1. Variation in treatment and survival of older patients with non-metastatic breast cancer in five European countries: a population-based cohort study from the EURECCA Breast Cancer Group
- Author
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Derks, M.G.M., Bastiaannet, E., Kiderlen, M., Hilling, D.E., Boelens, P.G., Walsh, P.M., Eycken, E. van, Siesling, S., Broggio, J., Wyld, L., Trojanowski, M., Kolacinska, A., Chalubinska-Fendler, J., Goncalves, A.F., Nowikiewicz, T., Zegarski, W., Audisio, R.A., Liefers, G.J., Portielje, J.E.A., Velde, C.J.H. van de, EURECCA Breast Canc Grp, and Health Technology & Services Research
- Subjects
Cancer Research ,Breast surgery ,medicine.medical_treatment ,Population ,Breast Neoplasms ,Disease-Free Survival ,Article ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Belgium ,Epidemiology of cancer ,Humans ,Medicine ,030212 general & internal medicine ,Stage (cooking) ,education ,Mastectomy ,Aged ,Neoplasm Staging ,Netherlands ,Aged, 80 and over ,education.field_of_study ,Relative survival ,business.industry ,Age Factors ,Disease Management ,Cancer ,Middle Aged ,medicine.disease ,Europe ,England ,Oncology ,030220 oncology & carcinogenesis ,Female ,Poland ,Neoplasm Recurrence, Local ,business ,Ireland ,Demography - Abstract
Background: Older patients are poorly represented in breast cancer research and guidelines do not provide evidence based recommendations for this specific group. We compared treatment strategies and survival outcomes between European countries and assessed whether variance in treatment patterns may be associated with variation in survival. Methods: Population-based study including patients aged ≥ 70 with non-metastatic BC from cancer registries from the Netherlands, Belgium, Ireland, England and Greater Poland. Proportions of local and systemic treatments, five-year relative survival and relative excess risks (RER) between countries were calculated. Results: In total, 236,015 patients were included. The proportion of stage I BC receiving endocrine therapy ranged from 19.6% (Netherlands) to 84.6% (Belgium). The proportion of stage III BC receiving no breast surgery varied between 22.0% (Belgium) and 50.8% (Ireland). For stage I BC, relative survival was lower in England compared with Belgium (RER 2.96, 95%CI 1.30-6.72, P
- Published
- 2018