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4 results on '"ERAB: The European Foundation for Alcohol Research"'

1. Dietary polyphenols in the prevention of stroke

Author

Matthias Eder, S Arranz, A. Vallverdu-Queralt, A Tressera-Rimbau, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III [Madrid] (ISC), Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA-UB, School of Pharmacy and Food Science, University of Barcelona, Food Research Division, Health Canada, Sciences Pour l'Oenologie (SPO), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre International d'Etudes Supérieures en Sciences Agronomiques (CIES), Université de Montpellier (UM), ERAB: The European Foundation for Alcohol Research [EA 1324, EA 1514, EA 1515, EA1517], ERAB: The European Foundation for Alcohol Research (CICYT) [AGL2016-79113-R], Instituto de Salud Carlos III (ISCIII) (CIBEROBN) from the Ministerio de Economia y Competitividad (MEC) (AEI/FEDER, UE), Generalitat de Catalunya (GC) [SGR 773], Instituto de Salud Carlos III (ISC), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université Montpellier 1 (UM1)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Vallverdu Queralt, Anna

Subjects
Aging, Pathology, Heart disease, [SDV]Life Sciences [q-bio], Physiology, Review Article, 030204 cardiovascular system & hematology, medicine.disease_cause, Biochemistry, Intestinal absorption, red wine polyphenols, 0302 clinical medicine, blood-pressure, Stilbenes, high cardiovascular risk, Stroke, Cause of death, lcsh:Cytology, food and beverages, General Medicine, density-lipoprotein cholesterol, e-deficient mice, olive oil, 3. Good health, cerebral-ischemia, Protective Agents, randomized controlled-trials, Quercetin, Oxidoreductases, black tea consumption, green tea, medicine.medical_specialty, Nitric Oxide, 03 medical and health sciences, medicine, Animals, Humans, lcsh:QH573-671, business.industry, Cancer, Polyphenols, Cell Biology, medicine.disease, Diet, Oxidative Stress, Blood pressure, Resveratrol, business, 030217 neurology & neurosurgery, Oxidative stress
Abstract

Polyphenols have an important protective role against a number of diseases, such as atherosclerosis, brain dysfunction, stroke, cardiovascular diseases, and cancer. Cardiovascular diseases are the number one cause of death worldwide: more people die annually from cardiovascular diseases than from any other cause. The most important behavioural risk factors of heart disease and stroke are unhealthy diet, physical inactivity, tobacco use, and excess alcohol intake. The dietary consumption of polyphenols has shown to be inversely associated with morbidity and mortality by cardio- and cerebrovascular diseases. It is well-known that the protective effects of polyphenolsin vivodepend on the grade how they are extracted from food and on their intestinal absorption, metabolism, and biological action with target tissues. The aim of this review was to summarise the relation between polyphenols of different plant sources and stroke in human intervention studies, animal models, and in vitro studies.

Published
2017
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2. Detection of a temporal structure in the rat behavioural response to an aversive stimulation in the emotional object recognition (EOR) task

Author

Manfredi Palacino, Giuseppe Crescimanno, Maurizio Casarrubea, Anna Brancato, Carla Cannizzaro, Gianluca Lavanco, INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Università degli Studi di Palermo, ERAB: The European Foundation for Alcohol Research, Casarrubea, Maurizio, Palacino, Manfredi, Brancato, Anna, Lavanco, Gianluca, Cannizzaro, Carla, and Crescimanno, Giuseppe

Subjects
Male, Emotions, Emotional object recognition task, Experimental and Cognitive Psychology, Stimulation, Anxiety, T-pattern analysis, Settore BIO/09 - Fisiologia, Task (project management), 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Memory task, Aversive stimulation, medicine, Animals, Learning, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, Rats, Wistar, Declarative memory, Novel object recognition task, 05 social sciences, Cognitive neuroscience of visual object recognition, Fear, Object (computer science), Rats, Exploratory Behavior, Visual Perception, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Temporal organization, medicine.symptom, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

Aim of the research was to investigate whether a temporal structure could be detected in the behavioural response to an aversive stimulation. A fear-related memory task was used in rats, placed in a modified version of the Novel Object Recognition task known as Emotional Object Recognition task, i.e. a behavioural assay that orbits around the declarative memory for an aversive experience. To this purpose, twelve male Wistar rats, divided in two groups (Control and Aversive memory), observed after 4 h (OR4h) and after 24 h (OR24h) from the delivery of an aversive stimulation, associated to a specific object, were used. Data were evaluated both in terms of conventional quantitative approaches and by means of T-pattern analysis, namely a multivariate technique able to unveil the temporal structure of behaviour and the relationships amongst the behavioural items in time. Results evidenced several changes between groups and over time as well. Mean occurrences and mean durations showed significant differences between OR4h and OR24h sessions and between Control and Aversive memory groups for behavioural items of Exploration, Object-related aversion and Immobility. T-pattern analysis revealed important changes of behavioural variability, complexity and repetitiveness, (i.e., the three main qualitative features of T-patterns) in the Aversive memory group. These outcomes highlight a simpler and linear behavioural profile, focused only on specific sequences of particularly repetitive events. Overall, the present study demonstrates a) the presence of a temporal organization of fear-related behavioural events and b) the influence of learning on the modifications observed over time.

Published
2021
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3. Alcohol consumption is associated with widespread changes in blood DNA methylation: Analysis of cross-sectional and longitudinal data

Author

Daniel F. Schmidt, Rory P. Wilson, Melanie Waldenberger, Laura Baglietto, Harindra Jayasekara, Benjamin Lehne, Graham G. Giles, Pierre Antoine Dugué, Jaspal S. Kooner, Melissa C. Southey, Xiaochuan Wang, Annette Peters, Karl-Heinz Ladwig, Dallas R. English, John C Chambers, Jihoon E. Joo, Christian Gieger, Roger L. Milne, Chol-Hee Jung, Gianluca Severi, Enes Makalic, Cancer Epidemiology Centre & Cancer Council Victoria [Melbourne, Australia], University of Melbourne-Melbourne School for Population and Global Health, Melbourne School of Population and Global Health [Melbourne], University of Melbourne, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, W2 1PG, Melbourne Bioinformatics [Australia], The University of MelbourneParkville, VIC, Australia., Department of Clinical and Experimental Medicine, University of Pisa, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), München, Technische Universität München, German Research Center for Cardiovascular Disease (DZHK), Partner site Munich Heart Alliance, Institute of Epidemiology and Medical Biometry, University of Ulm, Munich, Germany, Ealing Hospital, Imperial College Healthcare NHS Trust, Monash University [Clayton], Nanyang Technological University [Singapour], Imperial College Healthcare NHS Trust Oregon Department of Agriculture, ODA: 16/136/68 279143 Wellcome Trust, WT: 084723/Z/08/Z, 090532, RP‐PG‐0407‐10371, 098381 Cancer Council Victoria: 1026892, 1027505, 251553, 209057, 1050198, 1011618, 1074383, 504711, 1043616 Bundesministerium für Bildung und Forschung, BMBF VicHealth British Heart Foundation, BHF: SP/04/002 Münchner Zentrum für Gesundheitswissenschaften, Ludwig-Maximilians-Universität München National Institute for Health Research, NIHR National Health and Medical Research Council, NHMRC: 1088405 Horizon 2020 Framework Programme, H2020: 643774 ERAB: The European Foundation for Alcohol Research, ERAB: ERAB 2018 – EA1817 Medical Research Council, MRC: G0601966, G0700931 National Medical Research Council, NMRC: NMRC/STaR/0028/2017, and This work (MCCS) was supported by the Australian National Health and Medical Research Council (NHMRC) (Grant 1088405). MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC Grants 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria. Cases were ascertained through the Victorian Cancer Registry (VCR) and the Australian Cancer Database (Australian Institute of Health and Welfare). The nested case‐control methylation studies were supported by the NHMRC Grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383. M.C.S. is an NHMRC Senior Research Fellow (1061177). The KORA study was initiated and financed by the Helmholtz Zentrum München – German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. Furthermore, KORA research has been supported within the Munich Center of Health Sciences (MC‐Health), Ludwig‐Maximilians‐Universität, as part of LMUinnovativ. This work has received funding from the European Foundation for Alcohol Research (ERAB 2018 – EA1817). We thank all members of field staffs who were involved in the planning and conduct of the MONICA/KORA Augsburg studies. The LOLIPOP study is supported by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, the British Heart Foundation (SP/04/002), the Medical Research Council (G0601966, G0700931), the Wellcome Trust (084723/Z/08/Z, 090532, and 098381), the NIHR (RP‐PG‐0407‐10371), the NIHR Official Development Assistance (ODA, award 16/136/68), the European Union FP7 (EpiMigrant, 279143), and H2020 programs (iHealth‐T2D, 643774). We acknowledge support of the MRC‐PHE Centre for Environment and Health and the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards. The work was carried out in part at the NIHR/Wellcome Trust Imperial Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the Imperial College Healthcare NHS Trust, the NHS, the NIHR, or the Department of Health. We thank the participants and research staff who made the study possible. JC is supported by the Singapore Ministry of Health's National Medical Research Council under its Singapore Translational Research Investigator (STaR) Award (NMRC/STaR/0028/2017).

Subjects
Male, longitudinal data, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), Physiology, Alcohol, Disease, Epigenesis, Genetic, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Prospective Studies, education.field_of_study, 0303 health sciences, DNA methylation, Confounding, Regression analysis, Methylation, Middle Aged, epigenome-wide association study, Substance abuse, Psychiatry and Mental health, 030220 oncology & carcinogenesis, Female, Alcohol consumption, Cohort study, Adult, Alcohol Drinking, Longitudinal data, alcohol consumption, Population, 03 medical and health sciences, Genetic, cross-sectional data, EWAS, HM450 assay, Aged, CpG Islands, Cross-Sectional Studies, Genome-Wide Association Study, Humans, DNA Methylation, Epigenetics, education, 030304 developmental biology, Pharmacology, business.industry, Alcohol Consumption, Cross-sectional Data, Dna Methylation, Epigenome-wide Association Study, Ewas, Hm450 Assay, Longitudinal Data, medicine.disease, 030227 psychiatry, chemistry, business, 030217 neurology & neurosurgery, Epigenesis
Abstract

Background:DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart.Methods:Using the Illumina Infinium HumanMethylation450 BeadChip, DNA methylation measures were determined using baseline peripheral blood samples from 5,606 adult Melbourne Collaborative Cohort Study (MCCS) participants. For a subset of 1,088 of them, these measures were repeated using blood samples collected at follow-up, a median of 11 years later. Associations between alcohol intake and blood DNA methylation were assessed using linear mixed-effects regression models adjusted for batch effects and potential confounders. Independent data from the LOLIPOP (N=4,042) and KORA (N=1,662) cohorts were used to replicate associations discovered in the MCCS.Results:Cross-sectional analyses identified 1,414 CpGs associated with alcohol intake at P-7, 1,243 of which had not been reported previously. Of these 1,243 novel associations, 1,078 were replicated (PConclusion:Our study indicates that, for middle-aged and older adults, alcohol intake is associated with widespread changes in DNA methylation across the genome. Longitudinal analyses showed that the methylation status of alcohol-associated CpGs may change with changes in alcohol consumption.

Published
2021
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4. Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity … and return

Author

Cesare D’Amico, Martin Kuchar, Giuseppe Tringali, Vincenzo Micale, Salvatore Feo, Gianluca Lavanco, Valentina Castelli, Anna Brancato, Giuseppe Pizzolanti, Carla Cannizzaro, Università degli studi di Palermo - University of Palermo, INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, University of Catania [Italy], Università cattolica del Sacro Cuore [Roma] (Unicatt), University of Chemistry and Technology Prague (UCT Prague), ERAB: The European Foundation for Alcohol Research, Università di Catania, Brancato A., Castelli V., Lavanco G., Tringali G., Micale V., Kuchar M., D'amico C., Pizzolanti G., Feo S., Cannizzaro C., Admin, Oskar, Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), and Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt)

Subjects
Binge alcohol drinking, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, QH301-705.5, Medicine (miscellaneous), Nucleus accumbens, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Dopamine, Dopamine receptor D2, Internal medicine, Neuroplasticity, Medicine, Cannabidiol, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Biology (General), 030304 developmental biology, Dopamine transporter, 0303 health sciences, biology, Tyrosine hydroxylase, business.industry, Dopaminergic, Adolescence, Endocrinology, biology.protein, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Adolescence, Binge alcohol drinking, Cannabidiol, Nucleus accumbens, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress, (2) stress-axis functionality, and (3) dopaminergic and glutamatergic neuroadaptation in the NAc. We also assess the potential effects of the non-intoxicating phytocannabinoid cannabidiol, to counteract (or reverse) the development of detrimental consequences of binge-like alcohol exposuredimensions. Our results show that adolescent binge-like alcohol exposure alters the sensitivity to positive stimuli, exerts social and novelty-triggered anxiety-like behaviour, and passive stress-coping during early and prolonged withdrawal. In addition, serum corticosterone and hypothalamic and NAc corticotropin-releasing hormone levels progressively increase during withdrawal. Besides, NAc tyrosine hydroxylase levels increase at late withdrawal, while the expression of dopamine transporter, D1 and D2 receptors xpression is dynamically altered during binge and withdrawal. Furthermore, the expression of markers of excitatory postsynaptic signaling —PSD95, Homer-1 and -2 and the activity-regulated spine-morphing proteins Arc, LIM Kinase 1 and FOXP1—increase at late withdrawal. Notably, subchronic cannabidiol, during withdrawal, attenuates social- and novelty-induced aversion and passive stress-coping and rectifies the hyper-responsive stress axis and NAc dopamine and glutamate-related neuroplasticity. Overall, the exposure to binge-like alcohol levels in adolescent rats makes the NAc, during withdrawal, a locus minoris resistentiae as a result of perturbations in neuroplasticity and in stress-axis homeostasis. Cannabidiol holds a promising potential for increasing behavioural, neuroendocrine and molecular resilience against binge-like alcohol level’s harmful effects.

Published
2021
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