Search

Your search keyword '"ERSÖZ, Ezhar"' showing total 13 results
Start Over Author "ERSÖZ, Ezhar"
13 results on '"ERSÖZ, Ezhar"'

2. Protective Effects of Fuziline on Dobutamine-Induced Heart Damage in Mice

Author

Hacanli, Yasemin, Aydin, Mehmet Salih, Ersöz, Ezhar Korkmaz, Kankiliç, Nazim, Koyuncu, İsmail, Güldür, Muhammet Emin, Temiz, Ebru, Dikme, Reşat, Eği, Kadir, Çakmak, Yusuf, and Padak, Mahmut

Abstract

Introduction: Fuziline is one of the many antioxidants currently being tested to treat cardiac damage. In our study, histopathological and biochemical effects of fuziline were investigated in mice with dobutamine-induced heart damage in vitro. Methods: Thirty-two adult male BALB/c mice, average weight of 18-20 g, were randomly divided into four groups - Group 1 (sham, n=8), Group 2 (control, dobutamine, n=8), Group 3 (treatment 1, dobutamine + fuziline, n=8), and Group 4 (treatment 2, fuziline, n=8). Biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were measured. Interleukin 1 beta (IL-1β), NLR family, pyrin domain containing protein 3 (NLRP3), 8-hydroxy-deoxyguanosine (8-OHDG), gasdermin D (GSDMD), and galectin 3 (GAL-3) levels were analyzed by enzyme-linked immunosorbent assay method, and histopathological examination of heart tissues was performed. Results: When dobutamine + fuziline and fuziline groups were compared, troponin-I (P

Published
2023

6. Protective Effects of Fuziline on DobutamineInduced Heart Damage in Mice

Author

Hacanli, Yasemin, primary, Aydin, Mehmet Salih, additional, Ersöz, Ezhar Korkmaz, additional, Kankiliç, Nazim, additional, Koyuncu, İsmail, additional, Güldür, Muhammet Emin, additional, Temiz, Ebru, additional, Dikme, Reşat, additional, Eği, Kadir, additional, Çakmak, Yusuf, additional, and Padak, Mahmut, additional

Published
2023
Full Text
View/download PDF

7. Kardiyopulmoner Bypass'ta Sıvı Dengesinin Oksidan ve Antioksidan Denge Üzerine Etkisi.

Author

ERSÖZ, Ezhar, AYDIN, Mehmet Salih, KOÇARSLAN, Aydemir, KAFAF YAZAR, Lütfiye, HACANLI, Yasemin, and YAZAR, Mehmet

Subjects
*WATER-electrolyte balance (Physiology), *PREOPERATIVE period, *OXIDIZING agents, *ANTIOXIDANTS, *OXIDATIVE stress, *COMPARATIVE studies, *BLOOD plasma substitutes, *DESCRIPTIVE statistics, *POSTOPERATIVE period, *CARDIOPULMONARY bypass
Abstract

Background: We aim to contribute to open heart surgery by revealing how different fluids used as prime solution during Cardiopulmonary Bypass (CPB) affect oxidative stress. Materials and Methods: A total of 30 patients, 21 men and 9 women, who underwent open heart surgery for various reasons were included in this study. Patients according to the prime solutions used 1. Group: Lactic Ringer was divided into two groups as 2 Groups: Isolyte S. A total of 4 blood samples were taken from these patients after anesthesia induction, after cross-clamping during CPB, on the 1st day and the 5th day after the operation. Total antioxidant stress (TAS), total oxidative stress (TOS) and oxidative stress index (OSSI) were studied from the samples taken. The results were evaluated statistically. Results: Samples collected in this study were compared before prime solution (before CPB) and after CPB. In the group using Ringer Lactate (RL) on the 5th day postoperatively, the TOS value was statistically significantly lower than the preoperative period (p=0.015). Again, when the OSI values were compared, it was seen that the OSI value of the Ringer Lactate (RL) group was statistically significantly lower (p=0.032). Conclusions: As a result of our study, it was seen that the TOS and OSI values of the two types of prime solutions (Ringer Lactate and Isolayt S) frequently used during Cardiopulmonary Bypass (CPB) were lower in the Ringer Lactate (RL) group and superior in the Isolayt S group. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. Kaplı ve Kaplı Olmayan Oksijenatörlerde Kardiopulmoner Sistemlerin Antioksidanlar Üzerine Etkileri.

Author

ERSÖZ, Ezhar, HALİT ANDAÇ, Mehmet, HACANU, Yasemin, AYDIN, Mehmet Salih, and DİKME, Reşat

Subjects
*CARDIAC surgery, *SURGICAL therapeutics, *ANESTHESIA, *PREOPERATIVE period, *ANTIOXIDANTS, *DRUG infusion pumps, *POSTOPERATIVE period, *CARDIOPULMONARY bypass, *OXYGENATORS, *MECHANICAL hearts
Abstract

Background: We aim to contribute to the effects of coated and uncoated systems on antioxidants in Cardiopulmonary Bypass (CPB) and to possible surgical methods in clinical applications in line with the information we have obtained. Materials and Methods: Blood taken at 5 different times including anesthesia, pump entry, cross-clamp start, cross-clamp end, pump end from a total of 30 patients from 15 coated and 15 non-coated oxygenators included in open heart surgery surgery were included in the study. Results: As coated oxygenators (group I) and uncoated oxygenators (group II) included in the study according to demographic data; Thirty patients, 63.3 female and 36.7 male, underwent the procedure. Cross-clemp duration, total antioxidant capacity1 and 3 (TAOK1, TAOK 3), hemoglobin (Hgb), hematocrit (Hct) and platelet (Plt) values of the patient groups according to gender were not significantly different between the groups (p>0.05). Conclusions: It was concluded that coated and uncoated systems during Cardiopulmonary Bypass (CPB) did not affect Hgb, Hct, Plt and TAOK values in the preoperative, intraoperative and postoperative periods. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

9. COVID-19'da Ekstrakorporeal Membran Oksijenasyonun Kullanımı

Author

AMAÇ, Bişar, PADAK, Mahmut, DİKME, Reşat, KORKMAZ ERSÖZ, Ezhar, GÖÇ, Ömer, and HACANLI, Yasemin

Subjects
surgical procedures, operative, Health Care Sciences and Services, Covid-19,SARS Cov-2,Extracorporeal Membrane Oxygenation,Acute Respiratory Distress Syndrome, Sağlık Bilimleri ve Hizmetleri, Covid-19,SARS Cov-2,Ekstrakorporeal Membran Oksijenasyon,Akut Solunum Sıkıntısı Sendromu
Abstract

Coronaviruses are viruses that can cause disease in humans and animals. Generally, the disease involves the upper and lower respiratory tract. In late 2019, atypical pneumonia cases occurred in Wuhan, China. The most common symptoms in cases have been reported to be fever, cough and respiratory distress. Later, this coronavirus was named Covid-19 by the World Health Organization and was declared a pandemic. Acute Respiratory Distress Syndrome (ARDS) caused by Covid-19 is of great importance. Conventional treatment of ARDS is usually managed by adjuvant neuromuscular blockade and mechanical ventilation, depending on the severity of hypoxemia. Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary support tool for respiratory and heart failure. ECMO can be used in cases where conventional treatment has failed. Developments in ECMO technology and the reliability of ARDS in previous treatments increase its importance in Covid-19. It should be noted, however, that the role and outcome of ECMO in Covid-19 therapy is currently uncertain, requiring more clinical trials. As a result, ECMO can be used in Covid-19 therapy, ARDS and other indicative conditions where conventional therapy has failed., Koronavirüsler inanlarda ve hayvanlarda hastalık yapabilen virüslerdir. Genellikle hastalık üst ve alt solunum yollarını tutmaktadır. 2019 sonlarında Çin'nin Wuhan kentinde atipik pnömoni vakaları görülmüştür. Vakalarda en sık görülen belirtilerin ateş, öksürük ve solunum sıkıntısı olduğu bildirilmiştir. Daha sonra bu koronavirüs Dünya Sağlık Örgütü tarafından Covid-19 olarak adlandırılmış ve pandemi ilan edilmiştir. Covid-19'un neden olduğu Akut Solunum Sıkıntısı Sendromu (ARDS)'da büyük bir önem taşımaktadır. ARDS'nin konvansiyonel tedavisi genellikle hipokseminin şiddetine göre adjuvan nöromüsküler blokaj ve mekanik ventilasyon ile yönetilir. Ekstrakorporeal membran oksijenasyonu (ECMO), solunum ve kalp yetmezliği için bir kardiyopulmoner destek aracıdır. ECMO, konvansiyonel tedavinin başarısız olduğu durumlarda kullanılabilir. ECMO teknolojisindeki gelişmeler ve ARDS'nin geçmiş dönem tedavilerindeki güvenirliği Covid-19'da da önemini artırmaktadır. Ancak ECMO'nun Covid-19 tedavisindeki rolü ve sonucunun şu anda belirsiz olduğunu, daha çok klinik çalışma gerektirdiğini belirtmek gerekir. Sonuç olarak Covid-19 tedavisinde ECMO, konvansiyonel tedavinin başarısız olduğu ARDS ve diğer endikasyonel durumlarda kullanılabilir.

Published
2020

10. Relations of mirna's and Coronary Artery Diseases

Author

DİKME, Reşat, PADAK, Mahmut, KORKMAZ ERSÖZ, Ezhar, and HACANLI, Yasemin

Subjects
mikroRNA,miRNA,Koroner arter hastalığı, microRNA,coronary artery disease, Medicine, Tıp
Abstract

Son çalışmalar, miRNA'ların kalbin gelişimi ve düzgün çalışması için çok önemli olduğunu göstermiştir. Kalbin kardiyojenik transkripsiyon faktörleri nedeniyle ifade edilen birçok miRNA'sı vardır. Kardiyovasküler hastalıklar sırasında miRNA ekspresyonu önemli ölçüde değişir ve farklı miRNA ekspresyon seviyeleri spesifik kardiyovasküler bozukluklarla korelasyon gösterir. Bu derleme makalesi miRNA'lar hakkında ayrıntılı bilgi vererek hem klinik hem de subklinik koroner arter hastalığı ile korelasyonu hakkındaki mevcut kanıtları özetlemekte, ayrıca miRNA'ların koroner arter hastalığında potansiyel bir tanı ve prognostik biyobelirteç olarak araştırmanın gerekliliğini vurgulamaktadır., Recent studies have established that miRNAs are crucial for the development and proper functioning of the heart. The heart has many miRNAs expressed due to cardiogenic transcription factors. During cardiovascular diseases, miRNA expression varies significantly and different miRNA expression levels are correlated with specific cardiovascular disorders. This review article provides detailed information about miRNAs, summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD.

Published
2020

13. Protective Effects of Fuziline on Dobutamine-Induced Heart Damage in Mice.

Author

Hacanli Y, Aydin MS, Ersöz EK, Kankiliç N, Koyuncu İ, Güldür ME, Temiz E, Dikme R, Eği K, Çakmak Y, and Padak M

Subjects
Mice, Male, Animals, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Oxidative Stress, Antioxidants pharmacology, Necrosis, Dobutamine pharmacology, Heart Injuries
Abstract

Introduction: Fuziline is one of the many antioxidants currently being tested to treat cardiac damage. In our study, histopathological and biochemical effects of fuziline were investigated in mice with dobutamine-induced heart damage in vitro., Methods: Thirty-two adult male BALB/c mice, average weight of 18-20 g, were randomly divided into four groups - Group 1 (sham, n=8), Group 2 (control, dobutamine, n=8), Group 3 (treatment 1, dobutamine + fuziline, n=8), and Group 4 (treatment 2, fuziline, n=8). Biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values were measured. Interleukin 1 beta (IL-1β), NLR family, pyrin domain containing protein 3 (NLRP3), 8-hydroxy-deoxyguanosine (8-OHDG), gasdermin D (GSDMD), and galectin 3 (GAL-3) levels were analyzed by enzyme-linked immunosorbent assay method, and histopathological examination of heart tissues was performed., Results: When dobutamine + fuziline and fuziline groups were compared, troponin-I (P<0.05), NLRP3 (P<0.001), GSDMD (P<0.001), 8-OHDG (P<0.001), IL-1β (P<0.001), and GAL-3 (P<0.05) were found to be statistically significant. TOS level was the highest in the dobutamine group (P<0.001) and TAS level was the highest in the fuziline group (P<0.001). OSI level was statistically significant between the groups (P<0.001). In histopathological examination, focal necrosis areas were smaller in the dobutamine + fuziline group than in the dobutamine group, and cardiac myocytes were better preserved., Conclusion: Fuziline markedly reduced cardiac damage and pyroptosis in mice with dobutamine-induced heart damage by lowering the levels of GSDMD, 8-OHDG, IL-1β, and GAL-3. It also prevented necrosis of cardiac myocytes in histopathological evaluation.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results