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Alzheimer's Disease (AD), which is quite prevalent in our society, not only makes the lives of patients and their families more challenging but also brings significant economic burdens. Sideritis species are widely used in folk medicine due to their various effects such as anti-inflammatory, antimicrobial, diuretic, and antispasmodic properties. Although there are many studies with the hypothesis that ROS is effective in the pathogenesis of neurodegenerative diseases, there are not enough studies on Sideritis germanicopolitana Bornm. subsp. viridis Hausskn. ex Bornm. (SGV) and Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm. (SLL) species. In this study, the antioxidant activities of SGV and SLL plant extracts were compared using DPPH, FRAP, and CUPRAC methods to aid in AD treatment research. It was determined that SGV extract has higher DPPH (0.023±0.005 mg/mL), FRAP (1.074± 0.180 mM FeSO4/mg extract) and CUPRAC (2,988± 0,041 mM trolox equivalent/mg extract) activity potential than SLL extract. Additionally, as a result of cytotoxicity studies performed on SH-SY5Y neuroblastoma cells, ethanol extracts of SGV may be more suitable for use in AD at higher concentrations (250 µg/mL). [ABSTRACT FROM AUTHOR]

Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system. [ABSTRACT FROM AUTHOR]