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1. Childhood interstitial lung disease in Turkey: first data from the national registry

Author

Nayır-Büyükşahin, Halime, Emiralioğlu, Nagehan, Kılınç, Ayşe Ayzıt, Girit, Saniye, Yalçın, Ebru, Şişmanlar Eyüboğlu, Tuğba, Çobanoğlu, Nazan, Cinel, Güzin, Pekcan, Sevgi, Gökdemir, Yasemin, Oğuz, Berna, Orhan, Diclehan, Doğru, Deniz, Özçelik, Uğur, Başkan, Azer Kılıç, Arslan, Hüseyin, Çokuğraş, Haluk, Onay, Zeynep Reyhan, Oksay, Sinem Can, Tortop, Deniz Mavi, Aslan, Ayşe Tana, Kekeç, Handan, Zirek, Fazılcan, Tekin, Merve Nur, Gülen, Figen, Girgin Dindar, Bahar, Eryılmaz Polat, Sanem, Uytun, Salih, Yılmaz, Aslı İmran, Ünal, Gökçen, Eralp, Ela Erdem, Karadağ, Bülent, Hangül, Melih, Köse, Mehmet, Özsezen, Beste, Çakır, Erkan, Bingöl, Ayşen, Hızal, Mina, Kartal Öztürk, Gökçen, Uyan, Zeynep Seda, Ramaslı Gürsoy, Tuğba, Serbes, Mahir, and Kiper, Nural

Published
2024
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5. Comparison of clinical features of cystic fibrosis patients eligible but not on CFTR modulators to ineligible for CFTR modulators

Author

Nayır Büyükşahin, Halime, primary, Emiralioğlu, Nagehan, additional, Yalçın, Ebru, additional, Şen, Velat, additional, Selimoğlu Şen, Hadice, additional, Arslan, Hüseyin, additional, Başkan, Azer Kılıç, additional, Çakır, Fatma Betül, additional, Koray, Cem Fırat, additional, Yılmaz, Aslı İmran, additional, Ercan, Fatih, additional, Altıntaş, Derya Ufuk, additional, Serbes, Mahir, additional, Keskin, Özlem, additional, Arık, Elif, additional, Gülen, Figen, additional, Barlık, Meral, additional, Karcıoğlu, Oğuz, additional, Damadoğlu, Ebru, additional, Köse, Mehmet, additional, Ersoy, Ali, additional, Bingöl, Ayşen, additional, Başaran, Erdem, additional, Çakır, Eylül Pınar, additional, Aslan, Ayşe Tana, additional, Canıtez, Yakup, additional, Korkmaz, Merve, additional, Özdemir, Ali, additional, Harmancı, Koray, additional, Soydaş, Şule Selin, additional, Hangül, Melih, additional, Yüksel, Hasan, additional, Özcan, Gizem, additional, Korkmaz, Pervin, additional, Kılıç, Mehmet, additional, Gayretli Aydın, Zeynep Gökçe, additional, Çaltepe, Gönül, additional, Can, Demet, additional, Doğru, Sibel, additional, Kartal Öztürk, Gökçen, additional, Süleyman, Ayşe, additional, Topal, Erdem, additional, Özsezen, Beste, additional, Hızal, Mina, additional, Demirdöğen, Ezgi, additional, Ogun, Hamza, additional, Börekçi, Şermin, additional, Yazan, Hakan, additional, Çakır, Erkan, additional, Şişmanlar Eyüboğlu, Tuğba, additional, Çobanoğlu, Nazan, additional, Cinel, Güzin, additional, Pekcan, Sevgi, additional, Özçelik, Uğur, additional, and Doğru, Deniz, additional

Published
2024
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9. The Coronavirus Disease 2019 Pandemic and Time to Diagnosis for Childhood Pulmonary Diseases: Outcomes of a Tertiary Care Center.

Author

Erdal, Meltem Akgül, Büyükşahin, Halime Nayır, Güzelkaş, İsmail, Sunman, Birce, Alboğa, Didem, Emiralioğlu, Nagehan, Yalçın, Ebru, Doğru, Deniz, Özçelik, H. Uğur, and Kiper, Nural

Subjects
CYSTIC fibrosis diagnosis, TUBERCULOSIS diagnosis, ACADEMIC medical centers, DATA analysis, CILIARY motility disorders, KRUSKAL-Wallis Test, INTERSTITIAL lung diseases, TERTIARY care, CHILDREN'S hospitals, DESCRIPTIVE statistics, AGE factors in disease, ONE-way analysis of variance, STATISTICS, COMPARATIVE studies, DATA analysis software, COVID-19 pandemic, CHILDREN
Abstract

Objectives: Coronavirus disease 2019 pandemic caused many changes in the social behaviors of individuals and the provision of health systems. Many studies revealed reductions in the number of diagnoses and delays in diagnosis time during the pandemic. This study aimed to evaluate the effect of the pandemic on the time to diagnosis of major diseases of pediatric pulmonology. Materials and Methods: Newly diagnosed patients with cystic fibrosis (CF), childhood interstitial lung disease (chILD), tuberculosis (TB), and primary ciliary dyskinesia (PCD) were grouped into pandemic (group 1) and 2 consecutive pre-pandemic periods divided into equal intervals (groups 2 and 3). For each disease group, the time to diagnosis was compared between the specified periods. Results: A total number of patients were 171 in this study. In the CF group, there was no statistically difference in time to diagnosis between periods. In the chILD group, there was a statistically significant difference in time to diagnosis (P = .036) between groups (group 1: 2 months, group 2: 4 months and group 3: 10.5 months) that was not originated from pandemic period. In TB group there was no statistically significant difference between groups. In the PCD group, the impact of the pandemic on the time to diagnosis could not be clarified because the time interval to diagnosis (minimum: 2 years, maximum: 16 years) exceeded the studied periods (21 months). Conclusion: In our study, no effect found between the pandemic and age at diagnosis or time to diagnosis in patients with PCD, chILD, CF, and TB at our center. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Two cases with undefined childhood interstitial lung disease: Can it be related to telomere variants?

Author

Nayır Büyükşahin, Halime, Emiralioğlu, Nagehan, Yalçın, Ebru, Ozcan, H. Nursun, Oğuz, Berna, Utine, Gülen Eda, Kiper, Pelin Özlem, Karaosmanoğlu, Beren, Orhan, Diclehan, Unal, Sule, Güzelkaş, İsmail, Alboğa, Didem, Doğru, Deniz, Özçelik, Uğur, and Kiper, Nural

Subjects
*CILIARY motility disorders, *TELOMERASE reverse transcriptase, *HEMATOPOIETIC stem cell transplantation, *MEDICAL genetics, *VITAL capacity (Respiration), *INTERSTITIAL lung diseases, *PULMONARY alveolar proteinosis
Abstract

This article discusses two cases of childhood interstitial lung disease (chILD) that may be related to telomere variants. chILD is a condition that affects the lungs and has a genetic component. Telomeres are nucleoprotein complexes that protect chromosomes, and variants in telomere-related genes can cause interstitial lung disease in adults. While only two cases of telomere-related variants in children have been reported, these cases highlight the importance of evaluating telomere length and variants in children with chILD. Further research is needed to understand the role of telomere diseases in childhood interstitial lung disease. [Extracted from the article]

Published
2024
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14. Impact of interruption of CFTR modulator therapies

Author

Capraz Yavuz, Burcu, Yalcin, Ebru, Nayir Buyuksahin, Halime, Sunman, Birce, Guzelkas, Ismail, Alboga, Didem, Akgul Erdal, Meltem, Demir, Havva Ipek, Atan, Raziye, Emiralioglu, Nagehan, Dogru, Deniz, Ozcelik, Ugur, and Kiper, Nural

Published
2024
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15. The predictive role of lung clearance index on FEV1 decline in cystic fibrosis.

Author

Özsezen, Beste, Yalçın, Ebru, Emiralioğlu, Nagehan, Ünlü, Hande Konşuk, Tural, Dilber Ademhan, Caka, Canan, Sunman, Birce, Doğru, Deniz, Özçelik, Ugur, and Kiper, Nural

Abstract

Background. The lung clearance index (LCI) is a sensitive lung function index that is used to detect early lung disease changes in children with cystic fibrosis (CF). This study aimed to define the predictive role of baseline LCI, along with other potential factors on the change in forced expiratory volume in one second (FEV1) during one-year follow-up in CF patients who had a percent predicted (pp) FEV1 ≥80. Methods. LCI was concurrently performed on 57 CF patients who had ppFEV1 ≥80 at month zero. The ppFEV1 decline was evaluated prospectively during the one year follow up. The primary outcome of ppFEV1 decline in the study group in one year was dichotomized according to the median value for the decline in ppFEV1, which was 3.7. The LCI value predicting ppFEV1 decline at the end of one year was calculated with receiver operating characteristic curve analysis. Regression analysis was performed. Furthermore, a decision tree was constructed using classification and regression tree methods to better define the potential effect of confounders on the ppFEV1 decline. Results. The LCI value for predicting ppFEV1 decline >3.7% at the end of one year was 8.2 (area under the curve: 0.80) Multivariable regression analysis showed that the absence of the F508del mutation in at least one allele, LCI >8.2 and initial FEV1 z-score were predictors of a ppFEV1 decline >3.7 (p<0.001). Factors altering ppFEV1 decline>3.7% at the end of one-year evaluated by decision trees were as follows: initial FEV1 z-score, type of CFTR mutation, LCI value and initial weight-for-age z-score. Conclusions. LCI is sensitive for predicting ppFEV1 decline in patients with ppFEV1 ≥80 along with the initial FEV1-z-score and type of CFTR mutation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Childhood interstitial lung disease in Turkey: first data from the national registry

Author

Nayır-Büyükşahin, Halime, primary, Emiralioğlu, Nagehan, additional, Kılınç, Ayşe Ayzıt, additional, Girit, Saniye, additional, Yalçın, Ebru, additional, Şişmanlar Eyüboğlu, Tuğba, additional, Çobanoğlu, Nazan, additional, Cinel, Güzin, additional, Pekcan, Sevgi, additional, Gökdemir, Yasemin, additional, Oğuz, Berna, additional, Orhan, Diclehan, additional, Doğru, Deniz, additional, Özçelik, Uğur, additional, Başkan, Azer Kılıç, additional, Arslan, Hüseyin, additional, Çokuğraş, Haluk, additional, Onay, Zeynep Reyhan, additional, Oksay, Sinem Can, additional, Tortop, Deniz Mavi, additional, Aslan, Ayşe Tana, additional, Kekeç, Handan, additional, Zirek, Fazılcan, additional, Tekin, Merve Nur, additional, Gülen, Figen, additional, Girgin Dindar, Bahar, additional, Eryılmaz Polat, Sanem, additional, Uytun, Salih, additional, Yılmaz, Aslı İmran, additional, Ünal, Gökçen, additional, Eralp, Ela Erdem, additional, Karadağ, Bülent, additional, Hangül, Melih, additional, Köse, Mehmet, additional, Özsezen, Beste, additional, Çakır, Erkan, additional, Bingöl, Ayşen, additional, Hızal, Mina, additional, Kartal Öztürk, Gökçen, additional, Uyan, Zeynep Seda, additional, Ramaslı Gürsoy, Tuğba, additional, Serbes, Mahir, additional, and Kiper, Nural, additional

Published
2023
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17. Childhood interstitial lung disease in Turkey: First data from the national registry

Author

Nayır Büyükşahin, Halime, primary, Emiralioğlu, Nagehan, additional, Kılınç, Ayşe Ayzıt, additional, Girit, Saniye, additional, Yalçın, Ebru, additional, Şişmanlar Eyüboğlu, Tuğba, additional, Çobanoğlu, Nazan, additional, Cinel, Güzin, additional, Pekcan, Sevgi, additional, Gökdemir, Yasemin, additional, Oğuz, Berna, additional, Orhan, Diclehan, additional, Doğru, Deniz, additional, Özçelik, Uğur, additional, Kılıç Başkan, Azer, additional, Arslan, Hüseyin, additional, Çokuğraş, Haluk, additional, Onay, Zeynep Reyhan, additional, Can Oksay, Sinem, additional, Tortop, Deniz Mavi, additional, Aslan, Ayşe Tana, additional, Kekeç, Handan, additional, Zirek, Fazılcan, additional, Tekin, Merve Nur, additional, Gülen, Figen, additional, Girgin Dindar, Bahar, additional, Eryılmaz Polat, Sanem, additional, Uytun, Salih, additional, Yılmaz, Aslı İmran, additional, Ünal, Gökçen, additional, Erdem Eralp, Ela, additional, Karadağ, Bülent, additional, Hangül, Melih, additional, Köse, Mehmet, additional, Özsezen, Beste, additional, Çakır, Erkan, additional, Bingöl, Ayşen, additional, Gharibzadeh Hızal, Mina, additional, Oztürk, Gökçen, additional, Uyan, Zeynep Seda, additional, Ramaslı Gürsoy, Tuğba, additional, Altıntaş, Derya Ufuk, additional, Kiper, Nural, additional, and Child-Turkey-Collaboration, ., additional

Published
2023
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18. Evaluation of respiratory function at 6 years of age in patients with cystic fibrosis with frequent pulmonary exacerbations in the first 2 years of life

Author

ozkan tabakci, sati, primary, Cinel, Güzin, additional, Uytun, Salih, additional, Eryılmaz Polat, Sanem, additional, Yalçın, Ebru, additional, Kiper, Nural, additional, Akgül Erdal, Meltem, additional, Şen, Velat, additional, Savaş, Suat, additional, Çelebi, Özcan, additional, Ufuk Altıntaş, Derya, additional, Serbes, Mahir, additional, Ayzıt Kılınç, Ayşe, additional, Çokuğraş, Haluk, additional, Arslan, Hüseyin, additional, Yazan, Hakan, additional, Molla Kafi, Hale, additional, Çollak, Abdülhamit, additional, Ünal, Gökçen, additional, Yılmaz, Aslı İmran, additional, Çağlar, Hanife Tuğçe, additional, Irmak, İlim, additional, Damadoğlu, Ebru, additional, Kartal Öztürk, Gökçen, additional, Demir, Esen, additional, Başaran, Erdem, additional, Bingöl, Ayşen, additional, Canıtez, Yakup, additional, Çekiç, Şükrü, additional, Asfuroğlu, Pelin, additional, Tana Aslan, Ayşe, additional, Harmancı, Koray, additional, Kılıç, Gonca, additional, Köse, Mehmet, additional, Ersoy, Ali, additional, Hangül, Melih, additional, Özdemir, Ali, additional, Özcan, Gizem, additional, Çobanoğlu, Nazan, additional, Gayretli Aydın, Zeynep Gökçe, additional, Keskin, Özlem, additional, Yüksel, Hasan, additional, Özdoğan, Şebnem, additional, Topal, Erdem, additional, Çaltepe, Gönül, additional, Can, Demet, additional, Korkmaz Ekren, Pervin, additional, Kılıç, Mehmet, additional, Şişmanlar Eyüboğlu, Tuğba, additional, Pecan, Sevgi, additional, Çakır, Erkan, additional, Emiralioğlu, Nagehan, additional, Özçelik, Uğur, additional, and Doğru Ersöz, Deniz, additional

Published
2023
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19. Association between lung ultrasound findings, pulmonary function tests and chest radiography in children with cystic fibrosis

Author

Alboğa, Didem, primary, Emiralioğlu, Nagehan, additional, Oğuz, Berna, additional, Nayır Büyükşahin, Halime, additional, Güzelkaş, İsmail, additional, Sunman, Birce, additional, Akgül Erdal, Meltem, additional, Yalçın, Ebru, additional, Doğru, Deniz, additional, Özçelik, Uğur, additional, and Kiper, Nural, additional

Published
2023
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23. Patients with cystic fibrosis who could not receive the CFTR modulator treatment: What did they lose in 1 year?

Author

Uytun, Salih, primary, Cinel, Güzin, additional, Eryılmaz Polat, Sanem, additional, Özkan Tabakçı, Satı, additional, Kiper, Nural, additional, Yalçın, Ebru, additional, Ademhan Tural, Dilber, additional, Özsezen, Beste, additional, Şen, Velat, additional, Selimoğlu Şen, Hadice, additional, Ufuk Altıntaş, Derya, additional, Çokuğraş, Haluk, additional, Kılınç, Ayşe Ayzıt, additional, Başkan, Azer Kılıç, additional, Yazan, Hakan, additional, Çollak, Abdulhamit, additional, Uzuner, Selçuk, additional, Ünal, Gökçen, additional, Yılmaz, Aslı İmran, additional, Çağlar, Hanife Tuğçe, additional, Damadoğlu, Ebru, additional, Irmak, İlim, additional, Demir, Esen, additional, Kartal Öztürk, Gökçen, additional, Bingöl, Ayşen, additional, Başaran, Erdem, additional, Sapan, Nihat, additional, Canıtez, Yakup, additional, Tana Aslan, Ayşe, additional, Asfuroğlu, Pelin, additional, Harmancı, Koray, additional, Köse, Mehmet, additional, Hangül, Melih, additional, Özdemir, Ali, additional, Çobanoğlu, Nazan, additional, Özcan, Gizem, additional, Keskin, Özlem, additional, Yüksel, Hasan, additional, Özdoğan, Şebnem, additional, Topal, Erdem, additional, Çaltepe, Gönül, additional, Can, Demet, additional, Korkmaz Ekren, Pervin, additional, Kılıç, Mehmet, additional, Emiralioğlu, Nagehan, additional, Şişmanlar Eyüboğlu, Tuğba, additional, Pekcan, Sevgi, additional, Çakır, Erkan, additional, Özçelik, Uğur, additional, and Doğru, Deniz, additional

Published
2023
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24. Nintedanib Treatment in a Child with Pulmonary Fibrosis.

Author

AKGÜL ERDAL, Meltem, ALBOĞA, Didem, SUNMAN, Birce, ÖZCAN, H. Nursun, EMİRALİOĞLU, Nagehan, YALÇIN, Ebru, DOĞRU, Deniz, ÖZÇELIK, Uğur, and KİPER, Nural

Subjects
PULMONARY fibrosis, RADIOTHERAPY, LUNG diseases
Abstract

Copyright of Journal of Pediatric Disease / Türkiye Çocuk Hastalıkları Dergisi is the property of Turkish Journal of Pediatric Disease and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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27. Diffuse alveolar haemorrhage in children: an international multicentre study

Author

Ring, Astrid Madsen, primary, Schwerk, Nicolaus, additional, Kiper, Nural, additional, Aslan, Ayse Tana, additional, Aurora, Paul, additional, Ayats, Roser, additional, Azevedo, Ines, additional, Bandeira, Teresa, additional, Carlens, Julia, additional, Castillo-Corullon, Silvia, additional, Cobanoglu, Nazan, additional, Elnazir, Basil, additional, Emiralioğlu, Nagehan, additional, Eyuboglu, Tugba Sismanlar, additional, Fayon, Michael, additional, Gursoy, Tugba Ramaslı, additional, Hogg, Claire, additional, Kötz, Karsten, additional, Karadag, Bülent, additional, Látalová, Vendula, additional, Krenke, Katarzyna, additional, Lange, Joanna, additional, Manali, Effrosyni D., additional, Osona, Borja, additional, Papiris, Spyros, additional, Proesmans, Marijke, additional, Reix, Philippe, additional, Roditis, Lea, additional, Rubak, Sune, additional, Rumman, Nisreen, additional, Snijders, Deborah, additional, Stehling, Florian, additional, Weiss, Laurence, additional, Yalcın, Ebru, additional, Zirek, Fazilcan, additional, Bush, Andrew, additional, Clement, Annick, additional, Griese, Matthias, additional, Buchvald, Frederik Fouirnaies, additional, Nathan, Nadia, additional, and Nielsen, Kim Gjerum, additional

Published
2023
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28. Diffuse alveolar haemorrhage in children:an international multicentre study

Author

Ring, Astrid Madsen, Schwerk, Nicolaus, Kiper, Nural, Aslan, Ayse Tana, Aurora, Paul, Ayats, Roser, Azevedo, Ines, Bandeira, Teresa, Carlens, Julia, Castillo-Corullon, Silvia, Cobanoglu, Nazan, Elnazir, Basil, Emiralioğlu, Nagehan, Eyuboglu, Tugba Sismanlar, Fayon, Michael, Gursoy, Tugba Ramaslı, Hogg, Claire, Kötz, Karsten, Karadag, Bülent, Látalová, Vendula, Krenke, Katarzyna, Lange, Joanna, Manali, Effrosyni D., Osona, Borja, Papiris, Spyros, Proesmann, Marijke, Reix, Philippe, Roditis, Lea, Rubak, Sune, Rumman, Nisreen, Snijders, Deborah, Stehling, Florian, Weiss, Laurence, Yalcın, Ebru, Zirek, Fazilcan, Bush, Andrew, Clement, Annick, Griese, Matthias, Buchvald, Frederik Fouirnaies, Nathan, Nadia, Nielsen, Kim Gjerum, Ring, Astrid Madsen, Schwerk, Nicolaus, Kiper, Nural, Aslan, Ayse Tana, Aurora, Paul, Ayats, Roser, Azevedo, Ines, Bandeira, Teresa, Carlens, Julia, Castillo-Corullon, Silvia, Cobanoglu, Nazan, Elnazir, Basil, Emiralioğlu, Nagehan, Eyuboglu, Tugba Sismanlar, Fayon, Michael, Gursoy, Tugba Ramaslı, Hogg, Claire, Kötz, Karsten, Karadag, Bülent, Látalová, Vendula, Krenke, Katarzyna, Lange, Joanna, Manali, Effrosyni D., Osona, Borja, Papiris, Spyros, Proesmann, Marijke, Reix, Philippe, Roditis, Lea, Rubak, Sune, Rumman, Nisreen, Snijders, Deborah, Stehling, Florian, Weiss, Laurence, Yalcın, Ebru, Zirek, Fazilcan, Bush, Andrew, Clement, Annick, Griese, Matthias, Buchvald, Frederik Fouirnaies, Nathan, Nadia, and Nielsen, Kim Gjerum

Abstract

Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children's and adult interstitial lung disease (Cost Action CA16125) and chILD-EU CRC (the European Research Collaboration for Children's Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before the age of 18 years. Results Data of 124 patients from 26 centres (15 counties) were submitted, of whom 117 patients fulfilled the inclusion criteria. Diagnoses were idiopathic pulmonary haemosiderosis (n=35), DAH associated with autoimmune features (n=20), systemic and collagen disorders (n=18), immuno-allergic conditions (n=10), other childhood interstitial lung diseases (chILD) (n=5), autoinflammatory diseases (n=3), DAH secondary to other conditions (n=21) and nonspecified DAH (n=5). Median (IQR) age at onset was 5 (2.0–12.9) years. Most frequent clinical presentations were anaemia (87%), haemoptysis (42%), dyspnoea (35%) and cough (32%). Respiratory symptoms were absent in 23%. The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality was 13%. Long-term data demonstrated persistent abnormal radiology and a limited improvement in lung function. Conclusions Paediatric DAH is highly heterogeneous regarding underlying causes and clinical presentation. The high mortality rate and number of patients with ongoing treatment years after onset of disease underline that DAH is a severe and often chronic condition. This large international study paves the way for further prospective clinical trials that will in the long term allow evidence-based treatment and follow-up recommendations to be determined., Background Paediatric diffuse alveolar haemorrhage (DAH) is a rare heterogeneous condition with limited knowledge on clinical presentation, treatment and outcome. Methods A retrospective, descriptive multicentre follow-up study initiated from the European network for translational research in children’s and adult interstitial lung disease (Cost Action CA16125) and chILD-EU CRC (the European Research Collaboration for Children’s Interstitial Lung Disease). Inclusion criteria were DAH of any cause diagnosed before the age of 18 years. Results Data of 124 patients from 26 centres (15 counties) were submitted, of whom 117 patients fulfilled the inclusion criteria. Diagnoses were idiopathic pulmonary haemosiderosis (n=35), DAH associated with autoimmune features (n=20), systemic and collagen disorders (n=18), immuno-allergic conditions (n=10), other childhood interstitial lung diseases (chILD) (n=5), autoinflammatory diseases (n=3), DAH secondary to other conditions (n=21) and nonspecified DAH (n=5). Median (IQR) age at onset was 5 (2.0–12.9) years. Most frequent clinical presentations were anaemia (87%), haemoptysis (42%), dyspnoea (35%) and cough (32%). Respiratory symptoms were absent in 23%. The most frequent medical treatment was systemic corticosteroids (93%), hydroxychloroquine (35%) and azathioprine (27%). Overall mortality was 13%. Long-term data demonstrated persistent abnormal radiology and a limited improvement in lung function. Conclusions Paediatric DAH is highly heterogeneous regarding underlying causes and clinical presentation. The high mortality rate and number of patients with ongoing treatment years after onset of disease underline that DAH is a severe and often chronic condition. This large international study paves the way for further prospective clinical trials that will in the long term allow evidence-based treatment and follow-up recommendations to be determined.

Published
2023

29. Diffuse alveolar hemorrhage in children with interstitial lung disease:Determine etiologies!

Author

Knoflach, Katrin, Rapp, Christina Katharina, Schwerk, Nicolaus, Carlens, Julia, Wetzke, Martin, Emiralioğlu, Nagehan, Kiper, Nural, Ring, Astrid Madsen, Buchvald, Frederik, Manali, Effrosyni, Papiris, Spyros, Reu-Hofer, Simone, Kappler, Matthias, Schieber, Alexandra, Seidl, Elias, Gothe, Florian, Robinson, Peter N., Griese, Matthias, Knoflach, Katrin, Rapp, Christina Katharina, Schwerk, Nicolaus, Carlens, Julia, Wetzke, Martin, Emiralioğlu, Nagehan, Kiper, Nural, Ring, Astrid Madsen, Buchvald, Frederik, Manali, Effrosyni, Papiris, Spyros, Reu-Hofer, Simone, Kappler, Matthias, Schieber, Alexandra, Seidl, Elias, Gothe, Florian, Robinson, Peter N., and Griese, Matthias

Abstract

Objective: Diffuse alveolar hemorrhage (DAH) in children is a rare condition resulting from different underlying diseases. This study aimed at describing characteristics and diagnostic measures in children with ILD (children's interstitial lung disease, chILD) and DAH to improve the diagnostic approach by increasing clinician's awareness of diagnostic shortcomings. Patients and Methods: A retrospective data analysis of patients with ILD and DAH treated in our own or collaborating centers between 01/07/1997 and 31/12/2020 was performed. Data on clinical courses and diagnostic measures were systematically retrieved as case-vignettes and investigated. To assess suitability of diagnostic software-algorithms, the Human Phenotype Ontology (HPO) was revised and expanded to optimize conditions of its associated tool the “Phenomizer.”. Results: For 97 (74%) of 131 patients, etiology of pulmonary hemorrhage was clarified. For 34 patients (26%), no underlying condition was found (termed as idiopathic pulmonary hemorrhage, IPH). Based on laboratory findings or clinical phenotype/comorbidities, 20 of these patients were assigned to descriptive clusters: IPH associated with autoimmune features (9), eosinophilia (5), renal disease (3) or multiorgan involvement (3). For 14 patients, no further differentiation was possible. Conclusion: Complete and sometimes repeated diagnostics are essential for establishing the correct diagnosis in children with DAH. We suggest assignment of patients with IPH to descriptive clusters, which may also guide further research. Digital tools such as the Phenomizer/HPO are promising, but need to be extended to increase diagnostic accuracy.

Published
2023

30. Healthcare resource utilisation and medical costs for children with interstitial lung diseases (chILD) in Europe

Author

Seidi, Elias, Schwerk, Nicolaus, Carlens, Julia, Wetzke, Martin, Cunningham, Steve, Emiralioğlu, Nagehan, Kiper, Nural, Lange, Joanna, Krenke, Katarzyna, Ullmann, Nicola, Krikovszky, Dora, Maqhuzu, Phillen, Griese, Charlotte A, Schwarzkopt, Larissa, and Griese, Matthias

Subjects
Europe, Pulmonary and Respiratory Medicine, paediatric interstitial lung disease, Humans, Health Care Costs, Longitudinal Studies, Prospective Studies, Patient Acceptance of Health Care, Child, Lung Diseases, Interstitial, paediatric lung disaese
Abstract

BackgroundNo data on healthcare utilisation and associated costs for the many rare entities of children’s interstitial lung diseases (chILD) exist. This paper portrays healthcare utilisation structures among individuals with chILD, provides a pan-European estimate of a 3-month interval per-capita costs and delineates crucial cost drivers.MethodsBased on longitudinal healthcare resource utilisation pattern of 445 children included in the Kids Lung Register diagnosed with chILD across 10 European countries, we delineated direct medical and non-medical costs of care per 3-month interval. Country-specific utilisation patterns were assessed with a children-tailored modification of the validated FIMA questionnaire and valued by German unit costs. Costs of care and their drivers were subsequently identified via gamma-distributed generalised linear regression models.ResultsDuring the 3 months prior to inclusion into the registry (baseline), the rate of hospital admissions and inpatient days was high. Unadjusted direct medical per capita costs (€19 818) exceeded indirect (€1 907) and direct non-medical costs (€1 125) by far. Country-specific total costs ranged from €8 713 in Italy to €28 788 in Poland. Highest expenses were caused by the disease categories ‘diffuse parenchymal lung disease (DPLD)-diffuse developmental disorders’ (€45 536) and ‘DPLD-unclear in the non-neonate’ (€47 011). During a follow-up time of up to 5 years, direct medical costs dropped, whereas indirect costs and non-medical costs remained stable.ConclusionsThis is the first prospective, longitudinal study analysing healthcare resource utilisation and costs for chILD across different European countries. Our results indicate that chILD is associated with high utilisation of healthcare services, placing a substantial economic burden on health systems.

Published
2022

32. Factors associated with pulmonary functions of cystic fibrosis (CF) patients in the National Cystic Fibrosis Patient Registry: a retrospective cohort study

Author

BAŞARAN, ABDURRAHMAN ERDEM, ÇAKIR, ERKAN, PEKCAN, SEVGİ, CİNEL, GÜZİN, SÜLEYMAN, AYŞE, KILIÇ, MEHMET, KORKMAZ EKREN, PERVİN, CAN, DEMET, ÇALTEPE, GÖNÜL, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, YÜKSEL, HASAN, BİLGİÇ ELTAN, SEVGİ, KESKİN, ÖZLEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, Eryımaz polat, Sanem, TUĞCU, GÖKÇEN DİLŞA, ÖZDEMİR, ALİ, HANGÜL, MELİH, KÖSE, MEHMET, HARMANCI, KORAY, ASFUROĞLU, PELİN, ASLAN, AYŞE TANA, SAPAN, NİHAT, ÖZÇELİK, HAYRİYE UĞUR, BİNGÖL, AYŞEN, KARTAL ÖZTÜRK, GÖKÇEN, DEMİR, ESEN, IRMAK, İLİM, DAMADOĞLU, EBRU, ÇAĞLAR, HANİFE TUĞÇE, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, TÜREL, ÖZDEN, YAZAN, HAKAN, HEPKAYA, EVRİM, KILIÇ BAŞKAN, AZER, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ALTINTAŞ, DERYA UFUK, ŞEN, VELAT, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, SERTÇELİK, AHMET, ÇAKIR, BANU, EMİRALİOĞLU, NAGEHAN, ÇOBANOĞLU, FATMA NAZAN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, and DOĞRU ERSÖZ, DENİZ

Abstract

We review the oscillator construction of the unitary representations ofnoncompact groups and supergroups and study the unitary supermultiplets ofOSp(1/32,R) in relation to M-theory. OSp(1/32,R) has a singleton supermultipletconsisting of a scalar and a spinor field. Parity invariance leads us toconsider OSp(1/32,R)_L X OSp(1/32,R)_R as the "minimal" generalized AdSsupersymmetry algebra of M-theory corresponding to the embedding of two spinorrepresentations of SO(10,2) in the fundamental representation of Sp(32,R). Thecontraction to the Poincare superalgebra with central charges proceeds via adiagonal subsupergroup OSp(1/32,R)_{L-R} which contains the common subgroupSO(10,1) of the two SO(10,2) factors. The parity invariant singletonsupermultiplet of OSp(1/32,R)_L \times OSp(1/32,R)_R decomposes into aninfinite set of "doubleton" supermultiplets of the diagonal OSp(1/32,R)_{L-R}. There is a unique "CPT self-conjugate" doubletonsupermultiplet whose tensor product with itself yields the "massless"generalized AdS_{11} supermultiplets. The massless graviton supermultipletcontains fields corresponding to those of 11-dimensional supergravity plusadditional ones. Assuming that an AdS phase of M-theory exists we argue thatthe doubleton field theory must be the holographic superconformal field theoryin ten dimensions that is dual to M-theory in the same sense as the dualitybetween the N=4 super Yang-Mills in d=4 and the IIB superstring over AdS_5 XS^5.

Published
2022

33. YAŞAMIN İLK 2 YILINDA SIK PULMONER ALEVLENME GEÇİREN KİSTİK FİBROZİS HASTALARININ 6. YAŞLARINDAKİ PULMONER FONKSİYONLARININ SPİROMETRİ İLE DEĞERLENDİRİLMESİ

Author

Eryımaz polat, Sanem, EMİRALİOĞLU, NAGEHAN, ÇAKIR, ERKAN, PEKCAN, SEVGİ, KESKİN, ÖZLEM, KILIÇ, MEHMET, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, DAMADOĞLU, EBRU, BAŞARAN, ABDURRAHMAN ERDEM, IRMAK, İLİM, BİNGÖL, AYŞEN, ÇAĞLAR, HANİFE TUĞÇE, CANITEZ, YAKUP, ÇEKİÇ, ŞÜKRÜ, ÖZÇELİK, HAYRİYE UĞUR, DOĞRU ERSÖZ, DENİZ, ASFUROĞLU, PELİN, KORKMAZ EKREN, PERVİN, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, CAN, DEMET, ÇALTEPE, GÖNÜL, ÇOBANOĞLU, FATMA NAZAN, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, TURKUT, ASLI İMRAN, ÖZCAN, GİZEM, ÖZDEMİR, ALİ, HANGÜL, MELİH, ÜNAL, GÖKÇEN, ÇOLAK, ABDÜLHAMİT, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, MOLLA KAFİ, HALE, YAZAN, HAKAN, ARSLAN, HÜSEYİN, ERSOY, ALİ, ÇOKUĞRAŞ, HALUK CEZMİ, KÖSE, MEHMET, KILIÇ YILDIRIM, GONCA, HARMANCI, KORAY, ÖZKAN TABAKÇI, SATI, CİNEL, GÜZİN, ASLAN, AYŞE TANA, UYTUN, SALİH, YALÇIN, ELMAS EBRU, KILINÇ, AYŞE AYZIT, KİPER, EMİNE NURAL, AKGÜL ERDAL, MELTEM, SERBES, MAHİR, ŞEN, VELAT, SAVAŞ, SUAT, ÇELEBİ, ÖZCAN, YÜKSEL, HASAN, and ALTINTAŞ, DERYA UFUK

Published
2022

34. Turkish Thoracic Society Early Career Members Task Force Group’s Virtual Congress Notes: European Respiratory Society International Congress 2020

Author

Önyılmaz, Tuğba, Karaoğlanoğlu, Selen, Karakaş, Fatma Gülsüm, Gündüz Gürkan, Canan, Topçu, Dilara Ömer, Marım, Feride, Çetin, Nazlı, Polat Yuluğ, Demet, Acet Öztürk, Nilüfer Aylin, Yılmaz Kara, Bilge, Aydın Güçlü, Özge, Çiftçi Küsbeci, Tuba, Şerifoğlu, İrem, Arıkan, Hüseyin, Fırıncıoğluları, Ali, Töreyin, Zehra Nur, Emiralioğlu, Nagehan, Şişmanlar Eyüboğlu, Tuğba, Tokgöz Akyıl, Fatma, Yıldırım, Halime, Karadoğan, Dilek, Kızılırmak, Deniz, Akgün, Metin, Öncel, Aslı, Özçelik, Neslihan, Çakmakcı, Selin, Çelik, Pınar, Oğuz, Merve Sinem, Ataoğlu, Özlem, Günaydın, Fatma Esra, and Özden Sertçelik, Ümran

Abstract

In this article, Early Career Task Force Group members of the Turkish Thoracic Society summarize the European Respiratory Society 2020 virtual congress. Current developments in the field of respiratory diseases were compiled with the addition of sessions specific to coronavirus disease 2019 this year. Almost all of the congress sessions were examined, and the important and striking results of the congress were highlighted. Congress sessions were attended by expert researchers, and the prominent messages of each session were highlighted in short summaries. They were then grouped under relevant titles and ranked in order of meaning and relation. It was finalized by a team of researchers.

Published
2022

37. Clinical characteristics of patients requiring lung transplantation referral in national cystic fibrosis registry data.

Author

Onay, Zeynep Reyhan, Eyüboğlu, Tuğba Şismanlar, Aslan, Ayşe Tana, Gürsoy, Tuğba Ramaslı, Yalçın, Ebru, Kiper, Nural, Emiralioğlu, Nagehan, Şen, Hadice Selimoğlu, Şen, Velat, Ünal, Gökçen, Yılmaz, Aslı İmran, Kılınç, Ayşe Ayzıt, Çokuğraş, Haluk, Başkan, Azer Kılıç, Yazan, Hakan, Çollak, Abdulhamit, Uzuner, Selçuk, Şasihüseyinoğlu, Ayşe Şenay, Özcan, Dilek, and Altıntaş, Derya Ufuk

Abstract

Background. We aimed to determine the number of cystic fibrosis (CF) patients recorded in the Cystic Fibrosis Registry of Türkiye (CFRT) who were in need of lung transplantation (LT) referral and examine clinical differences between patients who were LT candidates due to rapid forced expiratory volume in one second (FEV₁) decline and LT candidates without rapid FEV₁ decline in the last year to identify a preventable cause in patients with such rapid FEV₁ decline. Methods. All CF patients recorded in the CFRT in 2018 were evaluated in terms of LT. Patients were divided into those with FEV₁ below 50% and in need of LT due to a decrease of 20% or more in the previous year (Group 1) and those who did not have FEV₁ decline of more than 20% in the previous year but had other indications for LT (Group 2). Demographic and clinical features were compared between the two groups. Results. Of 1488 patients registered in CFRT, 58 had a need for LT. Twenty patients were included in Group 1 and others in Group 2. Our findings did not reveal any significant variations in treatment, chronic infection status, or complications between the two groups. The average weight z-score was significantly higher in Group 1. Positive correlations were detected between weight z-score and FEV₁ in 2017 in Group 1 and between FEV₁ values in 2017 and 2018 in Group 2. Conclusions. There appears to be a relationship between the nutritional status and weight z-scores of CF patients and pulmonary function, which may indirectly affect the need for lung transplantation referral. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Turkish Thoracic Society early career members task force group's virtual congress notes: European Respiratory Society International Congress 2020

Author

Kızılırmak, Deniz, Karadoğan, Dilek, Yıldırım, Halime, Akyıl, Fatma Tokgöz, Şişmanlar Eyüboğlu, Tuğba, Emiralioğlu, Nagehan, Sertçelik, Ümran Özden, Günaydın, Fatma Esra, Ataoğlu, Özlem, Oğuz, Merve Sinem, Çakmakçı, Selin, Özçelik, Neslihan, Öncel, Aslı, Fırıncıoğulları, Ali, Kara, Bilge Yılmaz, Ömer, Dilara, Karaoğlanoğlu, Selen, Çetin, Nazlı, Karakaş, Fatma Gülsüm, Gürkan, Canan Gündüz, Marim, Feride, Önyılmaz, Tuğba, Yuluğ, Demet Polat, Acet Öztürk, Nilüfer Aylin, Aydın Güçlü, Özge, Çiftçi Küsbeci, Tuba, Şerifoğlu, İrem, Arıkan, Hüseyin, Töreyin, Zehra Nur, Çelik, Pınar, Akgün, Metin, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Karadoğan, Dilek, Özçelik, Neslihan, and Kara, Bilge Yılmaz

Subjects
Respiratory diseases, Lung health, European Respiratory Society, Congress highlights
Abstract

In this article, Early Career Task Force Group members of the Turkish Thoracic Society summarize the European Respiratory Society 2020 virtual congress. Current developments in the field of respiratory diseases were compiled with the addition of sessions specific to coronavirus disease 2019 this year. Almost all of the congress sessions were examined, and the important and striking results of the congress were highlighted. Congress sessions were attended by expert researchers, and the prominent messages of each session were highlighted in short summaries. They were then grouped under relevant titles and ranked in order of meaning and relation. It was finalized by a team of researchers Turkish Thoracic Society (TTS)

Published
2022

40. ERS international virtual congress 2021: Highlights from the Turkish thoracic society early career members

Author

Yumrukuz Şenel, Merve, Karadoğan, Dilek, Vardaloğlu, Ilgım, Develi, Elif, Çelik, Selma, Hızal, Mina, Özsezen, Beste, Öncel, Aslı, Can, İlknur, Hürsoy, Nur, Uyar, Kübra, Karakaş, Fatma Gülsüm, Er, Berrin, Asfuroğlu, Pelin, Gürsoy, Tuğba Ramaşlı, Şişmanlar Eyüboğlu, Tuğba, Çakır, Eylül Pınar, Ademhan, Dilber, Karaoğlanoğlu, Selen, Emiralioğlu, Nagehan, Acet Öztürk, Nilüfer Aylin, Marim, Feride, Güçlü, Özge Aydın, Çetin, Nazlı, Ömer Topçu, Dilara, Çelik, Pınar, Akgün, Metin, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Karadoğan, Dilek, and Hürsoy, Nur

Subjects
Respiratory diseases, Highlights, Congress, European respiratory society
Abstract

This review aimed to highlight some important points derived from the presentations of the European Respiratory Society 2021 Virtual International Congress by a committee formed by the Early Career Task Group of the Turkish Thoracic Society. We summarized a wide range of topics including current developments of respiratory diseases and provided an overview of important and striking topics of the congress. Our primary motivation was to give some up-to-date information and new developments discussed during congress especially for the pulmonologists who did not have a chance to follow the congress. This review also committed an opportunity to get an overview of the newest data in the diverse fields of respiratory medicine such as post-coronavirus disease 2019, some new interventional and technologic developments related to respiratory health, and new treatment strategies.

Published
2022

41. Ulusal Kistik Fibrozis Hasta Kayıt Sisteminde Yer Alan Altı Yaş Ve Üzeri Kistik Fibrozis Hastalarının Solunum Fonksiyonlarıyla İlişkili Faktörlerin İncelenmesi: Retrospektif Kohort Çalışması

Author

SAPAN, NİHAT, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, EMİRALİOĞLU, NAGEHAN, ÇAKIR, BANU, SERTÇELİK, AHMET, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, DOĞRU ERSÖZ, DENİZ, ŞEN, VELAT, ALTINTAŞ, DERYA UFUK, ÇOKUĞRAŞ, HALUK CEZMİ, KILINÇ, AYŞE AYZIT, KILIÇ BAŞKAN, AZER, ÖZÇELİK, HAYRİYE UĞUR, ÇAKIR, ERKAN, ÇOBANOĞLU, FATMA NAZAN, HEPKAYA, EVRİM, YAZAN, HAKAN, TÜREL, ÖZDEN, PEKCAN, SEVGİ, MOLLA KAFİ, HALE, TURKUT, ASLI İMRAN, ÜNAL, GÖKÇEN, CİNEL, GÜZİN, ÇAĞLAR, HANİFE TUĞÇE, SÜLEYMAN, AYŞE, KILIÇ, MEHMET, KORKMAZ EKREN, PERVİN, CAN, DEMET, ÇALTEPE, GÖNÜL, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, YÜKSEL, HASAN, DAMADOĞLU, EBRU, IRMAK, İLİM, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, BİLGİÇ ELTAN, SEVGİ, KESKİN, ÖZLEM, BİNGÖL, AYŞEN, BAŞARAN, ABDURRAHMAN ERDEM, ASLAN, AYŞE TANA, ASFUROĞLU, PELİN, HARMANCI, KORAY, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, KÖSE, MEHMET, HANGÜL, MELİH, ÖZDEMİR, ALİ, Eryımaz polat, Sanem, and TUĞCU, GÖKÇEN DİLŞA

Published
2021

42. Ülkemizde Kistik Fibrozis Yönetiminde Merkezler Arası Farklılıkların Değerlendirilmesi veUluslararası Kayıt Sistemleri ile Karşılaştırılması

Author

ASFUROĞLU, PELİN, ÖZDOĞAN, ŞEBNEM, ÖZDEMİR, ALİ, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, YAZAN, HAKAN, ÇAKIR, ERKAN, MOLLA KAFİ, HALE, TOPRAK, ALİ, EMİRALİOĞLU, NAGEHAN, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, Karadağ, Bülent, GÖKDEMİR, YASEMİN, ERDEM ERALP, ELA, ŞEN, VELAT, TURKUT, ASLI İMRAN, ÜNAL, GÖKÇEN, ÇAĞLAR, HANİFE TUĞÇE, ÇOKUĞRAŞ, HALUK CEZMİ, KILINÇ, AYŞE AYZIT, KILIÇ BAŞKAN, AZER, HEPKAYA, EVRİM, ALTINTAŞ, DERYA UFUK, ÖZCAN, DİLEK, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, BAŞARAN, ABDURRAHMAN ERDEM, BİNGÖL, AYŞEN, SAPAN, NİHAT, ÇEKİÇ, ŞÜKRÜ, DAMADOĞLU, EBRU, IRMAK, İLİM, ASLAN, AYŞE TANA, TUĞCU, GÖKÇEN DİLŞA, Eryımaz polat, Sanem, HARMANCI, KORAY, KÖSE, MEHMET, HANGÜL, MELİH, SÜLEYMAN, AYŞE, YÜKSEL, HASAN, KESKİN, ÖZLEM, ÖZCAN, GİZEM, TOPAL, ERDEM, CAN, DEMET, KORKMAZ EKREN, PERVİN, ÇALTEPE, GÖNÜL, KILIÇ, MEHMET, PEKCAN, SEVGİ, ÇOBANOĞLU, FATMA NAZAN, ÖZÇELİK, HAYRİYE UĞUR, and DOĞRU ERSÖZ, DENİZ

Published
2021

43. Modülatör Tedavi Endikasyonu Olan Kistik Fibrozisli Hastaların 1 Yıllık İzlemi: NelerKaybettiler?

Author

ASFUROĞLU, PELİN, SÜLEYMAN, AYŞE, SAPAN, NİHAT, DOĞRU ERSÖZ, DENİZ, HARMANCI, KORAY, KÖSE, MEHMET, ÇELİK, SEVİNÇ, ÖZÇELİK, HAYRİYE UĞUR, HANGÜL, MELİH, TURKUT, ASLI İMRAN, IRMAK, İLİM, ÇAKIR, ERKAN, ÜNAL, GÖKÇEN, DAMADOĞLU, EBRU, UZUNER, SELÇUK, ÇOLAK, ABDÜLHAMİT, YAZAN, HAKAN, ÖZDEMİR, ALİ, ÖZCAN, GİZEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÇOBANOĞLU, FATMA NAZAN, KESKİN, ÖZLEM, KILINÇ, AYŞE AYZIT, YÜKSEL, HASAN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, UYTUN, SALİH, Eryımaz polat, Sanem, ÖZKAN TABAKÇI, SATI, ÖZDOĞAN, ŞEBNEM, CİNEL, GÜZİN, EMİRALİOĞLU, NAGEHAN, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, ŞEN, VELAT, ALTINTAŞ, DERYA UFUK, ÇOKUĞRAŞ, HALUK CEZMİ, TOPAL, ERDEM, ÇALTEPE, GÖNÜL, BAŞARAN, ABDURRAHMAN ERDEM, CAN, DEMET, KORKMAZ EKREN, PERVİN, KILIÇ, MEHMET, BİNGÖL, AYŞEN, PEKCAN, SEVGİ, KARTAL ÖZTÜRK, GÖKÇEN, and DEMİR, ESEN

Published
2021

44. Health-Related Qualıty Of Lıfe Measures For Patıents Wıth Prımary Cılıary Dyskınesıa: A Multıcenter Study

Author

Karadağ, Bülent, SUNMAN, BİRCE, PEKCAN, SEVGİ, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, BİNGÖL, AYŞEN, BAŞARAN, AYŞEN, ÇAKIR, ERKAN, YAZAN, HAKAN, RAMASLI GÜRSOY, TUĞBA, MAVİ, DENİZ, ATAĞ, EMİNE, ÖZDEMİR, ALİ, ERDEM ERALP, ELA, ÖZÇELİK, HAYRİYE UĞUR, ERGENEKON, ALMALA PINAR, ÖZSEZEN, BESTE, YILMAZ YEĞİT, CANSU, ADEMHAN TURAL, DİLBER, Yanaz, Mürüvvet, EMİRALİOĞLU, NAGEHAN, GÖKDEMİR, YASEMİN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, and NAYIR, HALİME

Published
2021

45. Kistik Fibrozis Hastalarının Takibinde Ulusal Kistik Fibrozis Kayıt Sistemi'nin Önemi

Author

YÜKSEL, HASAN, ASLAN, AYŞE TANA, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, EMİRALİOĞLU, NAGEHAN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, TUĞCU, GÖKÇEN DİLŞA, Eryımaz polat, Sanem, HANGÜL, MELİH, ÖZCAN, GİZEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, SÜLEYMAN, AYŞE, CAN, DEMET, KORKMAZ EKREN, PERVİN, BAL, CEM MURAT, KILIÇ, MEHMET, CİNEL, GÜZİN, ÇOBANOĞLU, FATMA NAZAN, PEKCAN, SEVGİ, ÇAKIR, ERKAN, ÖZÇELİK, HAYRİYE UĞUR, DOĞRU ERSÖZ, DENİZ, ASFUROĞLU, PELİN, SELİMOĞLU ŞEN, HADİCE, ALTINTAŞ, DERYA UFUK, ÖZCAN, DİLEK, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, KILIÇ BAŞKAN, AZER, YAZAN, HAKAN, ERENBERK, UFUK, DOĞAN, GÜZİDE, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, KESKİN, ÖZLEM, ARIK, ELİF, KÜÇÜKOSMANOĞLU, OSMAN, IRMAK, İLİM, DAMADOĞLU, EBRU, KARTAL ÖZTÜRK, GÖKÇEN, GÜLEN, FİGEN, BAŞARAN, ABDURRAHMAN ERDEM, BİNGÖL, AYŞEN, ÇEKİÇ, ŞÜKRÜ, SAPAN, NİHAT, KILIÇ YILDIRIM, GONCA, HARMANCI, KORAY, KÖSE, MEHMET, ÖZDEMİR, ALİ, RAMASLI GÜRSOY, TUĞBA, and ŞEN, VELAT

Published
2021

46. Türkiye Ulusal Kistik Fibrozis Kayıt Sistemi üzerinden kistik fibrozis hastalarında kemik mineral yoğunluğuna etki eden faktörlerin değerlendirilmesi

Author

HARMANCI, KORAY, DOĞRU ERSÖZ, DENİZ, ÖZÇELİK, HAYRİYE UĞUR, ÇAKIR, ERKAN, ÇOBANOĞLU, FATMA NAZAN, ASLAN, AYŞE TANA, SAPAN, NİHAT, BAŞARAN, ABDURRAHMAN ERDEM, BİNGÖL, AYŞEN, KARTAL ÖZTÜRK, GÖKÇEN, DEMİR, ESEN, IRMAK, İLİM, DAMADOĞLU, EBRU, ÇAĞLAR, HANİFE TUĞÇE, TURKUT, ASLI İMRAN, ÜNAL, GÖKÇEN, YAZAN, HAKAN, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ALTINTAŞ, DERYA UFUK, ŞEN, VELAT, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, EMİRALİOĞLU, NAGEHAN, CİNEL, GÜZİN, Gençoğlu, Murat Yasin, TUĞCU, GÖKÇEN DİLŞA, Akyan Soydaş, Şule Selin, ÖZDOĞAN, ŞEBNEM, ÖZDEMİR, ALİ, HANGÜL, MELİH, KÖSE, MEHMET, YÜKSEL, HASAN, KESKİN, ÖZLEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, ASFUROĞLU, PELİN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, KORKMAZ EKREN, PERVİN, TOPAL, ERDEM, ÇALTEPE, GÖNÜL, CAN, DEMET, KILIÇ, MEHMET, and PEKCAN, SEVGİ

Published
2021

47. Ulusal Kistik Fibrozis Kayıt Sisteminde Kayıtlı Kistik Fibrozis Hastalarında Erken Pseudomonas aeruginosa Kolonizasyonu Olan ve Olmayan Hastaların Karşılaştırılması

Author

YAZAN, HAKAN, DOĞRU ERSÖZ, DENİZ, ÖZÇELİK, HAYRİYE UĞUR, ÇAKIR, ERKAN, PEKCAN, SEVGİ, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, KILIÇ, MEHMET, KORKMAZ EKREN, PERVİN, CAN, DEMET, ÇALTEPE, GÖNÜL, TOPAL, ERDEM, ÖZDOĞAN, ŞEBNEM, YÜKSEL, HASAN, KESKİN, ÖZLEM, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, ÖZCAN, GİZEM, ÖZDEMİR, aLİ, HANGÜL, MELİH, KÖSE, MEHMET, HARMANCI, KORAY, SAPAN, NİHAT, BİNGÖL, AYŞEN, BAŞARAN, ABDURRAHMAN ERDEM, DEMİR, ESEN, ASFUROĞLU, PELİN, IRMAK, İLİM, DAMADOĞLU, EBRU, ÇAĞLAR, HANİFE, TURKUT, ASLI İMRAN, KARTAL ÖZTÜRK, GÖKÇEN, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ALTINTAŞ, DERYA UFUK, ŞEN, VELAT, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, EMİRALİOĞLU, NAGEHAN, CİNEL, GÜZİN, ERYILMAZ POLAT, SANEM, TUĞCU, GÖKÇEN DİLŞA, OCAK, ECE, ASLAN, AYŞE TANA, and ÇOBANOĞLU, FATMA NAZAN

Published
2021

48. Ulusal Kistik Fibrozis Kayıt Sisteminde Kayıtlı Kistik Fibrozis Hastalarında Erken Pseudomonasaeruginosa Kolonizasyonu Olan ve Olmayan Hastaların Karşılaştırılması

Author

ŞEN, VELAT, YALÇIN, ELMAS EBRU, KİPER, EMİNE NURAL, ALTINTAŞ, DERYA UFUK, ASFUROĞLU, PELİN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, ÖZDEMİR, ALİ, OCAK, ECE, GAYRETLİ AYDIN, ZEYNEP GÖKÇE, KESKİN, ÖZLEM, YÜKSEL, HASAN, ÖZDOĞAN, ŞEBNEM, ÇOKUĞRAŞ, HALUK CEZMİ, DOĞRU ERSÖZ, DENİZ, EMİRALİOĞLU, NAGEHAN, CİNEL, GÜZİN, Eryımaz polat, Sanem, TUĞCU, GÖKÇEN DİLŞA, TOPAL, ERDEM, ÇALTEPE, GÖNÜL, CAN, DEMET, KORKMAZ EKREN, PERVİN, KILIÇ, MEHMET, PEKCAN, SEVGİ, ÇOBANOĞLU, FATMA NAZAN, ÇAKIR, ERKAN, ÖZÇELİK, HAYRİYE UĞUR, BİNGÖL, AYŞEN, YAZAN, HAKAN, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, ÇAĞLAR, HANİFE TUĞÇE, DAMADOĞLU, EBRU, IRMAK, İLİM, DEMİR, ESEN, KARTAL ÖZTÜRK, GÖKÇEN, BAŞARAN, ABDURRAHMAN ERDEM, SAPAN, NİHAT, ASLAN, AYŞE TANA, HARMANCI, KORAY, KÖSE, MEHMET, HANGÜL, MELİH, and ÖZCAN, GİZEM

Published
2021

49. Ülkemizde Kistik Fibrozis Yönetiminde Merkezler Arası Farklılıkların Değerlendirilmesi ve Uluslararası Kayıt Sistemleri ile Karşılaştırılması

Author

ASFUROĞLU, PELİN, ÖZDOĞAN, ŞEBNEM, BAŞARAN, ABDURRAHMAN ERDEM, ÖZCAN, DİLEK, BİNGÖL, AYŞEN, ALTINTAŞ, DERYA UFUK, HEPKAYA, EVRİM, SAPAN, NİHAT, ÇEKİÇ, ŞÜKRÜ, DAMADOĞLU, EBRU, IRMAK, İLİM, ERYILMAZ POLAT, SANEM, TUĞCU, GÖKÇEN DİLŞA, ÖZDEMİR, aLİ, HARMANCI, KORAY, KILIÇ BAŞKAN, AZER, KILINÇ, AYŞE AYZIT, ÇOKUĞRAŞ, HALUK CEZMİ, ÇAĞLAR, HANİFE, ÜNAL, GÖKÇEN, TURKUT, ASLI İMRAN, ŞEN, VELAT, ERDEM ERALP, ELA, GÖKDEMİR, YASEMİN, KARADAĞ, BÜLENT TANER, KİPER, EMİNE NURAL, YALÇIN, ELMAS EBRU, EMİRALİOĞLU, NAGEHAN, TOPRAK, ALİ, MOLLA KAFİ, HALE, ÇAKIR, ERKAN, YAZAN, HAKAN, ASLAN, AYŞE TANA, KÖSE, MEHMET, HANGÜL, MELİH, SÜLEYMAN, AYŞE, YÜKSEL, HASAN, KESKİN, ÖZLEM, ÖZCAN, GİZEM, TOPAL, ERDEM, CAN, DEMET, KORKMAZ EKREN, PERVİN, ÇALTEPE, GÖNÜL, KILIÇ, MEHMET, DEMİR, ESEN, ŞİŞMANLAR EYÜBOĞLU, TUĞBA, PEKCAN, SEVGİ, ÇOBANOĞLU, FATMA NAZAN, ÖZÇELİK, HAYRİYE UĞUR, DOĞRU ERSÖZ, DENİZ, and KARTAL ÖZTÜRK, GÖKÇEN

Published
2021

50. Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia

Author

Emiralioğlu, Nagehan, primary, Hekimoğlu, Rümeysa, additional, Kaya, Bengisu, additional, Bilgiç, Elif, additional, Atilla, Pergin, additional, Günaydın, Önder, additional, Tuğcu, Gökçen Dilşa, additional, Polat, Sanem Eryılmaz, additional, Hızal, Mina Gharibzadeh, additional, Yalçın, Ebru, additional, Doğru, Deniz, additional, Kiper, Nural, additional, and Özçelik, Uğur, additional

Published
2022
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