1. Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy. Cross-sectional Analyses of Baseline Data of the EUROCONDOR project
- Author
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Santos, Ana Rita, Ribeiro, Luisa, Bandello, Francesco, Lattanzio, Rosangela, Egan, Catherine, Frydkjaer-Olsen, Ulrik, Garcia-Arumi, Jose, Gibson, Jonathan, Grauslund, Jakob, Harding, Simon P, Lang, Gabriele E, Massin, Pascale, Midena, Edoardo, Scanlon, Peter, Aldington, Stephen J, Simao, Silvia, Schwartz, Christian, Ponsati, Berta, Porta, Massimo, Costa, Miguel Angelo, Hernandez, Cristina, Cunha-Vaz, Jose, Simo, Rafael, Early, European Consortium, Santos, Ana Rita, Ribeiro, Luísa, Bandello, Francesco, Lattanzio, Rosangela, Egan, Catherine, Frydkjaer-Olsen, Ulrik, García-Arumí, José, Gibson, Jonathan, Grauslund, Jakob, Harding, Simon P., Lang, Gabriele E., Massin, Pascale, Midena, Edoardo, Scanlon, Peter, Aldington, Stephen J., Simão, Sílvia, Schwartz, Christian, Ponsati, Berta, Porta, Massimo, Costa, Miguel Angelo, Hernández, Cristina, Cunha-Vaz, José, Simó, Rafael, and Repositório Científico do Instituto Politécnico do Porto
- Subjects
Male ,Pathology ,genetic structures ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Retinal Degeneration/diagnosis ,Type 2 diabetes ,Aged ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Diabetic Retinopathy ,Electroretinography ,Female ,Humans ,Middle Aged ,Retinal Degeneration ,Retinal Neurons ,Retinal Vessels ,Internal Medicine ,Endocrinology ,0302 clinical medicine ,medicine.diagnostic_test ,Neurodegeneration ,Diabetic retinopathy ,Retinal Vessel ,Retinal Vessels/pathology ,3. Good health ,Diabetes and Metabolism ,Retinal Neuron ,Type 2 ,Human ,medicine.medical_specialty ,030209 endocrinology & metabolism ,03 medical and health sciences ,Diabetes mellitus ,Ophthalmology ,Journal Article ,Diabetes Mellitus ,medicine ,Functional studies ,Cross-Sectional Studie ,business.industry ,Diabetes Mellitus, Type 2/complications ,Baseline data ,RA645.D54 ,medicine.disease ,Diabetic Retinopathy/diagnosis ,eye diseases ,030221 ophthalmology & optometry ,RE ,sense organs ,business ,Retinal Neurons/pathology - Abstract
This cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enrolled in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR) study (NCT01726075). Functional studies by multifocal electroretinography (mfERG) evaluated neurodysfunction, and structural measurements using spectral domain optical coherence tomography (SD-OCT) evaluated neurodegeneration. The mfERG P1 amplitude was more sensitive than the P1 implicit time and was lower in patients with Early Treatment of Diabetic Retinopathy Study (ETDRS) level 20–35 than in patients with ETDRS level
- Published
- 2017
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