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801 results on '"Earley, Christopher"'

1. Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction

Author

Schormair, Barbara, Zhao, Chen, Bell, Steven, Didriksen, Maria, Nawaz, Muhammad S., Schandra, Nathalie, Stefani, Ambra, Högl, Birgit, Dauvilliers, Yves, Bachmann, Cornelius G., Kemlink, David, Sonka, Karel, Paulus, Walter, Trenkwalder, Claudia, Oertel, Wolfgang H., Hornyak, Magdolna, Teder-Laving, Maris, Metspalu, Andres, Hadjigeorgiou, Georgios M., Polo, Olli, Fietze, Ingo, Ross, Owen A., Wszolek, Zbigniew K., Ibrahim, Abubaker, Bergmann, Melanie, Kittke, Volker, Harrer, Philip, Dowsett, Joseph, Chenini, Sofiene, Ostrowski, Sisse Rye, Sørensen, Erik, Erikstrup, Christian, Pedersen, Ole B., Topholm Bruun, Mie, Nielsen, Kaspar R., Butterworth, Adam S., Soranzo, Nicole, Ouwehand, Willem H., Roberts, David J., Danesh, John, Burchell, Brendan, Furlotte, Nicholas A., Nandakumar, Priyanka, Earley, Christopher J., Ondo, William G., Xiong, Lan, Desautels, Alex, Perola, Markus, Vodicka, Pavel, Dina, Christian, Stoll, Monika, Franke, Andre, Lieb, Wolfgang, Stewart, Alexandre F. R., Shah, Svati H., Gieger, Christian, Peters, Annette, Rye, David B., Rouleau, Guy A., Berger, Klaus, Stefansson, Hreinn, Ullum, Henrik, Stefansson, Kari, Hinds, David A., Di Angelantonio, Emanuele, Oexle, Konrad, and Winkelmann, Juliane

Published
2024
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4. Imaging arterial and venous vessels using Iron Dextran enhanced multi‐echo 3D gradient echo MRI at 7T.

Author

Li, Yinghao, Li, Wei, Paez, Adrian, Cao, Di, Sun, Yuanqi, Gu, Chunming, Zhang, Kaihua, Miao, Xinyuan, Liu, Peiying, Li, Wenbo, Pillai, Jay J., Lu, Hanzhang, van Zijl, Peter C. M., Earley, Christopher, Li, Xu, and Hua, Jun

Subjects
MAGNETIC resonance imaging, BLOOD vessels, IRON compounds, CONTRAST media, FERRIC oxide
Abstract

Iron Dextran is a widely used iron oxide compound to treat iron‐deficiency anemia patients in the clinic. Similar to other iron oxide compounds such as Ferumoxytol, it can also be used off‐label as an intravascular magnetic resonance imaging (MRI) contrast agent due to its strong iron‐induced T2 and T2* shortening effects. In this study, we seek to evaluate the feasibility of using Iron Dextran enhanced multi‐echo susceptibility weighted imaging (SWI) MRI at 7T to image arterial and venous blood vessels in the human brain. Phantom experiments were performed to measure the r2* relaxivity for Iron Dextran in blood, based on which the SWI sequence was optimized. Pre‐ and post‐infusion MR images were acquired in human subjects from which maps of arteries and veins were extracted. The post‐contrast SWI images showed enhanced susceptibility difference between blood and the surrounding tissue in both arteries and veins. Our results showed that the proposed Iron Dextran enhanced multi‐echo SWI approach allowed the visualization of blood vessels with diameters down to ~100 μm, including small blood vessels supplying and draining small brain structures such as the hippocampus. We conclude that Iron Dextran can be an alternative iron‐based MRI contrast agent for blood vessel imaging in the human brain. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Three Habits of the Most Successful Attorneys

Author

Earley, Christopher

Subjects
Career development -- Management -- Methods, Habit -- Evaluation, Skill learning -- Methods -- Management -- Evaluation, Generosity -- Management -- Methods -- Evaluation, Business success -- Methods -- Management, Competition (Psychology) -- Methods -- Evaluation -- Management, Company business management, Law
Abstract

* Successful attorneys compete with themselves rather than against fellow attorneys. * Successful attorneys are knowledge-seekers who are constantly curious and always seeking to learn new things. * The most successful attorneys are the most generous. They constantly give and share their time and expertise with no expectation of receiving anything in return., Nov 06, 2024 0 min read I constantly study successful attorneys. I'm always fascinated by what separates those attorneys who make it to the top and those who do not. [...]

Published
2024

7. The power of vulnerable.

Author

Earley, Christopher F.

Subjects
Professional development -- Psychological aspects -- Management, Psychic trauma in children -- Influence -- Management, Mental health -- Management, Vulnerability (Psychology) -- Management, Attorneys -- Psychological aspects -- Evaluation -- Management, Company business management
Abstract

Byline: Christopher F. Earley I was recently on an attorney panel and an audience member asked a question. The panel was a real and honest discussion about the importance of [...]

Published
2024

9. The Management of Restless Legs Syndrome: An Updated Algorithm

Author

Earley, Christopher J., Becker, Phillip, Berkowski, J. Andrew, Buchfuhrer, Mark J., Clemens, Stefan, Connor, James R., Ferré, Sergi, Hensley, Jennifer G., Jones, Byron C., Karroum, Elias G., Koo, Brian, Manconi, Mauro, Ondo, William, Richards, Kathy, Sharon, Denise, Silber, Michael H., Trotti, Lynn Marie, Uhl, George, Walters, Arthur S., Winkelman, John W., and Koo, Brian B.

Published
2021
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11. Brain Iron Dysregulation in Iron Deficiency Anemia‐Related Restless Leg Syndrome Revealed by Neuron‐Derived Extracellular Vesicles: A Case–Control Study.

Author

Manolopoulos, Apostolos, York, William, Pucha, Krishna Ananthu, Earley, Christopher J., and Kapogiannis, Dimitrios

Subjects
IRON in the body, RESTLESS legs syndrome, TRANSFERRIN receptors, IRON proteins, EXTRACELLULAR vesicles
Abstract

Brain iron deficiency (ID) and, to a degree, systemic ID have been implicated in restless leg syndrome (RLS) pathogenesis. Previously, we found increased ferritin in neuron‐derived extracellular vesicles (NDEVs) in RLS, suggesting a mechanism for depleting intracellular iron by secreting ferritin‐loaded NDEVs. In this study, we hypothesized that increased NDEV ferritin occurs even in RLS accompanied by systemic ID and that neuronal intracellular iron depletion in RLS also manifests as NDEV abnormalities in other iron regulatory proteins, specifically, decreased transferrin receptor (TfR) and increased ferroportin. To address these hypotheses, we studied 71 women with ID anemia, 36 with RLS, and 35 without RLS. Subjects with RLS again showed higher NDEV ferritin and also decreased TfR, suggesting diminished neuronal capacity for iron uptake. Findings inform a more complete understanding of the pathogenic role of neuronal iron homeostasis and dissociate it from peripheral ID. ANN NEUROL 2024;96:560–564 [ABSTRACT FROM AUTHOR]

Published
2024
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18. A randomized double‐blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia

Author

Short, Vanessa, primary, Allen, Richard, additional, Earley, Christopher J., additional, Bahrain, Huzefa, additional, Rineer, Stella, additional, Kashi, Kiumarce, additional, Gerb, Jesse, additional, and Auerbach, Michael, additional

Published
2024
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20. How to Go on Vacation and Not Work.

Author

Earley, Christopher

Subjects
Business plans -- Methods, Work-life balance -- Management, Delegation of authority -- Methods, Employee selection -- Methods, Vacations -- Management -- Evaluation, Office management -- Methods, Business planning -- Methods, Employee training -- Methods, Hiring, Company business management
Abstract

Aug 27, 2024 0 min read Summary * Create systems for everything you do in your office so you can pass that work to other people instead of having to [...]

Published
2024

21. How to Handle a Toxic Team Member.

Author

Earley, Christopher

Subjects
Law firms -- Management, Employee selection -- Management, Corporate culture -- Management, Work groups -- Management, Employee morale -- Management, Employees -- Beliefs, opinions and attitudes, Hiring, Company business management
Abstract

Summary * It is crucial to appreciate the potential impact a toxic team member can have on office morale and culture. * Even if the person is producing at a [...]

Published
2024

22. Provide Value and See Your Network Grow.

Author

Earley, Christopher

Subjects
Public speaking -- Demographic aspects -- Evaluation -- Usage, Business networks (Social groups) -- Management, Value (Economics) -- Management, Client development -- Methods, Company business management
Abstract

Share: There are many ways to expand your professional network, and some are more effective than others. But for me, the most effective way to expand my network is to [...]

Published
2023

23. On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa)

Author

Gu, Chunming, primary, Li, Yinghao, additional, Cao, Di, additional, Miao, Xinyuan, additional, Paez, Adrian G., additional, Sun, Yuanqi, additional, Cai, Jitong, additional, Li, Wenbo, additional, Li, Xu, additional, Pillai, Jay J., additional, Earley, Christopher J., additional, van Zijl, Peter C. M., additional, and Hua, Jun, additional

Published
2023
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26. Three Ways to Work Less and Make More Money.

Author

Earley, Christopher

Subjects
Work-life balance -- Methods -- Management, Delegation of authority -- Management, Attention -- Management, Work hours -- Management, Labor productivity -- Management, Self-control -- Methods, Company business management
Abstract

Lawyers have a reputation for working long hours and working late into the night. Working on the weekends has become standard in our industry. This grind can bring with it [...], * Constant email interruptions, unscheduled phone calls, and idle watercooler chitchat seriously add up over time. These are hours and hours that you can never get back. * Instead of doing 100 things each day, you should be doing ten. This frees you to do the work that truly matters and that moves you forward professionally. * Many solos are hesitant to take on payroll because they see it as an expense. But when you hire someone, you are making an investment. You are buying back your time.

Published
2024

27. Three Ways to Be the Best Boss Your Team Members Ever Had.

Author

Earley, Christopher

Subjects
Work groups -- Management, Leadership -- Methods, Company business management
Abstract

A leader leads by example, not by force.--Sun zu Law school falls short by not teaching and training future law firm owners enough about the business of law. In particular, [...]

Published
2024

34. The Flywheel: The Secret to Self-Perpetuating Growth for Your Law Firm.

Author

Earley, Christopher

Subjects
Good to Great: Why Some Companies Make the Leap and Others Don't (Nonfiction work), Corporate growth -- Methods -- Management -- Evaluation, Computer organization -- Methods -- Evaluation, Human resource management -- Methods -- Evaluation, Company business management, Systems management, Industry growth
Abstract

Share: Jim Collins' famous business book Good to Great: Why Some Companies Make the Leap and Others Don't (HarperBusiness, 2001) is a must read for any law firm owner and [...]

Published
2023

35. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

Author

Balkau, B, Ducimetière, P, Eschwège, E, Rancière, F, Alhenc-Gelas, F, Gallois, Y, Girault, A, Fumeron, F, Marre, M, Roussel, R, Bonnet, F, Bonnefond, A, Cauchi, S, Froguel, P, Cogneau, J, Born, C, Caces, E, Cailleau, M, Lantieri, O, Moreau, JG, Rakotozafy, F, Tichet, J, Vol, S, Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K, Bryc, Katarzyna, Elson, Sarah L, Fontanillas, Pierre, Furlotte, Nicholas A, Hinds, David A, Hromatka, Bethann S, Huber, Karen E, Kleinman, Aaron, Litterman, Nadia K, McIntyre, Matthew H, Mountain, Joanna L, Northover, Carrie AM, Pitts, Steven J, Sathirapongsasuti, J Fah, Sazonova, Olga V, Shelton, Janie F, Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y, Vacic, Vladimir, Wilson, Catherine H, Schormair, Barbara, Zhao, Chen, Bell, Steven, Tilch, Erik, Salminen, Aaro V, Pütz, Benno, Dauvilliers, Yves, Stefani, Ambra, Högl, Birgit, Poewe, Werner, Kemlink, David, Sonka, Karel, Bachmann, Cornelius G, Paulus, Walter, Trenkwalder, Claudia, Oertel, Wolfgang H, Hornyak, Magdolna, Teder-Laving, Maris, Metspalu, Andres, Hadjigeorgiou, Georgios M, Polo, Olli, Fietze, Ingo, Ross, Owen A, Wszolek, Zbigniew, Butterworth, Adam S, Soranzo, Nicole, Ouwehand, Willem H, Roberts, David J, Danesh, John, Allen, Richard P, Earley, Christopher J, Ondo, William G, Xiong, Lan, Montplaisir, Jacques, Gan-Or, Ziv, Perola, Markus, Vodicka, Pavel, Dina, Christian, Franke, Andre, Tittmann, Lukas, Stewart, Alexandre F R, Shah, Svati H, Gieger, Christian, Peters, Annette, Rouleau, Guy A, Berger, Klaus, Oexle, Konrad, Di Angelantonio, Emanuele, Müller-Myhsok, Bertram, and Winkelmann, Juliane

Published
2017
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40. On the optimization of 3D inflow‐based vascular‐space‐occupancy (iVASO) MRI for the quantification of arterial cerebral blood volume (CBVa).

Author

Gu, Chunming, Li, Yinghao, Cao, Di, Miao, Xinyuan, Paez, Adrian G., Sun, Yuanqi, Cai, Jitong, Li, Wenbo, Li, Xu, Pillai, Jay J., Earley, Christopher J., van Zijl, Peter C. M., and Hua, Jun

Subjects
BLOOD volume, MAGNETIC resonance imaging, SIGNAL-to-noise ratio, BLOOD vessels
Abstract

Purpose: The inflow‐based vascular‐space‐occupancy (iVASO) MRI was originally developed in a single‐slice mode to measure arterial cerebral blood volume (CBVa). When vascular crushers are applied in iVASO, the signals can be sensitized predominantly to small pial arteries and arterioles. The purpose of this study is to perform a systematic optimization and evaluation of a 3D iVASO sequence on both 3 T and 7 T for the quantification of CBVa values in the human brain. Methods: Three sets of experiments were performed in three separate cohorts. (1) 3D iVASO MRI protocols were compared to single‐slice iVASO, and the reproducibility of whole‐brain 3D iVASO MRI was evaluated. (2) The effects from different vascular crushers in iVASO were assessed. (3) 3D iVASO MRI results were evaluated in arterial and venous blood vessels identified using ultrasmall‐superparamagnetic‐iron‐oxides–enhanced MRI to validate its arterial origin. Results: 3D iVASO scans showed signal‐to‐noise ratio (SNR) and CBVa measures consistent with single‐slice iVASO with reasonable intrasubject reproducibility. Among the iVASO scans performed with different vascular crushers, the whole‐brain 3D iVASO scan with a motion‐sensitized‐driven‐equilibrium preparation with two binomial refocusing pulses and an effective TE of 50 ms showed the best suppression of macrovascular signals, with a relatively low specific absorption rate. When no vascular crusher was applied, the CBVa maps from 3D iVASO scans showed large CBVa values in arterial vessels but well‐suppressed signals in venous vessels. Conclusion: A whole‐brain 3D iVASO MRI scan was optimized for CBVa measurement in the human brain. When only microvascular signals are desired, a motion‐sensitized‐driven‐equilibrium–based vascular crusher with binomial refocusing pulses can be applied in 3D iVASO. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Getting Cases as a Small Law Firm in a Market Dominated by Big Law.

Author

Earley, Christopher

Subjects
Customer relationship management -- Methods, Small business -- Advertising -- Marketing -- Evaluation, Business networks (Social groups) -- Management, Client development -- Methods, Sole practitioners -- Advertising -- Marketing -- Evaluation, Company marketing practices, Customer relationship management, Company business management, Small business, SOHO
Abstract

Most if not all of us have in our market at least one law firm that seems to get all the business. These law firms have seemingly unlimited marketing dollars [...]

Published
2024

43. Welcoming New Team Members to Your Law Practice.

Author

Earley, Christopher

Subjects
Law firms -- Management, Employee selection -- Management, Employee morale -- Management, Employee development -- Management, Hiring, Company business management
Abstract

A key component of growing a law firm is not just finding the right people but making sure these people, once hired, are warmly welcomed. As part of their welcoming, [...]

Published
2024

44. Five Mistakes to Avoid When Starting Your Own Law Practice.

Author

Earley, Christopher

Subjects
Attorney referral service -- Management, Business networks (Social groups) -- Management, Internet marketing -- Management -- Methods, Social media -- Usage -- Marketing, Errors -- Prevention, Sole practitioners -- Management -- Marketing, Helping behavior -- Influence, Company marketing practices, Company business management
Abstract

I started my practice after law school and had very little, if any, clue as to what I was doing. I had to learn on the fly and through trial [...]

Published
2023

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