, Po-Hsiu Kuo, Hsi-Chung Chen, Wei J. Chen, Shiau-Shian Huang, and Jui Wang

Subjects
Male, medicine.medical_specialty, Health-seeking behavior, lcsh:RC435-571, Population, Cohort Studies, Depressive Disorder, Treatment-Resistant, Internal medicine, lcsh:Psychiatry, Medicine, Humans, education, Depression (differential diagnoses), Polypharmacy, education.field_of_study, Depressive Disorder, Major, business.industry, Early and lifetime comorbidities, Depression, Antidepressants, medicine.disease, Prescription pattern, Antidepressive Agents, Psychiatry and Mental health, Attributable risk, Anxiety, Major depressive disorder, Female, medicine.symptom, Treatment-resistant depression, business, Cohort study, Research Article
Abstract

Background To investigate the risk of treatment-resistant depression (TRD) in patients with depression by examining their clinical features, early prescription patterns, and early and lifetime comorbidities. Methods In total, 31,422 depressive inpatients were followed-up from diagnostic onset for more than 10-years. Patients were diagnosed with TRD if their antidepressant treatment regimen was altered ≥two times or if they were admitted after at least two different antidepressant treatments. Multiple Cox regression model were used to determine whether physical and psychiatric comorbidities, psychosis, and prescription patterns increased the risk of TRD by controlling for relevant demographic covariates. Survival analyses were performed for important TRD-associated clinical variables. Results Females with depression (21.24%) were more likely to suffer from TRD than males (14.02%). Early anxiety disorders were more commonly observed in the TRD group than in the non-TRD group (81.48 vs. 58.96%, p p Conclusion Our findings indicate the need to monitor early comorbidities and polypharmacy patterns in patients with depression associated with elevated TRD risk.

Published
2020

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