1. Modern diagnosis of GERD: the Lyon Consensus
- Author
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André J.P.M. Smout, Daniel Sifrim, Edoardo Savarino, Sabine Roman, Marcelo F. Vela, John E. Pandolfino, Mark A. Fox, Jan Tack, Peter J. Kahrilas, Michael F. Vaezi, François Mion, Albert J. Bredenoord, Frank Zerbib, Radu Tutuian, C. Prakash Gyawali, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Gastroenterology and Hepatology
- Subjects
BASE-LINE IMPEDANCE ,medicine.medical_specialty ,Esophageal pH Monitoring ,ESOPHAGOGASTRIC JUNCTION CONTRACTILITY ,Manometry ,gastroesophageal reflux disease ,Peptic ,GASTROESOPHAGEAL-REFLUX DISEASE ,Gastroenterology ,PROTON-PUMP INHIBITORS ,Impedance-pG, GERD, Manometry ,03 medical and health sciences ,0302 clinical medicine ,Clinical history ,Internal medicine ,Recent Advances in Clinical Practice ,medicine ,Humans ,Erosive oesophagitis ,SYMPTOM ASSOCIATION ANALYSIS ,Science & Technology ,Gastroenterology & Hepatology ,DILATED INTERCELLULAR SPACES ,medicine.diagnostic_test ,business.industry ,PH monitoring ,Reflux ,Endoscopy ,GERD ,medicine.disease ,24-HOUR PH-IMPEDANCE ,digestive system diseases ,Questionnaire data ,HIGH-RESOLUTION MANOMETRY ,MULTIPLE RAPID SWALLOWS ,INEFFECTIVE ESOPHAGEAL MOTILITY ,030220 oncology & carcinogenesis ,Ambulatory ,Gastroesophageal Reflux ,Impedance-pG ,030211 gastroenterology & hepatology ,business ,Life Sciences & Biomedicine - Abstract
Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal testing include advanced grade erosive oesophagitis (LA grades C and D), long-segment Barrett's mucosa or peptic strictures on endoscopy or distal oesophageal acid exposure time (AET) >6% on ambulatory pH or pH-impedance monitoring. A normal endoscopy does not exclude GERD, but provides supportive evidence refuting GERD in conjunction with distal AET
- Published
- 2018