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1. THU-078 Extra-hepatic organ failure in ACLF patients is associated with poor survival and limited curative therapy-results from AARC cohort

Author

Choudhury, Ashok Kumar, primary, Arora, Vinod, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Al-Mahtab, Mamun, additional, Devarbhavi, Harshad, additional, Eapen, CE, additional, Goel, Ashish, additional, Yaghi, Cesar, additional, Ning, Qin, additional, Chen, Tao, additional, Duan, Zhongping, additional, Hamid, Saeed Sadiq, additional, Jafri, Wasim, additional, Shukla, Akash, additional, Tan, Soek-Siam, additional, Kim, Dong Joon, additional, Saraya, Anoop, additional, Hu, Jinhua, additional, Sood, Ajit, additional, Goyal, Omesh, additional, Sahoo, Manoj, additional, Lee, Guan-Huei, additional, Treeprasertsuk, Sombat, additional, Thanapirom, Kessarin, additional, Mandot, Ameet, additional, Shah, Samir, additional, Lesmana, Laurentius A., additional, Ghazinyan, Hasmik, additional, V G, Mohan Prasad, additional, Dokmeci, A. Kadir, additional, Sollano, Jose, additional, Abbas, Zaigham, additional, Shrestha, Ananta, additional, Lau, George, additional, Payawal, Diana, additional, Shiha, Gamal, additional, Duseja, Ajay Kumar, additional, Taneja, Sunil, additional, Padaki, Nagaraja Rao, additional, Kulkarni, Anand, additional, Karim, Md. Fazal, additional, Dhiman, Radha Krishan, additional, Mishra, Ajay, additional, Alam, Shahinul, additional, Yokosuka, Osamu, additional, Chowdhury, Dr. Debashis, additional, Kedarisetty, Chandan, additional, Saigal, Dr Sanjiv, additional, Arora, Anil, additional, Kumar, Ashish, additional, Yattoo, Ghulam Nabi, additional, Koshy, Abraham, additional, Kumar, Ajay, additional, Elbasiony, Mohammed, additional, Rathi, Pravin, additional, Maharshi, Sudhir, additional, Dayal, V.M., additional, Jha, Ashish Kumar, additional, Kalista, Kemal Fariz, additional, Gani, Rino, additional, Yuen, Man-Fung, additional, Singh, Virendra, additional, Singh, Ayaskant, additional, Violeta, Sargsyan, additional, Huang, Chien-Hao, additional, Mukewar, Saurabh, additional, Xin, Shaojie, additional, Bhavani, Ruveena, additional, Panackel, Charles, additional, Dadhich, Sunil, additional, Sachdeva, Sanjeev, additional, Behera, Sanatan, additional, Maji, Prabir, additional, Kamani, Lubna, additional, Saithanyamurthi, Hemamala Venugopal, additional, Varghese, Dr. Joy, additional, Parikh, Pathik, additional, Javed, P, additional, Saraf, Neeraj, additional, Choudhary, Narendra S., additional, Roy, Akash, additional, Goenka, Mahesh, additional, Kalal, Chetan, additional, Devadas, Krishnadas, additional, Adali, Gupse, additional, Silva H, Janaka De, additional, Omata, Masao, additional, Sharma, Manoj, additional, and Sarin, Shiv Kumar, additional

Published
2024
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2. THU-052 Therapeutic plasma-exchange improves short-term survival in patients with ACLF admitted to intensive care unit with organ failures-a multinational AARC data analysis

Author

Maiwall, Rakhi, primary, Rao Pasupuleti, Samba Siva, additional, Choudhury, Ashok Kumar, additional, Arora, Vinod, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Al-Mahtab, Mamun, additional, Devarbhavi, Harshad, additional, Eapen, CE, additional, Goel, Ashish, additional, Yaghi, Cesar, additional, Ning, Qin, additional, Chen, Tao, additional, Jia, Jidong, additional, Duan, Zhongping, additional, Hamid, Saeed Sadiq, additional, Subhan, Amna, additional, Jafri, Wasim, additional, Shukla, Akash, additional, Tan, Soek-Siam, additional, Kim, Dong Joon, additional, Saraya, Anoop, additional, Hu, Jinhua, additional, Sood, Ajit, additional, Goyal, Omesh, additional, Midha, Vandana, additional, Sahoo, Manoj, additional, Lee, Guan-Huei, additional, Treeprasertsuk, Sombat, additional, Thanapirom, Kessarin, additional, Mandot, Ameet, additional, Shah, Samir, additional, Lesmana, Laurentius A., additional, Ghazinyan, Hasmik, additional, V G, Mohan Prasad, additional, Dokmeci, A. Kadir, additional, Sollano, Jose, additional, Abbas, Zaigham, additional, Shrestha, Ananta, additional, Lau, George, additional, Payawal, Diana, additional, Shiha, Gamal, additional, Duseja, Ajay Kumar, additional, Taneja, Sunil, additional, Verma, Nipun, additional, Padaki, Nagaraja Rao, additional, Kulkarni, Anand, additional, Sharma, Mithun, additional, Karim, Md. Fazal, additional, Dhiman, Radha Krishan, additional, Mishra, Ajay, additional, Alam, Shahinul, additional, Yokosuka, Osamu, additional, Chowdhury, Debashis, additional, Kedarisetty, Chandan, additional, Saigal, Sanjiv, additional, Arora, Anil, additional, Kumar, Ashish, additional, Koshy, Abraham, additional, Kumar, Ajay, additional, Elbasiony, Mohammed, additional, Rathi, Pravin, additional, Maharshi, Sudhir, additional, Dayal, V.M., additional, Jha, Ashish Kumar, additional, Kalista, Kemal Fariz, additional, Gani, Rino, additional, Yuen, Man-Fung, additional, Singh, Virendra, additional, Singh, Ayaskant, additional, Violeta, Sargsyan, additional, Huang, Chien-Hao, additional, Mukewar, Saurabh, additional, Xin, Shaojie, additional, Bhavani, Ruveena, additional, Panackel, Charles, additional, Dadhich, Sunil, additional, Sachdeva, Sanjeev, additional, Behera, Sanatan, additional, Maji, Prabir, additional, Kamani, Lubna, additional, Saithanyamurthi, Hemamala Venugopal, additional, Varghese, Dr. Joy, additional, Parikh, Pathik, additional, Javed, P, additional, Saraf, Neeraj, additional, Choudhary, Narendra S., additional, Roy, Akash, additional, Goenka, Mahesh, additional, Kalal, Chetan, additional, Devadas, Krishnadas, additional, De Silva H, Janaka, additional, and Sarin, Shiv Kumar, additional

Published
2024
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4. Nosocomial infections in cirrhosis are unpredictable and vary based on region of the world: CLEARED study

Author

Bajaj, Jasmohan S, primary, Wong, Florence, additional, Xie, Qing, additional, Kamath, Patrick S., additional, Topazian, Mark, additional, Sarin, Shiv Kumar, additional, Kumar, Shiva, additional, Marciano, Sebastián, additional, Tudehope, Fiona, additional, Gibson, Robert, additional, Doyle, Adam, additional, Riordan, Stephen, additional, Farias, Alberto Queiroz, additional, Faisal, Nabiha, additional, Tandon, Puneeta, additional, Lohoues, Marie Jeanne, additional, Benitez, Carlos, additional, Xian, Yongchao, additional, Zhu, Chuanwu, additional, Su, Minghua, additional, Jiang, Yongfang, additional, Zhao, Caiyan, additional, Wang, Lei, additional, Lu, Mingqin, additional, Zhang, Ning-Ping, additional, Li, Hai, additional, Zheng, Xin, additional, Tang, Hong, additional, Xu, Bin, additional, gao, zhiliang, additional, Lin, minghua, additional, Chen, Jinjun, additional, Liu, ChengHai, additional, Hu, Peng, additional, Allah, Belimi Hibat, additional, Fisseha, Henok, additional, Aravinthan, Aloysious, additional, Rajoriya, Neil, additional, Leith, Damien, additional, Adebayo, Danielle, additional, Yung, Diana, additional, Seto, Wai-Kay, additional, Katchman, Helena, additional, Nagral, Abha, additional, Kulkarni, Anand, additional, Eapen, CE, additional, Duseja, Ajay Kumar, additional, Saraya, Anoop, additional, Rela, Mohd., additional, Anora, Anil, additional, Dhiman, Radha Krishan, additional, Anand, Anil Chandra, additional, González-Huezo, Maria Sarai, additional, Perez Hernandez, Jose Luis, additional, Zazueta, Godolfino Miranda, additional, Castillo, Mauricio, additional, Velazquez, René Malé, additional, Velarde-Ruiz Velasco, Jose Antonio, additional, Cordova, Jacqueline, additional, Bhavani, Ruveena, additional, Okeke, Edith, additional, Allam, Dalia, additional, Tan, Hiang Keat, additional, Treeprasertsuk, Sombat, additional, Haktaniyan, Busra, additional, Gunduz, Feyza, additional, Yıldırım, Abdullah Emre, additional, Karasu, Zeki, additional, Ucbilek, Enver, additional, Adanir, Haydar, additional, Albhaisi, Somaya, additional, Asrani, Sumeet, additional, Reddy, K. Rajender, additional, Shaw, Jawaid, additional, Vargas, Hugo, additional, Biggins, Scott, additional, Thuluvath, Paul J., additional, Keaveny, Andrew, additional, Hayes, Peter, additional, Torre, Aldo, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Álvares-da-Silva, Mario, additional, George, Jacob, additional, Desalegn, Hailemichael, additional, Bush, Brian, additional, Thacker, Leroy, additional, Andres, Duarte Rojo, additional, and Choudhury, Ashok, additional

Published
2023
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8. Risk factors for short-term post discharge clinical outcomes in patients hospitalized with decompensated chronic liver disease: interim results from Global CLEARED study

Author

Bajaj, Jasmohan S., primary, Kamath, Patrick S., additional, Wong, Florence, additional, Hayes, Peter, additional, Idilman, Ramazan, additional, Torre, Aldo, additional, Topazian, Mark, additional, George, Jacob, additional, Álvares-da-Silva, Mario Reis, additional, Xie, Qing, additional, Sarin, Shiv Kumar, additional, Nagral, Abha, additional, Asrani, Sumeet, additional, Fallahzadeh, Mohammad Amin, additional, Albhaisi, Somaya, additional, Eapen, CE, additional, Goel, Ashish, additional, Duseja, Ajay Kumar, additional, Saraya, Anoop, additional, Yegurla, Jatin, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Lohoues, Marie Jeanne, additional, Allah, Belimi Hibat, additional, Cabello, Ricardo, additional, Bhavani, Ruveena, additional, Nik Arsyad, Nik MA, additional, Treeprasertsuk, Sombat, additional, Wejnaruemarn, Salisa, additional, Perez Hernandez, Jose Luis, additional, Zazueta, Godolfino Miranda, additional, Rajoriya, Neil, additional, Faulkes, Rosemary, additional, Yıldırım, Abdullah Emre, additional, Barutcu, Sezgin, additional, Kulkarni, Anand, additional, Sharma, Mithun, additional, Reddy, Rajender, additional, Rahematpura, Suditi, additional, Danielle, Adebayo, additional, Kennedy, James, additional, Gunduz, Feyza, additional, Aslan, Rahmi, additional, Arora, Anil, additional, Kumar, Ashish, additional, Allam, Dalia, additional, Kumar Patwa, Yashwi Haresh, additional, Castillo, Mauricio, additional, Tan, Hiang Keat, additional, Lun, Liou Wei, additional, Vargas, Hugo E., additional, Bayne, David, additional, Thuluvath, Paul J., additional, Sheshadri, Somya, additional, Haveri, Ajay, additional, Keaveny, Andrew, additional, Shaw, Jawaid, additional, Okeke, Edith, additional, David, Nyam P, additional, Aravinthan, Aloysious, additional, Venkatachalapathy, Suresh Vasan, additional, Sonavane, Amey, additional, Desalegn, Hailemichael, additional, Fisseha, Henok, additional, Bettinger, Dominik, additional, Schultheiss, Michael, additional, Biggins, Scott, additional, Filipek, Natalia, additional, Leith, Damien, additional, Forrest, Ewan, additional, González-Huezo, Maria Sarai, additional, Velazquez, René Malé, additional, Made, Lilian Torres, additional, Yung, Diana, additional, Karasu, Zeki, additional, Cao, Zhujun, additional, Katzman, Helena, additional, Rabinowich, Liane, additional, Benitez, Carlos, additional, Rojo, Andres Duarte, additional, Marciano, Sebastián, additional, Gandotra, Akash, additional, Bush, Brian, additional, Thacker, Leroy, additional, and Choudhury, Ashok, additional

Published
2022
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9. CLEARED Global consortium results highlight regional variation and need for equity in inpatient outcomes in hospitalized patients with Chronic Liver Disease

Author

Bajaj, Jasmohan S., primary, Kamath, Patrick S., additional, Wong, Florence, additional, Hayes, Peter, additional, Idilman, Ramazan, additional, Torre, Aldo, additional, Topazian, Mark, additional, George, Jacob, additional, Álvares-da-Silva, Mario Reis, additional, Xie, Qing, additional, Sarin, Shiv Kumar, additional, Nagral, Abha, additional, Haveri, Ajay, additional, Asrani, Sumeet, additional, Fallahzadeh, Mohammad Amin, additional, Albhaisi, Somaya, additional, Reddy, Rajender, additional, Rahematpura, Suditi, additional, Lohoues, Marie Jeanne, additional, Allah, Belimi Hibat, additional, Cabello, Ricardo, additional, Bhavani, Ruveena, additional, Nik Arsyad, Nik MA, additional, Treeprasertsuk, Sombat, additional, Wejnaruemarn, Salisa, additional, Perez Hernandez, Jose Luis, additional, Zazueta, Godolfino Miranda, additional, Rajoriya, Neil, additional, Faulkes, Rosemary, additional, Adebayo, Danielle, additional, Kennedy, James, additional, Yıldırım, Abdullah Emre, additional, Barutcu, Sezgin, additional, Eapen, CE, additional, Goel, Ashish, additional, Duseja, Ajay Kumar, additional, Saraya, Anoop, additional, Yegurla, Jatin, additional, Gandotra, Akash, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Kulkarni, Anand, additional, Sharma, Mithun, additional, Sonavane, Amey, additional, Vargas, Hugo E., additional, Bayne, David, additional, Gunduz, Feyza, additional, Aslan, Rahmi, additional, Arora, Anil, additional, Kumar, Ashish, additional, Keaveny, Andrew, additional, Thuluvath, Paul J., additional, Sheshadri, Somya, additional, Allam, Dalia, additional, Kumar Patwa, Yashwi Haresh, additional, Castillo, Mauricio, additional, Tan, Hiang Keat, additional, Lun, Liou Wei, additional, Shaw, Jawaid, additional, Okeke, Edith, additional, David, Nyam P, additional, Yung, Diana, additional, Biggins, Scott, additional, Filipek, Natalia, additional, Rojo, Andres Duarte, additional, Benitez, Carlos, additional, Marciano, Sebastián, additional, Desalegn, Hailemichael, additional, Fisseha, Henok, additional, Katchman, Helena, additional, Rabinowich, Liane, additional, Velazquez, René Malé, additional, Made, Lilian Torres, additional, González-Huezo, Maria Sarai, additional, Aravinthan, Aloysious, additional, Venkatachalapathy, Suresh Vasan, additional, Leith, Damien, additional, Forrest, Ewan, additional, Karasu, Zeki, additional, Bettinger, Dominik, additional, Schultheiss, Michael, additional, Cao, Zhujun, additional, Bush, Brian, additional, and Thacker, Leroy, additional

Published
2022
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10. THU-058 Portal vein thrombosis increases short-term mortality independent of liver disease severity score among hospitalized patients of decompensated cirrhosis-result from CLEARED consortium

Author

Choudhury, Ashok Kumar, Xie, Qing, Topazian, Mark, Torre, Aldo, Hayes, Peter, Desalegn, Hailemichael, Idilman, Ramazan, Cao, Zhujun, Álvares-da-Silva, Mario, George, Jacob, Seto, Wai-Kay, Wong, Florence, Kamath, Patrick S., Sarin, Shiv Kumar, Bush, Brian, Thacker, Leroy, Saraya, Anoop, Adanir, Haydar, Haktaniyan, Busra, Kulkarni, Anand, Barutcu, Sezgin, Asrani, Sumeet, Tang, Hong, González-Huezo, Maria Sarai, Eapen, CE, Thanapirom, Kessarin, Liu, Jing, Verna, Elizabeth, Rela, Mohd., Uysal, Alper, Cordova-Gallardo, Jacqueline, Velarde-Ruiz Velasco, Jose Antonio, Michalczuk, Matheus Truccolo, Pereira, Gustavo, Gutierrez, Oscar Morales, Pineda, Abraham Ramos, Nagral, Abha, P, David Nyam, Praharaj, Dibya Lochan, Aslan, Rahmi, Thuluvath, Paul J., Vargas, Hugo, Kosay, Tolga, Li, Beiling, Li, Jie, Venkatachalapathy, Suresh Vasan, Taneja, Sunil, Riordan, Stephen, Shaw, Jawaid, Yung, Diana, Doyle, Adam, James Fung, Yan Yue, Deng, Huan, Wang, Lei, Tan, Hiang Keat, Hala, Al-Tamimi, Zekry, Amany, Rabinowich, Liane, Su, Man, Wu, Xiaoping, Wang, Xinrui, Zhang, Yaodi, Zhao, Caiyan, Gao, Zhiliang, Guo, Feng, Schultheis, Michael, Tandon, Puneeta, Bobat, Bilal, Reddy, K. Rajender, Negrillo, Ricardo Cabello, Biggins, Scott, Verma, Nipun, and Bajaj, Jasmohan

Published
2024
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13. FRI-546 - Nosocomial infections in cirrhosis are unpredictable and vary based on region of the world: CLEARED study

Author

Bajaj, Jasmohan S, Wong, Florence, Xie, Qing, Kamath, Patrick S., Topazian, Mark, Sarin, Shiv Kumar, Kumar, Shiva, Marciano, Sebastián, Tudehope, Fiona, Gibson, Robert, Doyle, Adam, Riordan, Stephen, Farias, Alberto Queiroz, Faisal, Nabiha, Tandon, Puneeta, Lohoues, Marie Jeanne, Benitez, Carlos, Xian, Yongchao, Zhu, Chuanwu, Su, Minghua, Jiang, Yongfang, Zhao, Caiyan, Wang, Lei, Lu, Mingqin, Zhang, Ning-Ping, Li, Hai, Zheng, Xin, Tang, Hong, Xu, Bin, gao, zhiliang, Lin, minghua, Chen, Jinjun, Liu, ChengHai, Hu, Peng, Allah, Belimi Hibat, Fisseha, Henok, Aravinthan, Aloysious, Rajoriya, Neil, Leith, Damien, Adebayo, Danielle, Yung, Diana, Seto, Wai-Kay, Katchman, Helena, Nagral, Abha, Kulkarni, Anand, Eapen, CE, Duseja, Ajay Kumar, Saraya, Anoop, Rela, Mohd., Anora, Anil, Dhiman, Radha Krishan, Anand, Anil Chandra, González-Huezo, Maria Sarai, Perez Hernandez, Jose Luis, Zazueta, Godolfino Miranda, Castillo, Mauricio, Velazquez, René Malé, Velarde-Ruiz Velasco, Jose Antonio, Cordova, Jacqueline, Bhavani, Ruveena, Okeke, Edith, Allam, Dalia, Tan, Hiang Keat, Treeprasertsuk, Sombat, Haktaniyan, Busra, Gunduz, Feyza, Yıldırım, Abdullah Emre, Karasu, Zeki, Ucbilek, Enver, Adanir, Haydar, Albhaisi, Somaya, Asrani, Sumeet, Reddy, K. Rajender, Shaw, Jawaid, Vargas, Hugo, Biggins, Scott, Thuluvath, Paul J., Keaveny, Andrew, Hayes, Peter, Torre, Aldo, Idilman, Ramazan, Cao, Zhujun, Álvares-da-Silva, Mario, George, Jacob, Desalegn, Hailemichael, Bush, Brian, Thacker, Leroy, Andres, Duarte Rojo, and Choudhury, Ashok

Published
2023
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16. Von-Willebrand factor: A biomarker to predict in-hospital survival in patients with severe and very severe alcoholic hepatitis

Author

Eapen, CE, primary, Tiwari, PratapSagar, additional, Prasanna, KS, additional, Gandhi, PB, additional, Nair, SC, additional, Amirtharaj, GJ, additional, Balasubramanian, KA, additional, Ramachandran, Anup, additional, Mackie, Ian, additional, Zachariah, U, additional, Elias, E, additional, and Goel, Ashish, additional

Published
2020
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17. Low-volume plasma exchange and low-dose steroid to treat secondary hemophagocytic lymphohistiocytosis: A potential treatment for severe COVID-19?

Author

Eapen, CE, primary, Alexander, Vijay, additional, Zachariah, Uday, additional, Goel, Ashish, additional, Kandasamy, Subramani, additional, Chacko, Binila, additional, Punitha, JohnVictor, additional, Nair, Sukesh, additional, David, Vinoi, additional, Prabhu, Savit, additional, Balasubramanian, KA, additional, Mackie, Ian, additional, and Elias, Elwyn, additional

Published
2020
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18. Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study

Author

Baiges, Anna, Turon, Fanny, Simon-Talero, Macarena, Tasayco, Stephanie, Bueno, Javier, Zekrini, Kamal, Plessier, Aurelie, Franchi-Abella, Stephanie, Guerin, Florent, Mukund, Amar, Eapen, CE, Goel, Ashish, Shyamkumar, Nidugala Keshava, Coenen, Sandra, De Gottardi, Andrea, Majumdar, Avik, Onali, Simona, Shukla, Akash, Jose Carrilho, Flair, Nacif, Lucas, Primignani, Massimo, Tosetti, Giulia, La Mura, Vicenzo, Nevens, Frederik, Witters, Peter, Tripathi, Dhiraj, Tellez, Luis, Martinez, Javier, Alvarez-Navascues, Carmen, Fraile Lopez, Miguel Lopez, Procopet, Bogdan, Piscaglia, Fabio, de Koning, Barbara, Llop, Elba, Romero-Cristobal, Mario, Tjwa, Eric, Monescillo-Francia, Alberto, Senzolo, Marco, Perez-LaFuente, Mercedes, Segarra, Antonio, Sarin, Shiv Kumar, Hernandez-Gea, Virginia, Patch, David, Laleman, Wim, Hartog, Hermien, Valla, Dominique, Genesca, Joan, Carlos Garcia-Pagan, Juan, Garcia-Criado, Angeles, Darnell, Anna, Belmonte, Ernest, Ferrusquia-Acosta, Jose, Magaz, Marta, Vidal-Gonzalez, Judit, Horia, Stefanescu, Nicoara-Farcau, Oana, Joseph, Philip, Zachariah, Uday, Moses, Vinu, Mammen, Suraj, Ahmed, Munawwar, Koshy, George, Eapen, Anu, Sajith, KG, Vyas, FL, Raju, RS, Rymbai, Manbha L, Arulkumar, S, Ramachandran, Jeyamani, Elias, Elwyn, Baiges A., Turon F., Simon-Talero M., Tasayco S., Bueno J., Zekrini K., Plessier A., Franchi-Abella S., Guerin F., Mukund A., Eapen C.E., Goel A., Shyamkumar N.K., Coenen S., De Gottardi A., Majumdar A., Onali S., Shukla A., Carrilho F.J., Nacif L., Primignani M., Tosetti G., La Mura V., Nevens F., Witters P., Tripathi D., Tellez L., Martinez J., Alvarez-Navascues C., Fraile Lopez M.L., Procopet B., Piscaglia F., de Koning B., Llop E., Romero-Cristobal M., Tjwa E., Monescillo-Francia A., Senzolo M., Perez-LaFuente M., Segarra A., Sarin S.K., Hernandez-Gea V., Patch D., Laleman W., Hartog H., Valla D., Genesca J., Garcia-Pagan J.C., Gastroenterology & Hepatology, Pediatrics, and Surgery

Subjects
0301 basic medicine, Male, Vascular Malformations, medicine.medical_treatment, International Cooperation, Liver transplantation, 0302 clinical medicine, Malalties hereditàries, Hepatopulmonary syndrome, 610 Medicine & health, Child, Hepatic encephalopathy, Portal Vein, Malalties del fetge, Liver Neoplasms, vascular diseases of the liver, Middle Aged, Abernethy, Child, Preschool, 030211 gastroenterology & hepatology, Female, medicine.symptom, Genetic diseases, Adult, medicine.medical_specialty, Adenoma, Adolescent, Hypertension, Pulmonary, Asymptomatic, 03 medical and health sciences, Young Adult, extrahepatic portosytemic shunt, medicine, Humans, Liver diseases, Aged, Retrospective Studies, Abernethy Malformation, Hepatology, business.industry, Infant, Retrospective cohort study, medicine.disease, Pulmonary hypertension, Surgery, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, Hepatic Encephalopathy, Congenital malformation, Portosystemic shunt, business, Hepatopulmonary Syndrome
Abstract

Contains fulltext : 220051.pdf (Publisher’s version ) (Closed access) Congenital extrahepatic portosystemic shunt (CEPS) or Abernethy malformation is a rare condition in which splanchnic venous blood bypasses the liver draining directly into systemic circulation through a congenital shunt. Patients may develop hepatic encephalopathy (HE), pulmonary hypertension (PaHT), or liver tumors, among other complications. However, the actual incidence of such complications is unknown, mainly because of the lack of a protocolized approach to these patients. This study characterizes the clinical manifestations and outcome of a large cohort of CEPS patients with the aim of proposing a guide for their management. This is an observational, multicenter, international study. Sixty-six patients were included; median age at the end of follow-up was 30 years. Nineteen patients (28%) presented HE. Ten-, 20-, and 30-year HE incidence rates were 13%, 24%, and 28%, respectively. No clinical factors predicted HE. Twenty-five patients had benign nodular lesions. Ten patients developed adenomas (median age, 18 years), and another 8 developed HCC (median age, 39 years). Of 10 patients with dyspnea, PaHT was diagnosed in 8 and hepatopulmonary syndrome in 2. Pulmonary complications were only screened for in 19 asymptomatic patients, and PaHT was identified in 2. Six patients underwent liver transplantation for hepatocellular carcinoma or adenoma. Shunt closure was performed in 15 patients with improvement/stability/cure of CEPS manifestations. Conclusion: CEPS patients may develop severe complications. Screening for asymptomatic complications and close surveillance is needed. Shunt closure should be considered both as a therapeutic and prophylactic approach.

Published
2018

20. THU-040-AARC score: A dynamic model to predict outcome in acute on chronic liver failure patients

Author

kumar, karan, primary, Choudhury, Ashok Kumar, additional, Mahtab, Mamun Al, additional, Rahman, Salimur, additional, Alam, Mohd. Shahinul, additional, Devarbhavi, Harshad, additional, Chawla, yk, additional, Dhiman, rk, additional, Duseja, Ajay, additional, Taneja, Sunil, additional, Sarin, Shiv K, additional, Paulson, Irene, additional, Jain, Priyanka, additional, Kumar, Guresh, additional, Goel, Ashish, additional, Eapen, ce, additional, Sood, Ajit, additional, Midha, Vandana, additional, Goyal, Omesh, additional, Shukla, Akash, additional, Shah, Samir, additional, and Kalal, Chetan, additional

Published
2019
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21. THU-045-Natural history of sepsis, organ failure and organ dysfunction in critically ill patients with acute on chronic liver failure

Author

Mishra, Manjul, primary, Sarin, Shiv Kumar, additional, Rajan, Vijayraghavan, additional, Choudhury, Ashok, additional, Kumar, Guresh, additional, Jain, Priyanka, additional, Paulson, Irene, additional, Al-Mahtab, Mamun, additional, Rahman, Salimur, additional, Alam, Shahinul, additional, Devarbhavi, Harshad, additional, Chawla, Yogesh, additional, Dhiman, Radha Krishan, additional, Duseja, Ajay, additional, Taneja, Sunil, additional, Ning, Qin, additional, Ma, Ke, additional, Chen, Tao, additional, Duan, Zhongping, additional, Chen, Yu, additional, Eapen, Ce, additional, Goel, Ashish, additional, Tan, Soek-Siam, additional, Hamid, Saeed Sadiq, additional, Subhan, Amna, additional, Jafri, Wasim, additional, Kim, DongJoon, additional, Hu, Jinhua, additional, Amarapurkar, Deepak, additional, Sood, Ajit, additional, Midha, Vandana, additional, Goyal, Omesh, additional, Shukla, Akash, additional, Ghazinian, Hasmik, additional, Sahoo, Manoj, additional, Treeprasertsuk, Sombat, additional, Lee, Guan Huei, additional, Lim, Seng Gee, additional, Lesmana, Laurentius A., additional, Lesmana, Rinaldi, additional, Shah, Samir, additional, Kalal, Chetan, additional, Abbas, Zaigham, additional, s, Joyes, additional, Carpio, Gian, additional, GM, V, additional, Payawal, Diana, additional, Dokmeci, A. Kadir, additional, Shrestha, Ananta, additional, Lau, George, additional, and Yuen, Man-Fung, additional

Published
2019
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22. THU-053-Usefulness of lactate-free Asian Pacific Association for The Study of Liver acute-on-chronic liver failure research consortium ACLF score for predicting short-term mortality in patient with alcoholic liver disease

Author

Song, Do Seon, primary, Kim, Tae Yeob, additional, Kim, Hee Yeon, additional, Yoon, Eileen L, additional, Kim, Dong Joon, additional, Jia, Ji-Dong, additional, Choudhury, Ashok, additional, Al-Mahtab, Mamun, additional, Devarbhavi, Harshad, additional, Duan, Zhongping, additional, Chen, Yu, additional, Eapen, CE, additional, Goel, Ashish, additional, Ning, Qin, additional, Ma, Ke, additional, Chawla, Yogesh, additional, Dhiman, Radha Krishan, additional, Duseja, Ajay, additional, Taneja, Sunil, additional, Hamid, Saeed Sadiq, additional, Subhan, Amna, additional, Jafri, Wasim, additional, Tan, Soek-Siam, additional, Ghazinian, Hasmik, additional, Amarapurkar, Deepak, additional, Treeprasertsuk, Sombat, additional, Lee, Guan Huei, additional, Lim, Seng Gee, additional, Hu, Jinhua Hu, additional, Lesmana, Laurentius A., additional, Lesmana, Rinaldi, additional, Shukla, Akash, additional, Shah, Samir, additional, Kalal, Chetan, additional, Sahoo, Manoj, additional, Abbas, Zaigham, additional, s, Joyes, additional, Carpio, Gian, additional, Karim, Md. Fazal, additional, Lau, George, additional, Padaki, Nagaraja Rao, additional, Payawal, Diana, additional, Kadir Dokmeci, A., additional, Yuen, Man-Fung, additional, GM, V, additional, Yokosuka, Osamu, additional, Shrestha, Ananta, additional, Jain, Priyanka, additional, Paulson, Irene, additional, and Sarin, Shiv Kumar, additional

Published
2019
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26. Proteomic analysis reveals that apolipoprotein A1 levels are decreased in patients with Budd–Chiari syndrome

Author

Talens, Simone, Hoekstra, Jildou, Dirkx, Steffen P G, Darwish Murad, Sarwa, Trebicka, Jonel, Elias, Elwyn, Primignani, Massimo, García-Pagán, Juan-Carlos, Valla, Dominique, Janssen, Harry L A, Leebeek, Frank W G, Rijken, Dingeman C, Langlet, P, Lasser, L, Plessier, A, Condat, B, Bahr, M, Heller, J, Rossle, M, Fabris, F, Rosendaal, FR, Miranda, H, Hernandez-Guerra, M, Raffa, S, Lozano, R, Hadengue, Antoine, Morard, Isabelle, Mentha, Gilles, Eapen, CE, Hematology, and Gastroenterology & Hepatology

Subjects
Proteomics, medicine.medical_specialty, Apolipoprotein A-I/blood, Difference gel electrophoresis, Budd-Chiari Syndrome, Hepatic Veins, Bioinformatics, Gastroenterology, Liver disorder, Cohort Studies, chemistry.chemical_compound, High-density lipoprotein, Internal medicine, medicine, Humans, Electrophoresis, Gel, Two-Dimensional, Thrombosis/blood/etiology, ddc:616, Cholesterol, HDL/blood, Apolipoprotein A-I, ddc:617, Hepatology, biology, Cholesterol, HDL, Case-control study, Thrombosis, medicine.disease, Venous thrombosis, chemistry, Case-Control Studies, Budd–Chiari syndrome, biology.protein, Apolipoprotein A1, Budd-Chiari Syndrome/blood/complications
Abstract

Background & Aims: Budd-Chiari syndrome (BCS) is a rare vascular liver disorder caused by thrombosis of the hepatic veins. In some patients, no known thrombophilic factor can be identified. This study aimed to identify novel factors that might play a role in thrombosis in BCS-patients by using a proteomic approach. Methods: The abundance of plasma clot-bound proteins was compared between nine BCS-patients and nine controls by using two-dimensional difference gel electrophoresis. The protein with the most significant decrease in patients was identified by mass spectrometry. Plasma levels of this protein were measured and the results were validated in a large cohort of BCS-patients. Results: A total of 26 protein spots significantly differed (p

Published
2011

29. Etiology, Management, and Outcome of the Budd-Chiari Syndrome

Author

Darwish Murad, Sarwa, Plessier, A, Hernandez-Guerra, M, Fabris, F, Eapen, CE, Bahr, MJ, Trebicka, J, Morard, I, Lasser, L, Heller, J, Hadengue, A, Langlet, P, Miranda, H, Primignani, M, Elias, E, Leebeek, Frank, Rosendaal, FR, Garcia-Pagan, JC, Valla, DC, Janssen, HLA, Darwish Murad, Sarwa, Plessier, A, Hernandez-Guerra, M, Fabris, F, Eapen, CE, Bahr, MJ, Trebicka, J, Morard, I, Lasser, L, Heller, J, Hadengue, A, Langlet, P, Miranda, H, Primignani, M, Elias, E, Leebeek, Frank, Rosendaal, FR, Garcia-Pagan, JC, Valla, DC, and Janssen, HLA

Abstract

Background: The Budd-Chiari syndrome (BCS) is hepatic venous outflow obstruction. What is known about the syndrome is based on small studies of prevalent cases. Objective: To characterize the causes and treatment of incident BCS. Design: Consecutive case series of patients with incident BCS, enrolled from October 2003 to October 2005 and followed until May 2006. Setting: Academic and nonacademic hospitals in France, Spain, Italy, Great Britain, Germany, Belgium, the Netherlands, Portugal, and Switzerland. Patients: Persons older than 16 years with definite hepatic outflow obstruction diagnosed by imaging. Persons with hepatic outflow obstruction due to heart failure, sinusoidal obstruction syndrome, cancer, or liver transplantation were excluded. Measurements: Signs and symptoms; laboratory and imaging findings; diagnosis; treatment; and overall, transplantation-free, and intervention-free survival. Results: 163 incident cases of BCS were identified. Median follow-up was 17 months (range, 0.1 to 31 months). Most patients (84%) had at least 1 thrombotic risk factor, and many (46%) had more than 1; the most common was myeloproliferative disorders (49% of 103 tested patients). Patients were mainly treated with anticoagulation (140 patients [86%]), transjugular intrahepatic porto-systemic shunting (56 patients [34%]), or liver transplantation (20 patients [12%]), and 80 patients (49%) were managed noninvasively. Only 3 patients underwent surgical shunting. The survival rate was 87% (95% CI, 82% to 93%) at 1 year and 82% (CI, 75% to 88%) at 2 years. Limitation: Treatment was not standardized across all centers, and data on important clinical variables were missing for some patients. Conclusion: Most patients with BCS have at least 1 thrombotic risk factor, and many have more than 1; myeloproliferative disorders are most common. One- and 2-year survival rates are good with contemporary management, which includes noninvasive therapies (anticoagulation and diuretics) and in

Published
2009

39. Effect of Gluten Free Diet (GFD) on Celiac Disease and Gut Permeability in Patients with Celiac Disease and Idiopathic Non-cirrhotic Intrahepatic Portal Hypertension/Cryptogenic Chronic Liver Disease

Author

Maiwall, R, primary, Sophia, J, additional, Babji, S, additional, Zachariah, U, additional, Goel, A, additional, Kang, G, additional, Pulimood, AB, additional, Ramakrishna, B, additional, Balasubramanian, KA, additional, Madhu, K, additional, Chandy, G, additional, and Eapen, CE, additional

Published
2011
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50. Relationship between clock and star drawing and the degree of hepatic encephalopathy.

Author

Edwin N, Peter JV, John G, Eapen CE, and Graham PL

Abstract

Purpose of the study Current hepatic encephalopathy grading tools are limited because of complexity or subjectivity. The degree of constructional apraxia could serve as a simple, objective and reproducible tool to grade encephalopathy. Study design In this cross-sectional study of patients with chronic liver disease, the degree of constructional apraxia was judged by their ability to copy a star and clock face and compared with conventional encephalopathy grading by the West Haven Criteria (WHC) and the Porto Systemic Encephalopathy Index (PSEI). Three blinded observers independently graded the figures. Sensitivity, specificity and positive predictive value (PPV) of clock and star scores (score 0 implying no encephalopathy and >0 hepatic encephalopathy) were assessed against conventional scoring systems (WHC grade >0 or PSEI >=0.33 indicating encephalopathy). Mosaic and box plots were generated to assess if the degree of constructional apraxia correlated with the severity of encephalopathy. Results 71 patients were studied between October 2008 and July 2009; 11 (15.4%) had WHC grade 0, 32 (45%) grade 1, and 28 (39.4%) grades 2 and 3 encephalopathy. The sensitivity, specificity and PPV of the clock drawing for the diagnosis of encephalopathy was 85%, 80%, and 96%, respectively, and 77%, 70%, and 94%, respectively, for the star drawing. Box plots and intervals on mean PSEI showed an increasing relationship between clock/star scores and PSEI. There was substantial agreement between WHC and clock (weighted [kappa] 0.61) and star scores (weighted [kappa] 0.71). Inter-observer reliability was at least 0.70 for star and at least 0.79 for the clock score. Conclusion Clock and star drawing may serve as reproducible, inexpensive bedside tools for diagnosing and grading the severity of hepatic encephalopathy. [ABSTRACT FROM AUTHOR]

Published
2011

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