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Human thoracic discs were analyzed for collagen and collagen cross-links to determine the distribution due to segmental, age, and gender influences. Thoracic discs from 26 cadaveric spines (1 to 90 years old) were graded macroscopically, then separated into anular and nuclear samples. Only grade I (i.e., normal) disc samples were selected (n = 209). Pyridinoline and deoxypyridinoline cross-links were initially separated by column chromatography and analyzed by reverse-phase high-pressure liquid chromatography. The collagen content was lower and the extent of pyridinoline and deoxypyridinoline were significantly higher in the nucleus compared with the anulus (p < .001). The collagen content and extent of pyridinoline were significantly lower with increasing age in the anulus and nucleus (p < .001). Young male discs had a significantly higher extent of pyridinoline compared with females (p < .001). Age, gender, and disc region differences were found to have a significant influence on the biochemical composition of the normal disc extracellular matrix.

Individuals with Huntington's disease have a high prevalence of falls, but the specific factors that may increase the risk of falling have not been clearly identified in this clinical population. This study aimed to identify the characteristics of individuals with early to mid‐stage Huntington's disease who had a history of falls, compared with a cohort with no history of falls.Twenty‐four participants (10 non‐fallers and 14 recurrent fallers) with a diagnosis of early to mid‐stage Huntington's disease were included in this study. Falls data were collected using retrospective survey analysis. Participants were assessed using measures of balance (Berg Balance Scale), mobility (Rivermead mobility index [RMI]), fear of falling (Activity‐specific Balance Confidence Scale) and gait (6‐min walk test; 10‐m walk test self‐paced and dual tasking).There was no difference in severity of disease state between fallers (Unified Huntington Disease Rating Scale [UHDRS] motor 25.33) and non‐fallers (UHDRS motor 25.13) (p = 0.97). The prevalence of falls was high with 66.7% of participants reporting at least one fall and 58.3% reporting two or more falls in the past 12 months. There was no difference in age or gender between recurrent fallers and non‐fallers. Recurrent fallers had significantly lower scores on the Activity‐specific Balance Confidence Scale (p < 0.01) and the RMI (p < 0.05). The probability of falling increases rapidly with a RMI score of less than 10.Recurrent falls are common in people with Huntington's disease. Individuals with a history of falls were found to have a greater fear of falling and lower functional mobility performance than those who did not have a history of falls. These measures may be useful in the identification of individuals with Huntington's disease who might benefit from a falls prevention programme. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Introduction: Individuals with Huntington's disease have a high prevalence of falls, but the specific factors that may increase the risk of falling have not been clearly identified in this clinical population. This study aimed to identify the characteristics of individuals with early to mid-stage Huntington's disease who had a history of falls, compared with a cohort with no history of falls., Methods: Twenty-four participants (10 non-fallers and 14 recurrent fallers) with a diagnosis of early to mid-stage Huntington's disease were included in this study. Falls data were collected using retrospective survey analysis. Participants were assessed using measures of balance (Berg Balance Scale), mobility (Rivermead mobility index [RMI]), fear of falling (Activity-specific Balance Confidence Scale) and gait (6-min walk test; 10-m walk test self-paced and dual tasking)., Results: There was no difference in severity of disease state between fallers (Unified Huntington Disease Rating Scale [UHDRS] motor 25.33) and non-fallers (UHDRS motor 25.13) (p = 0.97). The prevalence of falls was high with 66.7% of participants reporting at least one fall and 58.3% reporting two or more falls in the past 12 months. There was no difference in age or gender between recurrent fallers and non-fallers. Recurrent fallers had significantly lower scores on the Activity-specific Balance Confidence Scale (p < 0.01) and the RMI (p < 0.05). The probability of falling increases rapidly with a RMI score of less than 10., Discussion: Recurrent falls are common in people with Huntington's disease. Individuals with a history of falls were found to have a greater fear of falling and lower functional mobility performance than those who did not have a history of falls. These measures may be useful in the identification of individuals with Huntington's disease who might benefit from a falls prevention programme. Copyright © 2014 John Wiley & Sons, Ltd., (Copyright © 2014 John Wiley & Sons, Ltd.)

Study Design: Single-cohort laboratory-based study., Objectives: To measure thoracic spine extension motion during bilateral arm elevation using functional radiography and photographic image analysis., Background: Impairment of thoracic spine extension motion may impact shoulder girdle function. Motion of the thoracic spine during arm movement has not been directly measured using functional radiographic analysis., Methods: In 21 asymptomatic men, thoracic kyphosis was measured in neutral standing and in end-range bilateral arm elevation, using lateral radiographs and photographic image analysis. Using both measurement techniques, the difference in thoracic kyphosis between the 2 body positions was used to quantify the range of extension motion of the thoracic spine. Bland-Altman plots were used to examine the agreement between measurement techniques. The relationship between the amount of thoracic kyphosis in neutral standing and kyphosis in full bilateral arm elevation was also examined., Results: The mean ± SD increase in thoracic extension with bilateral arm elevation was 12.8° ± 7.6° and 10.5° ± 4.4°, when measured from the radiographs and photographs, respectively. There was a significant correlation between the radiographic and photographic measurements of the amount of thoracic kyphosis measured in neutral posture (r = 0.71, P<.01) and for the kyphosis measured in full bilateral arm elevation (r = 0.79, P<.001). The mean difference between the 2 measurement techniques was 2.1° for kyphosis measured in neutral posture and 0.5° when measured in full bilateral arm elevation. The thoracic kyphosis angle measured in neutral posture was strongly correlated with the thoracic kyphosis angle measured in full bilateral arm elevation when measured with both radiographic (r = 0.80, P<.001) and photographic (r = 0.84, P<.001) techniques., Conclusion: In asymptomatic men, bilateral arm elevation is associated with movement of the thoracic spine toward extension, but the amount of movement is variable among individuals.

Study Design: Cross-sectional study., Objectives: To examine extension mobility of the thoracic spine in young, asymptomatic adults, with particular reference to the influence of subject position and magnitude of the thoracic kyphosis., Background: Impairment of thoracic extension motion is commonly associated with mechanical pain disorders in this region of the spine. Knowledge of normal thoracic mobility and the factors that may influence this motion is important in the evaluation and management of thoracic pain disorders., Methods: In 40 asymptomatic adults, the total and regional thoracic extension range of motion was measured using 2-dimensional photographic image analysis. Extension mobility was measured in standing, sitting, prone, and 4-point kneeling. The association between the magnitude of the habitual thoracic kyphosis and extension mobility was also examined., Results: When measured from the habitual standing position, the mean range of flexion was 11.5° (3.7°) and mean extension range was 8.7° (3.7°). Thoracic extension was significantly greater in unloaded positions compared to loaded positions (P<.001). The standing thoracic kyphosis angle was significantly correlated with the end range thoracic extension angle in all positions (r = 0.63-0.79, P<.001). There was a poor correlation between the thoracic kyphosis angle and thoracic extension range of motion in all positions (r = 0.11-0.34, P>.06)., Conclusion: When measured from the habitual standing position, thoracic extension range of motion in young individuals is small and poorly correlated with the magnitude of the standing thoracic kyphosis. Unloaded positions (4-point kneeling and prone), compared to positions that load the spine (standing and sitting), appear to promote a greater range of thoracic extension motion.

The purpose of this study was to evaluate the construct and content validity of the Neck Disability Index (NDI) and the Neck Pain and Disability Scale (NPAD) in patients with chronic, non-traumatic neck pain. Twenty patients (mean age=64.5 years) completed a patient-specific questionnaire, the Problem Elicitation Technique (PET), followed by the NDI and NPAD. Content validity was assessed by comparing the items of the NDI and NPAD with problems identified from the PET. Construct validity of the fixed-item questionnaires was examined by establishing the correlation with each other, and with the PET score. Eleven common problems were identified by patients through the PET, of which six were included in the NDI and seven included in the NPAD. The NDI and NPAD scores were strongly correlated (r=0.86, p<0.01), while the correlation between the PET and the fixed-item questionnaires was moderate (NDI: r=0.62, p<0.01; NPAD: r=0.71, p<0.01). Both the NDI and the NPAD include most of the functional problems common to this patient group, and display good content validity. The PET is better able to evaluate the problems specific to the individual patient and is therefore measuring a somewhat different construct to the fixed-item questionnaires.